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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis显示文摘 | Jean Frédéric Colombel Paul Rutgeerts Walter Reinisch Dirk Esser Yanxin Wang Yinghua Lang Colleen W. Marano Richard Strauss Bj?rn J. Oddens Brian G. Feagan Stephen B. Hanauer Gary R. Lichtenstein Daniel Present Bruce E. Sands William J. Sandborn | 2011 | Gastroenterology2011，，4： | 3 |
| 4 | 电渣重熔满足大型锻件的要求显示文摘与锭模浇注出低密度、带缩孔铸锭相比,高性能铸锭材料的生产趋于用重熔设备来实现,铸锭的力学性能也会更均匀。水冷铜结晶器中重熔的铸锭具有较高的材料产出量,从而使具有相同最终外形的铸锭其单锭的质量更小,密度更接近于锻造的材料。因此,后续的锻造工艺不需要高锻造比来生产高密度铸锭。在100t以下的铸锭通常可以在固定锭模中生产,并配以外部底加热装置,以避免可能的铸锭底部开裂;50t以上的铸锭采用高度复杂的拉锭系统配以多电极交换,在短的环形坩埚中重熔技术才是最经济的。大型的带有电极交换技术的电渣重熔炉,为生产超过钢厂中最大单个钢包浇铸质量的大尺寸铸锭提供了可能性。介绍了生产145t重铸锭的炉型设计。对于容易出现开裂的高度复杂的合金,可以通过应用隔热绝缘来生产。 | H Scholz U Biebricher G Brückmann D Esser | 2013 | 钢铁2013，48，10： | 2 |
| 5 | Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use显示文摘 | Blomeyer D Treutlein J Esser G | 2008 | Biol Psychiatry2008，63，： | 1 |
| 6 | Antiproliferative Wirkung von genistein auf kuhivierte retinale Pigmentepithelzellen vom Schwein显示文摘 | Krott R Lebek J Grisanti S Esser P Heimann K | 2000 | Olgatlmlmologica2000，214，4： | 1 |
| 7 | Vitrectomy for macular detachment associated with optic nerve pits显示文摘 | Bartz-Schmidt KU Heimann K Esser P | 1995 | Int Ophthalmol1995，19，6： | 1 |
| 8 | UVB-in- duced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo 显示文摘 | Wolfle U Esser P R Simon-Haarhaus B | 2011 | Free Radical Bio Med2011，50，9： | 1 |
| 9 | Imaging brilliant blue stained soil by means of electrical resistivity tomography 显示文摘 | KOESTEL J KASTEEL R KEMNA A ESSER O JAVAUX M BINLEY A VEREECKEN H | 2009 | Vadose Zone J2009，8，： | 1 |
| 10 | Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins 显示文摘 | Rossio JL Esser MT Suryanarayana K | | J Virol0，72，10： | 1 |
| 11 | Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model显示文摘 | Soltau J Zirrgiebel U Esser N | | 0，，2： | 1 |
| 12 | Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787! ZK222584, causes significant anti-art hritic effects in models of rheumatoid arthritis 显示文摘 | Grosios K Wood J Esser R | 2004 | Inflamm Res2004，53，4： | 1 |
| 13 | Graves' ophthalmopathy 显示文摘 | Eckstein A Esser J | 2010 | Internist (Berl)2010，51，5： | 1 |
| 14 | Mechanisms for the intracellular manipulation of organelles by conventional electroporation显示文摘 | Esser A T Smith K C Gowrishankar T R | 2010 | Biophysical Journal2010，98，11： | 1 |
| 15 | Vascular endothelial growth factor induces endothelial fenestrations in vitro显示文摘 | Esser S Wolburg K Wolburg H | 1998 | J Cell Bid1998，140，4： | 1 |
| 16 | Digraphs with Real and Gaussian Spectra显示文摘 | Esser F Harary F | 1980 | Discrete Applied Mathematics1980，，2： | 1 |
| 17 | Intracellular signal speciaficity in skeletal muscle in response to different modes of exercise显示文摘 | Nader GA Esser KA | 2001 | J Appl Physiol2001，90，5： | 1 |
| 18 | Triggering sleepslow waves by transcranial magnetic stimulation 显示文摘 | Massimini M Ferrarelli F Esser SK | 2007 | Proc NatlAcad Sci USA2007，104，20： | 1 |
| 19 | Pre operative MRI and surgical management in patients with nonpalpa ble breast cancer:the MONET-randomised controlled trial显示文摘 | Peters NH van Esser S van den Bosch MA | 2011 | Eur J Cancer2011，47，6： | 1 |
| 20 | Cognitive Computing显示文摘 | Modha D S Ananthanarayanan R Esser S K | 2011 | Communications of the ACM (S0001-0782)2011，54，8： | 1 |
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