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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 3 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 4 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 5 | Combined aniridic intrancular lens implantation and vitreoretinal surgery显示文摘 | Mehta H Jayaclev C Natarajan S | 2007 | Indian J Ophthalmol2007，55，5： | 1 |
| 6 | Concrete deterioration from physical attack by salts 显示文摘 | Haynes H O’Neill R Mehta P K | 1996 | Concr Int1996，18，1： | 1 |
| 7 | Clinical profiles and outcomes of acute type B aortic dissection in the current erat lessons from the international registry of aortic dissection(IRAD) 显示文摘 | Suzki T Mehta R H Ine H | 2003 | Circulation2003，108，11： | 1 |
| 8 | Studies on pendimethalin and fluchloralin residues in soil and onion 显示文摘 | Sharma R Mehta H M | 1989 | Indian J Agron1989，34，2： | 1 |
| 9 | Simulaneous pattern reversal ERG and VEP recordings effect of stimnlus field and central scotoma显示文摘 | Sakaue H Katsumi O Mehta M | 1990 | Imest Ophthalmol Vis Sci1990，31，： | 1 |
| 10 | Vector Analysis and Cintrol of Advanced Static VAR Compensators显示文摘 | Schauder C D Mehta H | 1993 | IEE Proceedings-C1993，140，4： | 1 |
| 11 | Disc degeneration as-sessed by quantitative T2* (3'2 Star) correlated with functional lumbar mechanics显示文摘 | Ellingson AM Mehta H Polly DW | 2013 | Spine2013，38，24： | 1 |
| 12 | Assessment of liver fibrosis by Transient Elastography in Persons with Hepatitis C Virus Infection or HIV-Hepatitis C Virus Coinfection显示文摘 | Gregory D Kirk Jacquie Astemborski Shruti H Mehta | 2009 | Clin infect Dis2009，48，7： | 1 |
| 13 | The social endocrinology of dominance: Basal testosterone predicts cortisol changes and behavior following victory and defeat显示文摘 | MEHTA P H JONES A C JOSEPHS R A | 2008 | Journal of Personality & Social Psychology2008，，94： | 1 |
| 14 | Vector analysis and control of advanced static VAR compensators显示文摘 | Schauder C Mehta H | 1993 | IEE Proceedings Generation Transmission and Distribution1993，140，4： | 1 |
| 15 | The levels of leptin adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia 显示文摘 | Hendler I Blackwell S C Mehta S H | 2005 | Am J Obstet Gynevol2005，193，32： | 1 |
| 16 | Aortic remodeling in type B aortic dissection:effects of endoascular stent-graft repair and medical treatment on true and false lumen olumes显示文摘 | Huptas S Mehta RH Kühl H | 2009 | J Endoasc Ther2009，16，1： | 1 |
| 17 | Human urotensin Ⅱ modulates collagen synthesis and the expression of MMP-1 in human endothelial cells显示文摘 | Mehta JL Chen K Zhang X Li D | 2004 | J Cardiovasc Pharmacol2004，44，5： | 1 |
| 18 | Syncope in acute aortic dissection :diagnostic, prognostic, and clinical implication显示文摘 | NALLAMOTHU B K MEHTA R H SAINT S | 2002 | Am J Med2002，113，： | 1 |
| 19 | ITF2 is a target of CXCR4 in MDA-MB-231 breast eaneer cells and is associated with reduced survival in estrogen reeeptor-negative breast cancer 显示文摘 | Appaiah H Bhat-Nakshatri P Mehta R | 2010 | Cancer Biol Ther2010，10，6： | 1 |
| 20 | Asynchronous interference mitigation in cooperative base station systems显示文摘 | Zhang H Mehta N B Molisch A F | 2008 | IEEE Transactions on Wireless Communications2008，7，1： | 1 |
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