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| 1 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial显示文摘 | Surya SAY Biere Mark I van Berge Henegouwen Kirsten W Maas Luigi Bonavina Camiel Rosman Josep Roig Garcia Suzanne S Gisbertz Jean HG Klinkenbijl Markus W Hollmann Elly SM de Lange H Jaap Bonjer Donald L van der Peet Miguel A Cuesta | 2012 | The Lancet . 2012 (9829)2012，，： | 3 |
| 3 | 10 Gb/s transmission over 700 km of standard single-mode fiber with 10cm chirped fiber grating compensator and duobinarytransmitter显示文摘 | Loh W H Laming R I Ellis A D | 1996 | Photon Technol Lett1996，，8： | 2 |
| 4 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 5 | Contrasting seed storage behaviour among different species of Meliaceae 显示文摘 | Hong T D Ellis R H | 1998 | Seed science and technology1998，26，1： | 1 |
| 6 | Formation of micronuclei in erythrocytes of the fathead minnow (Pimcphales promelas) after acute treatment with mitomycin C or cyclophosphamide 显示文摘 | WINTER M J ELLIS L C HUTCHINSON T H | 2007 | Mut Res2007，629，2： | 1 |
| 7 | Inspection,maintenance,and repair with partial observability显示文摘 | ELLIS H JIANG Mingxiang COROTIS R B | 1995 | Journal of Infrastructure System1995，1，2： | 1 |
| 8 | Selective use of radionraphic low- osmolality contrast media in the 1990s显示文摘 | Cohan R H Sonnad S S | 1996 | Radiology1996，200，： | 1 |
| 9 | Scmidwarf(sd-1),'green revolution'rice,contains a defective gibberellin 20-oxidase gene显示文摘 | Ellis M H Chandler P M | 2002 | PNAS2002，99，13： | 1 |
| 10 | Calibration of a calorimeter for thermal resisitance measurements of advanced insulation panels显示文摘 | Ellis M W Davis A H | 2000 | HVACR research2000，6，3： | 1 |
| 11 | Development and application of a new sessile drop contact angle method to assess soil water repellency 显示文摘 | Bachmann J Ellies A Hartge K H | 2000 | J Hydrol2000，23，： | 1 |
| 12 | Intestinal obstruction from adhesions-how big is the problem显示文摘 | Menzies D Ellis H | 1990 | Ann R Coll Surg Engl1990，72，1： | 1 |
| 13 | Survival of Dry and Ultra-Dry Seeds of Carrot, Groundnut, Lettuce, Oil seed Rape and Onion During Five Years Hermetic Storage at Two Temperatures 显示文摘 | ELLIS R H HONG T D ASTLEY D | 1996 | Seed Science and Technology1996，24，1： | 1 |
| 14 | A comparison of the low moisture content limit to the logarithmic relation between seed moisture content and longevity in twelve species显示文摘 | Ellis R H Hong T D Roberts E H | 1989 | Annals of Botany1989，，63： | 1 |
| 15 | CDM: taking stock and looking forward显示文摘 | Ellis J Winkler H Corfee-Morlot J | 2007 | Energy Policy2007，35，1： | 1 |
| 16 | PostopeIative adhesions:ten-year fo1low-up of 12584 patients under going lower abdominal surgery显示文摘 | Parker Mc Ellis H Momn B J | 2001 | Dis Colon Rectum2001，44，： | 1 |
| 17 | 'Perfect' markers for the Rht-Blb and Rht-Dlb dwarfing genes in wheat 显示文摘 | Ellis H Spielmeyer W Gale R | 2002 | Theoretical and Applied Genetics2002，105，67： | 1 |
| 18 | Use of low - osmolar agents and premedication to reduce the frequency of advers reactions to radiographic contrast medis: Asurvey of the society of uroradiology显示文摘 | Ellis J H Dunnick N R | 1995 | Radiology1995，194，： | 1 |
| 19 | Effect of mydriasis and different field strategies on digital image screening of diabetic eye disease 显示文摘 | Murgatroyd H Ellingford A Cox A Binnie M Ellis JD Macewen CJ | 2004 | Br J Ophthalmol2004，88，9： | 1 |
| 20 | A copia-like element in Pisum demonstrates the uses of dispersed repeated sequences in genetic analysis显示文摘 | Lee D Ellis T H N Tumer L | 1990 | Plant Mol Biol1990，15，： | 1 |
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