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| 1 | Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma显示文摘AIM: To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma (HCC)eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria.METHODS: Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were: (1) histological assessment of tumor grade by means of percutaneous biopsies; (2) determination of AFP mRNA status in the blood; (3) patient's eligibility for radical therapies.RESULTS: At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery (resection or liver transplantation) was performed in 29 patients,while 21 had percutaneous ablation procedures. After a median follow-up of 28 mo, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables (AFP mRNA, HCC grade and gross vascular invasion) resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile (AFP mRNA negative and well-differentiated tumor without gross vascular invasion) as independent survival variables.CONCLUSION: The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies. | Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico | 2005 | World Journal of Gastroenterology2005，11，44： | 12 |
| 2 | Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats 显示文摘 | Caderni G Filippo C D Luceri C | 2000 | Carcinogenesis2000，21，11： | 2 |
| 3 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 4 | Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment显示文摘 | Marfella R D'Amico M Di Filippo C | 2006 | J Am Coil Cardio2006，47，12： | 1 |
| 5 | The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes显示文摘 | Marfella R D'Amico M Di Filippo C | | 0，，： | 1 |
| 6 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 7 | Unusual presentation of haemophilia in two paediatric patients显示文摘 | Maia De Luca Francesca I. Calò Carducci Valeria Pansini Valentina Coletti Filippo M. Tucci Marco Cirillo Maura Acquila Maria Patrizia Bicocchi Patrizia D’Argenio Matteo Luciani | 2013 | Blood Coagulation & Fibrinolysis2013，，6： | 1 |
| 8 | Effects of agro- chemical treatments on the occurrence of Fusariurn ear rot andfumonisin contamination of maize in Southern Italy 显示文摘 | Filippo D C Vincenzo D C Miriam H | 2011 | Field Crops Research2011，123，2： | 1 |
| 9 | Myocardial infarctionin diabetic rats: role of hyperglycaemia on infarct size and early ex-pression of hypoxia-inducible factor 1 显示文摘 | Marfella R D'Amico M Di Filippo C | 2002 | Diabetologia2002，45，8： | 1 |
| 10 | Inhibition of 1,2- dimethylhydrazine-induced oxidative DNA damage in rat colon mucosa by black tea complex polyphenols显示文摘 | Lodovicim M Casalini C Filippo D E | 2000 | Food Chem Toxicol2000，38，12： | 1 |
| 11 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 12 | CSF proteome analy- sis in multiple sclerosis patients by two - dimensional electrophoresis 显示文摘 | Chiasserini D Di Filippo M Candeliere A | 2008 | Europ J Neurol2008，15，9： | 1 |
| 13 | WNT4 deficiency-a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome:a case report显示文摘 | Biason-Lauber A De Filippo G Konrad D | 2007 | Hum Reprod2007，22，1： | 1 |
| 14 | Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy显示文摘 | Lorena Losi Gabriele Luppi Margherita Gavioli Francesco Iachetta Federica Bertolini Roberto D’Amico Gordana Jovic Filippo Bertoni Anna Maria Falchi Pier Franco Conte | 2006 | International Journal of Colorectal Disease2006，，7： | 1 |
| 15 | Persistent Coronary No Flow After Wire Insertion Is an Early and Readily Available Mortality Risk Factor Despite Successful Mechanical Intervention in Acute Myocardial Infarction显示文摘 | Marco Valgimigli Gianluca Campo Patrizia Malagutti Maurizio Anselmi Leonardo Bolognese Flavio Ribichini Giacomo Boccuzzi Nicoletta de Cesare Alfredo E. Rodriguez Filippo Russo Raul Moreno Giuseppe Biondi-Zoccai Carlo Penzo José F. Díaz Fernández Giovanni | 2011 | JACC: Cardiovascular Interventions2011，，1： | 1 |
| 16 | Follow-up of a large population of asymptomatic/oligosymptomatic hyperckemic subjects显示文摘 | Elisabetta D’Adda Monica Sciacco Maria Elisa Fruguglietti Veronica Crugnola Valeria Lucchini Filippo Martinelli-Boneschi Chiara Zecca Costanza Lamperti Giacomo Pietro Comi Nereo Bresolin Maurizio Moggio Alessandro Prelle | 2006 | Journal of Neurology2006，，11： | 1 |
| 17 | Increased activity of the ubiquitin- proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment显示文摘 | Marfella R D'Amico M Filippo C | 2006 | J Am Coil Cardiol2006，47，： | 1 |
| 18 | Sensorless control of induction-motor drive based on robust Kalman filter and adaptive speed estimation显示文摘 | Alonge Francesco D’Ippolito Filippo Sferlazza Antonini | 2014 | IEEE Transactions on Industrial Electronic2014，61，3： | 1 |
| 19 | Synthesis of a transmembrane ionophore based on a c2 - symmetric polyhydroxysteroid derivative 显示文摘 | FILIPPO M D IZZO I SAVIGNANO L | 2003 | Tetrahedron2003，59，： | 1 |
| 20 | 显示文摘 | R. Marfella M. D'Amico C. Di Filippo E. Piegari F. Nappo K. Esposito L. Berrino F. Rossi D. Giugliano | 2002 | Diabetologia2002，，8： | 1 |
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