|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy显示文摘Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer immunotherapy.DCs require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 responses.DCs play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of DCs.We investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions occur.DCs that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce IL-12p70.NK cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte responses.Our data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy. | Thanh-Nhan Nguyen-Pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Soo-Young Bae Jae-Sook Ahn Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2012 | Cellular & Molecular Immunology2012，9，1： | 8 |
| 2 | C2 - ceramide induces vasedilation in phcnylcphrine -inducedpre-contracted rat thoracic aorta: role of RhoA/Rho- kinaseand intracellular Ca^2+ concentration 显示文摘 | Gil- Jin Jang Duck Sun Ahn Young- Eun Cho ct al | 2005 | Naunyn - Schmiedeberg''s Arch Phannacol2005，372，3： | 1 |
| 3 | Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma显示文摘 | Thanh-Nhan Nguyen-Pham Chang-Min Im Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju Lee Youn-Kyung Lee Duck Cho Jae-Sook Ahn Deok-Hwan Yang Yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee | 2011 | Leukemia Research2011，，： | 1 |
| 4 | Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma显示文摘 | Lee Sin-Ae Lee Sung-Yul Cho Ik-Hyun Oh Min-A Kang Eun-Sil Kim Yong-Bae Seo Woo Duck Choi Suyong Nam Ju-Ock Tamamori-Adachi Mimi Kitajima Shigetaka Ye Sang-Kyu Kim Semi Hwang Yoon-Jin Kim In-San Park Ki Hun Lee Jung Weon | 2008 | Journal of Clinical Investigation2008，，4： | 1 |
| 5 | Uncovered Versus Covered Self-Expanding Metallic Stents for Inoperable Malignant Distal Biliary Obstruction: A Prospective Randomized Multicenter Study显示文摘 | Young Deok Cho Young Koog Cheon Kyo-Sang Yoo Sung-Jo Bang Chang Duck Kim Jae Seon Kim Myung Hwan Roh Ho Gak Kim | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 6 | Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea显示文摘 | Kyung Ran Jun Woochang Lee Mi Sook Jang Sail Chun Gi-Won Song Kwan Tae Park Sung Gyu Lee Duck Jong Han Changwon Kang Dae-Yeon Cho Jin Q. Kim Won-Ki Min | 2009 | Transplantation2009，，8： | 1 |
| 7 | Multicenter Analysis of Clinicopathologic Features of Intraductal Papillary Mucinous Tumor of the Pancreas: Is It Possible to Predict the Malignancy Before Surgery?显示文摘 | Jin-Young Jang MD Sun-Whe Kim MD FACS Young Joon Ahn MD Yoo-Seok Yoon MD Min Gew Choi MD Kuhn Uk Lee MD Joon Koo Han MD Woo Ho Kim MD Young Joo Lee MD Song Chul Kim MD Duck Jong Han MD Yong Il Kim MD Seong Ho Choi MD Baik Hwan Cho MD Hee Chul Yu MD Dong | 2005 | Annals of Surgical Oncology2005，，2： | 1 |
| 8 | Polar solvent soluble and hydrogen absorbing polyaniline nanofibers显示文摘 | Abdelaziz Rahy Touria Rguig Sung June Cho Christopher E. Bunker Duck Joo Yang | 2010 | Synthetic Metals2010，，3： | 1 |
| 9 | Limited ability of capsule endoscopy to detect normally positioned duodenal papilla显示文摘 | Hwi Kong Yong Sik Kim Jong Jin Hyun Young Jig Cho Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Soon Ho Um Sang Woo Lee Jai Hyun Choi Chang Duck Kim Ho Sang Ryu Jin Hai Hyun | 2006 | Gastrointestinal Endoscopy2006，，4： | 1 |
| 10 | Label-Free White Blood Cell Classification Using Refractive Index Tomography and Deep Learning显示文摘Objective and Impact Statement.We propose a rapid and accurate blood cell identification method exploiting deep learning and label-free refractive index(RI)tomography.Our computational approach that fully utilizes tomographic information of bone marrow(BM)white blood cell(WBC)enables us to not only classify the blood cells with deep learning but also quantitatively study their morphological and biochemical properties for hematology research.Introduction.Conventional methods for examining blood cells,such as blood smear analysis by medical professionals and fluorescence-activated cell sorting,require significant time,costs,and domain knowledge that could affect test results.While label-free imaging techniques that use a specimen’s intrinsic contrast(e.g.,multiphoton and Raman microscopy)have been used to characterize blood cells,their imaging procedures and instrumentations are relatively time-consuming and complex.Methods.The RI tomograms of the BM WBCs are acquired via Mach-Zehnder interferometer-based tomographic microscope and classified by a 3D convolutional neural network.We test our deep learning classifier for the four types of bone marrow WBC collected from healthy donors(n=10):monocyte,myelocyte,B lymphocyte,and T lymphocyte.The quantitative parameters of WBC are directly obtained from the tomograms.Results.Our results show>99%accuracy for the binary classification of myeloids and lymphoids and>96%accuracy for the four-type classification of B and T lymphocytes,monocyte,and myelocytes.The feature learning capability of our approach is visualized via an unsupervised dimension reduction technique.Conclusion.We envision that the proposed cell classification framework can be easily integrated into existing blood cell investigation workflows,providing cost-effective and rapid diagnosis for hematologic malignancy. | DongHun Ryu Jinho Kim Daejin Lim Hyun-Seok Min In Young Yoo Duck Cho YongKeun Park | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
| 11 | Expanded natural killer cells augment the antimyeloma effect of daratumumab, bortezomib, and dexamethasone in a mouse model显示文摘The use of natural killer(NK)cells is a promising and safe immunotherapeutic approach in the field of cancer immunotherapy.However,combination treatments are required to enhance the effector functions and therapeutic efficacy of NK cells.In this study,we investigated the potential of daratumumab(Dara),bortezomib,and dexamethasone(Dvd)to augment the antitumor effects of NK cells in a multiple myeloma(MM)xenograft mouse model.NK cells were expanded and activated using the K562-OX40 ligand and membrane-bound IL-18 and IL-21 in the presence of IL-2 and IL-15 from peripheral blood mononuclear cells from MM patients.A human MM xenograft model was established using human RPMI8226-RFP-FLuc cells in NOD/SCID IL-2Rγnull(NSG)mice.Tumor-bearing mice were divided into six treatment groups:no treatment,expanded NK cells(eNKs),Dara,Dara+eNKs,Dvd,and Dvd+eNKs.Dvd treatment strongly enhanced the cytotoxicity of eNKs by upregulating expression of NK cell activation ligands,downregulating expression of NK cell inhibitory ligands,and promoting antibody-dependent cellular cytotoxicity.The combination of eNKs with Dvd significantly prolonged mouse survival and reduced the tumor burden and serum M-protein level.Furthermore,Dvd pretreatment significantly increased eNK persistence and homing to MM sites.Our findings suggest that Dvd treatment potentiates the antimyeloma effects of NK cells expanded and activated ex vivo by modulating immune responses in MM-bearing mice. | Jaya Lakshmi Thangaraj Seo-Yeon Ahn Sung-Hoon Jung Manh-Cuong Vo Tan-Huy Chu Minh-Trang Thi Phan Minsuk Kwon Kyung-Hwa Lee Mihee Kim Ga-Young Song Deok-Hwan Yang Jae-Sook Ahn Hyeoung-Joon Kim Duck Cho Je-Jung Lee | 2021 | Cellular & Molecular Immunology2021，18，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员