|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exercise-induced oxidative stress:Friend or foe?显示文摘The first report demonstrating that prolonged endurance exercise promotes oxidative stress in humans was published more than 4 decades ago.Since this discovery,many ensuing investigations have corroborated the fact that muscular exercise increases the production of reactive oxygen species(ROS)and results in oxidative stress in numerous tissues including blood and skeletal muscles.Although several tissues may contribute to exercise-induced ROS production,it is predicted that muscular contractions stimulate ROS production in active muscle fibers and that skeletal muscle is a primary source of ROS production during exercise.This contraction-induced ROS generation is associated with(1)oxidant damage in several tissues(e.g.,increased protein oxidation and lipid peroxidation),(2)accelerated muscle fatigue,and(3)activation of biochemical signaling pathways that contribute to exercise-induced adaptation in the contracting muscle fibers.While our understanding of exercise and oxidative stress has advanced rapidly during the last decades,questions remain about whether exercise-induced increases in ROS production are beneficial or harmful to health.This review addresses this issue by discussing the site(s)of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production. | Scott K.Powers Rafael Deminice Mustafa Ozdemir Toshinori Yoshihara Matthew P.Bomkamp Hayden Hyatt | 2020 | Journal of Sport and Health Science2020，9，5： | 13 |
| 2 | Elevated homocysteine levels in human immunodeficiency virus-infected patients under antiretroviral therapy: A meta-analysis显示文摘AIM: To evaluate the association between the levels of homocysteine(Hcy), folate, vitamin B12 in human immunodeficiency virus(HIV)-infected patients who were treated with antiretroviral therapy(ART) or not treated with ART.METHODS: The Pub Med and Scielo databases were searched. Eligible studies regarding plasma Hcy level in HIV-infected patients were firstly identified. After careful analysis by two independent researches, the identified articles were included in the review according to two outcomes(1) Hcy, folate and vitamin B12 blood concentration in HIV-infected subjects vs health controls and;(2) Hcy blood concentration in HIV-infected subjects under ART vs not treated with ART. RevM an(version 5.2) was employed for data synthesis.RESULTS: A total of 12 studies were included in outcome 1(1649 participants, 932 cases and 717 controls). Outcome 1 meta-analysis demonstrated higher plasma Hcy(2.05 μmol/L; 95% CI: 0.10 to 4.00, P < 0.01) and decreased plasma folate concentrations(-2.74 ng/m L; 95%CI:-5.18 to-0.29, P < 0.01) in HIV-infected patients compared to healthy controls. No changes in vitamin B12 plasma concentration were observed between groups. All studies included in the outcome 2 meta-analysis(1167 participants; 404 HIVinfected exposed to ART and 757 HIV-infected non-ART patients) demonstrated higher mean Hcy concentration in subjects HIV-infected under ART compared to nonART HIV subjects(4.13 μmol/L; 95%CI: 1.34 to 6.92, P < 0.01).CONCLUSION: This meta-analysis demonstrated that the levels of Hcy and folate, but not vitamin B12, were associated with HIV infection. In addition, Hcy levels were higher in HIV-infected patients who were under ART compared to HIV-infected patients who were not exposed to ART. Our results suggest that hyperhomocysteinemia should be included among the several important metabolic disturbances that are associated with ART in patients with HIV infection. | Rafael Deminice Talita Capoani Vieira Silva Vitor Hugo Fernando de Oliveira | 2015 | World Journal of Virology2015，4，2： | 2 |
| 3 | Creatine sup- plemcntation prevents the accumulation of fat in the livers of rats fed a high -fat diet显示文摘 | DEMINICE R Da SILVA R P LAMARRE S G | 2011 | J Nutr2011，141，10： | 1 |
| 4 | Betaine suppl- ementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism 显示文摘 | Deminice R da Silva RP Lamarre SG | 2015 | Amino Acids2015，11，1： | 1 |
| 5 | Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats显示文摘 | DEMINICE R PORTARI GV VANNUCCHI H | 2009 | Br J Nutr2009，102，1： | 1 |
| 6 | Plasma Malondialdehyde as Biomarker of Lipid Peroxidation: Effects of Acute Exercise显示文摘 | A. Spirlandeli R. Deminice A. Jordao | 2013 | Int J Sports Med2013，，： | 1 |
| 7 | Creatine supplementation reduces oxidative stress biomarkers after acute exercise in rats显示文摘 | Rafael Deminice Alceu Afonso Jordao | 2012 | Amino Acids2012，，2： | 1 |
| 8 | Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans显示文摘 | Rafael Deminice Flávia Troncon Rosa Gabriel Silveira Franco Alceu Afonso Jordao Ellen Cristini de Freitas | 2013 | Nutrition2013，，： | 1 |
| 9 | Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism显示文摘 | Rafael Deminice Gabriela Salim Ferreira de Castro Lucas Vieira Francisco Lilian Eslaine Costa Mendes da Silva Jo?o Felipe Rito Cardoso Fernando Tadeu Trevisan Frajacomo Bruno Gonzaga Teodoro Leonardo dos Reis Silveira Alceu Afonso Jordao | 2015 | The Journal of Nutritional Biochemistry2015，，4： | 1 |
| 10 | Alterations in renin-angiotensin receptors are not responsible for exercise preconditioning of skeletal muscle fibers显示文摘Endurance exercise training promotes a protective phenotype in skeletal muscle known as exercise pre-conditioning.Exercise preconditioning protects muscle fibers against a variety of threats including inactivity-induced muscle atrophy.The mechanism(s)responsible for exercise preconditioning remain unknown and are explored in these experiments.Specifically,we investigated the impact of endurance exercise training on key components of the renin-angiotensin system(RAS).The RAS was targeted because activation of the classical axis of the RAS pathway via angiotensinⅡtypeⅠreceptors(AT1Rs)promotes muscle atrophy whereas activation of the non-classical RAS axis via Mas receptors(MasRs)inhibits the atrophic signaling of the classical RAS pathway.Guided by prior studies,we hypothesized that an exercise-induced decrease in AT1Rs and/or increases in MasRs in skeletal muscle fibers is a potential mechanism responsible for exercise preconditioning.Following endurance exercise training in rats,we examined the abundance of AT1Rs and MasRs in both locomotor and respiratory muscles.Our results indicate that endurance exercise training does not alter the protein abundance of AT1Rs or MasRs in muscle fibers from the diaphragm,plantaris,and soleus muscles compared to sedentary controls(p>0.05).Furthermore,fluorescent angiotensinⅡ(AngⅡ)binding analyses confirm our results that exercise pre-conditioning does not alter the protein abundance of AT1Rs in the diaphragm,plantaris,and soleus(p>0.05).This study confirms that exercise-induced changes in RAS receptors are not a key mechanism that contributes to the beneficial effects of exercise preconditioning in skeletal muscle fibers. | Branden L.Nguyen Toshinori Yoshihara Rafael Deminice Jensen Lawrence Mustafa Ozdemir Hayden Hyatt Scott K.Powers | 2021 | Sports Medicine and Health Science2021，3，3： | 1 |
| 11 | Whey protein supplementation increases methionine intake but not homocysteine plasma concentration in rats显示文摘 | Deminice R Comparotto H Jordao A A | 2015 | Appl Physiol Nutr Metab2015，40，1： | 1 |
| 12 | Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats显示文摘 | Deminiceal R Portari G Vannucchi Vannucchi H | 2009 | British Journal of Nutrition2009，102，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员