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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Epidemiology of Helicobacter pylori infection in six Latin American countries (SWOG Trial S0701)显示文摘 | Carolina Porras Jesse Nodora Rachael Sexton Catterina Ferreccio Silvia Jimenez Ricardo L. Dominguez Paz Cook Garnet Anderson Douglas R. Morgan Laurence H. Baker E. Robert Greenberg Rolando Herrero | 2013 | Cancer Causes & Control2013，，2： | 2 |
| 3 | Dissecting anxiety-related QTLs in mice by univariate and multivariate mapping显示文摘To detect genes underlying anxiety-related traits in mice,we performed univariate and multivariate QTL mapping analyses of phenotypes obtained from 71 mice of the BXD recombinant inbred (RI) strains (n=528 mice) and their parental strains (C57BL/6J and DBA/2J).Separate and joint mapping analyses were carried out using a linkage map composed of 506 simple sequence repeats (SSRs).The main QTL effects,interactions between pairs of QTLs (epistasis),and their environmental interactions were estimated.The results showed that anxiety-related traits were influenced by multiple QTLs (five main effect QTLs and three epistatic QTLs).Ten potential anxiety-related candidate genes within the QTL intervals on chromosomes 5,13 and 15 were identified.Some of these genes have been reported previously to be associated with the anxiety response.Based on our results,it is suggested that the multivariate QTL mapping approach improves the statistical power for detecting QTL and the precision of parameter estimation.Moreover,multivariate mapping can also detect pleiotropic QTL effects. | ZHU ZhiHong ZHANG ChenHao WANG XuSheng COOK Melloni N WILLIAMS Robert LU Lu ZHU Jun | 2012 | Chinese Science Bulletin2012，57，21： | 2 |
| 4 | Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene显示文摘graphene 的共有原子价 functionalization 为定制它的性质提供机会并且是一些 graphene 合成技术的不可避免的后果。然而, functionalization 导致的变化很好没被理解。由使用原子来源控制氧和氮 functionalization 的程度,我们在原子规模在结构和性质学习了进化。虽然,原子氧 reversibly 介绍 epoxide 组,在类似的条件下面,原子氮不可逆转地创造包括的多样的功能代理, pyridinic,和 pyrrolic 氮。原子氧在迪拉克点离开费密能量(即, undoped ) ,虽然原子氮导致网做 n;然而,试验性的结果与为两是转变从的主导的电子效果一致去除到局部性的状态,和因此签名的损失 graphene 的电子结构。 | Alexander J. Marsden Peter Brommer James J. Mudd M. Adam Dyson Robert Cook Maria Asensio Jose Avila Ana Levy Jeremy Sloan David Quigley Gavin R. Bell Neil R. Wilson | 2015 | Nano Research2015，8，8： | 2 |
| 5 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 6 | Factors influencing bond strength of adhesive anchors显示文摘 | Cook Ronald A Konz Robert C | 2001 | ACI Structural Journal2001，98，： | 1 |
| 7 | The Oxford classifica- tion of IgA nephropathy : pathology definitions, correlations, and reproducibility显示文摘 | Roberts IS Cook H T Troyanov S | 2009 | Kidney lnt2009，76，5： | 1 |
| 8 | Space charge suppression of electrostatic induction spray charging显示文摘 | Robert Cooke J Steven C Cooper | 1997 | J of Electrostatics1997，4041，： | 1 |
| 9 | The Oxford classification of IgA nephropathy: pathology definitions, correlations, and repro-ducibi 1 ity 显示文摘 | Roberts ISD Cook ttT Troyanov S | 2009 | Kidney Int2009，76，7： | 1 |
| 10 | Targeting GRP78 and antiestrogen resistance in breast cancer显示文摘 | Katherine L Cook Pamela AG Clarke Robert Clarke | 2013 | Chem2013，，9： | 1 |
| 11 | Cerebral blood flow during cardiac operations: Comparison of Kety-Schmidt and xenon-133 clearance methods显示文摘 | David J. Cook Robert E. Anderson John D. Michenfelder William C. Oliver Thomas A. Orszulak Richard C. Daly Rex D. Bryce | 1995 | The Annals of Thoracic Surgery1995，，3： | 1 |
| 12 | Homocysteine Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine显示文摘 | Markus C. Stühlinger Philip S. Tsao Jeng-Horng Her Masumi Kimoto Robert F. Balint John P. Cooke | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
| 13 | Antigen-specific cytolysis by neutrophils and NK ceils expressing chimeric immune receptors bearing zeta or gamma signaling domains 显示文摘 | Roberts MR Cooke KS Tran AC | 1998 | J Immunol1998，161，1： | 1 |
| 14 | The Oxford classification of lgA nephropathy : pathology definitions, correlations, and reproducibility显示文摘 | Roberts ISD Cook HT Troyanov S | 2009 | Kidney lnt2009，76，： | 1 |
| 15 | A reflection model for computer graphics 显示文摘 | Robert L Cook Kenneth E Torrance | 1982 | ACM Transactions on Graphics1982，1，1： | 1 |
| 16 | The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility显示文摘 | Roberts IS Cook HT Troyanov S | 2009 | Kidney Int2009，76，5： | 1 |
| 17 | The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility显示文摘 | Roberts IS Cook HT Troyanov S | 2009 | Kidney Int2009，76，5： | 1 |
| 18 | The Oxford classification of IgA nephropathy: pathology definitions, correlations, and repro- ducibility 显示文摘 | ROBERTS I S COOK H T | 2009 | Kidney Int2009，76，5： | 1 |
| 19 | The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding显示文摘 | Thomas B. Thompson Thomas F. Lerch Robert W. Cook Teresa K. Woodruff Theodore S. Jardetzky | 2005 | Developmental Cell2005，，4： | 1 |
| 20 | Postnatal regulation of germ cells by activin: The establishment of the initial follicle pool显示文摘 | Sarah K. Bristol-Gould Pamela K. Kreeger Christina G. Selkirk Signe M. Kilen Robert W. Cook Jingjing L. Kipp Lonnie D. Shea Kelly E. Mayo Teresa K. Woodruff | 2006 | Developmental Biology2006，，1： | 1 |
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