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| 1 | Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells显示文摘人的表皮的生长因素受体 2 (HER2/neu,也作为 ErbB2 知道) overexpression 在癌症与差的预后和 chemoresistance 被相关。乳癌抵抗蛋白质(BCRP 和 ABCG2 ) 在许多癌症房间是为 multidrug 抵抗(MDR ) 负责的药流出泵。HER2 和 BCRP 在乳癌病人与差的治疗反应被联系,尽管在 HER2 和 BCRP 表示之间的关系不是清楚的。这里,我们证明进 MCF7 乳癌房间(MCF7/HER2 ) 的 HER2 的 transfection 经由 phosphatidylinositol 3-kinase (PI3K ) 导致了 BCRP 的一条起来规定 /Akt 和发信号的原子 factor-kappa B (NF-B ) 。有 PI3K 禁止者 LY294002, IB phosphorylation 禁止者 Bay11-7082,和 IB 的主导的否定异种的 MCF/HER2 房间的治疗禁止了导致 HER2 的 BCRP 倡导者活动。而且,我们发现 HER2 overexpression 导致了 MCF7 房间的一个增加的电阻到多重 antitumor 药象 paclitaxel (Taxol ) 那样, cisplatin (DDP ) , etoposide (VP-16 ) , adriamycin (ADM ) , mitoxantrone (MX ) ,和 5 氟尿嘧啶(5-FU ) 。而且, silencing BCRP 或有选择地的表示禁止 Akt 或 NF-B 的活动部分地至少敏化 MCF7/HER2 房间到这些化疗代理人。一起拿,通过表明小径的 PI3K/AKT/NF-B 的 BCRP 的起来规定在 MCF7 的调停 HER2 的 chemoresistance 起了一个重要作用房间,和 AKT, NF-B,和 BCRP 小径可能为治疗学的干预用作潜在的目标。 | Weijia Zhang Wei Ding Ye Chen Meilin Feng Yongmei Ouyang Yanhui Yu Zhimin He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 8 |
| 2 | Unsteady Numerical Simulation of Flow around 2-D Circular Cylinder for High Reynolds Numbers显示文摘在这份报纸, 2-D 计算分析在 supercritical 和上面转变的流动政体在光滑的圆形的柱体附近为不稳定的高级雷纳兹数字流动被进行,即 8. | Yanhui Ai Dakui Feng Hengkui Ye Lin Li | 2013 | Journal of Marine Science and Application2013，12，2： | 7 |
| 3 | Zonal method solution of radiative heat transfer in a one-dimensional long roller-hearth furnace in CSP显示文摘A radiative heat transfer mathematical model for a one-dimensional long furnace was set up in a through-type roller-hearth furnace (TTRHF) in compact strip production (CSP). To accurately predict the heat exchange in the furnace, modeling of the complex gas energy-balance equation in volume zones was considered, and the heat transfer model of heating slabs and wall lines was coupled with the radiative heat transfer model to identify the surface zonal temperature. With numerical simulation, the temperature fields of gas, slabs, and wall lines in the furnace under one typical working condition were carefully accounted and analyzed. The fundamental theory for analyzing the thermal process in TTRHF was provided. | Wenfei Wu Yanhui Feng Xinxin Zhang | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 4 |
| 4 | Scorpion venom heat-resistant protein decreases immunoreactivity of OX-42-positive microglia cells in MPTP-treated mice显示文摘BACKGROUND:Microglia function as the immune surveyors of the brain under normal physiological conditions.However,microglia become activated in response to brain injuries and immunological stimula-tion.OBJECTIVE:To explore the influence of scorpion venom(SV) heat-resistant protein on frontal cortex and hippocampal microglia cells in a mice model of Parkinson's disease.DESIGN,TIME AND SETTING:Randomized,controlled,cellular immunity study.The experiment was performed at the Physiology Department Laboratory in Dalian Medical University between June 2005 and July 2008.MATERIALS:Ninety-six healthy,C57Bl/6 mice;1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) from Sigma,USA;SV heat-resistant protein(Experimental Base Institute in Dalian Medical University).The mice were randomly divided into four groups(n = 24):normal control,negative control,model,and SV heat-resistant protein.METHODS:Mice in the model and SV heat-resistant protein groups were subcutaneously injected with MPTP(20 mg/kg) to model Parkinson's disease,while the normal control and negative control groups were injected with physiological saline in the neck for 8 successive days.In addition,mice in the model and nor-mal control groups were intraperitoneally injected with physiological saline 2 hours following administration,while SV heat-resistant protein and negative control groups were injected SV heat-resistant protein(0.01 mg/kg).MAIN OUTCOME MEASURES:Immunoreactivity of microglia cells in MPTP-treated mice.RESULTS:Compared with normal control mice,MPTP-treated mice displayed increased OX-42 expression in the brain.However,in the SV heat-resistant protein-treated mice,OX-42 expression was decreased,com-pared to the model group.In the model mouse group,the number of OX-42-positive microglia was increased in the frontal cortex,caudatum,and hippocampal hilus,compared to the normal control mice(P < 0.01).However,in the SV heat-resistant protein-treated mice,the number of OX-42-positive microglia significantly decreased in the frontal cortex,caudatum,and hippocampal hilus,compared to the model group(P < 0.01).CONCLUSION:SV heat-resistant protein inhibited MPTP-induced microglial activation in the mouse fron-tal cortex and hippocampus,resulting in reduced microglial activation in the brain. | Shengming Yin Deqin YU Xi Gao Yan Peng Yanhui Feng Jie Zhao Yiyuan Tang Wanqin Zhang | 2008 | Neural Regeneration Research2008，3，9： | 4 |
| 5 | Genome-wide comprehensive analysis of transcriptomes and small RNAs offers insights into the molecular mechanism of alkaline stress tolerance in a citrus rootstock显示文摘Alkaline stress has serious-negative effects on citrus production.Ziyang xiangcheng(Citrus junos Sieb.ex Tanaka)(Cj)is a rootstock that is tolerant to alkaline stress and iron deficiency.Trifoliate orange(Poncirus trifoliata(L.)Raf.)(Pt),the most widely used rootstock in China,is sensitive to alkaline stress.To investigate the molecular mechanism underlying the tolerance of Cj to alkaline stress,next-generation sequencing was employed to profile the root transcriptomes and small RNAs of Cj and Pt seedlings that were cultured in nutrient solutions along a three pH gradient.This two-level regulation data set provides a system-level view of molecular events with a precise resolution.The data suggest that the auxin pathway may play a central role in the inhibitory effect of alkaline stress on root growth and that the regulation of auxin homeostasis under alkaline stress is important for the adaptation of citrus to alkaline stress.Moreover,the jasmonate(JA)pathway exhibits the opposite response to alkaline stress in Cj and Pt and may contribute to the differences in the alkaline stress tolerance and iron acquisition between Cj and Pt.The dataset provides a wealth of genomic resources and new clues to further study the mechanisms underlying alkaline stress resistance in Cj. | Juxun Wu Junying Cao Mei Su Guizhi Feng Yanhui Xu Hualin Yi | 2019 | Horticulture Research2019，6，1： | 4 |
| 6 | Effects of HIV status notification on reducing the risk of sexual transmission of HIV in China显示文摘 | Bao Yugang Jing Jun Zhang Yanhui Li Huasheng Feng Liangui Ning Zhen Tan Hongzhuan | 2014 | Chinese Medical Journal2014，，24： | 4 |
| 7 | Polymer matrix mediated solvation of LiNO3 in carbonate electrolytes for quasi-solid high-voltage lithium metal batteries显示文摘Lithium(Li)metal is one of the most promising anodes for next-generation energy storage systems.However,the Li dendrite formation and unstable solid-electrolyte interface(SEI)have hindered its further application.Lithium nitrate(LiNO3)is extensively used as an effective electrolyte additive in ether-based electrolytes to improve the stability of lithium metal.Nevertheless,it is rarely utilized in carbonate electrolytes due to its low solubility.Here,a novel gel polymer electrolyte(GPE)consisting of poly(vinylidene fluoride)(PVDF),poly(methyl methacrylate)(PMMA),poly(ethylene oxide)(PEO)with LiN03 additive is proposed to solve this issue.In this GPE,polyether-based PEO serves as a matrix for dissolving LiNO3 which can be decomposed into a fast Li-ion conductor(Li3N)in conventional carbonate electrolytes to enhance the stability and Li^+conductivity of the SEI film.As a result,dendrite formation is effectively suppressed,and a significantly improved average Coulombic efficiency(CE)of 97.2%in Li-Cu cell is achieved.By using this novel GPE coupled with Li anode and LiNi0.5Mn0.3Co0.2O2(NMC532),excellent capacity retention of 94.1%and high average CE of over 99.2%are obtained after 200 cycles at 0.5 C.This work presents fresh insight into practical modification strategies on high-voltage Li metal batteries. | Zijian Wang Kai Yang Yongli Song Hai Lin Ke Li Yanhui Cui Luyi Yang Feng Pan | 2020 | Nano Research2020，13，9： | 3 |
| 8 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 9 | Computational and Experimental Study of Cooling Process in Coke Dry Quenching Experimental Shaft显示文摘Owing to its merits in energy savings, environmental protection and coke quality improvement, the Coke Dry Quenching (CDQ) technology is favorite in coke making industry today. In order to validate the mathematical model developed for the cooling process of real CDQ shaft, the one-seventh scale experimental setup was established. With the air as the working fluid and the coke as the packed bed, the coke and gas temperatures and the pressure drop in the cooling shaft were measured. A mathematical model based on the non-Darcian and non-thermal equilibrium model for the cooling process of the CDQ experimental shaft was presented. The computational results were compared to the experimental data. It was found that most numerical predictions were supported by the measured values. | Huafei Liu Xinxin Zhang Maolin Wu Yanhui Feng Yingbo Wang Dinan Wang Lie Xu Wenghua Zheng | 2002 | Journal of Thermal Science2002，11，2： | 2 |
| 10 | Numerical and experimental study on coke size distribution in bell-type charging in the CDQ shaft显示文摘The mechanism of coke size segregation in the radial direction of pre-chamber in coke dry quenching(CDQ)shaft was investigated by experiment and numerical analysis.The experimental apparatus was a cold three-dimensional semicircle model for bell-type charging,which was used to study the influences of different kinds of bells and different stock line levels on the radial dis- tribution of coke size in the radial direction of a pre-chamber.A mathematical model was used,which is capable of estimating the radial average size distribution as well as the radial deposit distribution of each particle size for multiple size coke with a few fixed parameters.The calculated results agree well with the experimental data,which proves the reliability of both experimental study and numerical analysis. | Zhicheng Liu Yanhui Feng Xinxin Zhang Lie Xu Zhendong Yu | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 2 |
| 11 | Fabrication, adsorption and photocatalytic properties of ZnTi0.6Fe1.4O4/Carbon nanotubes composites显示文摘ZnTi_xFe_(2–x)O_4 and ZnTi_(0.6)Fe_(1.4)O_4/Carbon nanotubes(ZT_(0.6)F_(1.4)/CNTs) composites were prepared by chemical co-precipitation method. The composition, microstructure, magnetic property, adsorption and photocatalytic activity of the prepared samples were characterized by means of modern analytical techniques. The results indicated that ZT_(0.6)F_(1.4)/CNTs composites not only held the original special structure and excellent adsorption properties of CNTs, but also had suitable magnetic property and excellent photocatalytic activity. The removal rate of the samples on Rhodamine B(RhB) depended on the adsorption of CNTs and the photocatalytic degradation of ZT_(0.6)F_(1.4) in the composites. The maximum adsorption amount(q_m) of ZT_(0.6)F_(1.4)/CNTs with the mass ratios of ZT_(0.6)F_(1.4) to CNTs(mZ/C)=1 was up to 17.153 mg g^(–1) for RhB, its adsorption behavior was in accord with Langmuir model, and its photocatalytic degradation activity on RhB had a positive correlation with the content of ZT_(0.6)F_(1.4) in the sample. The experimental results indicate that the total removal rate of composite with mZ/C=1 on RhB was more than 95% and the composite had good decontamination capability on industrial dye wastewater. In addition, the samples can be recovered conveniently, activated easily and had good performance for recycling. | Jiantao Feng Yanhui Hou Yechen Wang Xiya Wang Haifeng Chen Liangchao Li | 2016 | Science China Chemistry2016，59，8： | 2 |
| 12 | Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘H3K9me2 和 H3K27me2 是与抄写压抑联系的重要 epigenetic 标记,当 H3K4me3 与抄写激活被联系时。活跃、压抑的 histone methylations 以一种互相独占的方式散布,这被显示出,但是内在的机制糟糕被理解。这里,我们识别了 ceKDM7A,一个哲学博士(植物 homeodomain )- 并且 JmjC 包含域的蛋白质,为 H3K9me2 和 H3K27me2 特定的 histone demethylase。我们进一步证明 ceKDM7A 的 PHD 领域在染色体宽的水平绑了 H3K4me3 和与 ceKDM7A co 局部性的 H3K4me3。到 H3K4me3 的 PHD 域绑定的混乱在 vivo 减少了 demethylase 活动,并且 ceKDM7A 的损失减少了它的联系目标基因的表达式。这些结果显示 ceKDM7A 被招募到倡导者到 demethylate H3K9me2 和 H3K27me2 并且通过 PHD 领域的绑定激活基因表示到 H3K4me3。因此,我们的学习识别双特性的 histone demethylase 并且提供新奇卓见进 histone methylation 的规定。 | Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen | 2010 | Cell Research2010，20，8： | 2 |
| 13 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 14 | Monitoring wind turbine gearboxes显示文摘 | Yanhui Feng Yingning Qiu Christopher J. Crabtree Hui Long Peter J. Tavner | 2013 | Wind Energ2013，，5： | 1 |
| 15 | Synthesis of confined Ag nanowires within mesoporous silica via double solvent technique and their catalytic properties显示文摘 | Xiubing Huang Wenjun Dong Ge Wang Mu Yang Li Tan Yanhui Feng Xinxin Zhang | 2011 | Journal of Colloid And Interface Science2011，，1： | 1 |
| 16 | Prediction of Thermal Conductivity of Aluminum Nanocluster-Filled Mesoporous Silica (Al/MCM-41)显示文摘 | Congliang Huang Yanhui Feng Xinxin Zhang Jing Li Liu Cui Ge Wang Mu Yang | 2013 | International Journal of Thermophysics2013，，12： | 1 |
| 17 | An ionic liquid-modified graphene based molecular imprinting electrochemical sensor for sensitive detection of bovine hemoglobin显示文摘 | Zonghua Wang Feng Li Jianfei Xia Lin Xia Feifei Zhang Sai Bi Guoyu Shi Yanzhi Xia Jingquan Liu Yanhui Li Linhua Xia | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 18 | Numerical Analysis of Heat Transfer and Fluid Flow in Keyhole Plasma Arc Welding显示文摘 | Tao Zhang ChuanSong Wu Yanhui Feng | 2011 | Numerical Heat Transfer Part A: Applications2011，，8： | 1 |
| 19 | Modeling the transient heat transfer for the controlled pulse key-holing process in plasma arc welding显示文摘 | Junhua Sun Chuan Song Wu Yanhui Feng | 2011 | International Journal of Thermal Sciences2011，，9： | 1 |
| 20 | Zonal method solution of radiative heat transfer in a one- dimensional long roller-hearth furnace in CSP 显示文摘 | WU Wenfei FENG Yanhui ZHANG Xinxin | 2007 | Journal of University of Science and Technology Beijing: Mineral Metallurgy Materials (Eng Ed)2007，14，4： | 1 |
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