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55篇 您的检索式：作者名="Caldini"

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	题名	作者	年代	出处	被引量
1	Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells显示文摘AIM: Thiazolidinediones (TZD) are a new class of oral antidiabetic drugs that have been shown to inhibit growth of same epithelial cancer cells. Although TZD were found to be ligands for peroxisome proliferator-activated receptor γ (PPARγ), the mechanism by which TZD exert their anticancer effect is presently unclear. In this study,we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma.METHODS: The effects of TZD in pancreatic cancer cells were assessed in anchorage-independent growth assay.Expression of PPARγ was measured by reverse-transcription polymerase chain reaction and confirmed by Western blot analysis. PPARγ activity was evaluated by transient reporter gene assay. Flow cytometry and DNA fragmentationassay were used to determine the effect of TZD on cell cycle progression and apoptosis respectively. The effect of TZD on ductal differentiation markers was performed by Western blot.RESULTS: Exposure to TZD inhibited colony formation in a PPARγ-dependent manner. Growth inhibition was linked to G1 phase cell cycle arrest through induction of the ductal differentiation program without any increase of the apoptotic rate.CONCLUSION: TZD treatment in pancreatic cancer cells has potent inhibitory effects on growth by a PPAR-dependent induction of pacreatic ductal differentiation.	Elisabetta Ceni Tommaso Mello Mirko Tarocchi David W Crabb Anna Caldini Pietro Invernizzi Calogero Surrenti Stefano Milani Andrea Galli	2005	World Journal of Gastroenterology2005，11，8：	15
2	Cystatin C reference values and aging显示文摘	Ognibene A Mannucci E Caldini A		0，，06：	1
3	Inhibition of 4-nitroquinoline-1- oxide genotoxicity by Bacillus strains显示文摘	CALDINI G TROTrA F CENCI G	2002	Research in Microbiology2002，153，3：	1
4	Ceruloplasmin and transfer- rin in human seminal plasma:are they an index of seminiferous tu bular function显示文摘	Orlando C Caldini AL Barni T	1995	Fertil Steril1995，43，2：	1
5	Evidence for in vitro anti - genotoxicity of cheese non-starter lactobacilli 显示文摘	Caldini G Trotta F Corsetti A	2008	Antonie van Leeuwenhoek2008，93，12：	1
6	The c-erbB-2 oncogene amplification by competitive PCR in aneuploid cell clones flow sorted from breast cancer samples显示文摘	Vona C Caldini A Sestini R	1999	Clin Chem Lab Med1999，37，6：	1
7	Comparative levels of DNA breaks and sensitivity to oxidative stress in aged and senescent human fibroblasts: a distinctive pattern for centenarians 显示文摘	Chevanne M Caldini R Tombaccini D	2003	Biogerontology2003，4，2：	1
8	Dioxygenase activity and relative behaviour of Pseudomonas strains from soil in the presence of different aromatic compounds显示文摘	Cenci G Caldini G Boari L		0，，01：	1
9	Muhicenter evaluation of hemoglobin A assay on capillary electrophoresis 显示文摘	Marinova M Altinier S Caldini A	2013	Clin Chim Acta2013，424，：	1
10	inhibition of 4-nitroquinoline-l-oxide genotoxicity by bacillus strains显示文摘	Caldini G Trotta F Cenci G	2002	Research in Microbiology2002，153，3：	1
11	Multicenter evaluation of hemoglobin Alc assay on capillary electrophoresis 显示文摘	Marinova M Altinier S Caldini A	2013	Clin Chim Acta2013，424，：	1
12	CSF proteomic analysis in patients with normal pressure hydrocephalus selected for the shunt : CSF biomarkers of response to surgical treatment显示文摘	Scollato A Terreni A Caldini A	2010	Neurol Sci2010，31，：	1
13	Kinetic and immo- bilization studies on fungal glycosidases for aroma enhancement in wine显示文摘	CALDINI C BONOMI F PIFFERI P	1994	Enzyme Microb Technol1994，16，4：	1
14	Evidence for in vitro anti- genotoxicity of cheese non-starter lactobacilli显示文摘	Caldini G Trotta F Corsetti A	2008	Anton van Leeuw2008，93，：	1
15	Age-dependent physiological changes in the histoarehitecture of the articular cartilage of the rabbit mandibular condyle: a morpholngical and morphometric study显示文摘	Galhardo MS Caldini EG Battlehner CN	2012	Cells Tissues Organs2012，195，4：	1
16	Screening of potential lacto- bacilli antigenotoxicity by microbial and mammalian cell-based tests显示文摘	Caldini G Trotta F Villarini M	2005	Int J Food Microbiol2005，102，：	1
17	Cystatin C ref erence values and aging显示文摘	Ognibene A Mannucci E Caldini A	2006	Clin Biochem2006，39，6：	1
18	Expression and characterization of anionic components in the tubulointerstitial compartment of rat kidney during polymicrobial sepsis显示文摘	Chiara Adembri Valentina Selmi Luca Vitali Daniele Nosi Alessia Tani Giorgia Donata Zappoli Thyrion Giovanna Santoro Laura Bonaccini Gianfranco Avveduto Anna Lucia Caldini Eleonora Sgambati	2013	Acta Histochemica2013，，：	1
19	In vitro inhibitory activity of pro- biotic spore-forming bacilli against genotoxins显示文摘	Cenci G Caldini G Trotta F	2008	Lett Appl Micro- biol2008，46，：	1
20	Kinetic and immobilization studies on hancement in wine显示文摘	Caldini C Bonomi F Pifferi PG	1994	Enzyme and Microbial Technology1994，16，4：	1

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