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| 1 | Effects of 2-(1-hydroxypentyl)-benzoate on platelet aggregation and thrombus formation in rats显示文摘AIM: Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB),derivated from 3-n-butylphthalide (NBP), is a newly synthesized compound which is under development as a therapeutic drug for cerebral ischemia. In the present study, we used ex vivo platelet aggregation method and in vivo arteriovenous shunt model to evaluate the antiplatelet and antithrombotic effects of d/-PHPB. METHODS: In the test of platelet aggregation, dl-PHPB | YiZHANG LingWANG Li-yingZHANG Xiao-liangWANG | 2004 | Acta Pharmacologica Sinica2004，25，11： | 9 |
| 2 | Enhanced antitumor efficacy on hepatoma-bearing rats with adriamycin-loaded nanoparticles administered into hepatic artery显示文摘AIM: To investigate the antitumor activity of adriamycin (ADR) encapsulated in nanoparticles (NADR) and injected into the hepatic artery of hepatoma-bearing rats.METHODS: NADR was prepared by the interfacial polymerization method. Walker-256 carcinosarcomas were surgically implanted into the left liver lobes of 60 male Wistar rats, which were divided into 4 groups at random (15 rats per group). On the 7th day after implantation, normal saline (NS), free ADR (FADR), NADR, or ADR mixed with unloaded nanoparticles (ADR+NP) was respectively injected via the hepatic artery (i.a.) of rats in different groups. The dose of ADR in each formulation was 2.0 mg/kg body weight and the concentration was 1.0 mg/mL. Survival time, tumor enlargement ratio, and tumor necrosis degree were compared between each group.RESULTS: Compared with the rats that received NS i.a.,the rats that received FADR or ADR+NP acquired apparent inhibition on tumor growth, as well as prolonged their life span. Further significant anticancer efficacy was observed in rats that received i.a. administration of NADR. Statistics indicated that NADR brought on a more significant tumor inhibition and more extensive tumor necrosis, as compared to FADR or ADR+NP. The mean tumor enlargement ratio on the 7th day after NADR i.a. was 1.106. The mean tumorbearing survival time was 39.50 days. Prolonged life span ratio was 109.22% as compared with rats that accepted NS.CONCLUSION: Therapeutic effect of ADR on liver malignancy can be significantly enhanced by its nanopaticle formulation and administration via hepatic artery. | Jiang-HaoChen RuiLing QingYao LingWang ZhongMa YuLi ZheWang HuXu | 2004 | World Journal of Gastroenterology2004，10，13： | 8 |
| 3 | Comparative Analysis of Capital Productivity in China’s High-Tech Industries显示文摘While labor productivityis a topicof constant debate and hasbeen studied extensively, far less attention has been devoted to the question of capital productivity. Productive use of physical capital is an important source of economic growth and investment return. This paper presents a comparative study of capital productivity in China’s high-tech industry. Using a version of theperpetualinventory method (PIM), new estimates have been madeof the physical capital stock by sector. Capital productivity in China’s high-tech industry is higherthan intotalmanufacturing,butthegapbetweenthem hasbeen shrinking.Comparison with high-tech industries in the US., highlightsthat China’shigh-tech industries could play a moreimportant rolein the growth of manufacturing and the whole economy. | LingWang AdamSzirmai | 2005 | China & World Economy2005，13，2： | 5 |
| 4 | Migration and population genetics of the grain aphid Macrosiphum miscanti (Takahashi) in relation to the geographic distance and gene flow显示文摘The population genetics of the grain aphid Macrosiphum miscanti (Takahashi) is analyzed by microsatellite markers.Samples collected from 15 locations in China have been examined at 5 polymorphic microsatellite loci. Overall, genetic diversity displays a relation between the migration and gene flow in the grain aphid: a free and frequent gene flow is found in the eastern populations, and gene isolation occurs in the two western populations, especially Datong population and Guiyang population. The natural barriers may present an insurmountable obstacle preventing gene flow and aphid migration. However, a spatial genetic differentiation between populations is correlated with their geographical separation, indicating the geographic differentiation may play an important role in shaping the genetic structure of M. miscanti populations. In addition, most populations of grain aphids are out of Hardy-Weinberg equilibrium and there is heterozygote deficit. Based on F statistics, the average genetic differentiation among different geographical populations is relatively low. It seems that the long distance migration of the grain aphid may enhance gene flow and decrease genetic differentiation among different populations. | GUO Wei SHEN Zuorui LI Zhihong GAO Lingwang | 2005 | Progress in Natural Science:Materials International2005，15，11： | 4 |
| 5 | A fast input method for Tibetan based on word in unicode 显示文摘 | Wang Weilan Kun Lingwang | 2008 | Lecture Notes in Engineering and Computer Science2008，2168，1： | 1 |
| 6 | Association of circulating insulin‐like growth factor 1 with hepatocellular carcinoma: one cross‐sectional correlation study显示文摘 | Wei‐WenSu King‐TehLee Yao‐TsungYeh Maw‐SoanSoon Chao‐LingWang Ming‐LungYu Shen‐NienWang | 2010 | J. Clin. Lab. Anal2010，，3： | 1 |
| 7 | Rational Design of a Tetrameric Protein to Enhance Interactions between Self‐Assembled Fibers Gives Molecular Hydrogels显示文摘 | XiaoliZhang XinleiChu LingWang HuaiminWang GaolinLiang JinxiuZhang JiafuLong ZhimouYang | 2012 | Angew. Chem. Int. Ed2012，，18： | 1 |
| 8 | The isolation and characterization of Pik, a rice blast resistance gene which emerged after rice domestication显示文摘 | ChunZhai FeiLin ZhongqiuDong XiuyingHe BinYuan XiaoshanZeng LingWang QinghuaPan | 2010 | New Phytologist2010，，1： | 1 |
| 9 | Nurses’ knowledge and barriers regarding pain management in intensive care units显示文摘 | Hsiang‐LingWang Yun‐FangTsai | 2010 | Journal of Clinical Nursing (鈥?)2010，，21： | 1 |
| 10 | Color Correction Based on LMS and RGB Subspace显示文摘 | Zhu Yuanhong Wang Lijie Kong Lingwang | 2005 | SPIE2005，6043，3： | 1 |
| 11 | Association of circulating insulin‐like growth factor 1 with hepatocellular carcinoma: one cross‐sectional correlation study显示文摘 | Wei‐WenSu King‐TehLee Yao‐TsungYeh Maw‐SoanSoon Chao‐LingWang Ming‐LungYu Shen‐NienWang | 2010 | J Clin Lab Anal2010，，3： | 1 |
| 12 | Fabrication of High‐Strength Continuous Zirconia Fibers and Their Formation Mechanism Study显示文摘 | He‐YiLiu Xian‐QinHou Xin‐QiangWang Yan‐LingWang DongXu ChenWang WeiDu Meng‐KaiLü Duo‐RongYuan | 2005 | Journal of the American Ceramic Society2005，，12： | 1 |
| 13 | Inhibition of inflammatory responses by ambroxol,a mucolytic agent,in a murine model of acute lung injury by lipopolysaccharide显示文摘 | lingwang | 2004 | Intensive Care Med2004，30，： | 1 |
| 14 | Multipath for Agricultural and Rural Information Services in China显示文摘 | Ningning Ge Zhiyuan Zang Lingwang Gao | 2010 | Computer and Computing Technologies in Agriculture III2010，317，： | 1 |
| 15 | Effect of junction potential on the EMF of bielectrolyte solid-state sensors显示文摘The EMF (electromotive force) expressions of bielectrolyte solid-state sensors derived from classical thermodynamics are not rigorous. They are only applicable in some special situations. In order to expand their applicable scope, they should be derived from irreversible thermodynamics theory. There is a junction potential term in the EMF equations of double solid electrolyte sensors derived from irreversible thermodynamics. The junction potential involves the ion transference numbers and the electron transference numbers of two kinds of solid electrolytes. When the transference numbers of reaction ions in the two solid electrolytes equal 1 only,the junction potential term is zero and two types of EMF equations become the same. | FushenLi HuiXia LingWang YanhongZhang LifenLi | 2005 | Journal of University of Science and Technology Beijing2005，12，1： | 0 |
| 16 | Components of traditional Chinese medicine inhibit platelet aggregation by blocking ADP receptor subtypes P2Y1 and P2Y12显示文摘Platelets aggregation and thrombosis formation are major reasons of cardiovascular and cerebral vascular diseases.To develop new generative,potent and safe agents for inhibiting platelet aggregation and preventing above diseases are urgently required.Some traditional Chinese medicines of″Houxue Huayu″have been shown to inhibit platelet aggregation potently.In the present study the mechanisms and the molecular targets of puerarin,salvianolic acid B and the analogue of 3-n-butylphthalide,dl-PHPB were investigated and compared with ticlopidine.Four platelet aggregation inducers,ADP,arachidonic acid,collagen and thrombin were used in the study.It was found that puerarin and dl-PHPB specifically inhibited ADP induced platelet aggregation like ticlopidine did.However,salvianolic acid B inhibited both ADP and collagen induced platelet aggregations with similar potency.Due to existing two ADP receptor subtypes on platelets,P2Y1 and P2Y12,we studied the action of above compounds on the receptors and the signaling pathways.It was found that dl-PHPB decreased IP1 accumulation produced by ADP,but had no effect on IP1 level induced by m-3M3 FBS,an activator of PLC.M-3M3 FBS might attenuate the inhibitory effect of dl-PHPB on ADP-induced platelet aggregation.In addition,dl-PHPB did not affect cyclic AMP formation in platelets by ADP,which is different from P2Y12 antagonist ticlopidine.Puerarin showed the similar effects of dl-PHPB.Therefore,the actions of dl-PHPB and puerarin might be through P2Y1receptor-PLC-βpathway.Salvianolic acid B did not reduce the IP1 accumulation stimulated by ADP.It might act on the receptor subtype P2Y12.Our results suggest that components of Chinese herb medicine might be a resource for development of novel anti-platelet drugs. | Xiao-liangWANG Yi-yingLI Hong-yanYANG ShaofengXU LingWANG | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 17 | Climatic Characteristics of Rainstorm during the Flood Season in Shandong Province from 1961 to 2012显示文摘Based on daily precipitation data at 35 meteorological observation stations during the flood season in Shandong Province from 1961 to2012,the spatial and temporal variation characteristics of number of rainstorm days and rainstorm intensity were analyzed by conventional statistical methods. The results show that the number of rainstorm days and rainstorm intensity during the flood season in Shandong showed a decreasing trend from 1961 to 2012,but the decreases were not statistically significant at the 0. 05 level. Annual average number of rainstorm days during the flood season in Shandong over the past 52 years was 2.2d and had the changing periods of 3. 4 and quasi-8 a; the annual average rainstorm intensity was 67. 8 mm/d and had the changing periods of 2. 3,3. 3,6. 9 and quasi-12. 0 a. From 1961 to 2012,there was no abrupt climatic change in the number of rainstorm days and rainstorm intensity during the flood season in Shandong,and the number of rainstorm days and rainstorm intensity during the flood season in Shandong reduced from the middle and late 1970 s to the late 1980 s. The annual average number of rainstorm days and rainstorm intensity during the flood season in Shandong from 1961 to 2012 rose gradually from the northwest to the southeast. Rainstorm( continuous rainstorm) during the flood season appeared frequently,and rainstorm intensity was high in the south of Shandong Province,the south and east of Shandong Peninsula. | Li Rui Yin Chengmei Meng Lingwang | 2017 | Meteorological and Environmental Research2017，8，5： | 0 |
| 18 | Modified Multispectral Space for Color Representation显示文摘Conventional multispectral space for color representation is modified by algorithm of cluster analysis and principal component analysis. Results show that the newer modified multispectral space not only keeping the structure of the original space but eliminating zero crosses as well its accuracy of color representation is higher than the conventional. | PEI Xiandeng KONG Lingwang ZHU Yuanhong HUANG Hao | 2005 | Geo-Spatial Information Science2005，8，4： | 0 |
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