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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Mitochondrial dysfunction in osteoarthritis显示文摘 | Francisco J. Blanco Maria J. López-Armada Emilia Maneiro | 2004 | Mitochondrion2004，，5： | 2 |
| 3 | Why the Western Pacific Subtropical High Has Extended Westward since the Late 1970s显示文摘 | Zhou Tianjun Yu Rucong Zhang Jie Drange Helge Cassou Christophe Deser Clara Hodson Daniel L R Sanchez-Gomez Emilia Li Jian Keenlyside Noel Xin Xiaoge Okumura Yuko | 2009 | Journal of Climate2009，，8： | 2 |
| 4 | Suppression of neuron apoptosis by S nitroslation of caspases显示文摘 | TENNETI L D'EMILIA DM LIPTON SA | 1997 | Neurosci Lett1997，236，3： | 1 |
| 5 | Randomized trial of non-invasive ventilation combined with exercise training in patients with chronic hypercapnic failure due to Chronic Obstructive Pulmonary Disease显示文摘 | Eduardo Márquez-Martín Francisco Ortega Ruiz Pilar Cejudo Ramos Jose Luis López-Campos Borja Valencia Azcona Emilia Barrot Cortés | 2014 | Respiratory Medicine2014，，： | 1 |
| 6 | Quasi - clas- sical Trajectory Study of the N(2D) + H2→ NH + H and N (2D) + D2→ND + D Reactions: Vector Correlation显示文摘 | YUE X F ZHANG Y Q FENG H R EMILIA L W | 2010 | Journal of Molecular Structure: THEOCHEM2010，955，： | 1 |
| 7 | Lipochromes, vitamins, aromas and other components of virgin olive oil are affected by processing technology 显示文摘 | ALFONSO R PAOLO C EMILIA L | 2001 | Food Chem2001，73，4： | 1 |
| 8 | Carotid artery atherosclerosis and sleep disordered breathing in healthy elderly subjects: The Synapse cohort显示文摘 | Emilia Sforza Christian Boissier Magali Saint Martin Severine Feasson Jean Claude Barthélémy Frédéric Roche | 2012 | Sleep Medicine2012，，： | 1 |
| 9 | Failure behaviour wellbore cement in the presence of water and supercritical CO2显示文摘 | EMILIA L CHRISTOPHER J SPIERS C | 2009 | Energy Procedia2009，1，1： | 1 |
| 10 | Stable long-term indigo production by overexpression of dioxygenase genes using a chromosomal integrated cascade expression circuit 显示文摘 | Jose L R Emilia M R Angel C | 2005 | Journal of Biotechnology2005，116，： | 1 |
| 11 | Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis显示文摘 | WOJCIECH J EMILIA K MAGDALENA L D | | 0，，： | 1 |
| 12 | Redox potential and substituent effects in ferrocene derivatives: Ⅱ显示文摘 | Emilia M N Silva P R A Armando J L | 1994 | J Organomet Chem1994，480，： | 1 |
| 13 | Influence of ripeness grade on accumulation and extractability of grape skin anthocyanins in different eul- tivars显示文摘 | SUSANA R S ELVIRA S V EMILIA D L | 2008 | Journal of Food Composition and Analysis2008，21，： | 1 |
| 14 | Spore germination and gametophyte development in three species of Asplenium显示文摘 | EMILIA P STUART L ADRIANDYER | 1994 | Annals of Botany1994，73，： | 1 |
| 15 | Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly显示文摘 | Frédéric Roche Emilia Sforza Vincent Pichot Delphine Maudoux Arnaultd Garcin Sébastien Celle Michel Picard-Kossovsky Jean-Michel Gaspoz Jean Claude Barthélémy | 2008 | Sleep Medicine2008，，8： | 1 |
| 16 | Gypsum scale control by nit- rilotrimethylenephosphonic acid 显示文摘 | Marina P Emilia O Amedeo L | 2009 | Ind Eng Chem Res2009，，10： | 1 |
| 17 | Immobilization of Horseradish Peroxidase on Chitosan for Use in Nonaqueous Media显示文摘 | Bindhu L V Emilia T A | 2003 | Journal of Applied Polymer Science2003，88，6： | 1 |
| 18 | Bi-objective optimisation of the enzymatic hydrolysis of porcine blood protein显示文摘 | Raúl Pérez-Gálvez M. Carmen Almécija F. Javier Espejo Emilia M. Guadix Antonio Guadix | 2011 | Biochemical Engineering Journal2011，，3： | 1 |
| 19 | Mutants of Ralstonia(Pseduomonas) Solanacearum Sensitive to Antimicrobial Peptides are Altered in their Lipopolysaccharide Structure and are Avirulent in Tobacco显示文摘 | ELENA T EMILIA L S FRANCISCO G O | 1997 | J Bacteriol(S 0021-9193)1997，179，21： | 1 |
| 20 | Evaluation of polymerization shrinkage and hydroscopic expansion of fiber-reinforced biocomposites using optical fiber Bragg grating sensors显示文摘 | Emilia J A Outi H K Toni K L | 2008 | Dental Mater2008，24，12： | 1 |
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