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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 3 | A microsecond-pulse length,frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R L | 1992 | IEEE Trans on Plasma Sci1992，20，3： | 1 |
| 4 | 5-Fluorouracil as protracted continuous intravenous infusion can be added to full-dose docetaxel (Taxotere)-cisplatin in advanced gastric carcinoma:a phase Ⅰ-Ⅱ trial显示文摘 | Roth A D Maibach R Fazio N | 2004 | Ann Oncol2004，15，5： | 1 |
| 5 | Screening-photovoltaic bright solitons in lithium niobate and associated single-mode waveguides显示文摘 | FAZIO E RENZI F RINALDI R | 2004 | Applied Physics Letters2004，85，12： | 1 |
| 6 | Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubicin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized phase Ⅱ trial of the swiss group for clinical cancer research显示文摘 | Roth AD Fazio N Stupp R | 2007 | J Chn Oncoi2007，25，22： | 1 |
| 7 | Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubicin, cis- platin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized phase Ⅱ trial of the Swiss Group for Clinical Cancer Research 显示文摘 | Roth AD Fazio N Stupp R | 2007 | J Clin Oncol2007，25，22： | 1 |
| 8 | Implicit measures in social cogn ition research: their meaning and use 显示文摘 | FAZIO R H OLSON M A | | Annual Review of Psychology 200 30，54，： | 1 |
| 9 | Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin and epirubicin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma:a randomized phase 11 trial of the Swiss Group for Clinical Cancer Research 显示文摘 | Roth AD Fazio N Stupp R | 2007 | J Clin Oncol2007，25，22： | 1 |
| 10 | Detection of geometric phases in superconducting nano-circuits显示文摘 | FALCI G FAZIO R PALMA G M | 2000 | Nature2000，407，： | 1 |
| 11 | On the Automatic Aetivation of Attitudes 显示文摘 | Fazio R H etal | 1986 | Journal of Personality and Social Psyehology1986，50，2： | 1 |
| 12 | Hepatocellular carcinoma in Italian patients with cirrhosis显示文摘 | Colombo M de Franchis R Del Ninno E Sangiovanni A De Fazio C Tommasini M | | New England Journal of Medicine0，，： | 1 |
| 13 | Docetaxel,cisplatin,and fluorouracil;docetaxel and cisplatin;and epirubicin,cisplatin,and fluorouracil as systemic treatment for advanced gastric carcinoma:a randomized phase Ⅱ trial of the Swiss Group for Clinical Cancer Research显示文摘 | Roth AD Fazio N Stupp R | 2007 | J Clin Oncol2007，25，22： | 1 |
| 14 | A microsecond-pulse length, frequency-stabilized virtual-cathode oscillator using a resonant cavity显示文摘 | Fazio M V Freeman B L Hoeberlin R | 1992 | IEEE1992，20，3： | 1 |
| 15 | Bile analysis of drugs in postmortem cases 显示文摘 | Vanbinst R Koenig J Di Fazio V | 2002 | Forensic Sci Int2002，128，12： | 1 |
| 16 | Docetaxel neuropa- thy: a distal axonopathy显示文摘 | Fazio R Quattrini A Bolognesi A | 1999 | Acta Neuropathol1999，98，6： | 1 |
| 17 | Docetaxel, cisplatin, and fluorouracil; docetaxel and cisplatin; and epirubicin, cisplatin, and fluorouracil as systemic treatment for advanced gastric carcinoma: a randomized phase lI trial of the Swiss Group for Clinical Cancer Research 显示文摘 | Roth AD Fazio N Stupp R | 2007 | J Clin Oncol2007，25，22： | 1 |
| 18 | Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mistl 显示文摘 | Fazio EN Everest M Colman R | 2005 | J Endocrinol2005，187，3： | 1 |
| 19 | An exaggerated systolic blood pressure response to exercise is associated with cardiovascular re- modeling in subjects with prehypertension 显示文摘 | Fazio S Palmieri EA Izzo R | 2005 | Ital Heart J2005，6，11： | 1 |
| 20 | Beam-cavity ineraction physics for middly relativistic,intense-beam klystron amplifier显示文摘 | Carlsten B E Faehl R J Fazio M V | | 0，，05： | 1 |
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