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| 1 | Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment显示文摘Spondyloarthropathies(SpA) include many different forms of inflammatory arthritis and can affect the spine(axial SpA) and/or peripheral joints(peripheral SpA) with Ankylosing spondylitis(AS) being the prototype of the former. Extraarticular manifestations, like uveitis, psoriasis and inflammatory bowel disease(IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria. Bowel involvement seems to be the most common of these manifestations. Clinically evident IBD is observed in 6%-14% of AS patients, which is significantly more frequent compared to the general population. Besides, it seems that silent microscopic gut inflammation, is evident in around 60% in AS patients. Interestingly, occurrence of IBD has been associated with AS disease activity. For peripheral SpA, two different forms have been proposed with diverse characteristics. Of note, SpA(axial or peripheral) is more commonly observed in Crohn's disease than in ulcerative colitis. The common pathogenetic mechanisms that explain the link between IBD and SpA are still ill-defined. The role of dysregulated microbiome along with migration of T lymphocytes and other cells from gut to the joint('gut-joint' axis) has been recognized, in the context of a genetic background including associations with alleles inside or outside the human leukocyte antigen system. Various therapeutic modalities are available with monoclonal antibodies against tumour necrosis factor, interleukin-23 and interleukin-17, being the most effective. Both gastroenterologists and rheumatologists should be alert to identify the coexistence of these conditions and ideally follow-up these patients in combined clinics. | George E Fragoulis Christina Liava Dimitrios Daoussis Euangelos Akriviadis Alexandros Garyfallos Theodoros Dimitroulas | 2019 | World Journal of Gastroenterology2019，25，18： | 13 |
| 2 | 基于“肠-关节”轴探讨肠道微生物对膝骨关节炎的影响显示文摘近年来,随着微生物组学的飞速发展,现代医学提出了“肠-关节”轴概念。“肠-关节”轴在肠道微生物和关节疾病中扮演着重要角色。肠道微生物的紊乱导致慢性系统性低度炎症,进而加重骨关节炎的病理进程。调节肠道微生物的平衡可能会通过抑制胃肠或膝关节局部的免疫炎症反应来改善膝骨关节炎的症状。笔者基于“肠-关节”轴探讨肠道微生物对膝骨关节炎的潜在影响,以及肠道微生物治疗膝骨关节炎的可行性。 | 谭春霞 杨娜娜 齐翎羽 林璐璐 李月婕 杨静雯 刘存志 石广霞 | 2022 | 南京中医药大学学报2022，38，5： | 6 |
| 3 | HLA-Cw基因多态性与炎症性肠病的关系显示文摘目的 探讨人类白细胞抗原(HLA) -Cw等位基因与炎症性肠病(IBD)的相关性,以期发现IBD的易感基因。方法 采用序列特异性引物聚合酶链反应(PCR-SSP)方法,对100例溃疡性结肠炎(UC)、73例克罗恩病(CD)和106例健康对照进行HLA-Cw基因分型。结果 UC患者组HLA-Cw* 07基因表型频率为0.430,明显高于健康对照组(0.226),P=0.002;CD患者组HLA-Cw* 12基因表型频率为0.356,明显高于健康对照组(0.123),P=0.000。结论 HLA-Cw* 07基因可能与UC易感性密切相关;HLA-Cw*12基因可能与CD易感性密切相关。 | 张惠霞 李继昌 徐刚 刘占举 | 2011 | 中华内科杂志2011，50，10： | 3 |
| 4 | NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients显示文摘AIM:To investigate the small bowel of seronegative spondyloarthropathy(SpA) patients in order to ascertain the presence of mucosal lesions.METHODS:Between January 2008 and June 2010,54 consecutive patients were enrolled and submitted to avideo capsule endoscopy(VCE) examination.Historyand demographic data were taken,as well as the history of non-steroidal anti-inflammatory drug(NSAID) consumption.After reading each VCE recording,a capsule endoscopy scoring index for small bowel mucosal inflammatory change(Lewis score) was calculated.Statistical analysis of the data was performed.RESULTS:The Lewis score for the whole cohort was 397.73.It was higher in the NSAID consumption subgroup(P = 0.036).The difference in Lewis score between NSAID users and non-users was reproduced for the first and second proximal tertiles of the small bowel,but not for its distal third(P values of 0.036,0.001 and 0.18,respectively).There was no statistical significant difference between the groups with regard to age or sex of the patients.CONCLUSION:The intestinal inflammatory involvement of SpA patients is more prominent in NSAID users for the proximal/mid small bowel,but not for its distal part. | Mihai Rimba■ Mǎdǎlina Marinescu Mihail Radu Voiosu Cristian Rǎsvan Bǎicu■ Simona Caraiola Adriana Nicolau Doina Ni■escu Georgeta Camelia Badea Magda Ileana Parvu | 2011 | World Journal of Gastroenterology2011，17，8： | 1 |
| 5 | Inflammatory bowel disease-associated spondyloarthropathies显示文摘This issue presents a symposium held in Messina talking about inflammatory bowel disease(IBD) and associated spondyloarthropathies.The topic covers epidemiology and clinical manifestations of IBD-related arthropathies, common genetic and immunologic features, combined therapies for gut and joint inflammation, and future biologic therapies etc.I believe this series of articles will deeply facilitate understanding of and the approach to IBD and associated arthropathies. | Walter Fries | 2009 | World Journal of Gastroenterology2009，15，20： | 0 |
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