|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | JMJD3 is a histone H3K27 demethylase显示文摘组蛋白甲基化是参予细胞的过程的一个多样的数组的重要 epigenetic 现象并且被发现了与癌症被联系。几的 Recentidentification 嘘一 demethylases 证明了那嘘一甲基化是一个可逆过程。通过一条候选人途径,我们化学上有简历作为 H3K27demethylase 识别了 JMJD3。进 HeLa 房间的 JMJD3 的 Transfection 引起了整齐的乙醇 H3K27 的特定的减小,但是没在 di- 和单音的甲基 H3K27 上有效果,或嘘 H3K4 和 H3K9 上的一离氨酸 methylations。Theenzymatic 活动要求 JmjC 域和被建议了为余因子绑定重要的保存组氨酸。试管内生物化学的实验证明那 JMJD3directly 催化 demethylation。另外,我们发现 JMJD3 起来在前列腺癌症,和它的表示调整了在变形前列腺癌症是更高的。因此,我们作为能够把整齐的乙醇组从移开的 ademethylase 识别了 JMJD3 嘘一 H3 离氨酸 27 并且起来在前列腺癌症调整了。 | Yang Xiang Ziqi Zhu Gang Han Hanqing Lin Longyong Xu Charlie Degui Chen | 2007 | Cell Research2007，17，10： | 37 |
| 2 | Form-fnding methods for deployable mesh reflector antennas显示文摘Deployable high-frequency mesh reflector antennas for future communications and observations are required to obtain high gain and high directivity.In order to support these new missions,reflectors with high surface accuracy are widely required.The form-fnding analysis of deployable mesh reflector antennas becomes more vital which aims to determine the initial surface profle formed by the equilibrium prestress distribution in cables to satisfy the surface accuracy requirement.In this paper,two form-fnding methods for mesh reflector antennas,both of which include two steps,are proposed.The frst step is to investigate the prestress design only for the cable net structure as the circumferential nodes connected to the supporting truss are assumed fxed.The second step is to optimize the prestress distribution of the boundary cables connected directly to the supporting truss considering the elastic deformation of the antenna structure.Some numerical examples are carried out and the simulation results demonstrate the proposed form-fnding methods can warrant the deformed antenna reflector surface matches the one by design and the cable tension forces fall in a specifed range. | Li Tuanjie Jiang Jie Deng Hanqing Lin Zhanchao Wang Zuowei | 2013 | Chinese Journal of Aeronautics2013，26，5： | 15 |
| 3 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘Histone 离氨酸 methylation 能被 JmjC 包含域的蛋白质在 sequence-state-specific 和 methylation-state-specific 举止移开。然而,底层特性怎么样,决定,酶怎么被调整,大部分是未知的。我们最近发现了那 ceKDM7A,一个哲学博士 -- 并且 JmjC 包含域的蛋白质,是为 H3K9me2 特定的 histone demethylase, H3K27me2,和 PHD 摸绑定到 H3K4me3 指南在 vivo 的 demethylation 活动。为了为酶的活动和 PHD 的功能提供结构的卓见进分子的机制,摸,我们与包含 H3K4me3, H3K9me2,和 H3K27me2 修正的各种各样的联合的单身者或二肽一起在 apo 形式并且在建筑群解决了酶的六水晶结构。结构显示 H3K9me2 和 H3K27me2 以一种类似的方式与 ceKDM7A 交往,并且肽绑定特性被特定的相互作用的一个网络决定。结构的几何测量也揭示了与 PHD 手指和 H3K9me2 界限联系到 JmjC 领域的那 H3K4me3 从二个分开的分子,建议 trans-histone 肽绑定机制。因此,我们的全身的结构的研究重要地由催化领域而且更多揭示底层识别不仅,为 H3K9me2 和 H3K27me2 的 ceDKM7A 的双特性的分子的机制。 | Ying Yang Lulu Hu Ping Wang Haifeng Hou Yan Lin Yi Liu Ze Li Rui Gong Xiang Feng Lu Zhou Wen Zhang Yuhui Dong Huirong Yang Hanqing Lin Yiqin Wang Charlie Degui Chen Yanhui Xu | 2010 | Cell Research2010，20，8： | 3 |
| 4 | Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans显示文摘H3K9me2 和 H3K27me2 是与抄写压抑联系的重要 epigenetic 标记,当 H3K4me3 与抄写激活被联系时。活跃、压抑的 histone methylations 以一种互相独占的方式散布,这被显示出,但是内在的机制糟糕被理解。这里,我们识别了 ceKDM7A,一个哲学博士(植物 homeodomain )- 并且 JmjC 包含域的蛋白质,为 H3K9me2 和 H3K27me2 特定的 histone demethylase。我们进一步证明 ceKDM7A 的 PHD 领域在染色体宽的水平绑了 H3K4me3 和与 ceKDM7A co 局部性的 H3K4me3。到 H3K4me3 的 PHD 域绑定的混乱在 vivo 减少了 demethylase 活动,并且 ceKDM7A 的损失减少了它的联系目标基因的表达式。这些结果显示 ceKDM7A 被招募到倡导者到 demethylate H3K9me2 和 H3K27me2 并且通过 PHD 领域的绑定激活基因表示到 H3K4me3。因此,我们的学习识别双特性的 histone demethylase 并且提供新奇卓见进 histone methylation 的规定。 | Hanqing Lin Yiqin Wang Yanru Wang Feng Tian Pu Pu Yi Yu Hailei Mao Ying Yang Ping Wang Lulu Hu Yan Lin Yi Liu Yanhui Xu Charlie Degui Chen | 2010 | Cell Research2010，20，8： | 2 |
| 5 | Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis显示文摘 | Hongchang Gao Baijun Dong Xia Liu Hanqing Xuan Yiran Huang Donghai Lin | 2008 | Analytica Chimica Acta2008，，2： | 1 |
| 6 | Production of conjugated linoleic acids through KOH-catalyzed dehydration of ricinoleic acid显示文摘 | YANG Lin HUANG Yu WANG Hanqing | 2002 | Chemistry and Physics of Lipids2002，119，： | 1 |
| 7 | Production of conjugated linoleic acids through KOH-catalyzed dehydration of ricinoleic acid 显示文摘 | YANG Lin HUANG Yu WANG Hanqing | 2002 | Chemistry and Physics of Lipids2002，119，： | 1 |
| 8 | Design and development of a mitochondrial-targeted photosensitizer for two-photon fluorescence imaging and photodynamic therapy显示文摘Mitochondria are well-acknowledged as ideal targets for tumor therapy due to their important role in energy supply and cellular signal regulation.Mitochondria-specific photosensitizers have been reported to be critical for inducing cell apoptosis.Two-photon fluorescence imaging provides a new technique for delineating biological structures and activities in deep tissues.Herein,we developed a new aggregation-induced emission(AIE)active photosensitizer by attaching a pyridinium group for mitochondrial target-ing.The rationally designed photosensitizer(TTTP)exhibited excellent photophysical properties,good biocompatibility,reactive oxygen species(ROS)stimulation ability,anticancer efficacy,and two-photon imaging properties.TTTP was highly taken up by cells and accumulated specifically in mitochondria but was selectively cytotoxic to cancer cells.Under light irradiation,the generation of ROS was significantly boosted,leading to actively induced apoptosis.The in vivo tumor photodynamic therapeutic efficacy of TTTP showed significant inhibition of tumor growth.Furthermore,the underlying mechanism of TTTP tu-mor suppression revealed that the apoptosis agonist Bax was markedly up-regulated while the antagonist Bcl-xL was down-regulated.This research provides a potential mitochondrial-targeted phototherapeutic agent for effective therapy and two-photon fluorescence imaging. | Yu Chen Sheng Zhang Tianjiao Cheng Wei Lin Linlin Mao Zhonghui Chen Yang Yang Hanqing Huang Jinqiu Li Zhiyong Ke Zhong-Kai Cui | 2023 | Journal of Materials Science & Technology2023，，10： | 0 |
| 9 | An active bacterial anti-adhesion strategy based on directional transportation of bacterial droplets driven by triboelectric nanogenerators显示文摘An active bacterial anti-adhesion strategy based on directional transportation of bacterial droplets driven by a triboelectric nanogenerator(TENG)has not been reported to date,although passive defense approaches can prevent bacterial adhesion by regulating superwetting surfaces combined with incorporated antibacterial substances.Here a triboelectric nanogenerator driving droplet system(TNDDS)was built to drive directional transportation of bacterial droplets to be eliminated,which comprises TENG with periodical frictional Kapton film and aluminum foils and a superhydrophobic driving platform(SDP)with paralleled driving electrodes.The current generated by the TENG triboelectricity is transmitted to the paralleled driving electrodes to form an electric field driving the directional transportation of charged droplets.The critical value of the driven droplet volume on SDP is closely related to the distributed electrodes’distance and width,and the driving distance of droplets is related to the number of electrodes.More crucially,TNDDS can actively drive the charged droplets of prepared triangular silver nanoprisms(Ag NPs)forward and back to mix with and remove a tiny bacterial droplet on an open SDP or in a tiny semi-enclosed channel.Bacteria could be killed by releasing Ag+and effectively removed by TNDDS by regulating the motion direction.Generally,this approach offers a promising application for removing bacteria from material surfaces driven by TENG and opens a new avenue for bacterial anti-adhesion. | Jing Lin Jialin Li Shichang Feng Caiqin Gu Huajian Li Hanqing Lu Fei Hu Duo Pan Ben Bin Xu Zhanhu Guo | 2023 | Nano Research2023，16，1： | 0 |
| 10 | Identification and characterization of multipotential stem cells in immortalized normal ovarian surface epithelial cells显示文摘The ovarian surface epithelium(OsE)is a single layer of squamous-to-cuboidal epithelial cells that experience repetitive ovulatory rupture and subsequent repair.However,the characteristics of human immortalized ovarian surface epithelial cells(IOSE80)remain elusive.This study aims to determine whether IOSE80 cells have the characteristics of stem cell proliferation and multilineage differentiation and their application in regenerative medicine.IOsE80 cells are sequenced by high-throughput transcriptome analysis,and 5 sets of public data are used to compare the differences between IosE8o cells and bone marrow mesenchymal stem cells,pluripotent stem cells,and oocytes in transcriptome profiling.The IOsE80 cells present a cobblestone-like monolayer and express the epithelial cell marker KRT18;the stem cell markers IFITM3,ALDH1A1,and VIM;lowly express stem cell marker LGR5 and germ cell markers DDX4 and DAZL.In addition,the GO terms'regulation of stem cell proliferation','epithelial cell proliferation',etc.,are significantly enriched(P<0.05).IOSE80 cells have the potential to act as mesenchymal stem cells to differentiate into adipocytes with lipid droplets,osteoblasts,and chondroblasts in vitro.IOSE80 cells express pluripotent stem cell markers,including OCT4,SSEA4,TRA-1-60,and TRA-1-81,and they can be induced into three germ layers in vitro.IOSE80 cells also form oocyte-like cells in vitro and in vivo.In addition,IOSE80 cells exhibit robust proliferation,migration,and ovarian repair functions after in vivo transplantation.This study de-monstrates that losE8o cells have the characteristics of pluripotent/multipotent stem cells,indicating their im-portant role in tissue engineering and regenerative medicine. | Lin Hou Hanqing Hong Wenjiao Cao Liutong Wei Lichun Weng Shuang Yuan Chengqi Xiao Qiuwan Zhang Qian Wang Dongmei Lai | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 11 | Interfacial engineering of atomic platinum-doped molybdenum carbide quantum dots for high-rate and stable hydrogen evolution reaction in proton exchange membrane water electrolysis显示文摘Platinum(Pt)-based electrocatalysts remain the only practical cathode catalysts for proton exchange membrane water electrolysis(PEMWE),due to their excellent catalytic activity for acidic hydrogen evolution reaction(HER),but are greatly limited by their low reserves and high cost.Here,we report an interfacial engineering strategy to obtain a promising low-Pt loading catalyst with atomically Pt-doped molybdenum carbide quantum dots decorated on conductive porous carbon(Pt-MoCx@C)for high-rate and stable HER in PEMWE.Benefiting from the strong interfacial interaction between Pt atoms and the ultra-small MoCx quantum dots substrate,the Pt-MoCx catalyst exhibits a high mass activity of 8.00 A·mgPt−1,5.6 times higher than that of commercial 20 wt.%Pt/C catalyst.Moreover,the strong interfacial coupling of Pt and MoCx substrate greatly improves the HER stability of the Pt-MoCx catalyst.Density functional theory studies further confirm the strong metal-support interaction on Pt-MoCx,the critical role of MoCx substrate in the stabilization of surface Pt atoms,as well as activation of MoCx substrate by Pt atoms for improving HER durability and activity.The optimized Pt-MoCx@C catalyst demonstrates>2000 h stability under a water-splitting current of 1000 mA·cm^(−2)when applied to the cathode of a PEM water electrolyzer,suggesting the potential for practical applications. | Lulu Chen Yichao Huang Yanping Ding Ping Yu Fang Huang Wenbo Zhou Limin Wang Yangyang Jiang Haitao Li Hanqing Cai Lin Wang Hang Wang Meihong Liao Lianming Zhao Zhuangjun Fan | 2023 | Nano Research2023，16，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员