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| 1 | Intestinal bile acid physiology and pathophysiology显示文摘Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology. | Olga Martínez-Augustin Fermín Sánchez de Medina | 2008 | World Journal of Gastroenterology2008，14，37： | 7 |
| 2 | IBS and the role of otilonium bromide显示文摘 | Guy Boeckxstaens Enrico S. Corazziari Fermín Mearin Jan Tack | 2013 | International Journal of Colorectal Disease2013，，3： | 4 |
| 3 | Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak: One-Year Follow-up Cohort Study显示文摘 | Fermín Mearin Marc Pérez-Oliveras Antonia Perelló Jaume Vinyet Anabel Iba?ez Jordi Coderch Mónica Perona | 2005 | Gastroenterology2005，，1： | 2 |
| 4 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 5 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 6 | Proteomic characterization by 2-DE in bovine serum and whey from healthy and mastitis affected farm animals显示文摘 | Idoia Alonso-Fauste Marta Andrés María Iturralde Fermín Lampreave Javier Gallart María A. álava | 2011 | Journal of Proteomics2011，，10： | 2 |
| 7 | Depositional control of mineable coal bodies显示文摘 | | 1984 | Spe Publs Lnt Ass Sediment1984，，7： | 1 |
| 8 | Dep- ositional models in coal exploration and mine planning in appalachian region 显示文摘 | HORNE J C FERM J C CARUCCIO F T | 1976 | AAPG Bulletin1976，62，12： | 1 |
| 9 | Molecular typing of isolates of Clostridium perfringens from healthy and diseased pouhry显示文摘 | ENGSTROM B E FERME R C LINDBERG A et a l | 2003 | Vet Microbiol2003，94，3： | 1 |
| 10 | Depositional models in coal exploration and miner planing in Appalachian region 显示文摘 | Horne J C Ferm J C Baganz B P | 1976 | AAPG Bulle- tin1976，62，12： | 1 |
| 11 | Depositional models in coal exploration and mine planning in Appalachian Region显示文摘 | Horne J C Ferm J C | 1978 | AAPG Bulletin1978，62，12： | 1 |
| 12 | The antioxidant activity of wines determined by theABTS^+ * ^+ method: influence of sample dilution and time 显示文摘 | VILLANO D FERM a NDEZ-PACH a N M S A M | 2004 | Talanta2004，64，： | 1 |
| 13 | Viewpoint Invariant Texture Description Using Fractal Analysis显示文摘 | Yong Xu Hui Ji Cornelia Fermüller | 2009 | International Journal of Computer Vision2009，，1： | 1 |
| 14 | Delivering affordable workspace: Perspectives of developers and workspace providers in London显示文摘 | Ferm J | 2014 | Progress in Planning2014，93，10： | 1 |
| 15 | Modulation of anxoxic injury in CNS white matter by adenosine,and interaction between adenosine and GABA显示文摘 | Ferm R Wasnan SG Ransom BR | 1995 | J Neurophysiol1995，72，： | 1 |
| 16 | 显示文摘 | Ferm R J | 1957 | Chem Rev1957，57，4： | 1 |
| 17 | Testing Parabolic Surfaces with Annular Subaperture Interferograms显示文摘 | Ferm$ian Granados-Agust$ian J. Fausto Escobar-Romero Alejandro Cornejo-Rodr$iaguez | 2004 | Optical Review2004，，2： | 1 |
| 18 | Electrosprayionization for mass spectrometry of large biomolecules显示文摘 | FERM J B MANN M MENG C K | 1989 | Science1989，246，4926： | 1 |
| 19 | ,Methane oxidation in soil profiles of Dutch and Finnish coniferous forests with different soil texture and atmospheric nitrogen deposition显示文摘 | MARTIKAINEN P J FERM A | 1997 | Soil Biol Biochem1997，29，： | 1 |
| 20 | Conservative treatment of axillary adenopathy due to probable subclimeal breast cancer显示文摘 | gilcoq J R Calle R Ferme F | 1982 | Arch Surg1982，117，9： | 1 |
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