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| 1 | Double versus single homologous intrauterine insemination for male factor infertility: a systematic review and meta-analysis显示文摘男因素不孕影响 30 % -50%世界范围的不肥沃的夫妇,并且对这些病人的最佳的管理有增加的利息。在比较双、单个的子宫内的授精(IUI ) 的研究,向更高的怀孕的一个趋势评价在结合男因素不孕被观察。因此,我们开始执行元分析与男搭挡的精子检验双对单个的 IUI 的优势在结合男因素不孕。机会比率(或) 95 %信心间隔(CI ) 为怀孕率被计算。结果被根据结果的异质使用 Mantel-Haesel 或 DerSimonian 地主模型分析。总的来说,包含 1125 个 IUI 周期的五试用在元分析被包括。与有单个 IUI 的一个周期相比在有双 IUI 的一个周期以后的怀孕有双重的增加(或:2.0;95 %CI:1.07-3.75;P< 0.03 ) 。不过,这结果主要被归因于大试用的存在那象几乎 50 % 加权;在全面分析。敏感分析,排除这大试用,在两倍 IUI 周期之中向更高的怀孕率揭示了仅仅一个趋势(或:1.58;95 %CI:0.59-4.21 ) ,但是没有统计意义(P=0.20 ) 。我们系统的评论热点关于两倍 IUI 在的使用的可得到的证据结合男因素不孕碎片、弱。尽管可以向更高的怀孕率有一个趋势,当 IUI 的数字每周期被增加时,进一步大、设计得好的使随机化的审判被需要提供稳固的证据指导当前的临床的实践。 | Apostolos Zavos Alexandros Daoonte Antonios Garas Christina Verykouki Evangelos Papanikolao~ Georgios Anifandis Nikolaos P Polyzos | 2013 | Asian Journal of Andrology2013，15，4： | 9 |
| 2 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 3 | Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis显示文摘 | Stergios A. Polyzos Konstantinos A. Toulis Dimitrios G. Goulis Christos Zavos Jannis Kountouras | 2011 | Metabolism2011，，3： | 3 |
| 4 | Comment on “Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics”显示文摘Attaran et al[1] have recently shown that decreased susceptibility of established Helicobacter pylori(H. pylori) biofilms to specific antibiotics,was associated with the overtly enhanced transcription of two efflux pump genes,hp1165 and hef A,involved in specific resistance to tetracycline and multiple antibiotics,respectively. Apart from antibiotic exposure,secretion of multiple antimicrobial peptides,such as human β-defensins(hβDs),by the gastric epithelium upon Hp challenge,may act as early triggering events that positively impact biofilm formation and thus,antibiotic resistance. In this regard,we undertook genomic transcriptional studies using Hp 26695 strain following exposure to sublethal,similar to those present in the gastric niche,concentrations of hβDs in an attempt to provide preliminary data regarding possible mechanisms of immune evasion and selective sensitivity of Hp. Our preliminary results indicate that hβD exposure ignites a rapid response that is largely due to the activation of several,possibly interconnected transcriptional regulatory networks – origons-that ultimately coordinate cellular processes needed to maintain homeostasis and successful adaptation of the bacterium in the gastric environment. In addition,we have shown that both antibiotic and hβD resistance are mediated by dedicated periplasmic transporters,including the aforementioned efflux pump genes hp1165 and hef A,involved in active export of antibiotics from the cell membrane and/or,as recently suggested,substrate sensing and signalling. Furthermore,itappears that sublethal doses of hβDs may enhance biofilm formation by the sustained expression of,mainly,quorum sensing-related genes. In conclusion,we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. | Evangelos I Kazakos Nick Dorrell Stergios A Polyzos Georgia Deretzi Jannis Kountouras | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 5 | Weekly Gemcitabine for the Treatment of Biliary Tract and Gallbladder Cancer显示文摘 | Nikolas Tsavaris Christos Kosmas Panagiotis Gouveris Kostadinos Gennatas Aris Polyzos Despina Mouratidou Heracles Tsipras Helias Margaris George Papastratis Evanthia Tzima Nikitas Papadoniou Gavrilos Karatzas Efstathios Papalambros | 2004 | Investigational New Drugs2004，，2： | 2 |
| 6 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 7 | The Potenlial AdverseRole of Leptin Resistance in Nonalcoholic Fatly Liver Disease: AHypothesis Based on Critical Review of Literature 显示文摘 | Polyzos SA Kountouras J Zavos C | 2010 | Clin (ias-troenterol2010，45，1： | 1 |
| 8 | Second - line chem- otherapy with eapeeitabine (Xeloda) and doeetaxel ( Taxotere ) in previously treated, unresectable adenocarcinoma of pancreas : the fi- nal results of a phase II trial显示文摘 | Katopodis O Polyzos A Kentepozidis N et at | 2011 | Cancer Chemother Pharmaeol2011，67，2： | 1 |
| 9 | A systematic review of randomizedtrials for the treatm ent of poor ovarian, responders : is thereany light at the end of the tunnel- 显示文摘 | Polyzos NP-Devroey P | 2011 | Fertil Steril2011，96，： | 1 |
| 10 | Epidemiologic analysis of thyroid fine needle aspiration biopsies over a period of 18 years (1987-2004)显示文摘 | POLYZOS SA KITA M GOULIS DG | 2008 | Exp Clin Endocrinol Diabetes2008，116，8： | 1 |
| 11 | Striving towards efficiency in the Greek hospitals by reviewing case mix classifications显示文摘 | POLYZOS N M | 2002 | Health Policy2002，61，3： | 1 |
| 12 | Climcal considerations and sonographic findings of a large nonpedunculated primary cervical leiomyoma complicated by heavy vaginal haemorrhage: a case report and review of the literature显示文摘 | Varras M Hadjilira P Polyzos D | 2003 | Clin Exp Obstet Gynecol2003，30，23： | 1 |
| 13 | Modified CAPOX (capecitabine plus oxaliplatin) regimen every two weeks as second-line treatment in patients with advanced colorectal cancer previously treated with irinotecan-based frontline therapy: a multicenter phase Ⅱ study显示文摘 | Kakolyris S Souglakos J Polyzos A | 2008 | Oncology2008，74，12： | 1 |
| 14 | Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules显示文摘 | Polyzos SA Kita M Efstathiadou Z | 2008 | J Cancer Res Clin Oncol2008，134，9： | 1 |
| 15 | Hypersensitivity reactions to carboplatin administration are common but not always severe : a 10-year experience 显示文摘 | Polyzos A Tsavaris N Kosmas C | 2001 | Oncology2001，61，2： | 1 |
| 16 | Intraperitoneal dissemina- tion of endometrial cancer ceils after hysteroscopy : a systematic review and meta-analysis 显示文摘 | Polyzos NP Mauri D Tsioras S | 2010 | Int J Gynecol Cancer2010，20，： | 1 |
| 17 | New algorithm for OHSS prevention 显示文摘 | Papanikolaou EG Humaidan P Polyzos N | 2011 | Reprod Biol Endocrinol2011，9，： | 1 |
| 18 | Live birth rates after IVF are reduced by both low and high progesterone levels on the day of human chorionie gonadotrophin administration显示文摘 | Santos-Ribeiro S Polyzos NP Haentjens P | 2014 | Hum Reprod2014，29，： | 1 |
| 19 | Treatment failure and re- currence of Clostridium difficile infection following treatment with vancomycin or metronidazole 显示文摘 | Vardakas KZ Polyzos KA Patouni K | 2012 | Int J Antimicrob Agents2012，40，1： | 1 |
| 20 | Doeetaxel and Epirubicim supported by granulocyte colony-stimulating factor first line: in advanced breast cancer显示文摘 | Polyzos A Tsavaris N Kosmas C | 2003 | Anticancer Res2003，23，3： | 1 |
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