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| 1 | Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants显示文摘Objective:To demonstrate the in vitro antibacterial properties of five essential oils against ten bacterial strains and study the synergistic effect of the combination of essential oils with standard antibiotics.Methods:Origanum compactum,Chrysanthemum coronarium,Thymus willdenowii Boiss,Melissa officinalis and Origanum majorana L.were used alone and combined used with standard antibiotics to evaluate their antimicrobial activities.The disk diffusion method was employed.Results:The results showed that the combined application of the essential oils of the plants with antibiotics led to a synergistic effect in some cases,but antagonistic effect was also observed in some bacteria.Conclusions:This study shows that the combination of essential oils of the five plants with antibiotics may be useful in the fight against emerging microbial drug resistance. | Fadila Moussaoui Tajelmolk Alaoui | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，1： | 5 |
| 2 | Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis(Coss. & Dur.) Maire显示文摘Objective:To investigate the chemical composition of a moderately polar extract(CHC1_3 soluble part of the MeOH-H_2O extract) obtained from the aerial parts(leaves and flowers) of Centaurea diluta Ait.subsp.algeriensis(Coss.& Dur.) Maire,a species endemic to Algeria and Morocco on which no reports are available to date.To evaluate in vitro the cytotoxic,antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary metabolites.Methods:The cytotoxic effects of the extract were investigated on 3 human cancer cell lines i.e.the A549 non-small-cell lung carcinoma(NSCLC),the MCF7 breast adenocarcinoma and the U373 glioblastoma using a MTT colorimetric assay.Biological data allowed to guide the fractionation of the extract by separation and purification on silica gel 60(CC and TLC).The isolated compounds which were characterized by spectral analysis,mainly HR-ESIMS,HR-EIMS,UV and NMR experiments(~1H,^(13)C,COSY,ROESY,HSQC and HMBC) and comparison of their spectroscopic data with those reported in the literature,were evaluated for cytotoxic activities on six cancer cell lines(A549,MCF7,U373,Hs683 human glioma,PC3 human prostate and B16-F10 murine melanoma).The direct and indirect antibacterial and antifungal activities were determined using microdilution methods for the raw extract and TLC-bioautography and microdilution methods against standard and clinical strains for the isolated compounds.Results:The raw extract reduced cell viability with IC_(50)s of 27,25 and 21 μg/mL on A549,MCF7 and U373,respectively.Five secondary metabolites:two phenolic compounds(vanillin 1,paridol 3),a lignan[(-)-arctigenin 2]and two flavonoid aglycones(eupatilin 4 and jaceosidin 5),were then isolated from this extract.Moderate cytotoxic effects were observed for(-)-arctigenin 2(IC_(50)s:28 and 33μM on Hs683 and B16-F10,respectively),eupatilin 4(IC_(50)s:33 and 47 μM on B16-F10 and PC3,respectively) and jaceosidin 5(IC_(50)s:32 and 40 μM on PC3 and B16-F10,respectively).Conclusions:All the isolated compounds were described for the first time from this species.Although inactive against 7 tested microorganisms(fungi,bacteria and yeast,human or plant pathogens),the raw extract was able to potentiate the effect of beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus(MRSA),reducing the minimal inhibitory concentrations(MICs) by a factor of 2-32-fold.No synergy was found between the extract and streptomycin.From the five isolated compounds only jaseosidin 5 showed a moderate antimicrobial activity. | Hanene Zater Joelle Huet Veronique Fontaine Samir Benayache Caroline Stevigny Pierre Duez Fadila Benayache | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，6： | 2 |
| 3 | PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations 显示文摘 | Yunqing L Fadila G | 2008 | Cancer Res2008，68，6： | 1 |
| 4 | Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice显示文摘 | Bricambert Julien Miranda Jonatan Benhamed Fadila Girard Jean Postic Catherine Dentin Renaud | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 5 | Defining subregions and estimating benefits for a specific-adaptation strategy by breeding programs:a case study crop science madison显示文摘 | Paolo A Fadila B | 2005 | Nature2005，45，1： | 1 |
| 6 | PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations显示文摘 | Yunqing Li Fadila G | 2008 | Cancer Res2008，3，68： | 1 |
| 7 | A Comparative Classification of Aspect Mining Approaches显示文摘 | Nora B Said G Fadila A | 2006 | Journal of Computer Science2006，2，4： | 1 |
| 8 | How to limit radial artery spasm during percutaneous coronary interventions: The spasmolytic agents to avoid spasm during transradial percutaneous coronary interventions (SPASM3) study显示文摘 | Julien Rosencher Aurès Cha?b Franck Barbou Marc‐Antoine Arnould Arthur Huber Emmanuel Salengro Arnaud Jégou Philippe Allouch Stéphane Zuily Fadila Mihoub Olivier Varenne | 2014 | Cathet. Cardiovasc. Intervent2014，，5： | 1 |
| 9 | A flavonoid with cytotoxic activity and other constituents from Centaurea africana显示文摘 | Ramdane Seghiri Ouahiba Boumaza Ratiba Mekkiou Samir Benayache Paul Mosset José Quintana Francisco Estévez Francisco León Jaime Bermejo Fadila Benayache | 2009 | Phytochemistry Letters2009，，： | 1 |
| 10 | Photovoltaic solar cells industry wastewater treatment 显示文摘 | DROUICHE NADJIB DJOUADI - BELKADA FADILA OUSLIMANE TARIK | 2013 | Desali- nation And Water Treatment2013，51，3133： | 1 |
| 11 | O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver显示文摘 | Guinez Céline Filhoulaud Ga?lle Rayah-Benhamed Fadila Marmier Solenne Dubuquoy Céline Dentin Renaud Moldes Marthe Burnol Anne-Fran?oise Yang Xiaoyong Lefebvre Tony Girard Jean Postic Catherine | 2011 | Diabetes2011，，5： | 1 |
| 12 | Diesel engine combus- tion modeling for hardware in the loop application: Effects of ignition delay time model 显示文摘 | Fadila Maroteaux Charbel Saad | 2013 | Energy2013，57，： | 1 |
| 13 | Rhabdomyolysis secondary to influenza a infection: a case report and review of the literature显示文摘 | Fadila MF Wool KJ | 2015 | N Am J Med Sci2015，7，3： | 1 |
| 14 | Liver-specific inhibition of chrebp improves hepatic steatosis and insulin resistance in ob/ob mice显示文摘 | Renaud D Fadila B Isabelle H | 2006 | Diabetes2006，55，8： | 1 |
| 15 | Sesquiterpene lactones from Centaurea musimomum . Antiplasmodial and cytotoxic activities显示文摘 | Kamel Medjroubi Fadila Benayache Jaime Bermejo | 2005 | Fitoterapia2005，，： | 1 |
| 16 | A new guaianolide and other constituents from Achillea ligustica显示文摘 | Azzedine Boudjerda Hanene Zater Samir Benayache Jean-Claude Chalchat Javier González-Platas Francisco León Ignacio Brouard Jaime Bermejo Fadila Benayache | 2007 | Biochemical Systematics and Ecology2007，，： | 1 |
| 17 | The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans显示文摘 | Benhamed Fadila Denechaud Pierre-Damien Lemoine Maud Robichon Céline Moldes Marthe Bertrand-Michel Justine Ratziu Vlad Serfaty Lawrence Housset Chantal Capeau Jacqueline Girard Jean Guillou Hervé Postic Catherine | 2012 | EN2012，，6： | 1 |
| 18 | Tamoxifen Treatment and Risk of Endometrial Cancer: An Overview显示文摘 | Fadila Kouhen Fadoua Rais Naoual Benhmidou Mohammed Afif Sanaa Elmajjaoui Hanan Elkacemi Tayeb Kebdani Noureddine Benjaafar | 2016 | Journal of Health Science2016，4，1： | 0 |
| 19 | ANALYSIS OF THE CYCLONIC VORTEX AND EVALUATION OF THE PERFORMANCE OF THE RADAR INTEGRATED NOWCASTING SYSTEM(RAINS) DURING THE HEAVY RAINFALL EPISODE WHICH CAUSED FLOODING IN PENANG, MALAYSIA ON 5 NOVEMBER 2017显示文摘Even though Malaysia is relatively safe from the direct path of tropical cyclones nevertheless the passage of such systems over the neighbouring seas and their tail effect present a unique challenge for forecasters. In rare situations, tropical cyclones had made landfall on Malaysian shores such as Typhoon Vamei in 2001 and Tropical Storm Greg in 1996. Hence it is vital to forecast the severity of the heavy rainfall events associated with low pressure systems to assist the disaster management agencies in decision making. Towards this endeavour, the Malaysian Meteorological Department(MMD) utilises a nowcasting system called Radar Integrated Nowcasting System(RaINS) which uses a combination of radar data and Numerical Weather Prediction(NWP) data. RaINS was adapted from SWIRLS(Short-range Warning of Intense Rainstorms in Localised Systems) developed by the Hong Kong Observatory(HKO) and operationalised in MMD in August 2017. This paper studies the cyclonic vortex and synoptic features during the heavy rainfall event that caused major flooding in Penang, Malaysia on 5 November 2017. This paper also investigates the performance of RaINS in predicting the rain cloud distribution and intensity during that event. It is found that RaINS is capable of forecasting the rain cloud distribution and intensity reasonably well in the very short-term period of 1-3 hours. The forecasts are verified by comparing the RaINS forecast data with observed radar echo. | DIONG JEONG YIK YIP WENG SANG NURSALLEH K.CHANG FADILA JASMIN FAKARDDIN AMBUN DINDANG MUHAMMAD HELMI ABDULLAH | 2018 | Tropical Cyclone Research and Review2018，7，4： | 0 |
| 20 | Asymptotic properties of a nonparametric conditional density estimator in the local linear estimation for functional data via a functional single-index model显示文摘This paper deals with the conditional density estimator of a real response variable given a functional random variable(i.e.,takes values in an infinite-dimensional space).Specifically,we focus on the functional index model,and this approach represents a good compromise between nonparametric and parametric models.Then we give under general conditions and when the variables are independent,the quadratic error and asymptotic normality of estimator by local linear method,based on the single-index structure.Finally,wecomplete these theoretical advances by some simulation studies showing both the practical result of the local linear method and the good behaviour for finite sample sizes of the estimator and of the Monte Carlo methods to create functional pseudo-confidence area. | Fadila Benaissa Abdelmalek Gagui Abdelhak Chouaf | 2022 | Statistical Theory and Related Fields2022，6，3： | 0 |
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