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| 1 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 2 | Contribution of platelets to tumour metastasis显示文摘 | GAY L J FELDING HABERMANN B | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 3 | Proving a distribution-free generation of the Condorcet Jury theorem 显示文摘 | Owen G B Grofman B Feld S L | 1989 | Mathematical Social Science1989，17，： | 1 |
| 4 | Hepatitis B Virus S Gene Mutations in a Patient With Chronic Active Hepatitis With Circulating Anti-HBs Antibodies 显示文摘 | Mathet VL Feld M Espinola L | 2003 | J Med Virol2003，69，1： | 1 |
| 5 | Quenchant performance analysis using computer simulation 显示文摘 | RETI T FELDE I HORVATH L | 1996 | Heat Treatment of Metals1996，，1： | 1 |
| 6 | Quenchant Performance Analysis Computer Simulation显示文摘 | Reti T Felde I Horvath L | 1996 | Heat Treatment of Metals1996，，1： | 1 |
| 7 | Employee ownership:A conceptual model of process and effects显示文摘 | Pierce J L Ruben feld SA and Morgan S | 1991 | Academy of Management Review1991，16，1： | 1 |
| 8 | Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection显示文摘 | Chen L Borozan I Feld J | 2005 | Gastroenterolo- gy2005，128，5： | 1 |
| 9 | A functional role for KLF6- SV1 in lung adenocarcinoma prognosis and chemotherapy response 显示文摘 | DiFeo A Feld L Rodriguez E | 2008 | CancerRes2008，68，4： | 1 |
| 10 | Acute Spontaneous tumor lysis syndrome in adenocarcinoma of the lung a case report显示文摘 | Feld J Mehta H Burkes R L | 2000 | Am J Clin Oncol2000，23，： | 1 |
| 11 | New therapeutic agents for chronic hepatitis B显示文摘 | Mayur Brahmania Jordan Feld Ambreen Arif Harry L A Janssen | 2016 | The Lancet Infectious Diseases2016，，2： | 1 |
| 12 | Rendering unto caesar or electioneering forcaesar?Loss of church tax exemption for participation inelectoral politics显示文摘 | FELD ALAN L | 2001 | Boston College Law Review2001，2001，： | 1 |
| 13 | Screening dipstick urinalysis: a time to change显示文摘 | Kaplan R E Springate J E Feld L G | 1997 | Pediatrics1997，100，6： | 1 |
| 14 | Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circula- ting anti -HBs antibodies显示文摘 | MATHET V L FELD M ESPINOLA L | 2003 | J Med Virol2003，69，1： | 1 |
| 15 | Detecting measurement bias in respondent reports of personal networks显示文摘 | FELD S L CARTER W C | 2002 | Social Networks2002，24，： | 1 |
| 16 | Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circulating anti-HBs antibodies显示文摘 | MATHET VL FELD M ESPINOLA L | 2003 | J Med Virol2003，69，： | 1 |
| 17 | The impact of referendums on the centralization of public goods provi- sion: A political economy approach 显示文摘 | Schnellenbach J Feld L P Schaltegger C | 2010 | Economics of Governance2010，11，： | 1 |
| 18 | Safety of kidney biopsy in pedi atric transplantation : a report of the Controlled Clinical Trials in Pedi atric Transplantation Trial of Induction Therapy Study Group 显示文摘 | Benfield M R Herrin J Feld L | 1999 | Transplantation1999，67，4： | 1 |
| 19 | Safety of kidney biopsy in pediatric transplantation:a report of the controlled clinical trials in pediatric transplantation trial of induction therapy study group显示文摘 | BENFIELD MR HERRIN J FELD L | 1999 | Transplantation1999，67，： | 1 |
| 20 | Selective pressure affects transfer and establishment of a Lactobacillus plantarum resistance plasmid in the gastrointestinal environment显示文摘 | FELD L SCHJORRING S HAMMER K | 2008 | Journal of Antimicrobial Chemotherapy2008，61，4： | 1 |
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