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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Antiproliferative Wirkung von genistein auf kuhivierte retinale Pigmentepithelzellen vom Schwein显示文摘 | Krott R Lebek J Grisanti S Esser P Heimann K | 2000 | Olgatlmlmologica2000，214，4： | 1 |
| 3 | Vitrectomy for macular detachment associated with optic nerve pits显示文摘 | Bartz-Schmidt KU Heimann K Esser P | 1995 | Int Ophthalmol1995，19，6： | 1 |
| 4 | UVB-in- duced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo 显示文摘 | Wolfle U Esser P R Simon-Haarhaus B | 2011 | Free Radical Bio Med2011，50，9： | 1 |
| 5 | Multiresidue analysis of beta-agonists in bovine and porcine urine, feed and hair using liq- uid chromatography electrospray ionisation tan- dem mass spectrometry显示文摘 | NIELEN M W F LASAROMS J J P ESSERS M L | 2008 | Analytical and Bio- analytical Chemistry2008，391，1： | 1 |
| 6 | Bone development in dairy heifers fed diets with and without supplemental phosphorus显示文摘 | Esser N M P C Hoffman W K Coblentz | | Anita Sci Vol 86 E-Suppl 2/J Dairy Sei Vol 91 E-Suppl10，481，： | 1 |
| 7 | Apoptosis in proliferative vitreoretinal disorders: possible involvement of TGF-β induced RPE cell apoptosis显示文摘 | Esser P Heimann K Bartz-schmidt KU Fontana A Schraermeyer U Thumann G | 1997 | Exp Eye Res1997，65，： | 1 |
| 8 | Relationships between functional and structural corticospinal tract integrity and walk- ing post stroke 显示文摘 | Jayaram G Stagg CJ Esser P | 2012 | Clin Neurophysiol2012，123，12： | 1 |
| 9 | Stereocontrol in pinacol ring-contraction of cyclopeptidyl glycols: The diazonamide C10 problem显示文摘 | Chen X Esser L Harran P G | 2000 | Angew Chem Int Ed2000，39，： | 1 |
| 10 | Proliferative retinal diseases:myofibroblasts cause chronic vitreoretinal traction显示文摘 | Walshe R Esser P Wiedemann P | 1992 | Br J Ophthalmol1992，76，9： | 1 |
| 11 | Deep desulfurization of oil refinerystreams by extraction with ionic liquids显示文摘 | Esser J Wasserscheid P Jess A | 2004 | Green chemistry2004，3，2： | 1 |
| 12 | A diagnostic compendium to the genusHemicriconemoides (Tylenchida: Criconematidae)显示文摘 | Esser R P Vovlas N | 1990 | Soil and CropSci Soc Fla Proc1990，，49： | 1 |
| 13 | The effect of dietary phosphorus on bone development in dairy heifers显示文摘 | Esser N M P C Hoffman W K Coblentz | 2009 | J Dairy Sci2009，92，4： | 1 |
| 14 | Three additional species in the genus Hemicricone moides Chitwood and Birchfield, 1957 Nematoda: Tylenchida 显示文摘 | Esser R P | 1960 | Nematologica1960，5，1： | 1 |
| 15 | Dosimetric accuracy andclinical quality of Acuros XB and AAA dose calculation algorithmfor stereotactic and conventional lung volumetric modulated arctherapy plans显示文摘 | KROON P S HOL S ESSERS M | 2013 | Radiat Oncol2013，8，： | 1 |
| 16 | Deep desulfurization of oil refinery streams by extraction with ionic liquids显示文摘 | Esser J Wasserscheid P Jess A | 2004 | Green Chemistry2004，6，7： | 1 |
| 17 | Progression of coronary atheroscleroeic disease assessed by cine videodensitometry: relation to clinical risk factor 显示文摘 | SHEA S SCIACCA R R ESSER P | 1986 | Am J Cardio1986，57，8： | 1 |
| 18 | CD95(Fas/APO-1) antibody-mediated apoptosis of human retinal pigment epithelial cells显示文摘 | Esser P Heimann K Abts H | 1995 | Biochem Biophys Res Commun1995，213，： | 1 |
| 19 | Wood anatomy of Oleaceae显示文摘 | Baas P Esser P M van den Western M E T ZANDEE M | 1988 | IAWA Bull1988，9，： | 1 |
| 20 | A diagnostic compendium to the genus Hemicriconemoides ( Tylenchida : Criconematidae ) 显示文摘 | Esser R P Vovlas N | 1990 | Pro ceedings: Soil and Crop Science Society of Florida1990，，49： | 1 |
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