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| 1 | Remains of the day:Biliary complications related to single-port laparoscopic cholecystectomy显示文摘AIM:To assesse the rate of bile duct injuries(BDI)and overall biliary complications during single-port laparoscopic cholecystectomy(SPLC)compared to conventional laparoscopic cholecystectomy(CLC).METHODS:SPLC has recently been proposed as an innovative surgical approach for gallbladder surgery.So far,its safety with respect to bile duct injuries has not been specifically evaluated.A systematic review of the literature published between January 1990 and November 2012 was performed.Randomized controlled trials(RCT)comparing SPLC versus CLC reporting BDI rate and overall biliary complications were included.The quality of RCT was assessed using the Jadad score.Analysis was made by performing a meta-analysis,using Review Manager 5.2.This study was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.A retrospective study including all retrospective reports on SPLC was also performed alongside.RESULTS:From 496 publications,11 RCT including 898patients were selected for meta-analysis.No studies were rated as high quality(Jadad score≥4).Operative indications included benign gallbladder disease operated in an elective setting in all studies,excluding all emergency cases and acute cholecystitis.The median follow-up was 1 mo(range 0.03-18 mo).The incidence of BDI was 0.4%for SPLC and 0%for CLC;the difference was not statistically different(P=0.36).The incidence of overall biliary complication was 1.6%for SPLC and 0.5%for CLC,the difference did not reached statistically significance(P=0.21,95%CI:0.66-15).Sixty non-randomized trials including 3599 patients were also analysed.The incidence of BDI reported then was 0.7%.CONCLUSION:The safety of SPLC cannot be assumed,based on the current evidence.Hence,this new technology cannot be recommended as standard technique for laparoscopic cholecystectomy. | Pierre Allemann Nicolas Demartines Markus Schfer | 2014 | World Journal of Gastroenterology2014，20，3： | 14 |
| 2 | 回顾性分析中对计算机化压力-流率测定数据的质量控制及其效果显示文摘目的 在回顾性分析中对计算机化的压力 流率测定数据进行质量控制 ,比较质控前后数据以说明各种赝像对结果分析的影响 ,阐明回顾性质量控制的必要性。 方法 对 5 82条计算机制作的压力 流率曲线进行人工抹平更正 ,并读出最大尿流率 (Qmax)及其对应的逼尿肌压力(Pdet.Qmax) ,应用梗阻系数 (OCO)检测尿道阻力、国际尿控协会 (ICS)列线图分类和诊断梗阻、Sch fer列线图对梗阻进行分级。人工阅读结果与计算机读取结果进行统计学比较。 结果 人工更正后Qmax呈现一致性降低 (P <0 .0 0 1) ,平均降低 1.17ml/s,83.1%曲线的人工阅读值Qmax降低范围在 0 .1~ 1.9ml/s;Pdet.Qmax呈非显著性下降 (P >0 .0 5 ) ,平均降低 0 .75cmH2 O(1cmH2 O =0 .0 98kPa) ;OCO呈显著性增高 (P <0 .0 5 ) ,平均增高 0 .0 6 7。人工更正后 ,梗阻分布与程度出现显著性差别 ,ICS列线图梗阻百分数由 6 9.8%增至 73.9% (P <0 .0 5 ) ,非梗阻由 8.8%降至 5 .3% (P <0 .0 5 ) ;Sch fer列线图梗阻百分数由 72 .5 %增至 77.3% (P <0 .0 1) ,非梗阻由 9.1%降至 5 .5 % (P <0 .0 1)。使用ICS列线图及Sch fer列线图 ,人工更正后分别有 11.0 %和 2 8.9%的曲线改变了在列线图中的分类或分级 ;分别有 6 .9%及 7.2 | 廖利民 Werner Schfer | 2002 | 中华泌尿外科杂志2002，23，5： | 13 |
| 3 | 青藏高原中东部第四纪冰碛物暴露年龄的测定及其意义显示文摘青藏高原上大面积的冰盖通常会对亚洲乃至全球气候产生深远的影响。青藏高原第四纪冰川形成的时间和范围成为人们关注的热点。本研究利用就地成因的宇宙核素暴露年龄测定方法,对唐古拉山和理塘地区的第四纪冰碛物进行了^10Be、^28Al和^21Ne暴露年龄测定,首次获得了青藏高原的第四纪冰川核素暴露年龄。三种核素暴露年龄的一致性显示每期冰碛物沉积有一个确定的暴露时期,测试结果表明唐古拉山和理塘地区出现了两期第四纪冰期,一期形成于距今1.6~8万年,另一期形成于距今16-18万年。 | 赵志中 乔彦松 Joerg SCHFER 王燕 王敏 Christian SCHLüCHTER | 2006 | 地学前缘2006，13，5： | 9 |
| 4 | Thermophysical properties of the Ni-based alloy Nimonic 80A up to 2400 K显示文摘Nimonic 80A is a nickel-chromium alloy which is strengthened by additions of titanium and aluminium. The alloy is used for high temperature, high strength applications. Wire shaped Nimonic 80A samples are resistively volume heated as part of a fast capacitor discharge circuit. Time resolved measurements with sub-μs resolution of current through the specimen are performed with a Pearson probe, voltage drop across the specimen is measured with knife-edge contacts and ohmic voltage dividers and the radiance temperature of the sample with a pyrometer. These measurements allow to de- termine heat of fusion as well as heat capacity and electrical resistivity at initial geometry of Nimonic 80A as a function of temperature in the solid and in the liquid phase up to 2400 K. | B.Wilthan R.Tanzer W.Schützenhfer G.Pottlacher | 2006 | Rare Metals2006，25，5： | 5 |
| 5 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 6 | Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C显示文摘AIM: To assess systematically the spectrum and extent of depressive symptoms comparing patient groups receiving peginterferon or conventional interferon.METHODS: Ninety-eight patients with chronic hepatitis C and interferon-based therapy (+ribavirin) were consecutively enrolled in a longitudinal study. Patients were treated with conventional interferon alfa-2b (48/98patients; 5 MIU interferon alfa-2b thrice weekly) or peginterferon alfa-2b (50/98 patients; 80-150 μgpeginterferon alfa-2b) in combination with weight-adapted ribavirin (800-1 200 mg/d). Repeated psychometric testing was performed before, three times during and once after antiviral therapy: Depression was evaluated by the Hospital Anxiety and Depression Scale (HADS), anger/hostility by the Symptom Checklist-90 Items Revised (SCL-90-R).RESULTS: Therapy with pegylated interferon alfa-2bproduces comparable scores for depression (ANOVA:P = 0.875) as compared to conventional interferon.Maximums of depression scores were even higher and cases of clinically relevant depression were frequent during therapy with peginterferon. Scores for anger/hostility were comparable for both therapy subgroups.CONCLUSION: Our findings suggest that the extent and frequency of depressive symptoms in total are not reduced by peginterferon. Monitoring and management of neuropsychiatric toxicity especially depression have to be considered as much as in antiviral therapy with unmodified interferon. | Michael R Kraus Arne Sch(a|¨)fer Herbert Csef Michael Scheurlen | 2005 | World Journal of Gastroenterology2005，11，12： | 5 |
| 7 | 采用自适应算法进行便携式电池电量的计量显示文摘 | Yevgen Barsukov Bernd Krafth fer | 2004 | 电子设计应用2004，，10： | 4 |
| 8 | Effects of sleep bruxism on functional and occlusal parameters:a prospective controlled investigation显示文摘This study was conducted to verify the results of a preceding retrospective pilot study by means of a prospective controlled investigation including a larger sample size.Therefore,the aim of this clinical investigation was to analyze the relationship between sleep bruxism and several functional and occlusal parameters.The null hypothesis of this study was that there would be no differences among sleep bruxism subjects and non-sleep bruxism controls regarding several functional and occlusal parameters.Fifty-eight sleep bruxism subjects and 31 controls participated in this study.The diagnosis sleep bruxism was based on clinical criteria of the American Academy of Sleep Medicine.Sixteen functional and occlusal parameters were recorded clinically or from dental study casts.Similar to the recently published retrospective pilot study,with a mean slide of 0.77 mm(s.d.,0.69 mm) in the sleep bruxism group and a mean slide of 0.4 mm(s.d.,0.57 mm) in the control group,the evaluation of the mean comparison between the two groups demonstrated a larger slide from centric occlusion to maximum intercuspation in sleep bruxism subjects(Mann-Whitney U-test;P50.008).However,following Bonferroni adjustment,none of the 16 occlusal and functional variables differed significantly between the sleep bruxism subjects and the non-sleep bruxism controls.The present study shows that the occlusal and functional parameters evaluated do not differ between sleep bruxism subjects and non-sleep bruxism subjects.However,as the literature reveals a possible association between bruxism and certain subgroups of temporomandibular disorders,it appears advisable to incorporate the individual adaptive capacity of the stomatognathic system into future investigations. | Michelle Alicia Ommerborn Maria Giraki Christine Schneider Lars Michael Fuck Jrg Handschel Matthias Franz Wolfgang Hans-Michael Raab Ralf Schfer | 2012 | International Journal of Oral Science2012，4，3： | 4 |
| 9 | Weak Vertical Diffusion Allows Maintenance of Cold Halocline in the Central Arctic显示文摘In spring preceding the record minimum summer ice cover detailed microstructure measurements were made from drifting pack ice in the Arctic Ocean, 110 km from the North Pole. Profiles of hydrography, shear, and temperature microstructure collected in the upper water column covering the core of the Atlantic Water are analyzed to determine the diapycnal eddy diffusivity, the eddy diffusivity for heat, and the turbulent flux of heat. Turbulence in the bulk of the cold halocline layer was not strong enough to generate significant buoyancy flux and mixing. Resulting turbulent heat flux across the upper cold halocline was not significantly different than zero. The results show that the low levels of eddy diffusivity in the upper cold halocline lead to small vertical turbulent transport of heat, thereby allowing the maintenance of the cold halocline in the central Arctic. | Ilker FER | 2009 | Atmospheric and Oceanic Science Letters2009，2，3： | 3 |
| 10 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 11 | Amifostine enhances the antioxidant and hepatoprotective effects of UW and HTK preservation solutions显示文摘AIM:To investigate whether amifostine contributes to the antioxidant and cytoprotective effects of histidinetryptophan-ketoglutarate(HTK)and University of Wisconsin(UW)preservation solutions.METHODS:Forty-eight Sprague Dawley male ratswere equally divided into six groups:(1)ringer Lactate(RL)group;(2)RL+amifostine(RL+A)group;(3)HTK group;(4)HTK+A group;(5)UW group;and(6)UW+A group.Rats in the RL+A,HTK+A and UW+A groups were administered amifostine intraperitoneally at a dose of 200 mg/kg prior to laparotomy.The RL group was perfused with RL into the portal vein.The RL+A group were perfused with RL into the portal vein after amifostine administration.The HTK group received an HTK perfusion while the HTK+A group received an HTK perfusion after administration of amifostine.The UW group received a perfusion of UW,while the UW+A group received a UW perfusion after amifostine administration.Liver biopsy was performed to investigate histopathological,immunochemical[transferase mediated dUTP nick end labeling(TUNEL),inducible nitric oxide syntetase(iNOS)]and ultrastructural alterations.Biochemical alterations were determined by examining levels of alanine aminotransferase,alkaline phosphatase and nitric oxide in the perfusion fluid.RESULTS:Pathological sinusoidal dilatation and centrilobular hydropic alteration were significantly lower in the groups that received amifostine prior to preservation solution perfusion.Although the best results were obtained in the UW+A group,we did not observe a statistically significant difference between the UW+A and HTK+A groups.iNOS grades were significantly lower in the amifostine groups 12 h after treatment.When the amifostine groups were compared against each other,the iNOS grades obtained from the UW+A and HTK+A groups were similar while the RL+A group had a much poorer score.TUNEL assays demonstrated a lower apoptosis ratio in the amifostine groups than in the non-amifostine groups 12 h after treatment.No statistically significant difference was observed between the UW+A and HTK+A groups for apoptosis.Cellular ultrastructure was best preserved in the UW+A and HTK+A groups.CONCLUSION:Here,we show that preoperative administration of a single dose of amifostine is sufficientto minimize the preservation damage in hepatic cells. | Sami Akbulut Sinasi Sevmis Hamdi Karakayali Nilüfer Bayraktar Muge Unlukaplan Ergun Oksuz Atilla Dagdeviren | 2014 | World Journal of Gastroenterology2014，20，34： | 3 |
| 12 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 13 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 14 | 型煤用粘结剂的种类和成分显示文摘0 前言粘结剂指的是可把粉煤粘结起来制成型煤的物质。凡是与煤亲合且能在冷却和硬化后形成坚实固体的物质,均可作为型煤粘结剂。型煤粘结剂的历史可上(?)到16世纪中叶,但直到1832年由E.Marsais申请的专利才带来了技术上的突破。他采用煤焦油沥青作为粘结剂,明显地提高了型煤强度。直到1976年,煤焦油沥青一直是最主要的型煤粘结剂。但是,在1974年颁布了严格的环保条例,限制了煤焦油沥青的广泛应用。因此人们转而采用石油沥青或木质素磺酸盐水溶液作为代用粘结剂。人们也曾对聚氨酯等塑性物料作了不少实验。 | H.G.Sch(a|¨)fer 林文元 | 1989 | 煤炭综合利用译丛1989，，3： | 2 |
| 15 | Lyocell纤维和羊毛混纺物的染色显示文摘介绍了Lyocell和与羊毛混纺的Lyocell的染色。Lyocell在短时间和低温(室温、60℃、80℃)条件下用直接染料进行染色,具有高的匀染性,色泽深并具有足够好的耐水洗牢度。但是,Lyocell只有在温度T>80℃和时间t>30min下染色,直接染料才能完全透过Lyocell纤维的整个纤维截面。直接染料和酸性染料、2:1金属络合染料和反应性染料的混合物对Lyocell纤维和羊毛混纺物进行染色,可获得良好的匀染性、深色泽、同色调深浅效果和对纤维质量没有损伤的耐水牢度。Lyocell/羊毛混纺物运用一浴法,在95℃下染色30min效果最佳。 | K.Schfer 彭燕红 | 1998 | 国际纺织导报1998，0，2： | 2 |
| 16 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 17 | ACCF 2012 Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations显示文摘 | L. Kristin Newby Robert L. Jesse Joseph D. Babb Robert H. Christenson Thomas M. De Fer George A. Diamond Francis M. Fesmire Stephen A. Geraci Bernard J. Gersh Greg C. Larsen Sanjay Kaul Charles R. McKay George J. Philippides William S. Weintraub | 2012 | Journal of the American College of Cardiology2012，，23： | 2 |
| 18 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 19 | 北冰洋上层双扩散阶梯热通量的分析显示文摘北冰洋中,低温低盐的上层水与高温高盐的大西洋水之间,广泛存在着稳定的双扩散阶梯。基于锚定剖面仪、冰基剖面仪和微结构剖面仪的数据,对温盐廓线中的阶梯进行研究,分析阶梯的热通量。固定跟踪了锚定剖面仪的3个阶梯,研究阶梯参数随时间的变化。发现由经验公式得出的上下两界面的热通量差,与混合层内热量的变化有较好的相关性。利用微结构剖面仪数据,计算阶梯界面通过分子热传导输送的热通量。当选取最大位温梯度时,算出的传导热通量与经验公式算出的热通量接近。因此,实验室研究得到的热通量经验公式,可以用于计算北冰洋双扩散阶梯的热通量。 | 宋雪珑 周生启 Ilker Fer | 2014 | 海洋学报2014，36，1： | 2 |
| 20 | Computed tomography in gastrointestinal stromal tumors显示文摘 | Nadir Ghanem Carsten Altehoefer Alex Furtw?ngler Jan Winterer Oliver Sch?fer Oliver Springer Elmar Kotter Mathias Langer | 2003 | European Radiology2003，，7： | 2 |
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