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| 1 | A New Type of Hybrid Fish-like Microrobot显示文摘为了与游泳,走,并且漂浮开发似鱼的 microrobot 的一种新类型,打手势,在我们的过去的研究,我们开发了离子的进行激活的混合 microrobot 聚合物电影(ICPF ) 致动器。但是 microrobot 在走和漂浮的运动有一些问题。在这篇论文,我们建议混合 microrobot 的一个概念(看见图 1 ) 。microrobot 被一双尾的鳍,有腿的一个底和一连串的人工的游泳膀胱激活。分别地,我们与腿和一个人工的游泳膀胱开发了底的一个原型并且为评估他们的特征执行了实验。试验性的结果证明有腿的底能分别地认识到 6 mm/s 的走的速度和 7.1 degrees/s 的旋转速度,并且人工的游泳膀胱的原型有 2.6 mN 的最大的漂浮。试验性的结果也显示 microrobot 有一些优点,例如走有自由的 2 度的运动,不平的表面(沙论文) 上的走的能力,可控制的漂浮,等等。这种似鱼的 microrobot 为工业、医药的应用程序被期望。关键词 Biomimetic 运动 - 离子的进行聚合物电影(ICPF ) 致动器 - 混合 microrobot - 在水下 microrobot 魏章收到了他的 B.Sc。并且来自中国(UESTC ) 的电子科技的大学的 M.Sc 学位,中国在 2001 和 2004,分别地。当前,他是 Kagawa 大学里的一个博士候选人,日本。他研究在上在水下利用人工的肌肉的 microrobot,例如为工业和生物医学的应用的爱奥尼亚的进行的聚合物电影(ICPF ) 致动器。他出版了超过 10 篇审阅杂志和会议论文在最近二年。他的兴趣包括 legged microrobots。张先生是一个 IEEE 学生成员。郭淑祥收到了他的 B.Sc。并且 M.Sc。在从长春的 mechanical engineering 的学位光学和好力学开创,长春,中国在 1983 并且在 1986,分别地,并且在来自名古屋大学的 mechano 信息科学和系统的博士学位,名古屋,日本,在 1995。在 1995,他是在 Mie 大学的一个学院成员, Mie,日本并且在 1998 在 Kagawa 大学, Kagawa,日本。当前,他是有在 Kagawa 大学的聪明的机械系统工程的系的一个教授。他出版了大约 140 篇审阅杂志和会议论文。他的当前的研究兴趣包括微机器人学和 mechatronics,为最小的侵略外科的微机器人学系统,微导管系统,微泵,和聪明的材料(SMA, ICPF ) 基于致动器。收到的研究从机械工程师( JSME )的日本协会的 Tokai 节授于的郭博士, Tokai 科技基础,和最好糊 IS 国际会议的奖品,控制科技上的 2003 国际会议的最好的论文奖品和 IEEE ROBIO2004 的最好的会议论文奖品在 1997 , 1998 , 2000 , 2003 和 2004 ,分别地。Kinji Asaka 在 1991 从京都大学在科学收到了他的博士学位。他当前是人工的房间研究组,的一个组领导人为先进工业科技(AIST ) 的国家研究所的房间工程的研究院。他的当前的研究兴趣包括界面的电气化学和聚合物致动器。阿萨卡博士是聚合物科学,日本和仪器和控制和工程师的协会的协会的一个成员。 | Kinji Asaka | 2006 | International Journal of Automation and computing2006，3，4： | 8 |
| 2 | Development of an Amphibious Turtle-Inspired Spherical Mother Robot显示文摘 | Liwei Shi Shuxiang Guo Shilian Mao Chunfeng Yue Maoxun Li Kinji Asaka | 2013 | Journal of Bionic Engineering2013，10，4： | 7 |
| 3 | Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘 | Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai | 2007 | Toxicology2007，，2： | 3 |
| 4 | Novel alternative transplantation therapy for orthotopic liver transplantation in liver failure:A systematic review显示文摘BACKGROUND Orthotopic liver transplantation(OLT)is the only treatment for end-stage liver failure;however,graft shortage impedes its applicability.Therefore,studies investigating alternative therapies are plenty.Nevertheless,no study has comprehensively analyzed these therapies from different perspectives.AIM To summarize the current status of alternative transplantation therapies for OLT and to support future research.METHODS A systematic literature search was performed using PubMed,Cochrane Library and EMBASE for articles published between January 2010 and 2018,using the following MeSH terms:[(liver transplantation)AND cell]OR[(liver transplantation)AND differentiation]OR[(liver transplantation)AND organoid]OR[(liver transplantation)AND xenotransplantation].Various types of studies describing therapies to replace OLT were retrieved for full-text evaluation.Among them,we selected articles including in vivo transplantation.RESULTS A total of 89 studies were selected.There are three principle forms of treatment for liver failure:Xeno-organ transplantation,scaffold-based transplantation,and cell transplantation.Xeno-organ transplantation was covered in 14 articles,scaffold-based transplantation was discussed in 22 articles,and cell transplantation was discussed in 53 articles.Various types of alternative therapies were discussed:Organ liver,25 articles;adult hepatocytes,31 articles;fetal hepatocytes,three articles;mesenchymal stem cells(MSCs),25 articles;embryonic stem cells,one article;and induced pluripotent stem cells,three articles and other sources.Clinical applications were discussed in 12 studies:Cell transplantation using hepatocytes in four studies,five studies using umbilical cord-derived MSCs,three studies using bone marrow-derived MSCs,and two studies using hematopoietic stem cells.CONCLUSION The clinical applications are present only for cell transplantation.Scaffold-based transplantation is a comprehensive treatment combining organ and cell transplantations,which warrants future research to find relevant clinical applications. | Tomoaki Furuta Kinji Furuya Yun-Wen Zheng Tatsuya Oda | 2020 | World Journal of Transplantation2020，10，3： | 3 |
| 5 | Hepatic stellate cells in liver development, regeneration, and cancer显示文摘 | Yin Chunyue Evason Kimberley J Asahina Kinji Stainier Didier Y R | 2013 | Journal of Clinical Investigation2013，，5： | 3 |
| 6 | The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer显示文摘 | Manabu Ohta Hiroyuki Konno Tatsuo Tanaka Megumi Baba Kinji Kamiya Tuyoshi Syouji Kenji Kondoh Masaya Watanabe Hirofumi Terada Satoshi Nakamura | 2002 | Cancer Letters2002，，2： | 2 |
| 7 | Dualistic role of platelets in living donor liver transplantation: Are they harmful?显示文摘Platelets are anucleate fragments mainly involved in hemostasis and thrombosis,and there is emerging evidence that platelets have other nonhemostatic potentials in inflammation,angiogenesis,regeneration and ischemia/reperfusion injury(I/R injury),which are involved in the physiological and pathological processes during living donor liver transplantation(LDLT).LDLT is sometimes associated with impaired regeneration and severe I/R injury,leading to postoperative complications and decreased patient survival.Recent studies have suggested that perioperative thrombocytopenia is associated with poor graft regeneration and postoperative morbidity in the short and long term after LDLT.Although it is not fully understood whether thrombocytopenia is the cause or result,increasing platelet counts are frequently suggested to improve posttransplant outcomes in clinical studies.Based on rodent experiments,previous studies have identified that platelets stimulate liver regeneration after partial hepatectomy.However,the role of platelets in LDLT is controversial,as platelets are supposed to aggravate I/R injury in the liver.Recently,a rat model of partial liver transplantation(LT)was used to demonstrate that thrombopoietin-induced thrombocytosis prior to surgery accelerated graft regeneration and improved the survival rate after transplantation.It was clarified that platelet-derived liver regeneration outweighed the associated risk of I/R injury after partial LT.Clinical strategies to increase perioperative platelet counts,such as thrombopoietin,thrombopoietin receptor agonist and platelet transfusion,may improve graft regeneration and survival after LDLT. | Chen Liang Kazuhiro Takahashi Kinji Furuya Nobuhiro Ohkohchi Tatsuya Oda | 2022 | World Journal of Gastroenterology2022，28，9： | 2 |
| 8 | Enhanced hepatic differentiation in the subpopulation of human amniotic stem cells under 3D multicellular microenvironment显示文摘BACKGROUND To solve the problem of liver transplantation donor insufficiency,an alternative cell transplantation therapy was investigated.We focused on amniotic epithelial cells(AECs)as a cell source because,unlike induced pluripotent stem cells,they are cost-effective and non-tumorigenic.The utilization of AECs in regenerative medicine,however,is in its infancy.A general profile for AECs has not been comprehensively analyzed.Moreover,no hepatic differentiation protocol for AECs has yet been established.To this end,we independently compiled human AEC libraries,purified amniotic stem cells(ASCs),and co-cultured them with mesenchymal stem cells(MSCs)and human umbilical vein endothelial cell(HUVECs)in a 3D system which induces functional hepatic organoids.AIM To characterize AECs and generate functional hepatic organoids from ASCs and other somatic stem cells METHODS AECs,MSCs,and HUVECs were isolated from the placentae and umbilical cords of cesarean section patients.Amnion and primary AEC stemness characteristics and heterogeneity were analyzed by immunocytochemistry,Alkaline phosphatase(AP)staining,and flow cytometry.An adherent AEC subpopulation was selected and evaluated for ASC purification quality by a colony formation assay.AEC transcriptomes were compared with those for other hepatocytes cell sources by bioinformatics.The 2D and 3D culture were compared by relative gene expression using several differentiation protocols.ASCs,MSCs,and HUVECs were combined in a 3D co-culture system to generate hepatic organoids whose structure was compared with a 3D AEC sphere and whose function was elucidated by immunofluorescence imaging,periodic acid Schiff,and an indocyanine green(ICG)test.RESULTS AECs have certain stemness markers such as EPCAM,SSEA4,and E-cadherin.One AEC subpopulation was also either positive for AP staining or expressed the TRA-1-60 and TRA-1-81 stemness markers.Moreover,it could form colonies and its frequency was enhanced ten-fold in the adherent subpopulation after selective primary passage.Bioinformatics analysis of ribose nucleic acid sequencing revealed that the total AEC gene expression was distant from those of pluripotent stem cells and hepatocytes but some gene expression overlapped among these cells.TJP1,associated with epidermal growth factor receptor,and MET,associated with hepatocyte growth factor receptor,were upregulated and may be important for hepatic differentiation.In conventional flat culture,the cells turned unviable and did not readily differentiate into hepatocytes.In 3D culture,however,hepatic gene expression of the AEC sphere was elevated even under a two-step differentiation protocol.Furthermore,the organoids derived from the MSC and HUVEC co-culture showed 3D structure with polarity,hepatic-like glycogen storage,and ICG absorption/elimination.CONCLUSION Human amniotic epithelial cells are heterogeneous and certain subpopulations have high stemness.Under a 3D co-culture system,functional hepatic organoids were generated in a multicellular microenvironment. | Kinji Furuya Yun-Wen Zheng Daisuke Sako Kenichi Iwasaki Dong-Xu Zheng Jian-Yun Ge Li-Ping Liu Tomoaki Furuta Kazunori Akimoto Hiroya Yagi Hiromi Hamada Hiroko Isoda Tatsuya Oda Nobuhiro Ohkohchi | 2019 | World Journal of Stem Cells2019，11，9： | 2 |
| 9 | Hepatoblastoma in a dog显示文摘 | Atsushi SHIGA Kinji SHIROTA Takuo SHIDA | 1997 | Vet Med Sci1997，59，12： | 1 |
| 10 | Varions application of vesonant pressure sensor chip based on 3 -D micromachining显示文摘 | Kinji Harada Kyoichi Keda | 1999 | Sensors and Actuators1999，73，： | 1 |
| 11 | A new stereospecific cross-coupling by the palladium-catalyzed rection of 1 -alkenylboranes with 1-alkenyl or 1-alkynyl halides 显示文摘 | Norio Miyaura Kinji Yamada Akira Suzuki | 1979 | Tetrahedron Letters1979，20，： | 1 |
| 12 | Applications in Rapidly Changing Environments 显示文摘 | Kinji Mori | 1998 | IEEEComputer1998，31，4： | 1 |
| 13 | Collagen alteration in vascular remodeling by hemodynamic factors显示文摘 | Y. Ishikawa Noriko Asuwa Toshiharu Ishii Kinji Ito Yoshikiyo Akasaka Takao Masuda Lijun Zhang Hideko Kiguchi | 2000 | Virchows Archiv2000，，2： | 1 |
| 14 | Application in Rapidly Changing Environments 显示文摘 | Kinji Mori | 1998 | IEEE Computer1998，31，4： | 1 |
| 15 | Effects of Ca and Sr addition on mechanical properties of a cast AZgl magnesium alloy at room and elevated temperature 显示文摘 | Kinji Hirai Hidetoshi Somekawa Yorinobu Takigawa | 2005 | Materials Science andEngineering2005，403，12： | 1 |
| 16 | Effects of Ca and Sr addition on mechanical properties of a cast AZgl magnesium alloy at room and elevated temperature 显示文摘 | Kinji Hirai Hidetoshi Somekawa Yorinobu Takigawa | 2005 | Materials Science and Engineering A2005，403，： | 1 |
| 17 | Effects of Ca and Sr addition on mechanical properties of a cast AZ91 magnesium alloy at room and elevated temperature 显示文摘 | Hirai Kinji Somekawa Hidetoshi Takigawa Yorinobu | 2005 | Materials Science and Engineering A2005，403，： | 1 |
| 18 | Histopathological predictor for regional lymph node metastasis in gastric cancer显示文摘 | Hiroshi Morita Yukio Ishikawa Yuri Akishima-Fukasawa Kinji Ito Yoshikiyo Akasaka Chiaki Nishimura Yoshinori Igarashi Kazumasa Miki Toshiharu Ishii | 2009 | Virchows Archiv2009，，2： | 1 |
| 19 | Various application of vesonant pressure sensor chip based on 3-D micromachining显示文摘 | Kyoichi Ikeda | 1999 | Sensors and Actuators A1999，73，： | 1 |
| 20 | New canker diseases of Abies veitchii and Acer crataegifolium caused by Neonectria castaneicola显示文摘 | Takao Kobayashi Yuuri Hirooka Keiko T. Natsuaki Yuusuke Kawashima Kinji Ushiyama | 2005 | Journal of General Plant Pathology2005，，2： | 1 |
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