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| 1 | Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer显示文摘There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer.A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)],peritonectomy,hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been developed.In this article,we assess the indications,safety and eff icacy of this treatment,review the relevant studies and introduce our experiences.The aims of NIPS are stage reduction,the eradication of peritoneal free cancer cells,and an increased incidence of complete cytoreduction (CC-0) for PC.A complete response after NIPS was ob-tained in 15 (50%) out of 30 patients with PC.Thus,a signif icantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ 6.Using a multivariate analysis to examine the survival benef it,CC-0 and NIPS are identified as significant indicators of a good outcome.However,the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection important.The best indications for multidisciplinary therapy are localized PC (PCI≤6) from resectable gastric cancer that can be completely removed during a peritonectomy.NIPS and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer. | Yutaka Yonemura Ayman Elnemr Yoshio Endou Mitsumasa Hirano Akiyoshi Mizumoto Nobuyuki Takao Masumi Ichinose Masahiro Miura | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 27 |
| 2 | Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘 | Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai | 2007 | Toxicology2007，，2： | 3 |
| 3 | Effects of Neoadjuvant Intraperitoneal/Systemic Chemotherapy (Bidirectional Chemotherapy) for the Treatment of Patients with Peritoneal Metastasis from Gastric Cancer显示文摘 | Yutaka Yonemura Ayman Elnemr Yoshio Endou Haruaki Ishibashi Akiyoshi Mizumoto Masahiro Miura Yan Li Lapo Bencini | 2012 | International Journal of Surgical Oncology2012，，： | 2 |
| 4 | Role of MMP-7 in the formation of peritoneal dissemination in gastric cancer显示文摘 | Yutaka Yonemura Yoshio Endou Hideto Fujita Sachio Fushida Etsurou Bandou Keizou Taniguchi Kouichi Miwa Kazuo Sugiyama Takuma Sasaki | 2000 | Gastric Cancer2000，，2： | 2 |
| 5 | Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2 - 40 显示文摘 | Yonemura Y Endou Y Tabachi K | 2006 | Hum Pathol2006，37，： | 1 |
| 6 | Roles of organic anion transporters (OATs) and a urate transporter( URAT1 )in the pathophys-iology of human disease 显示文摘 | Enomoto A H Endou | 2005 | Clin Exp Nephrol2005，9，3： | 1 |
| 7 | c Myc is crucial for the expression of LAT1 in MIA Paca 2 human pancreatic cancer cellsr显示文摘 | HayashiK Jutabha P Endou H | 2012 | Oneol Rep2012，28，3： | 1 |
| 8 | Electronic structure and adsorption properties of precious metals and their oxides: Density functional calculations 显示文摘 | Broclawik E Haber J Endou A | 1997 | J Mol Catal A: Chem1997，119，13： | 1 |
| 9 | Characterization of uremic toxin transport by organic anion transporters in the kidney显示文摘 | Deguchi T Kusuhara H Takadate A Endou H Otagiri M Sugiyama Y | 2004 | Kidney Int2004，65，1： | 1 |
| 10 | Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40显示文摘 | Yonemura Y Endou Y Tabachi K | 2006 | Hum Pathol2006，37，9： | 1 |
| 11 | Involvement of H2O2 production in cisplalin-induced nephrotoxicity显示文摘 | Tsutsumishita Y Onda T Okada K Takeda M Endou H Futaki S | 1998 | Biochem Biophys Res Commun1998，242，2： | 1 |
| 12 | Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer显示文摘 | Yonemura Y Endou Y Kimura K | 2000 | Clin Cancer Res2000，6，11： | 1 |
| 13 | Cisplatin-induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin-1β converting enzyme (ICE) family of proteases but inhibited by overexpression of Bcl-2显示文摘 | Michio Takeda Mami Kobayashi Isao Shirato Takako Osaki Hitoshi Endou | 1997 | Archives of Toxicology1997，，10： | 1 |
| 14 | Urate transport across the apical membrane of renal proximal tubules显示文摘 | Endou H Anzai N | 2008 | Nucleosides Nucleotides Nucleic Acids2008，27，6： | 1 |
| 15 | Inverse expression of S100A4and E - cadherin is associated with metastatic potential in gastric cancer 显示文摘 | Yinemura Y Endou Y Kimura K | 2000 | Clin Cancer Res2000，6，11： | 1 |
| 16 | Renal urate handling clinical rel-evance of recent advances J显示文摘 | Anzai N Enomoto A Endou H | 2005 | Cultrheumatol Ren2005，7，： | 1 |
| 17 | Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4 显示文摘 | MITA Y DOBASHI K ENDOU K | 2002 | Immunol Lett2002，81，1： | 1 |
| 18 | Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer显示文摘 | Yonemura Y Endou Y kimura K | 2000 | Clin cancer Res2000，6，11： | 1 |
| 19 | Surgical treatment for peritoneal carcinomatosis from gastric cancer显示文摘 | Y. Yonemura Y. Endou T. Sasaki M. Hirano A. Mizumoto T. Matsuda N. Takao M. Ichinose M. Miura Y. Li | 2010 | European Journal of Surgical Oncology2010，，12： | 1 |
| 20 | Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells显示文摘 | Morita N Kusuhara H Sekine T Endou H Sugiyama Y | 2001 | J Pharmacol Exp Ther2001，298，3： | 1 |
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