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| 1 | Hepato protective effect of Picrorrhiza kurroa on tissue defence system in D-galactosamineinduced hepatitis in rats显示文摘 | R Anandan T Devaki | 1999 | Fitoterapia1999，70，1： | 1 |
| 2 | Effect of squalene on cyclophosphamide - induced toxicity显示文摘 | S Senthilkumar T Devaki BM Manohar | 2006 | Clinica Chimica Acta2006，，： | 1 |
| 3 | Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury显示文摘 | Vimal V Devaki T | 2004 | Biomedi & Pharmacother2004，58，： | 1 |
| 4 | Romidepsin (depsipeptide) induced cell cycle arrest, apoptosis and histone hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression显示文摘 | VINODHKUMAR R SONG Y S DEVAKI T | 2008 | Biomedicine Pharmacotherapy2008，62，2： | 1 |
| 5 | Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: Role of drug metabolizing microsomal enzyme system, tumor necrosis factor-a and fate of liver cell structural integrity显示文摘AIM: To assess the defensive nature of Sargassum polycystum (S. polycystum) (Brown alga) against acetaminophen (AAP)-induced changes in drug metabolizing mi crosomal enzyme system, tumor necrosis factor (TNF-α) and fine structural features of the liver during toxic hepatitis in rats. METHODS: Male albino Wistar strain rats used for the study were randomly categorized into 4 groups. GroupⅠconsisted of normal control rats fed with standard diet. GroupⅡrats were administered with acetaminophen (800 mg/kg body weight, intraperitoneally). GroupⅢrats were pre-treated with 5. polycystum extract alone. GroupⅣrats were orally pre-treated with S. polycystum extract (200 mg/kg body weight for 21 d) prior to acetaminophen induction (800 mg/kg body weight, intraperitoneally). Serum separated and liver was excised and microsomal fraction was isolated for assaying cytochrome P450, NADPH Cyt P450 reductase and bs. Serum TNF-αwas detected using ELISA. Fine structural features of liver were examined by transmission electron microscopy. RESULTS: Rats intoxicated with acetaminophen showed considerable impairment in the activities of drug metabolizing microsomal enzymes, such as cytochrome P450, NADPH Cyt P450 reductase and bs when compared with the control rats. The rats intoxicated with acetaminophen also significantly triggered serum TNF-αwhen compared with the control rats. These severe alterations in the drug metabolizing enzymes were appreciably prevented in the rats pretreated with 5. polycystum. The rats pretreated with S. polycystum showed considerable inhibition in the elevation of TNF-αcompared to the rats intoxicated with acetaminophen. The electron microscopic observation showed considerable loss of structural integrity of the endoplasmic reticulum, lipid infiltration and ballooning of mitochondria in the acetaminophen-intoxicated rats, whereas the rats treated with S. polycystum showed considerable protection against acetaminophen-induced alterations in structural integrity. CONCLUSION: These observations suggest that the animals treated with 5. polycystum extract may have the ability to protect the drug metabolizing enzyme system and mitochondrial functional status from free radical attack, thereby showing its defense mechanism in protecting hepatic cells from acetaminophen toxic metabolite N-acetyl-para-benzoquinone-imine (NAPQI). | H Balaji raghavendran A Sathivel T Devaki | 2006 | World Journal of Gastroenterology2006，12，24： | 1 |
| 6 | Effect of squalene on eyclophosphamide- nduced toxicity显示文摘 | Senthilkumar S Devaki T Manohar BM | 2006 | Clin Chem Acta2006，364，12： | 1 |
| 7 | Effect of squalenein cyclophosphamide induced toxicity显示文摘 | Senthilkumar S Devaki T Manohar BM | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 8 | Effect of squalene on cyclophosphamide-induced toxicity显示文摘 | Senthilkumara S Devaki T Manohar BM | 2006 | Clini-ca Chimica Acta2006，364，1： | 1 |
| 9 | Hepato protective effect of Picrorhiza kurroa on tissue defense system in D-galactosamine induced hepa titis in rats显示文摘 | Anandan R Devaki T | 1999 | Fitoterapia1999，70，1： | 1 |
| 10 | Hepatoprotective Effect of Allicin on Tissue Defense System in Galactosamine/Endotoxin Challenged Rats 显示文摘 | VIMAL V DEVAKI T | 2004 | J Ethnopharmacol (S0378 -6411)2004，90，1： | 1 |
| 11 | Hepatoprotective effect of Picrorrhiza kurroa ontissue defence system in D-galactosamine-induced hepatitis in rats显示文摘 | ANANDAN R DEVAKI T | 1999 | Fitotempia1999，70，1： | 1 |
| 12 | Hepato protective effect of Picrorrhiza kurroa on tissue defence system in D-galactosamine induced hepatitis in rats显示文摘 | R Anandan T Devaki | 1999 | Fitoterapia1999，70，1： | 1 |
| 13 | Hepatoprotective nature of seaweed alcoholic extract on acetaminophen induced hepatic oxidative stress显示文摘 | Raghavendran HRB Sathivel A Devaki T | | 0，，1： | 1 |
| 14 | Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats显示文摘 | Ravikumar V Shivashangari KS Devaki T | 2005 | Mol Cell Biochem2005，269，12： | 1 |
| 15 | Effect of L-arginine and L-lysine on lysosomal hydrolases and membrane bound phosphatases in experimentally induced myocardial infarction in rats显示文摘 | Ebenezar KK Sathish V Devaki T | 2003 | Mol Cell Biochem2003，247，： | 1 |
| 16 | Effect of arginine and lysine on mitochondrial function during isoproterenol induced myocardial infarction in rats显示文摘 | Ebenezar K K Sathish V Devaki T | 2003 | Nutrition Research2003，23，10： | 1 |
| 17 | Effect of squalene in cyclophosphamide induced toxicity 显示文摘 | Senthilkumar S Devaki T Manohar BM | 2006 | Clin Chim Acta2006，364，： | 1 |
| 18 | , Biochemical changes on the cardioprotective effect of nicorandil and arnlodipine dur- ing experimental myocardial infarction in rats 显示文摘 | Sathish V Ebenezar K Devaki T | 2003 | Pharmacol Res2003，48，6： | 1 |
| 19 | Observatory science with eXTP显示文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s. | Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig Alessandro Riggio Jerome Rodriguez Pablo Rodríguez-Gil Patrizia Romano Agata Rózańska Takanori Sakamoto Tuomo Salmi Ruben Salvaterra andrea Sanna andrea Santangelo Tuomas Savolainen Stéphane Schanne Hendrik Schatz LiJing Shao andy Shearer Steven N.Shore Ben W.Stappers Tod E.Strohmayer Valery F.Suleimanov Jirí Svoboda F.-K.Thielemann Francesco Tombesi Diego F.Torres Eleonora Torresi Sara Turriziani andrea Vacchi Stefano Vercellone Jacco Vink Jian-Min Wang JunFeng Wang Anna L.Watts ShanShan Weng Nevin N.Weinberg Peter J.Wheatley Rudy Wijnands Tyrone E.Woods Stan E.Woosley ShaoLin Xiong YuPeng Xu Zhen Yan George Younes WenFei Yu Feng Yuan Luca Zampieri Silvia Zane andrzej A.Zdziarski Shuang-Nan Zhang Shu Zhang Shuo Zhang Xiao Zhang Michael Zingale | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 0 |
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