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| 1 | Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats显示文摘Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the development of anticancer targeting drug. Hesperetin(HP), one of the abundant flavonoids found naturally in citrus fruits, has received considerable attention in anti-cancer promotion and progression. The present study was conducted to decipher the role of 0.5 ml hesperetin conjugated gold nanoparticles(Au-m PEG(5000)-S-HP NPs) during diethylnitrosamine(DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the better antioxidant that possesses anti-inflammatory,anti-proliferation and anticarcinogenic properties and may modulate signaling pathways.The confirmation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized by HR-TEM with EDAX, and DLS with Zeta potential techniques. The drug encapsulation efficiency and release properties were carried out in PBS at pH 7.4 for Au-mPEG(5000)-S-HP and compared with the control pure hesperetin(HP).Here, we review the role of mast cell counts, tumor necrosis factor alpha(TNF-α), transcription factor nuclear factor-κB(NF-κB), levels of glycoconjugates, proliferating cell nuclear antigen(PCNA) and argyrophilic nucleolar organizing regions, are the master regulator of inflammation and proliferation, in the development of hepatocellular injury, liver fibrosis and HCC. DEN-administered animals showed increased mast cell counts, tumor necrosis factor alpha, transcription factor nuclear factor-κB, glycoconjugates, proliferating cell nuclear antigen, and argyrophilic nucleolar organizing regions. Whereas Au-mPEG(5000)-S-HP NPs supplementation considerably suppressed all the above abnormalities. These results suggest that the Au-m PEG(5000)-S-HP NPs exhibited the better potential anticancer activity by inhibiting cell inflammation and proliferation in DEN-induced hepatocellular carcinogenesis. | Gokuladhas Krishnan Jayakumar Subramaniyan Pramila Chengalvarayan Subramani Barath Muralidharan Devaki Thiruvengadam | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 2 | Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats显示文摘Objective:To investigate the effect of lycopene on lipoprotein metabolism during D-galactosamine/lipopolysacchoride(D-Gal/LPS)induced hepatitis in experimentul rats.Methods:The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase(LPL),lecithincholesterol acyl transferase(LCAT)and hepatic triglyceride lipase(HTCL).Lipo protein analyses were done by the estimation of very low density lipoprotein cholesterol(VLDL),low density lipoprotein cholesterol(LDL)and high density lipoprotein cholesterol(HDL).Remits:The toxic insult of D-galactosamine/lipopolysaccharide(D-Gal/LPS)in experimental group of animals reduces the normal values of lipid metabolizing enzymes due to liver injury.The significant drop in the levels of HDL and concomitant increase in the values of VLDL and LDL were observed.The pretreatment of lycopene restore these altered values to near normal level in experimental group of animals.Conclusions:In the light of results,it can be concluded that administration lycopene stabilizes the lipoprotein levels by regulating the lipid metabolizing enzymes through its antioxidant defense and helps to maintain the normal lipid metabolism during toxic injury in liver. | Sheik Abdulazeez Sheriff Thiruvengadam Devaki | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 4 |
| 3 | Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells显示文摘Objective:To examine the role of carvacrol in modulating PI3 K/AKT signaling involved in human breast cancer pathogenesis using in vitro experimental model MCF-7 cells.Methods:MTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol(0–250μmol/L)at different time points(24 and 48 h).The nuclear morphology was assessed in MCF-7 cells with propidium iodide(PI)and acridine orange/ethidium bromide(AO/EB)staining and analyzed by fluorescence microscopy.Events like cell cycle arrest and apoptosis were observed by flow cytometric analysis and expressions of p-Rb,cyclin D1,cyclin-dependent kinase 4(CDK4),CDK6,Bax,Bcl-2,PI3 K/p-AKT were analyzed by immunoblot.Results:Carvacrol significantly reduced cell viability with the half maximal inhibitory concentration value of 200μmol/L at 24 and 48 h(P<0.05).importantly,there was a significant increase in the accumulation of the G0/G1 phase upon treatment with carvacrol in MCF-7 cells(P<0.05 or P<0.01).A remarkable decrease in protein expressions of p-Rb,cyclin D1,CDK4 and CDK6 denoted cell cycle arrest(P<0.05 or P<0.01).In addition,carvacrol treatment significantly inhibited PI3 K/p-AKT protein expressions leading to induction of apoptosis mediated by decreased Bcl2 and increased Bax protein expressions.Further,Annexin V/PI staining by FACS analysis,dual staining by AO/EB and PI staining studies suggested induction of apoptosis by carvacrol through PI3 K/Akt signaling pathway in MCF-7 cells.Conclusion:Carvacrol significantly inhibited the breast cancer MCF-7 cell proliferation and induced apoptosis via suppressing PI3/AKT signaling pathway. | Ashok Mari Gopikrishnan Mani Sirpu Natesh Nagabhishek Gopaiakrishnan Balaraman Nirmala Subramanian Fathima Bushra Mirza Jagan Sundaram Devaki Thiruvengadam | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 3 |
| 4 | Hepato protective effect of Picrorrhiza kurroa on tissue defence system in D-galactosamineinduced hepatitis in rats显示文摘 | R Anandan T Devaki | 1999 | Fitoterapia1999，70，1： | 1 |
| 5 | Changes in the antenna size of Photosystem I and Photosystem II in Synechococcus sp. strain PCC 7942 grown in the presence of SANDOZ 9785 — a Photosystem II inhibitor显示文摘 | Madhulika Srivastava Devaki Bhaya Salil Bose | 1994 | Photosynthesis Research1994，，2： | 1 |
| 6 | Clozapine inducedmyopericarditis : early recognition improves clinical outcome显示文摘 | Razminia M Salem Y Devaki S | 2006 | AmJ Ther2006，13，3： | 1 |
| 7 | Chronic stress-induced oxi- dative damage and hyperlipidemia are accompanied by atherosclerotic development in rats 显示文摘 | Devaki M Nirupama R Yajurvedi HN | 2013 | Stress2013，16，2： | 1 |
| 8 | Effect of squalene on cyclophosphamide - induced toxicity显示文摘 | S Senthilkumar T Devaki BM Manohar | 2006 | Clinica Chimica Acta2006，，： | 1 |
| 9 | Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury显示文摘 | Vimal V Devaki T | 2004 | Biomedi & Pharmacother2004，58，： | 1 |
| 10 | Romidepsin (depsipeptide) induced cell cycle arrest, apoptosis and histone hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression显示文摘 | VINODHKUMAR R SONG Y S DEVAKI T | 2008 | Biomedicine Pharmacotherapy2008，62，2： | 1 |
| 11 | Synergistic interactions of Ferulic acid with Ascorbic acid: Its cardioprotective role during isoproterenol induced myocardial infarction in rats显示文摘 | Surinder Kumar Yogeeta Arunachalam Gnanapragasam Subramanian Senthil Kumar Rajakannu Subhashini Arumugam Sathivel Thiruvengadum Devaki | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 12 | Current epidemiology of hepatitis E virus infection in the United States: Low seroprevalence in the National Health and Nutrition Evaluation Survey显示文摘 | Ivo Ditah Fausta Ditah Pardha Devaki Calistus Ditah Patrick S. Kamath Michael Charlton | 2014 | Hepatology2014，，3： | 1 |
| 13 | Antihepatotoxic Effect of Punica granatum . Acetone Extract Against Isoniazid- and Rifampicin-Induced Hepatotoxicity显示文摘 | Surinderkumar Yogeeta Hanumanth Rao Balaji Ragavender Thiruvengadam Devaki | 2007 | Pharmaceutical Biology2007，，： | 1 |
| 14 | Changes in the antenna size of Photosystem I and Photosystem II in Synechococcus sp. strain PCC 7942 grown in the presence of SANDOZ 9785 — a Photosystem II inhibitor显示文摘 | Madhulika Srivastava Devaki Bhaya Salil Bose | 1994 | Photosynthesis Research1994，，2： | 1 |
| 15 | Catalytic performanceof nano crystalline HZSM-5 in ethanol to gasoline(ETG) reaction显示文摘 | NAGABHATLA V SANDEEP K S JITENDRA K PATA S DEVAKI N | 2012 | Fuel2012，95，1： | 1 |
| 16 | Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: Role of drug metabolizing microsomal enzyme system, tumor necrosis factor-a and fate of liver cell structural integrity显示文摘AIM: To assess the defensive nature of Sargassum polycystum (S. polycystum) (Brown alga) against acetaminophen (AAP)-induced changes in drug metabolizing mi crosomal enzyme system, tumor necrosis factor (TNF-α) and fine structural features of the liver during toxic hepatitis in rats. METHODS: Male albino Wistar strain rats used for the study were randomly categorized into 4 groups. GroupⅠconsisted of normal control rats fed with standard diet. GroupⅡrats were administered with acetaminophen (800 mg/kg body weight, intraperitoneally). GroupⅢrats were pre-treated with 5. polycystum extract alone. GroupⅣrats were orally pre-treated with S. polycystum extract (200 mg/kg body weight for 21 d) prior to acetaminophen induction (800 mg/kg body weight, intraperitoneally). Serum separated and liver was excised and microsomal fraction was isolated for assaying cytochrome P450, NADPH Cyt P450 reductase and bs. Serum TNF-αwas detected using ELISA. Fine structural features of liver were examined by transmission electron microscopy. RESULTS: Rats intoxicated with acetaminophen showed considerable impairment in the activities of drug metabolizing microsomal enzymes, such as cytochrome P450, NADPH Cyt P450 reductase and bs when compared with the control rats. The rats intoxicated with acetaminophen also significantly triggered serum TNF-αwhen compared with the control rats. These severe alterations in the drug metabolizing enzymes were appreciably prevented in the rats pretreated with 5. polycystum. The rats pretreated with S. polycystum showed considerable inhibition in the elevation of TNF-αcompared to the rats intoxicated with acetaminophen. The electron microscopic observation showed considerable loss of structural integrity of the endoplasmic reticulum, lipid infiltration and ballooning of mitochondria in the acetaminophen-intoxicated rats, whereas the rats treated with S. polycystum showed considerable protection against acetaminophen-induced alterations in structural integrity. CONCLUSION: These observations suggest that the animals treated with 5. polycystum extract may have the ability to protect the drug metabolizing enzyme system and mitochondrial functional status from free radical attack, thereby showing its defense mechanism in protecting hepatic cells from acetaminophen toxic metabolite N-acetyl-para-benzoquinone-imine (NAPQI). | H Balaji raghavendran A Sathivel T Devaki | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
| 17 | Effect of squalene on eyclophosphamide- nduced toxicity显示文摘 | Senthilkumar S Devaki T Manohar BM | 2006 | Clin Chem Acta2006，364，12： | 1 |
| 18 | Effect of squalenein cyclophosphamide induced toxicity显示文摘 | Senthilkumar S Devaki T Manohar BM | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 19 | Cardioprotective effect of picrorrhiza Kurroa against isoproterenol-induced myocardial stress in rats显示文摘 | Subramaniam Hari Senthil Kumar Rangasamy Anandan Thiruvengadam Devaki | 2001 | Fitoterapia2001，72，4： | 1 |
| 20 | Effect of squalene on cyclophosphamide-induced toxicity显示文摘 | Senthilkumara S Devaki T Manohar BM | 2006 | Clini-ca Chimica Acta2006，364，1： | 1 |
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