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| 1 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 2 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 3 | Improved corrosion resistance and thermal stability of sintered Nd-Fe-B magnets with holmium substitution显示文摘The effects of Ho substitution for Nd on the microstructure, corrosion resistance and thermal stability of the Nd-Fe-B magnets were investigated. The(Nd,Ho)-O phase was formed with increasing Ho substitution. The results of potentiodynamic polarization and highly accelerated stress test show improved corrosion resistance with increasing Ho substitution. The optimum mass loss 0.29 mg/cm^2 is achieved.Moreover, the average temperature coefficients for remanence and coercivity in the range of 25-150℃are both closer to zero, indicating improved thermal stability. The mechanisms for the improved corrosion resistance and thermal stability are discussed in relation to the microstructure featuring the(Nd,Ho)-O phase. | Jinghui Di Shuai Guo Ling Chen Pengpeng Yi Guangfei Ding Kan Chen Ming Li Don Lee Aru Yan | 2018 | Journal of Rare Earths2018，36，8： | 11 |
| 4 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 5 | High-Performance Flexible Asymmetric Supercapacitor Based on CoAl-LDH and rGO Electrodes显示文摘A flexible asymmetric supercapacitor(ASC)based on a Co Al-layered double hydroxide(Co Al-LDH)electrode and a reduced graphene oxide(r GO) electrode was successfully fabricated. The Co Al-LDH electrode as a positive electrode was synthesized by directly growing Co Al-LDH nanosheet arrays on a carbon cloth(CC)through a facile hydrothermal method, and it delivered a specific capacitance of 616.9 F g^(-1)at a current density of1 A g^(-1). The r GO electrode as a negative electrode was synthesized by coating r GO on the CC via a simple dipcoating method and revealed a specific capacitance of110.0 F g^(-1)at a current density of 2 A g^(-1). Ultimately,the advanced ASC offered a broad voltage window(1.7 V)and exhibited a high superficial capacitance of1.77 F cm^(-2)at 2 m A cm^(-2)and a high energy density of0.71 m Wh cm^(-2)at a power density of 17.05 m W cm^(-2),along with an excellent cycle stability(92.9% capacitance retention over 8000 charge–discharge cycles). | Shuoshuo Li Pengpeng Cheng Jiaxian Luo Dan Zhou Weiming Xu Jingwei Li Ruchun Li Dingsheng Yuan | 2017 | Nano-Micro Letters2017，9，3： | 10 |
| 6 | Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system显示文摘 | Pengpeng Liu Lijiang Long Kai Xiong Bo Yu Nannan Chang Jing-Wei Xiong Zuoyan Zhu Dong Liu | 2014 | Cell Research2014，24，7： | 8 |
| 7 | Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio显示文摘 | Lijiang Long Hong Guo Di Yao Kai Xiong Yongjun Li Pengpeng Liu Zuoyan Zhu Dong Liu | 2015 | Cell Research2015，25，5： | 7 |
| 8 | Re–Os Dating of Bitumen from Paleo–Oil Reservoir in the Qinglong Antimony Deposit, Guizhou Province, China and Its Geological Significance显示文摘Abundant organic inclusions are present in the Qinglong antimony deposit. However, the source rocks of these organic matters have not been reliably identified. Recently, a paleo–oil reservoir was found in the Qinglong antimony deposit. In view of similar components of gaseous hydrocarbon, we propose that the organic matters observed in inclusions in Qinglong antimony deposit would come from this paleo–oil reservoir. We used the Re–Os dating method to determine the age of the bitumen from this paleo–oil reservoir, and obtained an isochron age of 254.3±2.8 Ma. The age indicates that the oilgeneration from source rock occurred in the early Late Permian, earlier than the Sb mineralization age(~148±8.5 Ma) in the Qinglong antimony deposit area. After oil generation from Devonian source rock, first and secondary migration, the crude oil have probably entered into the fractures and pores of volcanic rocks and limestone and formed a paleo–oil reservoir in the western wing of Dachang anticline. As burial process deepened, the crude oil has turned into natural gas, migrates into the core of Dachang anticline and formed a paleo–gas reservoir. The hydrocarbons(including CH_4) in the reservoirs can serve as reducing agent to provide the sulfur required for Sb mineralization through thermal chemical reduction of sulfates. Therefore, the formation of oil–gas in the area is a prerequisite for the Sb mineralization in the Qinglong antimony deposit. | WANG Pengpeng HU Yuzhao LIU Lu JIANG Xiaojun LI Chao Chad Joseph Bartholomew ZHANG Guiquan | 2017 | Acta Geologica Sinica(English Edition)2017，91，6： | 6 |
| 9 | Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway显示文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer. | Yehui Shi Wenwen Zhang Yingnan Ye Yanan Cheng Lei Han Pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu | 2018 | Cancer Biology & Medicine2018，15，3： | 6 |
| 10 | Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China,2000-2014显示文摘Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China.Integron,a conserved DNA sequence,which is carried on episomal genetic structures,plays a very important role in development of antibiotic resistance.This systematic analysis was based on MEDLINE and EMBASE databases.We summarized the distribution and proportion of different types of gene cassette arrays of integrons(including class 1,2,3 and atypical class 1 integron) from clinical bacteria isolates in China.Fifty-six literatures were included in this study.Most of the strains were Gram-negative bacteria(94.1%,7,364/7,822) while only 5.9% strains were Grampositive bacteria.Class 1 integrons were detected in 54.2%(3956/7295) Gram-negative strains.aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA17-aadA5 were detected in 426 Gramnegative bacteria.This study identified 12 novel gene cassette arrays which have not been previously found in any species.All the novel gene cassette arrays were detected from Gram-negative bacteria.A regional characteristic of distribution of integrons was presented in this study.The results highlight a need for continuous surveillance of integrons and provide a guide for future research on integron-mediated bacteria resistance. | Wenying Xia Ting Xu Tingting Qin Pengpeng Liu Yun Liu Haiquan Kang Bing Gu Ping Ma | 2016 | The Journal of Biomedical Research2016，30，4： | 5 |
| 11 | Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats显示文摘Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce sperm count; however, the underlyingmechanisms remain unknown. Herein, we show that oral administration of BPA (2 μg/kg) for consecutive 14 daysin adult rats (BPA rats) significantly reduced the sperm count and the number of germ cells compared to controls.The serum levels of testosterone and follicle-stimulating hormone (FSH), as well as the level of GnRH mRNA inBPA rats were lower than those of control rats. Testosterone treatment could partially rescue the reduction of germcells in BPA rats. Notably, the number of apoptotic germ cells was significantly increased in BPA rats, which wasinsensitive to testosterone. Furthermore, the levels of Fas, FasL and caspase-3 mRNA in the testicle of BPA ratswere increased in comparison with controls. These results indicate that exposure to a low dose of BPA impairsspermatogenesis through decreasing reproductive hormones and activating the Fas/FasL signaling pathway. | Pengpeng Jin Xiaoli Wang Fei Chang Yinyang Bai Yingchun Li Rong Zhou Ling Chen | 2013 | The Journal of Biomedical Research2013，27，2： | 5 |
| 12 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 13 | Single-shot compressed ultrafast photography: a review显示文摘Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames.This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot.With recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security protection.We review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields. | Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun Lihong V.Wange | 2020 | Advanced Photonics2020，2，1： | 5 |
| 14 | Time-Variant Reliability-Based Multi-Objective Fuzzy Design Optimization for Anti-Roll Torsion Bar of EMU显示文摘Although various types of anti-roll torsion bars have been developed to inhibit excessive roll angle of the electric multiple unit(EMU)car body,it is critical to ensure the reliability of structural design due to the complexity of the problems involving time and uncertainties.To address this issue,amulti-objective fuzzy design optimization model is constructed considering time-variant stiffness and strength reliability constraints for the anti-roll torsion bar.A hybrid optimization strategy combining the design of experiment(DoE)sampling and non-linear programming by quadratic lagrangian(NLPQL)is presented to deal with the design optimization model.To characterize the effect of time on the structural performance of the torsion bar,the continuous-time model combined with Ito lemma is proposed to establish the time-variant stiffness and strength reliability constraints.Fuzzy mathematics is employed to conduct uncertainty quantification for the design parameters of the torsion bar.A physical programming approach is used to improve the designer’s preference and to make the optimization results more consistent with engineering practices.Moreover,the effectiveness of the proposed method has been validated by comparing with current methods in a practical engineering case. | Pengpeng Zhi Zhonglai Wang Bingzhi Chen Ziqiang Sheng | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 5 |
| 15 | Experimental and Modeling Study of the Regular Polygon Angle-spiral Liner in Ball Mills显示文摘Load behavior is one of the most critical factors affecting mills' energy consumption and grinding efficiency,and is greatly affected by the liner profiles. Generally, as liner profiles vary, the ball mill performances are extremely different. In order to study the performance of the ball mill with regular polygon angle-spiral liners(RPASLs), experimental and numerical studies on three types of RPASLs, including regular quadrilateral, pentagonal and hexagonal, are carried out. For the fine product of desired size, two critical parameters are analyzed: the energy input to the mill per unit mass of the fine product, E*, and the rate of production of the fine product, F*. Results show that the optimal structure of RPASLs is Quadrilateral ASL with an assembled angle of 50°. Under this condition, the specific energy consumption E* has the minimum value of 303 J per fine product and the production rate F* has the maximum value of 0.323. The production rate F* in the experimental result is consistent with the specific collision energy intensity to total collision energy intensity ratio E_s/E_t in the simulation. The relations between the production rate F* and the specific energy consumption E* with collision energy intensity E_s and E_t are obtained. The simulation result reveals the essential reason for the experimental phenomenon and correlates the mill performance parameter to the collision energy between balls,which could guide the practical application for Quadrilateral ASL. | Yi SUN Man LIANG Xiaohang JIN Pengpeng JI Jihong SHAN | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 4 |
| 16 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 17 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 18 | Physical characteristics of high-rank coal reservoirs in different coal-body structures and the mechanism of coalbed methane production显示文摘The physical characteristics of coal reservoirs are important for evaluating the potential for gas desorption,diffusion,and seepage during coalbed methane(CBM)production,and influence the performance of CBM wells.Based on data from mercury injection experiments,low-temperature liquid nitrogen adsorption,isothermal adsorption,initial velocity tests of methane diffusion,and gas natural desorption data from a CBM field,herein the physical characteristics of reservoirs of high-rank coals with different coal-body structures are described,including porosity,adsorption/desorption,diffusion,and seepage.Geometric models are constructed for these reservoirs.The modes of diffusion are discussed and a comprehensive diffusion-seepage model is constructed.The following conclusions were obtained.First,the pore distribution of tectonically deformed coal is different from that of normal coal.Compared to normal coal,all types of pore,including micropores(<10 nm),transitional pores(10-100run),mesopores(100-1000 nm),and macropores(>1000 nm),are more abundant in tectonically deformed coal,especially mesopores and macropores.The increase in pore abundance is greater with increasing tectonic deformation of coal;in addition,the pore connectivity is altered.These are the key factors causing differences in other reservoir physical characteristics,such as adsorption/desorption and diffusion in coals with different coal-body structures.Second,normal and cataclastic coals mainly contain micropores.The lack of macropores and its bad connectivity limit gas desorption and diffusion during the early stage of CBM production.However,the good connectivity of micropores is favorable for gas desorption and diffusion in later gas production stage.Thus,because of the slow decline in the rate of gas desorption,long-term gas production can easily be obtained from these reservoirs.Third,under natural conditions the adsorption/desorption properties of granulated and mylonitized coal are good,and the diffusion ability is also enhanced.However,for in situ reservoir conditions,the high dependence of reservoir permeability on stress results in a weak seepage of gas;thus,desorption and diffusion is limited.Fourth,during gas production,the pore range in which transitional diffusion takes place always increases,but that for Fick diffusion decreases.This is a reason for the reduction in diffusion capacity,in which micropores and transitional pores are the primary factors limiting gas diffusion.Finally,the proposed comprehensive model of CBM production under in situ reservoir conditions elucidates the key factors limiting gas production,which is helpful for selection of reservoir stimulation methods. | ZHANG XiaoDong DU ZhiGang LI PengPeng | 2017 | Science China Earth Sciences2017，60，2： | 4 |
| 19 | Integration of nanoscale light emitters:an efficient ultraviolet and blue random lasing from NaYF_4:Yb/Tm hexagonal nanocrystals显示文摘Near infrared light-controlled release of payloads from ultraviolet-sensitive(UV-sensitive) polymer hydrogels or nanocarriers is one of the most promising strategies for biotherapy. Here, we propose the concept of light activation of NaYF_4:20%Yb, 2%Tm nanocrystals(NCs). NaYF_4:20%Yb, 2%Tm NCs are synthesized by a solvothermal method. Effective upconversion luminescence from NaYF_4:20%Yb, 2%Tm NCs excited by a continuous wave(CW) 980 nm laser is obtained. The NaYF_4:20%Yb, 2%Tm NCs are then used as a laser gain medium and sandwiched between Al and quartz reflectors to form laser microcavities. UV and blue upconverted random lasing is obtained from the laser microcavities. Hence, we verify explicitly that the NaYF_4:Yb, Tm NCs support UV and blue upconversion random lasing via a 980 nm nanosecond laser excitation. Our work provides what we believe is a new concept for precision and localized cancer therapy by external light excitation. | YA-PEI PENG WEI LU PENGPENG REN YIQUN NI YUNFENG WANG LONG ZHANG YU-JIA ZENG WENFEI ZHANG SHUANGCHEN RUAN | 2018 | Photonics Research2018，6，10： | 4 |
| 20 | Dynamics of unstable continental subduction:Insights from numerical modeling显示文摘Numerical experiments are used in this study to systematically investigate the effects of convergence rate,crustal rheological strength,and lithospheric thermal structure on the dynamics of continental collision.The study focuses on the types,conditions and processes of unstable continental subduction.Modelling results suggest that the development of unstable continental subduction can be promoted by conditions that tend to decrease rheological strength of the lithosphere,such as low crustal rheological strength,'hot'thermal structure of the lithosphere,or low convergence rate.Unstable subduction mode can be further categorized into three types:(1)multi-stage slab breakoff,(2)continuously'flowing'of fluid-like slab into the upper mantle,and(3)large-scale detachment of the thickened orogenic root.These three types of unstable continental subduction are respectively associated with(1)a low convergence rate,(2)'hot'thermal structure of the lithosphere with a high convergence rate,and(3)moderate-high crustal rheological strength with a low convergence rate.It is also revealed that the evolution of crustal melting is dominated by the deformation pattern of continental collision,which is mainly controlled by crustal rheological strength.The modelling results have important implications for understanding of continental subduction mode selection under specific geodynamic conditions. | HUANGFU PengPeng WANG YueJun FAN WeiMing LI ZhongHai ZHOU YongZhi | 2017 | Science China Earth Sciences2017，60，2： | 3 |
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