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| 1 | Depression in patients with irritable bowel syndrome in Jos,Nigeria显示文摘AIM: To study the brain-gut interaction and the effect of behavioral or psychiatric conditions on irritable bowel syndrome (IBS) in an African population. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria. The entry of each patient was confirmed following detailed explanations of the questions. Four hundred and eighteen patients were studied. Subjects satisfying the Rome Ⅱ criteria for IBS were physically examined and stool microscopy was done to identify the presence of “alarm factors”. Depression was diagnosed using the symptom-check list adapted from the Research Diagnostic Criteria (DSM-Ⅳ) of the American Psychiatric Association. RESULTS: Seventy-five (56.8%) of the 132 IBS patients were depressed whereas only 54 (20.1%) of the 268 non-IBS patients were depressed. There was a significant relationship between IBS and depression (χ2 = 54.29, Odds ratio = 5.21, 56.8 ± 8.4 vs 20.1 ± 5.2, P = 0.001). Even though constipation predominant IBS patients were more likely to be depressed, no significant relationship was found between the subtype of IBS and depression (χ2 = 0.02, OR = 0.95, P = 0.68). CONCLUSION: IBS is significantly associated with major depression but not gender and bowel subtypes of the patients. Patients with IBS need to be evaluated for depression due to the highly significant relationship between the two conditions. | Nimzing G Ladep Taiwo J Obindo Moses D Audu Edith N Okeke Abraham O Malu | 2006 | World Journal of Gastroenterology2006，12，48： | 22 |
| 2 | 基因组和转录组学分析WHOⅡ/Ⅲ级大脑弥漫性胶质瘤的分子分型有助于患者的预后分层显示文摘将大脑胶质瘤在组织学分类和临床病理上分出Ⅱ级和Ⅲ级,这对WHO而言是一个重大的挑战。本文作者设想利用大规模基因组和转录组学分析是否能分出更为明确的不同预后类型。作者基于微阵列的基因组和转录组方法分析了137例原发大脑胶质瘤,病例来自一个前瞻性的德国胶质瘤网( German Glioma Network),其中包括61例WHO II级和76例WHO III级的肿瘤患者。用综合生物信息学分析确定分子亚型,然后将其与组织学、分子生物标记和患者预后相联系,分子生物标志物包括异柠檬酸脱氢酶1或2( IDH1/2),1p/19q联合缺失和端粒酶逆转录酶(TERT)基因启动子突变。通过基因组分析将其分为5个的胶质瘤组,包括3个IDH1/2突变型和2个IDH1/2野生型。通过表达谱分析发现8个不同的转录组(5个IDH1/2突变型,3个IDH1/2野生型),它们与基因组只有部分关联。结合DNA为基础的分子分层和临床预后划分为3个主要预后组,他们有着特异的基因组突变。 IDH1/2突变和1p/19q染色体联合缺失的患者预后最好。 IDH1/2野生型胶质瘤和类似胶质母细胞瘤基因组变异[包括7q染色体获得(+7q),10q染色体缺失(-10q),TERT启动子突变和癌基因扩增]的患者预后最差。IDH1/2突变但1p/19q染色体正常的患者(主要是星形细胞瘤)和IDH1/2野生型,但没有+7q/-10q 基因型及 TERT启动子突变的胶质瘤患者处于中间位的生存期。这种分子分层将患者分为不同的预后组比组织学分类更好。加入基因组分类的基因表达谱分析并不能更进一步促进预后分层。 | Michael W Ruthild G Edith W 陈达阳 王行富 | 2015 | 临床与实验病理学杂志2015，31，7： | 9 |
| 3 | Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation显示文摘Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult hippocampus.However,this effect has not been observed in long-term sleep deprivation.The precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this process.In this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword clusterization.Our results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate gyrus.We observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep deprivation.In addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated group.These findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived conditions.All procedures performed in this study were approved by the Animal Ethics Committee of the University of Guadalajara,Mexico(approval No.CI-16610)on January 2,2016. | Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 5 | Role of p70s6 protein kinase in angiotensin Ⅱ induced protein synthesis in vascular smooth muscle cells显示文摘 | Edith G Sylvain M | 1995 | J Bio Chem1995，270，： | 1 |
| 6 | P-glycoprotein is strongly expression in the luminal membranes of the endothelium of blood vessels in the brain显示文摘 | EDITH B MICHEL D LUCIAN G | 1997 | Biochem J1997，326，： | 1 |
| 7 | The influence of site quality,silviculture and region on wood density mixed model in Quereus petraea Liebl显示文摘 | J can-Christophe Hervě Gěrard Nepveu | 2004 | Forest Ecology and Management2004，189，： | 1 |
| 8 | Mutagenicity of aristolochic acids(Ⅰ,Ⅱ)and aristolic acid I in new YG strins in Samonella typhimurium highly sensitive to certain mutagenic nitroarenes显示文摘 | Edith Gtzl Schimmer O | 1993 | Mutagenesis1993，8，1： | 1 |
| 9 | Heat-shock response of Pinus and Picea seedlings显示文摘 | DAVID J G EDITH T | 1994 | Tree Physiology1994，14，1： | 1 |
| 10 | The relation between actual and perceived interactivity显示文摘 | Voorveld Hilde A M Neijens Peter C Smit Edith G | 2011 | Journal of Advertising2011，40，2： | 1 |
| 11 | Expression of the rabies virus nucleoprotein in plants at high-levels and evaluation of immune responses in mice显示文摘 | Irene Perea Arango Elizabeth Loza Rubio Edith Rojas Anaya Teresa Olivera Flores Luis Gonzalez de la Vara Miguel Angel Gómez Lim | 2008 | Plant Cell Reports2008，，4： | 1 |
| 12 | The influence of site qual- ity, silviculture and region on wood density mixed model in Quercus petraea Liebl显示文摘 | Edith G Jean C H Gerard N | 2004 | Forest Ecology and Man- agement2004，，189： | 1 |
| 13 | Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation显示文摘 | Celina G Jorge A Edith A | 2008 | The Journal of Clinical Investigation2008，118，6： | 1 |
| 14 | Generation of c-reactive protein and complements components in atherosclerotic plaques显示文摘 | YASOJIMA K SCHWAB G EDITH G | 2001 | Am J Pathol2001，158，： | 1 |
| 15 | Physicochemical and enzyme characterization of small and large starch granules isolated from two maize cultivars显示文摘 | RubíG U Edith A Ana P B R | 2010 | Cereal Chemistry2010，87，1： | 1 |
| 16 | The effect of ceftriaxone on the anaerobic bacterial flora and the bacterial enzymatic activity in the intestinal tract显示文摘 | G. W. Welling Ph. D. Geke J. Meijer-Severs M. S. Gé Helmus Edith Santen R. H. J. Tonk Hilly G. Vries- Hospers M. D. Ph. D. D. Waaij M. D. Ph. D | 1991 | Infection1991，，5： | 1 |
| 17 | Generation of C-reactive protein and complement components in atherosclerotic plaques显示文摘 | Yasojima K Schwab C Edith G | 2001 | Am J Pathol2001，58，： | 1 |
| 18 | Inflammatory cytokines in the CNS 显示文摘 | Edith G McGeer Patrick L | 1997 | Pharmacol Pathophysiol1997，7，3： | 1 |
| 19 | Genetic analysis of the Interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease显示文摘 | Laurence T Tiphaine G Edith Lubos MD | 2005 | Circulation2005，112，： | 1 |
| 20 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
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