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| 1 | SHRIMP U-Pb zircon age of the Jinbaoshan ultramafic intrusion,Yunnan Province,SW China显示文摘SHRIMP U-Pb zircon dating gives ages of 260.6 ± 3.5 Ma and 260.7 ± 5.6 Ma for serpentinised wehrlite and plag-hornblendite in the Jinbaoshan ultramafic intrusion,respectively. The results indicate that the Jinbaoshan intrusion was emplaced at ca.260 Ma and contemporaneous with the Emeishan continental flood basalts (ECFB),similar to other mafic-ultramafic intrusions of the Emeishan large igneous prov-ince (LIP). The new ages provide a geochronological constraint on the origin of the Jinbaoshan ul-tramafic intrusion. It confirms that the Jinbaoshan ultramafic intrusion belongs to the Emeishan LIP that formed at ca. 260 Ma. | TAO Yan MA YanSheng MIAO LaiCheng ZHU FeiLin | 2009 | Chinese Science Bulletin2009，54，1： | 16 |
| 2 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 3 | Distribution and existing state of indium in the Gejiu Tin polymetallic deposit, Yunnan Province, SW China显示文摘The Gejiu tin polymetallic deposit, located in the southwest margin of the South China Belt bordering on the Yangtze Block, is hosted in Triassic carbonates. This study shows that there is an indium enrichment in the ores.Indium mainly exists in sphalerite-rich massive sulfide ores with a concentration of 198.3–1570 ppm; the indium concentration in sphalerite ranges from 493.3 up to4781 ppm. The inferred indium reserve in the Gejiu Sn deposit is over 4000 t, indicating that the Gejiu tin deposit is a giant In-bearing Sn-polymetallic deposit, similar to the Dachang and Dulong in southwest China. Sphalerite with a high Fe value(8.05–13.27 wt%) is the predominant indium carrier mineral; meanwhile chalcopyrite plays the secondary indium carrier role. EPMA mapping result shows that indium is likely distributed homogeneously and presented as a substitution for Zn in sphalerite. | Yubang Li Yan Tao Feilin Zhu Mingyang Liao Feng Xiong Xianze Deng | 2015 | Chinese Journal Of Geochemistry2015，34，4： | 7 |
| 4 | Geochemical Characteristics and Metallogenesis of the Qingkuangshan Ni-Cu-PGE Mineralized Mafic-Ultramafic Intrusion in Huili County, Sichuan Province, SW China显示文摘The Qingkuangshan Ni-Cu-PGE deposit, located in the Xiaoguanhe region of Huili County, Sichuan Province, is one of several Ni-Cu-PGE deposits in the Emeishan Large Igneous Province (ELIP). The ore-bearing intrusion is a mafic-ultramafic body. This paper reports major elements, trace elements and platinum-group elements in different types of rocks and sulfide-mineralized samples in the intrusion. These data are used to evaluate the source mantle characteristics, the degree of mantle partial melting, the composition of parental magma and the ore-forming processes. The results show that Qingkuangshan intrusion is part of the ELIP. The rocks have trace element ratios similar to the coeval Emeishan basalts. The primitive mantle-normalized patterns of Ni-Cu-PGE have positive slopes, and the ratios of Pd/Ir are lower than 22. The PGE compositions of sulfide ores and associated rocks are characterized by Ru depletion. The PGE contents in bulk sulfides are slightly depleted relative to Ni and Cu, which is similar to the Yangliuping Ni-Cu-PGE deposit. The composition of the parental magma for the intrusion is estimated to contain about 14.65 wt% MgO, 48.66 wt% SiO2 and 15.48 wt% FeOt, and the degree of mantle partial melting is estimated to be about 20%. In comparison with other typical Ni-Cu-PGE deposits in the ELIP, the Qingkuangshan Ni-Cu-PGE deposit has lower PGE contents than the Jinbaoshan PGE deposit, but has higher PGE contents than the Limahe and Baimazhai Ni-Cu deposit, and has similar PGE contents to the Yangliuping Ni-Cu-PGE deposit. The moderate PGE depletions in the bulk sulfide of the Qingkuanghan deposit suggest that the parental magma of the host intrusion may have undergone minor sulfide segregation at depth. The mixing calculations suggests that an average of 10% crustal contamination in the magma, which may have been the main cause of sulfide saturation in the magma. We propose that sulfide segregation from a moderately PGE depleted magma took place prior to magma emplacement at Qingkuangshan, that small amounts of immiscible sulfide droplets and olivine and chromite crystals were suspended in the ascending magma, and that the suspended materials settled down when the magma passed trough the Qingkuangshan conduit. The Qingkuangshan sulfide-bearing intrusion is interpreted to a feeder of Emeishan flood basalts in the region. | ZHU Feilin TAO Yan HU Ruizhong MA Yansheng | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 5 |
| 5 | High-resolution algorithm based on temporal-spatial extrapolation显示文摘To enhance the resolution of parameter estimation with limited samples received by a short passive array, an iterative nonparametric algorithm for estimating the frequencies and direction-of-arrivals (DOAs) of signals is proposed. The cost function is constructed using l2-norm Gaussian entropy combined with an additional constraint, l2-norm constraint or linear constraint. By minimizing the cost functions in the temporal and the spatial dimensions using corresponding iteration algorithms respectively, the sparse discrete Fourier transforms (DFTs) of temporal and spatial samples are obtained to represent the extrapolated sequences with much larger sizes than the original samples. Then frequency and angle estimates are obtained by performing the traditional simple methods on the extrapolated sequences. It is shown that the proposed algorithm offers increased resolution and significantly reduced sidelobes compared with the periodogram and beamforming based methods. And it achieves high precision compared with the high-resolution method with lower computational burden. Some numerical simulations and real data processing results are presented to verify the effectiveness of the method. | Xueya Yang Baixiao Chen Feilin Qi | 2010 | Journal of Systems Engineering and Electronics2010，21，1： | 3 |
| 6 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 7 | The isolation and characterization of Pik, a rice blast resistance gene which emerged after rice domestication显示文摘 | ChunZhai FeiLin ZhongqiuDong XiuyingHe BinYuan XiaoshanZeng LingWang QinghuaPan | 2010 | New Phytologist2010，，1： | 1 |
| 8 | Feasibility of sentinel lymph node biopsy omission after integration of ^(18)F-FDG dedicated lymph node PET in early breast cancer: a prospective phase II trial显示文摘Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast cancer.The present study aimed to evaluate the negative predictive value(NPV)of 18F-FDG dedicated lymph node positron emission tomography(LymphPET)in cN0 patients.Methods:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by SLNB.In the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of LymphPET.Here,we report the results of the first stage.The primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological reports.Forty patients had LN-macro,and 16 patients had only lymph node micrometastasis.Of the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET. | Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang Feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 9 | Syn-collision Biotite Hornblende Granodiorite from the Zedong Area,Tibet:Zircon U–Pb Isotope Chronology,Petro-geochemistry,and Geodynamic Significance显示文摘Cu–Au mineralization is rare in the Jurassic–Early Tertiary batholiths related to the India–Asia collision. Geochemical analysis and U–Pb isotope chronology was carried out on Shuangbujiere biotite hornblende granodiorite from the Zedong area. Zircon grains of the biotite hornblende granodiorite show oscillatory growth zonation and have high Th/U ratios of 1.08–2.39, indicating a magmatic origin for the zircons. Geochrological test yielded a LA-ICP-MS U-Pb age of 51.5±1.0 Ma, suggesting that the emplacement age of the biotite hornblende granodiorite is Early Eocene. The Shuangbujiere biotite hornblende granodiorites have geochemical features characteristic of adakite and are associated with a calc–alkaline metaluminous I-type granite enriched in Sr, high in Mg~#(49.6–54.9) and Sr/Y, and depleted in Y and Yb. These results indicate that this intrusion formation may have been associated with crustal thickening caused by the early collision of the Indian and Eurasian Plates. As the process of crustal thickening continued, the heating of the underplated basaltic magma caused the thickened lower crust amphibolite to dehydrate the melt and form a high-K calc–alkaline adakitic melt at about 848°C. Meanwhile, magma mixing of the underplated basaltic melt and high-K calc–alkaline adakitic melt formed a high-Mg# adakite representative of the sys-collisional tectonic setting. | ZHU Feilin SHI Zeming XIONG Fuhao NI Shijun BAI Mei | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 1 |
| 10 | Heterogeneity between primary colon carcinoma and paired lymphatic andhepatic metastases显示文摘 | Huanrong Lan Ketao Jin Bojian Xie Na Han Binbin Cui Feilin Cao Lisong Teng | 2012 | Molecular Medicine Reports2012，，5： | 1 |
| 11 | Assessment of the influence of climate factors on condition levels of voatile organic compounds (VOCs)in Canadian Homes 显示文摘 | Feilin P Otson R | 1994 | Atmospheric Environmenment1994，28，： | 1 |
| 12 | High-resolution Algorithm Based on Temporal-spatial Extrapolation显示文摘 | Yang Xueya Chen Baixiao Qi Feilin | | 0，，01： | 1 |
| 13 | G-quadruplexes folding mediates downregulation of PBX1 expression in melanoma显示文摘Dear Editor,Pre-B-cell leukemia homeobox transcription factor 1(PBX1)is identified at t(1;19)chromosomal translocations in acute pre-B-cell leukemia and is involved in regulating multiple biological processes.1 Importantly,accumulating evidence have suggested that dysregulation of PBX1 have been shown to be involved in tumorigenesis,poor prognosis and drug resistance.1 It has been shown that the expression of PBX1 is increased in melanoma cells and overexpression of PBX1 significantly promotes the melanoma cell growth. | Yutong Sui Feilin Liu Song Zheng Xiaomei Liu Pingli Sun Chunli Yao Yingyao Zhang Hongwen Gao Xinghua Gao Jinyu Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 14 | Geochemical characteristics of the platinum-group elements in the Abulangdang ultramafic intrusion,Sichuan Province,China显示文摘The contents of the platinum-group elements (PGEs: Os, Ir, Ru, Rh, Pt, Pd) in the Abulangdang ultramafic intrusion have been determined using ICP-MS after nickel sulfide fire assay preconcentration. Different samples show significant differences in absolute PGE abundance. They display a pronounced negative incline in mantle-normalized patterns which are characterized by strong enrichment in IPGEs (Os, Ir, Ru) and depleting to slight enrichment in PPGEs (Rh, Pt, Pd). The characteristics of PGE distribution in the Abulangdang rocks are due to the combined action of sulfide and non-sulfide (spinel/chromite or alloy or micro-granular aggregation of metals). In comparison with the mafic-ultramafic rocks which host Ni-Cu-PGE deposits in the Emeishan Large Igneous Province (ELIP), it is assumed that the Abulangdang ultramafic intrusion may be the product of early-stage magma activity in the ELIP. | MA Yansheng TAO Yan ZHONG Hong ZHU Feilin ZHOU Jiaxi | 2009 | Chinese Journal Of Geochemistry2009，28，3： | 0 |
| 15 | Assessment of Urban Climate Environment and Configuration of Ventilation Corridor:A Refined Study in Xi'an显示文摘Integrating urban spatial landscape(USL) parameters into refined climate environment assessment is important. By taking the central urban area(CUA) of Xi’an, China as an example, this study develops an evaluation method based on Urban Climatic Map(UCMap) technology. We define surface urban heat island intensity(SUHI) and surface ventilation potential coefficient(VPC), which can effectively reflect local urban climate. Based on SUHI and VPC,we analyze the influences of seven typical USL metrics including building height(BH), building density(BD), floor area ratio(FAR), sky view factor(SVF), frontal area index(FAI), surface roughness length(RL), and vegetation cover(VC). Then, we construct a comprehensive evaluation model and create an urban climate zoning map on a 100-m resolution. The climate optimization on the map is performed for configuration of possible ventilation corridors and identification of associated control indicators. The results show that the main factors affecting SUHI in the CUA of Xi’an are VC and BD, which explain 87.9% of the variation in SUHI, while VPC explains 50% of the variation in SUHI. The main factors affecting VPC are BH, FAR, FAI, and RL, all of which contribute to more than 95% of the variation in VPC. The evaluation model constructed by SUHI, VPC, and VC can divide the CUA into climate resource spaces, climate preservation spaces, climate sensitive spaces, and climate restoration spaces. On this basis, a ventilation corridor network of 3 level-1 corridors(each over 500 m wide), 6 level-2 corridors(each over 500 m wide) and 13 level-3 corridors(each over 50 m wide) is established. Meanwhile, the main quantitative control indicators selected from the USL metrics are proved to be capable of ensuring smooth implementation of the planned corridors at different levels. | Bing DANG Yonghong LIU Hongliang LYU Xia ZHOU Wupeng DU Chunyi XUAN Pei XING Ruozi YANG Feilin XIONG | 2022 | Journal of Meteorological Research2022，36，6： | 0 |
| 16 | A nomogram to predict adjuvant chemotherapy recommendation in breast cancer patients with intermediate recurrence score显示文摘Objective: The indication of adjuvant chemotherapy recommendation(ACR) in breast cancer patients with intermediate recurrence score(RS) is controversial. This study investigated the relationship between routine clinicopathological indicators and ACR, and established a nomogram for predicting the probability of ACR in this subset of patients.Methods: Data for a total of 504 consecutive patients with intermediate RS from January 2014 to December2016 were retrospectively reviewed. A nomogram was constructed using a multivariate logistic regression model based on data from a training set(378 cases) and validated in an independent validation set(126 cases). A Youdenderived cut-off value was assigned to the nomogram for accuracy evaluation.Results: The multivariate logistic regression analysis identified that age, histological grade, tumor size, lymph node(LN) status, molecular subtype, and RS were independent predictors of ACR. A nomogram based on these predictors performed well. The P value of the Hosmer-Lemeshow test for the prediction model was 0.286. The area under the curve(AUC) values were 0.905 [95% confidence interval(95% CI): 0.876–0.934] and 0.883(95%CI: 0.824–0.942) in the training and validation sets, respectively. The accuracies of the nomogram for ACR were84.4% in the training set and 82.1% in the validation set.Conclusions: We developed a nomogram to predict the probability of ACR in breast cancer patients with intermediate RS. This model may aid the individual risk assessment and guide treatment decisions in clinical practice. | Feilin Qu Xiaosong Chen Xiaochun Fei Lin Lin Weiqi Gao Yu Zong Jiayi Wu Ou Huang Jianrong He Li Zhu Weiguo Chen Yafen Li Kunwei Shen | 2018 | Chinese Journal of Cancer Research2018，30，2： | 0 |
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