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| 1 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 2 | 10 Gb/s transmission over 700 km of standard single-mode fiber with 10cm chirped fiber grating compensator and duobinarytransmitter显示文摘 | Loh W H Laming R I Ellis A D | 1996 | Photon Technol Lett1996，，8： | 2 |
| 3 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 4 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 5 | Effect of osmotic stress on yield and polyolcontent of dicarboximide sensitive and resistant strains of Neurospora crassa 显示文摘 | Ellis S W Grindle M | 1981 | Mycol Res1981，95，： | 1 |
| 6 | Fuel cell systems efficient,flexible energy conversion for the 21st century显示文摘 | Von Spakovsky M R Nelson D J | 2001 | Proc IEEE2001，89，12： | 1 |
| 7 | Scmidwarf(sd-1),'green revolution'rice,contains a defective gibberellin 20-oxidase gene显示文摘 | Ellis M H Chandler P M | 2002 | PNAS2002，99，13： | 1 |
| 8 | Calibration of a calorimeter for thermal resisitance measurements of advanced insulation panels显示文摘 | Ellis M W Davis A H | 2000 | HVACR research2000，6，3： | 1 |
| 9 | ' Perfect' markers for the Rht-B1b and Rht-D1b dwarfing genes in wheat 显示文摘 | Ellis MH Spielmeyer W Gale KR Rebetzke GJ & Richards RA | 2002 | Theoretical and Applied Genetics2002，105，： | 1 |
| 10 | For durable concrete, fly ash does not replace cement显示文摘 | ELLIS W E | 1992 | Concrete International1992，，7： | 1 |
| 11 | Effect of room temperature and dietary amino acid concentration on performance of lactating sows 显示文摘 | Johnston L J Ellis M Libal G W | 1999 | Journal of Animal Science1999，77，： | 1 |
| 12 | Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypo-dium distachyon to challenge by Magnaporthe grisea 显示文摘 | Allwood J W Ellis D I Heald J K | 2006 | The Plant Journal2006，46，3： | 1 |
| 13 | Recurrent laryngeal nerve palsy and endotracheal intubation显示文摘 | Ellis P D M Pallister W K | 1975 | The Journal of Laryngology & Otology1975，89，8： | 1 |
| 14 | 'Perfect' markers for the Rht-Blb and Rht-Dlb dwarfing genes in wheat 显示文摘 | Ellis H Spielmeyer W Gale R | 2002 | Theoretical and Applied Genetics2002，105，67： | 1 |
| 15 | Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin 显示文摘 | Edman J C Ellis L Blacher R W | 1985 | Nature1985，317，6034： | 1 |
| 16 | On-line molecular weight distribution estimation and control in batch polymerization显示文摘 | Ellis M F Taylor T W Jensen K F | 1994 | AIChE Journal1994，40，3： | 1 |
| 17 | Pancocast tumors:Improved survival with preoperative and postoperative radiotherapy显示文摘 | Shahian D M Neptune W B Ellis Jr F H | 1987 | Ann Thorac Surg1987，43，1： | 1 |
| 18 | The measurement of postoperativepain : a comparison of intensity scales in younger and older surgical pa-tients显示文摘 | Gagliese L Weizblit N Ellis W e? al | 2005 | Pain2005，17，3： | 1 |
| 19 | ARMA processes and reliability based design of wastewater treatment facilities 显示文摘 | Ellis G W Grasso D Ge X | 1993 | Journal of Environmental Engineering1993，119，3： | 1 |
| 20 | Effect of organic-matter type and thermal maturity on methane adsorption in shale-gas sys- t eras显示文摘 | Zhang T W Ellis G S Ruppel S C | | Organic Geochemistry0，47，： | 1 |
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