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| 1 | Effect of Processing and Composition on the Structure and Properties of P/M EP741NP Type Alloys显示文摘A study was carried out on the effects of processing and composition on the structure and properties of P/M EP741NP type alloys. The objectives of this study were to understand the role of Hf in a P/M superalloy containing high niobium used in aircraft engines and to determine the effects of extrusion and forging the powders as contrasted to HIPing (hot isostatic pressing) only. Two alloys of the P/M EP741NP composition were atomized: one alloy contained 0.26%Hf and the other was Hf free. After the as-atomized powders from both alloys were characterized, the powders were extruded into billets, forged and heat treated. After each process, the microstructures were characterized by SEM and the phases were extracted and identified by X-ray diffraction. The presence of Hf in the residues was probed by EDS (energy dispersive spectroscopy). The alloys were given the published Russian heat treatment as well as a more conventional heat treatment more typical of western powder alloys. Tensile, creep and stress rupture mechanical property tests were run. Results of the structural behavior of the alloys after each processing step will be presented and discussed. The role of the Hf on the mechanical proper- ties will be discussed. | John Radavich Tadeu Carneiro David Furrer Joseph Lemsky Anthony Banik | 2007 | Chinese Journal of Aeronautics2007，20，2： | 7 |
| 2 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 3 | Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats显示文摘AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying. | Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda | 2016 | World Journal of Gastroenterology2016，22，25： | 5 |
| 4 | Distribution and origin of polycyclic aromatic hydrocarbons in surface sediments from an urban river basin at the Metropolitan Region of Curitiba,Brazil显示文摘The concentrations of 16 polycyclic aromatic hydrocarbons(PAHs) were determined in surface sediment samples from nine sites located at the Iguau River Basin in the Metropolitan Region of Curitiba,Brazil to evaluate their distribution and sources.The total concentration of the PAHs was greater for sediments from highly urbanized areas,while the sediments from the Iraí Environmental Protection Area(Iraí EPA) showed significantly low concentrations.The sediments from the Iguau and Barigui rivers were classified as highly contaminated,while those from the Cercado and Curralinho rivers were classified as moderately contaminated.The predominance of PAHs containing two to four aromatic rings in most of the samples suggested the direct input of raw sewage into the water resources evaluated.Benzo[g,h,i]perylene,dibenzo[a,h]anthracene and indeno[1,2,3-cd]pyrene were predominant in sediments from the areas under the greatest urban and industrial development.The correlation between thermodynamic stability and the kinetics of evolution presented by the isomeric pairs indicated that combustion is the predominant source of PAHs in the sediments because the combustion of fossil fuels affected most of the points evaluated,followed by combustion of biomass and eventually combustion of oil product inputs.In general,the results showed that areas under strong urban influence,as well as the Iraí EPA,receive contributions of PAHs from similar sources. | Natalicio Ferreira Leite Patricio Peralta-Zamora Marco Tadeu Grassi | 2011 | Journal of Environmental Sciences2011，23，6： | 4 |
| 5 | Mechanisms involved in the therapeutic properties of mesenchymal stem cells显示文摘 | Lindolfo da Silva Meirelles Aparecida Maria Fontes Dimas Tadeu Covas Arnold I. Caplan | 2009 | Cytokine and Growth Factor Reviews2009，，5： | 3 |
| 6 | Storage temperature and type of cut affect the biochemical and physiological characteristics of fresh-cut purple onions显示文摘 | Natalia Dallocca Berno Jaqueline Visioni Tezotto-Uliana Carlos Tadeu dos Santos Dias Ricardo Alfredo Kluge | 2014 | Postharvest Biology and Technology2014，，： | 2 |
| 7 | Mechanisms involved in the therapeutic properties of mesenchymal stem cells显示文摘 | Lindolfo da Silva Meirelles Aparecida Maria Fontes Dimas Tadeu Covas Arnold I. Caplan | 2009 | Cytokine and Growth Factor Reviews2009，，5： | 2 |
| 8 | The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression显示文摘巨噬细胞(目的) 的 Apoptosis 禁止者,人的 Spα 的一个相当或相同事物;,是一只老鼠 scavenger 受体的可溶的成员充满半胱氨酸的总科(SRCR-SF ) 。这个家庭集成没有统一功能还为被描述了的天生、适应的有免疫力的房间表示的一组蛋白质。多种的功能被归功于瞄准,从在在到在自体免疫的病理的类脂化合物新陈代谢和反煽动性的效果的 thymic 选择期间的淋巴细胞的生存能力支持。在现在的报告,目的病原体绑定性质被探索了。由使用在哺乳动物的细胞表示的目的(rAIM ) 的一种 recombinant 形式,这蛋白质能绑并且聚集克积极、克否定的细菌,以及病原、腐生的真菌的种类,这被显示出。重要地,浆液也绑在目的微生物和分泌物的从老鼠的内长的目的很快在跟随暴露到保存微生物引起的房间墙部件的老鼠怒气巨噬细胞被导致。老鼠 splenocytes 上的 ligands 也是的著名细菌、真菌的像使用费的受体(TLR ) 导致的 Cytokine 版本面对 rAIM 禁止了。而且,联系病原体的分子的模式(PAMP ) 的老鼠模型导致了腐败细菌、真菌的起源的吃惊证明浆液目的层次以一种时间依赖者方式变化了。总的来说,这些数据建议那个目的由在病原体侵略期间支持天生的体液的防卫起一个一般 homeostatic 作用。 | Vanesa G. Martinez Cristina Escoda-Ferran Ines Tadeu Simees Satoko Arai Marc Orta Mascaro Esther Carreras Mario Martinez-Florensa Jose Yelamos Toru Miyazaki Francisco Lozano | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 9 | Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. | Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 10 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 11 | Pro- and Anti-inflammatory Cytokines in Steatosis and Steatohepatitis显示文摘 | Fabiola Rabelo Claudia P. M. S. Oliveira Joel Faintuch Daniel F. C. Mazo Vicencia M. R. Lima Jose Tadeu Stefano Hermes V. Barbeiro Francisco G. Soriano Venancio A. Ferreira Alves Flair J. Carrilho | 2010 | Obesity Surgery2010，，7： | 1 |
| 12 | Analytical evaluation ofthe acoustic insulation provided by double infinite walls 显示文摘 | Antonio J M P Tadeu A Godinho L | 2003 | Journal of Sound and Vibration2003，263，1： | 1 |
| 13 | A three-dimensional acoustics model using the method of fundamental solutions显示文摘 | Julieta Antonio Antonio Tadeu Luis Godinho | 2008 | Engineering Analysis with Boundary Elements2008，32，： | 1 |
| 14 | Validation of the 'International Consultation on Incontinence Questionnaire-Short Form' (ICIQ-SF) for Portuguese显示文摘 | Jose Tadeu Nunes Tamanini Miriam Dambros Carlos Arturo Levi D'Ancona | 2004 | Rev Saude Publica2004，38，3： | 1 |
| 15 | 显示文摘 | Tadeu A Antonio J Mateus D | 2004 | Applied Acoustics2004，65，1： | 1 |
| 16 | Commer cial Appiication of Niobium in Thin Fiims显示文摘 | TADEU CARNEIRO | 1999 | TIC BULLETIN1999，，100： | 1 |
| 17 | Sound insulation provided by single and double panel walls a comparison of analytical solutions versus experimental results 显示文摘 | Antonio Tadeu Julieta Antonio Diogo Mateus | 2004 | Applied Acoustics2004，65，： | 1 |
| 18 | Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of São Paulo, Brazil显示文摘Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of society.In this paper we modelled and simulated a test-trace-andquarantine strategy to control the COVID-19 outbreak in the State of São Paulo,Brasil.The State of São Paulo failed to adopt an effective social distancing strategy,reaching at most 59%in late March and started to relax the measures in late June,dropping to 41%in 08 August.Therefore,São Paulo relies heavily on a massive testing strategy in the attempt to control the epidemic.Two alternative strategies combined with economic evaluations were simulated.One strategy included indiscriminately testing the entire population of the State,reaching more than 40 million people at a maximum cost of 2.25 billion USD,that would reduce the total number of cases by the end of 2020 by 90%.The second strategy investigated testing only symptomatic cases and their immediate contacts e this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.The conclusion is that if the State of São Paulo had decided to adopt the simulated strategy on April the 1st,it would have been possible to reduce the total number of cases by 90%at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts. | Marcos Amaku Dimas Tadeu Covas Francisco Antonio Bezerra Coutinho Raymundo Soares Azevedo Neto Claudio Struchiner Annelies Wilder-Smith Eduardo Massad | 2021 | Infectious Disease Modelling2021，6，1： | 1 |
| 19 | Green's functions for two- and-a-half-dimensional elastodynamic problems显示文摘 | TADEU A J B KAUSEL E | 2000 | Journal of Engineering Mechanics ASCE2000，126，10： | 1 |
| 20 | Advances in lentiviral vectors: a patent review显示文摘 | PICANCO CASTRO V MARIA DE SOUSA RUSSO CARBOLANTE E TADEU COVAS D | 2012 | Recent Pat DNA Gene Seq2012，6，2： | 1 |
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