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| 1 | Neurotherapeutic potential of erythropoietin after ischemic injury of the central nervous system显示文摘Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used for treating anemia of different origins. However, it became clear that EPO could also work in a neuroprotective, antiapoptotic, antioxidative, angiogenetic and neurotropic way. It causes stimulation of cells to delay cell apoptosis, especially in the central nervous system. In rodent models of focal cerebral ischemia, EPO showed an impressive reduction of infarct size by 30% and improvement of neurobehavioral outcome by nearly 40%. A large animal model dealing with ischemia and reperfusion of the spinal cord showed that EPO could reduce the risk of spinal cord injury significantly. In addition, some clinical studies tested whether EPO works in real live clinical settings. One of the most promising studies showed the innocuousness and improvements in follow-up, outcome scales and in infarct size, of EPO-use in humans suffering from ischemic stroke. Another study ended unfortunately in a negative outcome and an increased overall death rate in the EPO group. The most possible reason was the involvement of patients undergoing simultaneously systemic thrombolysis with recombinant tissue plasminogen activator. An experimental study on rats demonstrated that administration of EPO might exacerbate tissue plasminogen activator-induced brain hemorrhage without reducing the ischemic brain damage. This case shows clearly how useful animal models can be to check negative side effects of a treatment before going into clinical trials. Other groups looked in human trials at the effects of EPO on the outcome after ischemic stroke, relation to circulating endothelial progerdtor cells, aneurysmal subarachnoid hemorrhage, traumatic brain injury, hemoglobin transfusion thresholds and elective first-time coronary artery bypass surgery. Most of the results were pos-让ive, but are based mostly on small group sizes. However, some of the most neglected facts when focusing on experimental setups of ischemia of the central nervous system are issues like age and comorbidities. It might be extremely worthy to consider these points for future projects, because EPO might influence all these factors. | Florian Simon Nicolaos Floros Wiebke Ibing Hubert Schelzig Artis Knapsis | 2019 | Neural Regeneration Research2019，14，8： | 15 |
| 2 | Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease显示文摘AIM To study the genetic association and epistatic interaction of the interleukin(IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease(IBD). METHODS A total of 159 pediatric inflammatory IBD patients(Crohn's disease,n = 136; ulcerative colitis,n = 23) and 129 matched controls were studied for genetic association of selected single nucleotide polymorphisms(SNPs) of the IL-10 gene and the genes IL10 RA,IL10 RB,STAT3,and HO1,from the IL-10/STAT3 signaling pathway. As interactions between SNPs from different loci may significantly affect the associated risk for disease,additive(a) and dominant(d) modeling of SNP interactions was also performed to examine highorder epistasis between combinations of the individual SNPs. RESULTS The results showed that IL-10 rs304496 was associated with pediatric IBD(P = 0.022),but no association was found for two other IL-10 SNPs,rs1800872 and rs2034498,or for SNPs in genes IL10 RA,IL10 RB,STAT3,and HO1. However,analysis of epistatic interaction among these genes showed significant interactions:(1) between two IL-10 SNPs rs1800872 and rs3024496(additive-additive P = 0.00015,Bonferroni P value(Bp) = 0.003);(2) between IL-10 RB rs2834167 and HO1 rs2071746(dominant-additive,P = 0.0018,Bp = 0.039); and(3) among IL-10 rs1800872,IL10 RB rs2834167,and HO1 rs2071746(additivedominant-additive,P = 0.00015,Bp = 0.005),as well as weak interactions among IL-10 rs1800872,IL-10 rs3024496,and IL-10RA(additive-additive-additive,P = 0.003; Bp = 0.099),and among IL10 RA,IL10 RB,and HO1 genes(additive-dominant-additive,P = 0.008,Bp = 0.287).CONCLUSION These results indicate that both the IL-10 gene itself,and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway,contribute to the risk of pediatric IBD. | Zhenwu Lin Zhong Wang John P Hegarty Tony R Lin Yunhua Wang Sue Deiling Rongling Wu Neal J Thomas Joanna Floros | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 3 | Epithelioid angiosarcoma of the adrenal gland associated with chronic arsenical intoxication? 显示文摘 | Livaditou A Alexiou G Floros D | 1991 | Pathol Res Pract1991，187，23： | 1 |
| 4 | Access to private equity and real firm activity: Evidence from PIPEs显示文摘 | James R. Brown Ioannis V. Floros | 2011 | Journal of Corporate Finance2011，，1： | 1 |
| 5 | EconomicRestructuring, Gender and the Allocation of Time 显示文摘 | Floro M S | 1995 | World Development1995，，11： | 1 |
| 6 | Optimization of edible whey protein films containing preservatives for water vapor permeability,water solubility and sensory characteristics显示文摘 | Ozdemir M Floros J D | 2008 | Journal of Food Engineering2008，86，： | 1 |
| 7 | Ion-bombardment-induced whisker formation on graphite显示文摘 | Floro JA Rossnagel S M Robinson R S | 1983 | J Vac Sci Technol1983，1，： | 1 |
| 8 | Acoustically assisted diffusion through membranes and biom aterial显示文摘 | Floros J D Liang H | 1994 | Food Techn1994，48，12： | 1 |
| 9 | Surfactant proteins:molecular genetics of neonatal pulmonary diseases显示文摘 | Floros J Kala P | 1998 | Annu Rev Physiol1998，60，： | 1 |
| 10 | Price linkages between the US, Japan and UK stock markets显示文摘 | Floros C | 2005 | Financial Markets and Portfolio Management2005，19，16： | 1 |
| 11 | ,Transmission disequilibrium test of two unlinked disease loci: application to respiratory distress syndrome 显示文摘 | Fan R Floros J Xiong M | 2002 | Adv Appl in Stat2002，1，： | 1 |
| 12 | Real time vision based multi-person tracking for mobile robotics and intelligent vehicles 显示文摘 | Mitzel D Floros G Sudowe P | 2011 | Intelligent Robotics and Applications Lecture Notes in Com- puter Science2011，7102，2： | 1 |
| 13 | Human SP -A: then and now 显示文摘 | FLOROS J KARINCH A M | 1995 | Am J Physiol1995，268，21： | 1 |
| 14 | Dynamic correlation between stock market and oil prices: The case of oil-importing and oil-exporting countries显示文摘 | George Filis Stavros Degiannakis Christos Floros | 2011 | International Review of Financial Analysis2011，，3： | 1 |
| 15 | Optimization of edible whey protein filmscontaining preservatives for water vapor permeability,water solubilityand sensory characteristics显示文摘 | OZDEMIR M FLOROS J D | 2008 | Journal of Food Engineering2008，86，2： | 1 |
| 16 | Effects of Emerging Food Processing Techniques on the Packaging Materials显示文摘 | Ozen B F Floros J D | 2001 | Trends Food Sci Technol2001，12，： | 1 |
| 17 | Cisplatin - induced apoptosis in HL- 60 human promyelocytic leukemia cells : differential expression of BCL2 and novel apoptosis- related gene BCL2L12 显示文摘 | Floros KV Thomadaki H Katsaros N | 2003 | Ann NY Acad Sci2003，1010，： | 1 |
| 18 | Shell games: On the value of shell companies显示文摘 | Ioannis V. Floros Travis R.A. Sapp | 2011 | Journal of Corporate Finance2011，，4： | 1 |
| 19 | Effect of radiofrequency catheter ablation on the biochemical marker ischemia modified albumin显示文摘 | Debashis Roy Juan Quiles Manas Sinha Dimitrios Floros David Gaze Paul Collinson Gary F Baxter Juan Carlos Kaski | 2004 | The American Journal of Cardiology2004，，2： | 1 |
| 20 | Hedging effectiveness in Greek stock index futures market, 1999-2001 显示文摘 | Floros C Vougas D V | 2006 | Internation- al Research Journal of Finance and Economics2006，5，： | 1 |
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