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| 1 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 2 | Network thermodynamics revisited显示文摘 | Edwin R Lewis | 1995 | BioSystems1995，，34： | 1 |
| 3 | Network thermodynamics revisited 显示文摘 | Edwin R Lewis | 1995 | BioSystems1995，，34： | 1 |
| 4 | The subprime mortgage market:familiar lessons in a new context显示文摘 | Lewis D.Johnson Edwin H.Neave | | 0，，01： | 1 |
| 5 | The coordination chemistry of 4'-phenyl-2,2':6,2'-terpyridine and bis(4'-phenyl-2,2':6,2'-terpyridine)nickel(Ⅱ) chloride decahydrate 显示文摘 | Edwin C C Jack Lewis Michael C L | 1990 | Inorganica ChimicaActa1990，178，： | 1 |
| 6 | Measles-containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years 显示文摘 | Nicole P Klein Edwin Lewis Roger Baxter | 2012 | Pediatrics2012，129，5： | 1 |
| 7 | Knowledge,in novation and share value显示文摘 | LEWIS D J EDWIN H N BOHUMIR P | | 0，，02： | 1 |
| 8 | Allelopathy: A possible mechanism of suppression of plant-parasitic nematodes by entomopathogenic nematodes显示文摘 | Parwinder S G Edwin E Lewis | 1999 | Nematology1999，1，78： | 1 |
| 9 | Landslides triggered by the 8 October 2005 Kashmir earthquake显示文摘 | Lewis A. Owen Ulrich Kamp Ghazanfar A. Khattak Edwin L. Harp David K. Keefer Mark A. Bauer | 2007 | Geomorphology2007，，1： | 1 |
| 10 | Mud Pump Failure Analysis 显示文摘 | Lewis 1 I Edwin C | 1981 | Petroleum Engineer International1981，53，8： | 1 |
| 11 | Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation显示文摘 | Steven N. Singh X. Charlene Tang Bramah N. Singh Paul Dorian Domenic J. Reda Crystal L. Harris Ross D. Fletcher Satish C. Sharma J. Edwin Atwood Alan K. Jacobson H. Daniel Lewis Becky Lopez Dennis W. Raisch Michael D. Ezekowitz | 2006 | Journal of the American College of Cardiology2006，，4： | 1 |
| 12 | Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population显示文摘 | David R. Bangsberg Frederick M. Hecht Edwin D. Charlebois Andrew R. Zolopa Mark Holodniy Lewis Sheiner Joshua D. Bamberger Margaret A. Chesney Andrew Moss | | AIDS0，，： | 1 |
| 13 | The role of eloudlets in hostile environments 显示文摘 | Mahadev Satyanarayanan Grace A Lewis Edwin J | 2013 | IEEE Pervasive Compu- ting2013，12，4： | 1 |
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