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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 3 | Prioritizing abandoned coal mine reclamation projects within the contiguous United States using Geographic information system extrapolation显示文摘 | Yuri G~ Andrew V Matthew R and Erica M | 2003 | Environmental Management2003，32，： | 1 |
| 4 | Gene therapy for diabetes:metabolic effects of helperdependent adenoviral exendin 4 expression in a diet-induced obesity mouse model显示文摘 | Susan L S Erica V G Vijay Y | 2008 | Mol Ther2008，16，11： | 1 |
| 5 | Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma显示文摘 | Asunción Fernández-Barral Jose Luis Orgaz Pablo Baquero Zaheer Ali Alberto Moreno María Tiana Valentí Gómez Erica Riveiro-Falkenbach Carmen Ca?adas Sandra Zazo Corine Bertolotto Irwin Davidson Jose Luis Rodríguez-Peralto Ignacio Palmero Federico Rojo Lass | 2014 | Neoplasia2014，，： | 1 |
| 6 | Using the Yeast Interaction Trap and Other Two-Hybrid Based Approaches to Study Protein-Protein Interactions显示文摘 | Erica A Golemis | 2001 | Methods2001，24，3： | 1 |
| 7 | Cooperation mechanism taxonomy for wireless sensor and actor networks显示文摘 | Erica R I Luis V G | | 0，，01： | 1 |
| 8 | Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis显示文摘 | Richard P G ten Broek Yama Issa Evert J P van Santbrink Nicole D Bouvy Roy F P M Kruitwagen Johannes Jeekel Erica A Bakkum Maroeska M Rovers Harry van Goor | 2013 | BMJ (oct )2013，，031： | 1 |
| 9 | A novel real-time PCR assay for the specific identification and quantification of Weissella viridescens in blood sausages显示文摘 | ERICA M G ROMERO-SANTACREU L JAIME I | 2015 | International Journal of Food Microbiology2015，215，： | 1 |
| 10 | Divideandprosper:consumers’reactionstopartitionedprices显示文摘 | MorwitzV EricA G EricJJ | 1998 | JournalofMarketingResearch1998，35，11： | 1 |
| 11 | Ecological design applied显示文摘 | John Todd Erica J G Brown Erik Wells | 2003 | Ecol Eng2003，20，5： | 1 |
| 12 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 13 | Ecological design applied显示文摘 | John Todd Erica J G Brown Erik Wells | 2003 | Ecological Engineering2003，20，： | 1 |
| 14 | A total synthesis prompts the structure revision of haouamine B显示文摘 | Matveenko M Liang G X Erica M W Lauterwasser | 2012 | J Am Chem Soc2012，134，22： | 1 |
| 15 | Late onset renal allograft anastomotic pseudoaneutysm with absent Doppler signal显示文摘 | John G B Zarrin S Erica G | 1992 | J Urol1992，148，12： | 1 |
| 16 | The interaction of hepatitis A virus (HAV) with soluble forms of its cellular receptor 1 (HAVCRI) share the physiological requirements of infectivity in cell culture 显示文摘 | Erica S Krishnamurthy K Gerardo G K | 2009 | Virology Journal2009，6，： | 1 |
| 17 | Elevated blood lead levels in children are associated with lower erythropoietin concentrations显示文摘 | Erica LL David JS Patrick G | 1998 | J Pediatr1998，134，： | 1 |
| 18 | Rethinking loyalty 显示文摘 | Bob M Basak D G Erica N (2012) | 2012 | Annals of Tourism Research2012，39，2： | 1 |
| 19 | (+)-And(-)–bomeol:efficacious positive modulators of GABA action at human recombinantα1β2γ2 L GABA(A)receptors显示文摘 | RENEE E G ERICA L C GRAHAM A R J | 2005 | Biochemical Pharmacology2005，69，7： | 1 |
| 20 | Safety Benefits of Traffic Calming 显示文摘 | Sany R Z Erica G Suzanne H | 1997 | Journal of Transportation Research Board1997，157，1： | 1 |
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