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| 1 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 2 | Simeprevir with Peginterferon/Ribavirin for Treatment-Na?ve Hepatitis C Genotype 1 Patients in Japan: CONCERTO-1, a Phase III Trial显示文摘 | Norio Hayashi Namiki Izumi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Hepatology2014，，： | 3 |
| 3 | 消减食品加工过程中的真菌毒素:来自欧洲和东南亚的经验分享显示文摘在世界范围内,由真菌毒素造成的经济损失估计达数十亿美元,给人类和动物带来安全风险。粮食中真菌毒素的预防可以通过食品加工过程中进行真菌毒素的消减处理。在过去几十年里,虽然发表的科技论文中报道了大量真菌毒素防控措施,但实际生产往往需要更容易实施的、简单易行的建议和指导方针。欧洲和东南亚在真菌毒素处理到数据分析、风险评估到污染防控、差异分析到流通途径等方面可以做到相互协作,互相补充。欧洲和东南亚政府及相关行业必须在综合考虑地域、农业系统和不同国家消费者偏好的背景下,寻求平衡食品安全和地区贸易二者关系,协同管控食品供应链。以谷物为例,加工过程包括初级加工(谷物清理和碾磨操作)和二次加工(如烘焙过程中的发酵和烘烤),欧洲尤其关注烘焙食品安全性及全麦面包生产工艺对呕吐毒素的影响。结合农业、咖啡工业和科学研究人员的专业知识及亚洲咖啡生产者的具体情况,重点关注东南亚地区咖啡中赭曲霉毒素A污染问题。在农场环境中减少真菌毒素的措施给咖啡农民带来了较大的挑战,包括在规范种植农场模式下咖啡生产者和消费者之间社会经济效益和个人行为模式的相关影响因素。随着世界变得更加全球化,食品和饲料供应链也变得日趋复杂,因此,需要制定更全面的策略来确保食品供给及品质安全。 | Paula Alvito Jonathan Barcelo Johan De Meester Elias Rito Michele Suman | 2021 | 粮油食品科技2021，29，6： | 3 |
| 4 | Dimeric inhibins in amniotic fluid, maternal serum, and fetal serum in human pregnancy显示文摘 | Riley SC Crossley JA Ritoe SC Horne A Shade M Ellis PM Aitken DA Groome NP | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 5 | Design and synthese of 2-methyl-2-{4-phenoxy}propionic acids:a new class of dual PPARα/γagonists显示文摘 | Etgen G J Rito C J | 2001 | J Med Chem2001，44，13： | 1 |
| 6 | Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies显示文摘 | Namiki Izumi Norio Hayashi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Gastroenterology2014，，5： | 1 |
| 7 | Maternal serum inhibinA in pregnancies complicated by insulin dependent diabetes melli-tus显示文摘 | Wallace EM Crossley JA Ritoe SC | 1997 | Br J Obstet Gynaecol1997，104，8： | 1 |
| 8 | Effect of different biofloc levels on microbial activity, water quality and performance of Litopenaeus vannamei in a tank system operated with no water exchange显示文摘 | Rodrigo Schveitzer Rafael Arantes Patrícia Fóes S. Costódio Carlos M. do Espírito Santo Luis Vinatea Arana Walter Quadros Seiffert Edemar Roberto Andreatta | 2013 | Aquacultural Engineering2013，，： | 1 |
| 9 | Practical application of aqueous two-phase partition to process development for the recovery of biological products 显示文摘 | Rito P M | 2004 | Journal of Chromatography B2004，807，1： | 1 |
| 10 | A multiadaptive sampling technique for cost-effective network measurements 显示文摘 | Silva J M C Carvalho P Rito Lima S | 2013 | Computer Networks2013，57，17： | 1 |
| 11 | Dipyridamole stress echocardiography vs dipyridamole sestamibi scintigraphy for diagnosing coronary artery disease in left bundle-branch block显示文摘 | VIGNA C STANISLAO M DE RITO V | 2001 | Chest2001，120，5： | 1 |
| 12 | Real- time simulation of heat transfer in continuous casting显示文摘 | Seppo Louhenkilpi grkki Laitinen Rito Nieminen | 1993 | Metallurgical and Material Transactions B1993，24，： | 1 |
| 13 | Maternal serum inhibin - A in pregnancies complicated by insulin dependent diabetes mellitus 显示文摘 | Wallace EM Crossley JA Ritoe SC | 1997 | Br J Obstet Gynaecol1997，104，： | 1 |
| 14 | Aesthetics and Bridge Design 显示文摘 | Rito A | 1992 | Structural Engineering International1992，6，2： | 1 |
| 15 | Communications System for Down-hole Measurements 显示文摘 | Mijarez-Castro Rito Rodriguez-Rodriguez H Joaquin Pascasio-Maldonado David | 2013 | Journal of Applied Sciences and Technology2013，11，6： | 1 |
| 16 | Design and synthesis of 2-methyl-2-{4- phenoxy} propionic acids:a new class of dual PPARα/γ agonists显示文摘 | Brooks D A Etgen G J Rito C J | 2001 | J Med Chem2001，44，13： | 1 |
| 17 | The Effect Of Public Debt and other determinants on the economic growth of selected european coun显示文摘 | Humberto Nuno Rito Ribeiro Tadas Vaicekanskas | 2012 | Economics And Management2012，，17： | 1 |
| 18 | A simplified culturemethod for Blastocystis hominis显示文摘 | Rito ZL Luis H Naquira C | 2000 | Revista MexicanaPatolagia Clinica2000，47，1： | 1 |
| 19 | Design and synthesis of a-aryloxy-a-methylhydrocinnamic acids:a novel class of dual peroxisome proliferator activated receptor α/γ agonists显示文摘 | Xu YP Rito CJ Etgen GJ | 2004 | J Med Chem2004，47，10： | 1 |
| 20 | Effect of different biofloc levels on microbial activity, water quality and performance of Litopenaeus vannamei in a tank system operated with no water exchange显示文摘 | Rodrigo Schveitzer Rafael Arantes Patrícia Fóes S. Costódio Carlos M. do Espírito Santo Luis Vinatea Arana Walter Quadros Seiffert Edemar Roberto Andreatta | 2013 | Aquacultural Engineering2013，，： | 1 |
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