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5篇 您的检索式：作者名="Donald Small"

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		题名	作者	年代	出处	被引量
	1	FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation显示文摘Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other drugs.We investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia cells.The combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML samples.Venetoclax also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway inhibition.Gilteritinib treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to BCL-2.Venetoclax treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from BCL-2.Treatment with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased apoptosis.These findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM expression.This study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment.	Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small	2021	Signal Transduction and Targeted Therapy2021，6，6：	2
	2	The Acute Hemodynamic Effects of MitraClip Therapy显示文摘	Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar	2011	Journal of the American College of Cardiology2011，，16：	1
	3	Potential for global mapping of development via a nightsat mission显示文摘	Christopher D. Elvidge Jeffrey Safran Benjamin Tuttle Paul Sutton Pierantonio Cinzano Donald Pettit John Arvesen Christopher Small	2007	GeoJournal (-)2007，，1：	1
	4	Percutaneous Mitral Repair With the MitraClip System显示文摘	Ted Feldman Saibal Kar Michael Rinaldi Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow William Gray Reginald Low Howard C. Herrmann Scott Lim Elyse Foster Donald Glower	2009	Journal of the American College of Cardiology2009，，8：	1
	5	Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration显示文摘	Hamdi K Hamdi Jacob Reznik Raquel Castellon Shari R Atilano John M Ong Nitin Udar Jeffrey H Tavis Annette M Aoki Anthony B Nesburn David S Boyer Kent W Small Donald J Brown M Cristina Kenney	2002	Biochemical and Biophysical Research Communications2002，，3：	1

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