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| 1 | 成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) | 2007 | 国际脑血管病杂志2007，15，7： | 234 |
| 2 | 短暂性脑缺血发作的定义和评价:美国心脏协会/美国卒中协会卒中委员会、心血管外科和麻醉委员会、心血管放射学和介入委员会、心血管护理委员会和外周血管病跨学科委员会对医疗卫生专业人员发布的科学声明:美国神经病学学会确认该声明作为神经科医生继续教育工具的价值显示文摘本科学声明面向为短暂性脑缺血发作(transient ischemic attacks,TIA)患者提供医疗诊治的临床医生和相关医疗卫生人员。采用正规的证据复习方法对1990-2007年7月期间Medline数据库进行系统的文献检索,并运用证据表、汇总分析和病例资料的合并分析,对数据进行综合处理。本文支持以下基于组织学的TIA定义:局灶性脑、脊髓或视网膜缺血引起的短暂性神经功能障碍发作,且无急性脑梗死。TIA患者的近期卒中风险较高,可根据临床量表、血管影像学和磁共振弥散加权成像进行风险分层。诊断推荐包括:TIA患者应在发病24h内接受神经影像学评价,最好是应用包括弥散序列在内的MRI;应进行无创性颈部血管成像检查,最好是无创性颅内血管成像;对于未能确定血管病因的患者,TIA发病后应尽快进行心电图检查,也应考虑持续心电监测和超声心动图检查;应进行常规血液化验;对于发病72h内就诊并且ABCD^2评分≥3分(提示近期复发风险较高)或在门诊不能迅速完成诊断评价的TIA患者,应收入院治疗。 | J. Donald Easton Jeffrey L. Saver Gregory W. Albers Mark J. Alberts Seemant Chaturvedi Edward Feldmann Thomas S. Hatsukami Randall T. Higashida S. Claibome Johnston Chelsea S. Kidwell Helmi L. Lutsep Elaine Miller Ralph L. Sacco 李海峰 高翔(译) | 2009 | 国际脑血管病杂志2009，，9： | 86 |
| 3 | 成人自发性脑出血处理指南——2007年更新版 美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南 美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S.Ogilvy Paul Vespa Mario Zuccarello 王玉洁 刘娟 白璇 李新辉 孙虹 姚志成 张慧 牛英翔 | 2008 | 中华脑血管病杂志(电子版)2008，2，1： | 29 |
| 4 | 脑动静脉畸形的处理:美国心脏协会/美国卒中协会对医疗卫生专业人员发布的科学声明显示文摘背景本声明旨在复习目前脑动静脉畸形(brain arteriovenous malformations,bAVMs)的临床资料,为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词,讨论描述性文字和制定建议。作者通过PubMed、Medline或Embase完成各自相关章节的文献检索,时间截止到2015年1月底。声明草稿由同行评议专家以及卒中委员会科学监督委员会和卒中委员会领导委员会进行预先审查。结果本科学声明的重点细分为流行病学、诊断、自然史、治疗方案(包括开颅手术、立体定向放射外科和栓塞治疗的作用)以及破裂和未破裂bAVMs的处理,并且确定了需要更多证据支持的领域。结论bAVMs是一种相对少见但非常重要的出血性卒中病因,尤其是在年轻成人中。本声明描述了目前关于破裂和未破裂bAVMs的自然史和治疗方法的知识现状,同时提供了处理建议以及对将来研究的提示。 | Colin P. Derdeyn Gregory J. Zipfel Felipe C. Albuquerque Daniel L. Cooke Edward Feldmann Jason P. Sheehan James C. Tomer 盖延廷 王威 简新革 檀书斌 李彦江 彭方强 刘旻谛 宋冬雷 | 2017 | 国际脑血管病杂志2017，25，8： | 12 |
| 5 | The importance of glutathione and phytochelatins on the selenite and arsenate detoxification in Arabidopsis thaliana显示文摘We investigated the role of glutathione(GSH) and phytochelatins(PCs) on the detoxification of selenite using Arabidopsis thaliana. The wild-type(WT) of Arabidopsis thaliana and its mutants(glutathione deficient Cad 2–1 and phytochelatins deficient Cad 1–3) were separately exposed to varying concentrations of selenite and arsenate and jointly to both toxicants to determine their sensitivities. The results of the study revealed that, the mutants were about 20-fold more sensitive to arsenate than the WT, an indication that the GSH and PCs affect arsenate detoxification. On the contrary, the WT and both mutants showed a similar level of sensitivity to selenite, an indication that the GSH and PCs do not significantly affect selenite detoxification. However, the WT is about 8 times more sensitive to selenite than to arsenate, and the mutants were more resistant to selenite than arsenate by a factor of 2. This could not be explained by the accumulation of both elements in roots and shoots in exposure experiments. The co-exposure of the WT indicates a synergistic effect with regards to toxicity since selenite did not induce PCs but arsenic and selenium compete in their PC binding as revealed by speciation analysis of the root extracts using HPLC–ICP–MS/ESI–MS. In the absence of PCs an antagonistic effect has been detected which might suggest indirectly that the formation of Se glutathione complex prevent the formation of detrimental selenopeptides. This study, therefore, revealed that PC and GSH have only a subordinate role in the detoxification of selenite. | Fatai Adigun Aborode Andrea Raab Matthias Voigt Leticia Malta Costa Eva M.Krupp Joerg Feldmann | 2016 | Journal of Environmental Sciences2016，28，11： | 6 |
| 6 | Possible leap ahead in filovirus therapeutics显示文摘 | Darrvl Falzarano Heinz Feldmann | 2014 | Cell Research2014，24，6： | 5 |
| 7 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 8 | Ebola haemorrhagic fever显示文摘 | Heinz Feldmann Thomas W Geisbert | 2011 | The Lancet2011，，9768： | 3 |
| 9 | Epidemiology of vestibular vertigo: A neurotologic survey of the general population显示文摘 | H K. Neuhauser M von Brevern A Radtke F Lezius M Feldmann T Ziese T Lempert | 2005 | Neurology2005，，6： | 2 |
| 10 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 11 | Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis显示文摘 | Tsung-Cheng Chang Erik A. Wentzel Oliver A. Kent Kalyani Ramachandran Michael Mullendore Kwang Hyuck Lee Georg Feldmann Munekazu Yamakuchi Marcella Ferlito Charles J. Lowenstein Dan E. Arking Michael A. Beer Anirban Maitra Joshua T. Mendell | 2007 | Molecular Cell2007，，： | 2 |
| 12 | T-DNA insertion mutagenesis in Arabidopsis:going back and forth显示文摘 | AZPIROZ L R FELDMANN K A | 1997 | Trends Genet1997，13，4： | 1 |
| 13 | Role of cytokines in rheumatoid arthritis显示文摘 | Feldmann M Brennan FM Maini RN | 1996 | Annu Rev Immunol1996，14，： | 1 |
| 14 | A System of Steel-elastomer Sandwich Plates for Strengthening Orthotropic Bridge Decks显示文摘 | FELDMANN M SEDLACEK G GEBLER A | | Mechanics of Composite Materials0，43，2： | 1 |
| 15 | The SABRE gene is required for normal cell expansion in Arabidopsis 显示文摘 | Aeschbacher R A Hauser M T Feldmann K A Benfey P N | 1995 | Genes& Development1995，9，3： | 1 |
| 16 | Optical investigation of Bloch oscillations in a semiconductor superlattice显示文摘 | Feldmann J | 1992 | Phys Rev B1992，46，： | 1 |
| 17 | Factors associated with early presentation of acute stroke显示文摘 | Feldmann E Gordon N Brooks JM | 1993 | Stroke1993，24，12： | 1 |
| 18 | Interleukin -6 in the synovial membrane in rheumatoid arthritis 显示文摘 | FIELD M CHU C Q FELDMANN M | 1991 | Rheumatol Int1991，11，： | 1 |
| 19 | GJB2 mutations and degree of hearing loss: a multicenter study显示文摘 | Snoeckx R Huygen P Feldmann D | 2005 | Am J Hum Genet2005，77，： | 1 |
| 20 | Clinical outcome after Chev- ron- Akin double osteotomy versus isolated Chevron procedure: a prospective matched group analysis 显示文摘 | Lechler P Feldmann C Kock FX | 2012 | Arch Orthop Trauma Surg2012，1，： | 1 |
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