|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 生物质燃烧颗粒物的定量分析和化学形态显示文摘用电子探针技术开展单个含钾颗粒物的分析表征 .第一种方法用蒙特卡洛方法模拟电子束与样品复杂的相互作用 ,对于KCl晶粒取得的计算结果与理论值一致 .K/Cl比的均值为 0 996 ,标准偏差为 0 0 1 2 .由于晶形不规则和热稳定性差 ,K2 SO4 和KHSO4 的结果没有达到KCl的准确度 .其K/S比的均值和标准偏差分别为 1 90 5±0 0 1 3和 1 0 1 4± 0 0 72 .第二种方法用回归分析方法处理了同一种类若干数目的颗粒物分析数据 .直接用同种类标准颗粒物的分析结果校准 ,进行定量分析和化学形态识别 .研究结果表明 ,非洲草原大火燃烧排放时 ,含钾颗粒经历了逐步酸化的过程 .在排放时主要以KCl形态存在 ,少量是K2 SO4 和复盐 .在大气传输过程中逐渐酸化 ,主要转变成KHSO4 .少量停空时间长的颗粒则继续酸化 ,成为高度富硫的颗粒 . | 刘咸德 李玉武 董树屏 Van EspenP Adams F Maenhaut W | 2002 | 环境化学2002，21，3： | 13 |
| 2 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 3 | Hepatic expression and cellular distribution of the glucose transporter family显示文摘Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required. | Sumera Karim David H Adams Patricia F Lalor | 2012 | World Journal of Gastroenterology2012，18，46： | 5 |
| 4 | Targeting DNA Double-Strand Breaks with TAL Effector Nucleases显示文摘 | Christian Michelle Cermak Tomas Doyle Erin L Schmidt Clarice Zhang Feng Hummel Aaron Bogdanove Adam J Voytas Daniel F | 2010 | Genetics2010，，2： | 3 |
| 5 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 6 | Magnitude of modulation of gene expression in aneuploid maize depends on the extent of genomic imbalance显示文摘Aneuploidy has profound effects on an organism,typically more so than polyploidy,and the basis of this contrast is not fully understood.A dosage series of the maize long arm of chromosome 1(1L)was used to compa re relative global gene expression in diffe rent types and degrees of aneuploidy to gain insights into how the magnitude of genomic imbalance as well as hypoploidy affects global gene expression.While previously available methods require a selective examination of specific genes,RNA sequencing provides a whole-genome view of gene expression in aneuploids.Most studies of global aneuploidy effects have concentrated on individual types of aneuploids because multiple dose aneuploidies of the same genomic region are difficult to produce in most model genetic organisms.The genetic toolkit of maize allows the examination of multiple ploidies and 1-4 doses of chromosome arms.Thus,a detailed examination of expression changes both on the varied chromosome arms and elsewhere in the genome is possible,in both hypoploids and hyperploids,compared with euploid controls.Previous studies observed the inverse trans effect,in which genes not varied in DNA dosage were expressed in a negative relationship to the varied chromosomal region.This response was also the major type of changes found globally in this study.Many genes varied in dosage showed proportional expression changes,though some were seen to be partly or fully dosage compensated.It was also found that the effects of aneuploidy were progressive,with more severe aneuploids producing effects of greater magnitude. | Adam F·Johnson Jie Hou Hua Yang Xiaowen Shi Chen Chen Md Soliman Islam Tieming Ji Jianlin Cheng James A·Birchler | 2020 | Journal of Genetics and Genomics2020，47，2： | 3 |
| 7 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 8 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 9 | Ethylene biosynthesis: identification of 1-aminocyclopropane-1-carboxylic acid as an intermediate in the conversion of methionine to ethylene 显示文摘 | Adams D O Yang S F | 1979 | Proc Natl Acad Sci1979，76，1： | 2 |
| 10 | Bee Parasitic Mite Syndrome(II):The Role of Varroa Mite and Virues 显示文摘 | Hung A C F Adams J R Shimanuki H | 1995 | American Bee Journal1995，12，： | 2 |
| 11 | Changes in the epidemiolngic profile of sudden infant death syndrome as rates decline among California infants:1990-1995显示文摘 | Adams E J Chavez G F Steen D | 1998 | Pediatrics1998，102，6： | 1 |
| 12 | Surrogate end points in heart failure 显示文摘 | LEC C R ADAMS K F PATTERSON J H | 2002 | Ann Pharmacother2002，36，3： | 1 |
| 13 | Effect of organic acids on aluminum toxicity in subsoils显示文摘 | Hue N V Craddock G R Adams F | 1986 | Soil Science Society of America Journal1986，50，： | 1 |
| 14 | Selected contribution:acute cellular and molecular responses to resistance exorcise显示文摘 | Haddad F Adams G R | 2002 | J Appl Physiol2002，93，1： | 1 |
| 15 | Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy显示文摘 | Adam R Levi F | 1996 | Ann Surg1996，224，4： | 1 |
| 16 | Nefopam, a nonsedative benzoxazocine analgesie, selectively reduees the shivering threshold in unanesthetized subjects 显示文摘 | Alfnnsi P Adam F Passard A | 2004 | Anesthesiology2004，，1： | 1 |
| 17 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 18 | Interatomic Potentials Form First-Principles Calculations,the Force-Matching Method显示文摘 | Ercolessi F Adams J B | 1994 | Europhysics Letters1994，26，08： | 1 |
| 19 | Surgical treatment of the ischemic mitral valve显示文摘 | Adams DH Filsoufi F Aklog L | 2002 | J Heart Valve Dis2002，，： | 1 |
| 20 | Intratumoral de-livery of boronated epidermal growth factor for neutron cap-ture therapy of brain tumors显示文摘 | Yang W Barth R F Adams D M | 1997 | Carcer Res1997，57，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员