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| 1 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 2 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 3 | Ablation of High-Intensity Focused Ultrasound Assisted with SonoVue on Rabbit VX2 Liver Tumors: Sequential Findings with Histopathology, Immunohistochemistry, and Enzyme Histochemistry显示文摘 | Wen Luo Xiaodong Zhou Ming Yu Guangbin He Xiaoying Zheng Qiuyang Li Qing Liu Zenghui Han Jun Zhang Yunqiu Qian | 2009 | Annals of Surgical Oncology2009，，8： | 2 |
| 4 | Alpha-fetoprotein-thymidine kinase–luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liver显示文摘 | Xincheng Lu Hong Guo Joseph Molter Hui Miao Lizabeth Gerber Yiduo Hu Ellen L. Barnes Hannes Vogel Zhenghong Lee Guangbin Luo Bingcheng Wang | 2010 | Journal of Hepatology2010，，1： | 1 |
| 5 | A Blm–Recql5 partnership in replication stress response显示文摘Deficiencies in DNA damage response and repair not only can result in genome instability and cancer predisposition,but also can render the cancer cells intrinsically more vulnerable to certain types of DNA damage insults.Particularly,replication stress is both a hallmark of human cancers and a common instigator for genome instability and cell death.Here,we review our work based on the genetic knockout studies on Blm and Recql5,two members of the mammalian RecQ helicase family.These studies have uncovered a unique partnership between these two helicases in the implementation of proper mitigation strategies under different circum-stances to promote DNA replication and cell survival and suppress genome instability and cancer.In particular,current studies have revealed the presence of a novel Recql5/RECQL5-dependent mechanism for suppressing replication fork collapse in response to global replication fork stalling following exposure to camptothecin(CPT),a topoisomerase I inhibitor,and a potent inhibitor of DNA replication.The unique partnership between Blm and Recql5 in coping with the challenge imposed by replication stress is discussed.In addition,given that irinotecan and topotecan,two CPT derivatives,are currently used in clinic for treating human cancer patients with very promising results,the potential implication of the new findings from these studies in anticancer treatments is also discussed. | Xincheng Lu Hua Lou Guangbin Luo | 2011 | Journal of Molecular Cell Biology2011，3，1： | 0 |
| 6 | Nitrogen-doped graphite encapsulated Fe/Fe3C nanoparticles and carbon black for enhanced performance towards oxygen reduction显示文摘Non-noble metal(NNM)catalysts have recently attracted intensive interest for their high catalytic performance towards oxygen reduction reaction(ORR)at low cost.Herein,a novel NNM catalyst was synthesized by the simple pyrolysis of carbon black,urea and a Fe-containing precursor,which exhibits excellent ORR catalytic activity,superior durability and methanol tolerance versus the Pt/C catalyst in both alkaline and acidic solutions.Scanning electron microscopy(SEM),transmission electron microscopy(TEM)and X-ray diffraction(XRD)characterizations demonstrate that the product is a nitrogen-doped hybrid of graphite encapsulated Fe/Fe3C nanoparticles and carbon black.X-ray photoelectron spectrum(XPS)and electrochemical analyses indicate that the catalytic performance and chemical stability correlate closely with a nitrogen-rich layer on the Fe/Fe3C nanoparticle after pyrolysis with presence of urea,leading to the same four-electron pathway towards ORR as the Pt/C catalyst.The hybrid is prospective to be an efficient ORR electrocatalyst for direct methanol fuel cells with high catalytic performance at low cost. | Jie Zhu Zewei Xiong Jiming Zheng Zhihong Luo Guangbin Zhu Chao Xiao Zhengbing Meng Yibing Li Kun Luo | 2019 | Journal of Materials Science & Technology2019，35，11： | 0 |
| 7 | Fine-tuning of quantitative traits显示文摘The low-hanging fruits in plant breeding were harvested a long time ago.Now is the time for optimizing the desired traits,which often requires minor but significant changes in quantitative traits.Quantitative traits can be affected by slight changes in expression levels.However,genetic variation in gene-regulatory regions may be rare and difficult to identify(Rodríguez-Leal et al.,2017).Therefore,methods to induce gradual changes in gene expression are highly warranted. | Guangbin Luo Michael Palmgren | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
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