|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver venous deprivation versus portal vein embolization before major hepatectomy:future liver remnant volumetric and functional changes显示文摘Background:We previously showed that embolization of portal inflow and hepatic vein(HV)outflow(liver venous deprivation,LVD)promotes future liver remnant(FLR)volume(FLR-V)and function(FLR-F)gain.Here,we compared FLR-V and FLR-F changes after portal vein embolization(PVE)and LVD.Methods:This study included all patients referred for liver preparation before major hepatectomy over 26 months.Exclusion criteria were:unavailable baseline/follow-up imaging,cirrhosis,Klatskin tumor,two-stage hepatectomy.99mTc-mebrofenin SPECT-CT was performed at baseline and at day 7,14 and 21 after PVE or LVD.FLR-V and FLR-F variations were compared using multivariate generalized linear mixed models(joint modelling)with/without missing data imputation.Results:Baseline FLR-F was lower in the LVD(n=29)than PVE group(n=22)(P<0.001).Technical success was 100%in both groups without any major complication.Changes in FLR-V at day 14 and 21(+14.2%vs.+50%,P=0.002;and+18.6%vs.+52.6%,P=0.001),and in FLR-F at day 7,14 and 21(+23.1%vs.+54.3%,P=0.02;+17.6%vs.+56.1%,P=0.006;and+29.8%vs.+63.9%,P<0.001)differed between PVE and LVD group.LVD(P=0.009),age(P=0.027)and baseline FLR-V(P=0.001)independently predicted FLR-V variations,whereas only LVD(P=0.01)predicted FLR-F changes.After missing data handling,LVD remained an independent predictor of FLR-V and FLR-F variations.Conclusions:LVD is safe and provides greater FLR-V and FLR-F increase than PVE.These results are now evaluated in the HYPERLIV-01 multicenter randomized trial. | Boris Guiu François Quenet Fabrizio Panaro Lauranne Piron Christophe Cassinotto Astrid Herrerro François-Régis Souche Margaux Hermida Marie-Ange Pierredon-Foulongne Ali Belgour Serge Aho-Glele Emmanuel Deshayes | 2020 | Hepatobiliary Surgery and Nutrition2020，9，5： | 10 |
| 2 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 3 | Improving outcomes of biliary atresia: French national series 1986–2009显示文摘 | Christophe Chardot Chantal Buet Marie-Odile Serinet Jean-Louis Golmard Alain Lachaux Bertrand Roquelaure Frédéric Gottrand Pierre Broué Alain Dabadie Frédéric Gauthier Emmanuel Jacquemin | 2013 | Journal of Hepatology2013，，6： | 4 |
| 4 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 5 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 6 | Liver regeneration biology:Implications for liver tumour therapies显示文摘The liver has remarkable regenerative potential,with the capacity to regenerate after 75%hepatectomy in humans and up to 90%hepatectomy in some rodent models,enabling it to meet the challenge of diverse injury types,including physical trauma,infection,inflammatory processes,direct toxicity,and immunological insults.Current understanding of liver regeneration is based largely on animal research,historically in large animals,and more recently in rodents and zebrafish,which provide powerful genetic manipulation experimental tools.Whilst immensely valuable,these models have limitations in extrapolation to the human situation.In vitro models have evolved from 2-dimensional culture to complex 3 dimensional organoids,but also have shortcomings in replicating the complex hepatic micro-anatomical and physiological milieu.The process of liver regeneration is only partially understood and characterized by layers of complexity.Liver regeneration is triggered and controlled by a multitude of mitogens acting in autocrine,paracrine,and endocrine ways,with much redundancy and cross-talk between biochemical pathways.The regenerative response is variable,involving both hypertrophy and true proliferative hyperplasia,which is itself variable,including both cellular phenotypic fidelity and cellular trans-differentiation,according to the type of injury.Complex interactions occur between parenchymal and non-parenchymal cells,and regeneration is affected by the status of the liver parenchyma,with differences between healthy and diseased liver.Finally,the process of termination of liver regeneration is even less well understood than its triggers.The complexity of liver regeneration biology combined with limited understanding has restricted specific clinical interventions to enhance liver regeneration.Moreover,manipulating the fundamental biochemical pathways involved would require cautious assessment,for fear of unintended consequences.Nevertheless,current knowledge provides guiding principles for strategies to optimise liver regeneration potential. | Christopher Hadjittofi Michael Feretis Jack Martin Simon Harper Emmanuel Huguet | 2021 | World Journal of Clinical Oncology2021，12，12： | 2 |
| 7 | Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids显示文摘 | Alexandre Louvet Emmanuel Diaz Sébastien Dharancy Hugues Coevoet Frédéric Texier Thierry Thévenot Pierre Deltenre Valérie Canva Christophe Plane Philippe Mathurin | 2007 | Journal of Hepatology2007，，3： | 2 |
| 8 | Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis显示文摘 | Christophe Aubé Frédéric Oberti Nouri Korali Marc-Antoine Namour Didier Loisel Jean-Yves Tanguy Emmanuelle Valsesia Christophe Pilette Marie Christine Rousselet Pierre Bedossa Hervé Rifflet Moussa Y Ma?ga Dominique Penneau-Fontbonne Christine Caron Paul C | 1999 | Journal of Hepatology1999，，3： | 2 |
| 9 | Evaluation of a new, rapid,and quantitative D-Dimer test in patients with suspected pulmonary embolism显示文摘 | Emmanuel O Christophe L Luc B | 1998 | Am J Pespir Crit Care Med1998，158，1： | 1 |
| 10 | The neural net- work involved in a bimanual Tactile-tactile matching discrimi- nation cask: a functional imaging study at 3 T显示文摘 | Habas Christophe Emmanuel Alain Cabanis | 2007 | Neuroradiol- ogy2007，49，8： | 1 |
| 11 | FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer:A randomized GERCOR study显示文摘 | Christophe T Thierry A Emmanuel A | 2004 | Clin on Co2004，22，2： | 1 |
| 12 | Building core competeneies in crisis management through organizational learning显示文摘 | Roux-Dufort Christophe and Emmanuel Metais | 1999 | Technological Forecasting and Social Change1999，，： | 1 |
| 13 | Non-Alcoholic Fatty Liver Disease (NAFLD): New challenge for general practitioners and important burden for health authorities?显示文摘 | Mohamed H. Ahmed Emmanuel O. Abu Christopher D. Byrne | 2010 | Primary Care Diabetes2010，，3： | 1 |
| 14 | The role oftopography and erosion in the development and architecture ofshallow-water coral bioherms(Tortonian-Messinian,Cabo deGata,SE Spain)显示文摘 | Raphal B Emmanuelle V Christophe K | 2009 | Palaeogeography Palaeoclimatology Palaeoecology2009，281，： | 1 |
| 15 | A Destressing “Deafness” in French?显示文摘 | Emmanuel Dupoux Christophe Pallier Nuria Sebastian Jacques Mehler | 1997 | Journal of Memory and Language1997，，3： | 1 |
| 16 | World Health Organization,'Global Tuberculosis Control:WHO Report 2011 ',Geneva,2011 显示文摘 | Larissa Kamgue Sidze Emmanuel Mouafo Tekwu Christopher Kuaban | 2013 | Advances in Infectious Diseases2013，3，1： | 1 |
| 17 | Iso-scallop tool path generation in 5-axis milling 显示文摘 | Tournier Christophe Duc Emmanuel | 2005 | The International Journal of Advanced Manufacturing Technology2005，25，910： | 1 |
| 18 | A simplified model to explore the root cause ofstick-slip vibrations in drilling systems with drag bits显示文摘 | Thomas Richard Christophe Germay Emmanuel De-tournay | 2007 | Journal of Sound and Vibration2007，305，： | 1 |
| 19 | Geotrichum candidum produces several lipases with markedly different substrate specifities显示文摘 | Emmanuelle Charton | 1991 | Eur J Biochem1991，202，： | 1 |
| 20 | Cancer Stem Cells in Breast: Current Opinion and Future Challenges显示文摘 | Charafe-jauffret Emmanuelle Monville Florence Ginestier Christophe Dontu Gabriela Birnbaum Daniel Wicha Max S | 2008 | Pathobiology2008，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员