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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | AIN-93 purified diets for laboratory in the rodents: Final report of the American Institute of Nutrition ad hoc Writing Committee on the reformulation of the AIN- 76A rodent diet显示文摘 | REEVES P G NIELSEN F H Jr FAHEY G C | 1993 | J Nutr1993，123，： | 1 |
| 5 | Man-made Diamonds显示文摘 | Bundy F P Strong H M Wentorf Jr R H | 1955 | Nature1955，176，9： | 1 |
| 6 | Isolation and character- ization of a Lactobacillus plantarum bacteriophage, ~JL-1, from a cucumber fermentation显示文摘 | Lu Z Breidt Jr F Fleming H | 2003 | Int J Food Microbiol2003，84，2： | 1 |
| 7 | Nomenclature and glossary of the matrix metaUoproteinases显示文摘 | NAGASE H BARRETY A J WOESSNER J F Jr | 1992 | Matrix Suppl1992，1，： | 1 |
| 8 | Isolation system for vibration control of stay cables显示文摘 | Inho H Jong S L Jr Spencer B F | 2009 | Journal of Engineering Mechanics2009，135，1： | 1 |
| 9 | Soil microbial biomass and selected soil enzyme activities effect of fertilization and cropping practices显示文摘 | Bolton H Jr Elliott L F Papendick R I | 1985 | Soil Bio Biochem1985，17，3： | 1 |
| 10 | Benchmark problems in structural control part I:Active mass driver system 显示文摘 | SPENCER B F Jr DYKE S J DEOSKAR H S | 1998 | Earthquake Engineering and Structural Dynamics1998，27，11： | 1 |
| 11 | Pancocast tumors:Improved survival with preoperative and postoperative radiotherapy显示文摘 | Shahian D M Neptune W B Ellis Jr F H | 1987 | Ann Thorac Surg1987，43，1： | 1 |
| 12 | State-of-the-art of semiactive control systems using MR fluid dampers in civil engineering applications显示文摘 | Jung H J Spencer B F Jr Ni Y Q | 2004 | Structural Engineering and Mechanics2004，17，34： | 1 |
| 13 | Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction显示文摘 | Apple F S Christenson R H Valdes R Jr | 1999 | Clin Chem1999，45，： | 1 |
| 14 | Synergistic enhancement of antitumor immunity with adoptively transferred tumor-specific CD4^+ and CD8^+ T cells and intratumoral lymphotacin transgene expression显示文摘 | Huang H Li F Gordon JR | 2002 | Cancer Res2002，62，7： | 1 |
| 15 | The Laves and Chiphases in a Modified 12Cr Stainless Alloy显示文摘 | Versnyder F L Beattle JR H J | 1955 | Trans of ASM1955，47，： | 1 |
| 16 | Apollonian networks:simultaneously scale-free,small world,euclidean,space filling, and with matching Graphs显示文摘 | Andrade Jr J S Herrmann H J Andrade R F S | 2005 | Physical Review Letters2005，94，： | 1 |
| 17 | Synthesis of high porosity, monolithic alumina aerogels 显示文摘 | Poco J F Satcher Jr J H Hrubesh L W | 2001 | Journal of Non-Crystalline Solids2001，285，： | 1 |
| 18 | Septic arthritis in children显示文摘 | MORREY B F BIANCO A J Jr RHODES K H | 1975 | Orthop Clin Noah Am1975，6，4： | 1 |
| 19 | Intavesical Bacillus Calmette-Guerin therapy for in situ transitional cell carcinoma involving the prostate urethra显示文摘 | Bretton P R Herr H W Whitmore W F Jr | 1989 | J Urol1989，141，： | 1 |
| 20 | Twisting orientation and the role of transient states in polymer crystallization显示文摘 | Keith H D Padden Jr F J | 1984 | Polymer1984，25，： | 1 |
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