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| 1 | Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia显示文摘我们的以前的研究证明了砷三氧化物(ATO ) 在与无形的贫血症(AA ) 对待病人有临床的功效。然而,机制尚待被阐明。骨头髓的重要部件造血的微型环境,骨头髓间充质的干细胞(BMSC ) ,经常在 AA 病人被改变。在这研究, AA BMSC 是容易的被导致进 adipocytes 而非造骨细胞,这被发现。ATO 治疗能部分至少恢复 AA BMSC 的区别不平衡。我们进一步在 AA BMSC 区别作为一个关键管理者识别了 miR-204。酶记者试金证明 miR-204 能直接绑在 Runx2 mRNA 的 3-untranslated 区域,调整成骨的一个关键抄写因素。而且, adipogenic 区别被支持, osteogenic 区别在 miR-204 被禁止过去表示的房间而成骨被提高, adipocyte 形成在房间被禁止,那失去了 miR-204 功能,它建议了它的内长的功能。一起我们证明 ATO 能禁止 adipogenic 区别,但是在 AA BMSC 支持 osteogenic 区别,在 AA 病人为 ATO 临床的功效提供可能的解释。MiR-204 戏在调整 BMSC 区别的一个关键角色,和下面调整的 miR-204 表示可能是新奇策略对待 AA。 | Junmei Zhao Chao Wang Yongping Song Baijun Fang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 7 |
| 2 | Reduced intensity conditioning and co-transplantation of unrelated peripheral stem cells combined with umbilical cord mesenchymal stem/stroma cells for young patients with refractory severe aplastic anemia显示文摘 | Yuewen Fu Qian Wang Jian Zhou Shengquan Liu Baijun Fang Xudong Wei Yongping Song | 2013 | International Journal of Hematology2013，，6： | 2 |
| 3 | Systemic Infusion of FLK1+ Mesenchymal Stem Cells Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis in Mice显示文摘 | Baijun Fang Mingxia Shi Lianming Liao Shaoguang Yang Yuhao Liu Robert Chunhua Zhao | 2004 | Transplantation2004，，1： | 2 |
| 4 | Multiorgan engraftment and muhilineage differentiation by human fetal bone marrow Flk1^ +/CD31 -/CD34 - Progenitors 显示文摘 | Fang Baijun Shi Mingxia Liao Lianming | 2003 | J Hematother Stem Cell Res2003，12，6： | 1 |
| 5 | Multiorgan engraftment and muhilineage differentiation by human fetal bone marrow FIk1 ^+/CD31 -/CD34- Progenitors 显示文摘 | Fang Baijun Shi Mingxia Liao Lianming | 2003 | J Hema Stem Cell Res2003，12，6： | 1 |
| 6 | Multipotency of Flk1 + CD34 ? progenitors derived from human fetal bone marrow显示文摘 | Baijun Fang Lianming Liao Mingxia Shi Shaoguang Yang Robert Chunhua Zhao | 2004 | The Journal of Laboratory and Clinical Medicine2004，，4： | 1 |
| 7 | Hemangioblastic characteristics of fetal bone marrow–derived Flk1 + CD31 ? CD34 ? cells显示文摘 | Hong Guo Baijun Fang Lianming Liao Zhigang Zhao Jiewen Liu Huishu Chen Steven H. Hsu Qi Cui Robort Chunhua Zhao | 2003 | Experimental Hematology2003，，7： | 1 |
| 8 | Ⅰdentification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang Baijun Zheng Chunmei Liao Lianming | 2005 | Blood2005，105，7： | 1 |
| 9 | Multipotency of Flk1 + CD34-progenitors derived from human fetal bone marrow显示文摘 | Baijun Fang Lianming Liao Mingxia Shi | 2004 | J Lab Clin Med2004，143，4： | 1 |
| 10 | Comparison of human post-embryonic, multipotent stem cells derived from various tissues显示文摘 | Baijun Fang Ning Li Yongping Song Quande Lin Robert Chunhua Zhao | 2009 | Biotechnology Letters2009，，7： | 1 |
| 11 | Characterization of cancer stem-like cells in a novel STI571-resistant chronic myeloid leukemia cell line显示文摘Objective:To characterize a novel chronic myeloid leukemia(CML)cell line and to further elucidate the mechanisms of resistance to STI571.Methods:A novel K562 cell line(K562/VP16)was achieved after exposure of the K562 cells to VP16.A small subpopulation(K562/VP16 SP)that was capable of excluding Hoechst 33342 in the K562/VP16 cell line was isolated by flow cytometry sorting.The rest of the K562/VP16 cells were classified as non-SP K562/VP16.The mechanisms involved in K562/VP16 SP cells which became resistant to STI571 were studied.Results:The levels of Bcr-Abl and Abl proteins were similar in the K562 cell line and in non-SP K562/VP16 and K562/VP16 SP cells.The multidrug-resistant gene 1(MDR1)expression of the 170 kDa P-glycoprotein(P-gp)was detected in K562/VP16 non-SP and K562/VP16 SP cells but not in K562 cells.The expression levels of P-gp in the two K562/VP16 cell lines were similar.Compared with non-SP K562/ VP16,the K562/VP16 SP cells were more resistant to STI571.This resistance could hardly be reversed by many multidrug resistance inhibitors.In addition,in vivo study showed that the K562/VP16 SP cells induced tumorigenesis in mice,while the K562/VP16 non-SP cells failed to do so.Conclusion:A novel K562 cell line,K562/VP16,was generated.A small side popula- tion K562/VP16 SP cells,had high resistance to STI571 treatment and more tumorigenic than the K562 cells.It may represent the cancer stem cells of the K562/VP16 cell line. | Baijun Fang Yongping Song Yanli Zhang Quande Lin Xudong Wei | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 0 |
| 12 | Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow, heart, liver, muscle, lung, derma, kidney, and fat显示文摘Previously,we reported that a cell population derived from human fetal bone marrow(BM),termed here Flk1+CD34−postembryonic pluripotent stem cells(PPSCs)that have the characteristics of mesenchymal stem cells(MSCs),could differentiate into ectodermal,endodermal and mesodermal cell types at the single cell level in vitro,and that these cells could also differentiate into the epithelium of liver,lung,gut,as well as the hematopoietic and endothelial lineages after transplantion into irradiated non-obese diabetic/severe combined immunodeficient(NOD/SCID)mice.In this study,we further isolated pluripotent stem cells from human fetal heart,liver,muscle,lung,derma,kidney,and fat and then analyzed the characteristics and function of these stem cells.It was found that the phenotype of the culture-expanded pluripotent stem cells from different fetal tissues was similar to BM-derived Flk1^(+)CD34^(−)PPSCs,i.e.Flk1 and CD44 positive,GlyA,CD34,CD45,class I-HLA and HLA-DR negative.Morphologically,these cells were fibroblast-like and the doubling time was about 30 h.More importantly,culture-expanded pluripotent stem cells from all these fetal tissues were able to differentiate into cells with morphologic and phenotypic characteristics of adipocytes,osteocytes,neurons,glial cells and hepatocytes.These pluripotent stem cells with characteristics similar to fetal BM-derived Flk1^(+)CD34^(−)PPSCs can be selected and cultured from tissues other than the BM.This phenomenon may help explain the“stem cell plasticity”found in multiple human tissues.In addition,as fetal BM-derived Flk1^(+)CD34^(−)PPSCs,these pluripotent stem cells from different fetal tissues had the capacity for self-renewal and multi-lineage differentiation even after being expanded for more than 40 population doublings in vitro.Thus,they may be an ideal source of stem cells for treatment of inherited or degenerative diseases. | FANG Baijun SONG Yongping ZHAO Chunhua SHI Mingxia LIN Quande | 2007 | Frontiers of Medicine2007，1，2： | 0 |
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