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| 1 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南(续前)显示文摘7静脉溶栓
7.1静脉rtPA
急性卒中的静脉溶栓治疗现已得到普遍接受。美国FDA于1996年批准静脉应用rtPA,部分基于NINDSrtPA卒中试验结果。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，8： | 975 |
| 2 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 3 | Pediatric liver transplantation显示文摘In previous decades,pediatric liver transplantation has become a state-of-the-art operation with excellent success and limited mortality.Graft and patient survival have continued to improve as a result of improvements in medical,surgical and anesthetic management,organ availability,immunosuppression,and identification and treatment of postoperative complications.The utilization of split-liver grafts and living-related donors has provided more organs for pediatric patients.Newer immunosuppression regimens,including induction therapy,have had a significant impact on graft and patient survival.Future developments of pediatric liver transplantation will deal with long-term followup,with prevention of immunosuppression-related complications and promotion of as normal growth as possible.This review describes the state-of-the-art in pediatric liver transplantation. | Marco Spada Silvia Riva Giuseppe Maggiore Davide Cintorino Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，6： | 20 |
| 4 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 5 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 6 | Advances in Tropical Soil Characterization via Portable X-Ray Fluorescence Spectrometry显示文摘Portable X-ray fluorescence(pXRF) spectrometers can be used to determine the elemental composition easily, rapidly, and without using chemical reagents, which is very important for tropical regions due to the lack of detailed soil characterization data. Moreover,pXRF data can be used to predict the results of more expensive, time-consuming, and conventional laboratory analyses. This study sought to determine the elemental composition of various soil profiles using pXRF. Two operational modes(Trace Mode and General Mode) and two scanning time(30 and 60 s) were assessed to determine their effects on the correlation of pXRF dataset with respect to conventional inductively coupled plasma(ICP)-optical emission spectrometry analysis. This relationship has been reported in previous studies, however, few studies were performed on tropical soils, which are unique. Furthermore, such relationships establish the viability of developing prediction models directly from pXRF data. Linear regression was applied to develop calibration models for the prediction of ICP analysis results and exchangeable and available elemental contents based on pXRF data. High coefficients of determination(R^2) were obtained for Ca(0.87), Cu(0.90), Fe(0.95), Mn(0.85), Cr(0.95), V(0.72), and Ni(0.90), with adequate validation. Statistically significant results were not found for Al, K, Zn, Ti, and Zr. The models predicting the exchangeable Ca based on the total Ca from p XRF reached an R^2 of up to 0.85. Operational modes influenced the pXRF results. Our results illustrate that pXRF holds great promise for tropical soil characterization and the development of prediction models, justifying the need for larger-scale studies in tropical countries worldwide. | Elen A. SILVA David C. WEINDORF Sergio H. G. SILVA Bruno T. RIBEIRO Giovana C. POGGERE Teotonio S. CARVALHO Mariana G. M. GONQALVES Luiz R. G. GUILHERME Nilton CURI | 2019 | Pedosphere2019，29，4： | 5 |
| 7 | 带小直径纵筋并外包CFRP的RC圆墩抗震性能研究显示文摘桥梁震害调查显示,钢筋混凝土(RC)桥墩易受损,影响震后救援和灾后重建。采用小直径纵筋替换受损纵筋并外包碳纤维布(CFRP)的技术修复受损桥墩可缩短震后修复周期,节省重建费用。以某不规则连续梁桥的RC圆墩为工程背景,选择小直径纵筋的长度和直径、外包CFRP层数为参数,开展7根缩尺比例为1∶6的RC圆墩试件的拟静力试验;选用OpenSees建立有限元模型,采用试验结果验证其准确性,并开展参数分析。研究结果表明:设置小直径纵筋的桥墩的塑性变形集中在小直径纵筋高度范围内,桥墩破坏被限制在塑性铰区域内;与未设置小直径纵筋的桥墩相比,小直径纵筋使桥墩承载力降低20%~27%,但桥墩位移延性提高42%~85%,曲率延性提高47%~242%,耗能性能提高32%~56%;在满足桥墩承载力设计要求的情况下,使用小直径纵筋可有效提高桥墩抗震性能;设置小直径纵筋的桥墩在小直径纵筋区域内的实测CFRP最大应变明显大于未设置的试件,说明对设置小直径纵筋的桥墩外包CFRP,可防止桥墩过早破坏,提高延性;随着小直径纵筋长度增大或直径减小,桥墩耗能性能先增大后减小;建议以钢筋疲劳寿命需求为下限,塑性铰长度为上限选择小直径纵筋长度;选择满足保证塑性铰以外的纵筋受力始终在弹性范围内的条件下的最大直径为小直径纵筋直径;增大修复区域的混凝土强度可弥补设置小直径纵筋造成的桥墩承载力降低。 | 薛俊青 DAVIDE Lavorato 聂尚杰 陈俊臻 BRISEGHELLA Bruno NUTI Camillo | 2022 | 中国公路学报2022，35，2： | 4 |
| 8 | Early graft dysfunction following adult-to-adult livingrelated liver transplantation:Predictive factors and outcomes显示文摘AIM:To describe a condition that we define as early graft dysfunction(EGD)which can be identified preoperatively. METHODS:Small-for-size graft dysfunction following living-related liver transplantation(LRLT)is characterized by EGD when the graft-to-recipient body weight ratio(GRBWR)is below 0.8%.However, patients transplanted with GRBWR above 0.8%can develop dysfunction of the graft.In 73 recipients of LRLT(GRBWR>0.8%),we identified 10 patients who developed EGD.The main measures of outcomes analyzed were overall mortality,number of re-transplants and length of stay in days(LOS).Furthermore we analyzed other clinical pre-transplant variables,intraoperative parameters and post transplant data.RESULTS:A trend in favor of the non-EGD group(3-mo actuarial survival 98%vs 88%,P=0.09;3-mo graft mortality 4.7%vs 20%,P=0.07)was observed as well as shorter LOS(13 d vs 41.5 d;P=0.001)and smaller requirement of peri-operative Units of Plasma (4 vs 14;P=0.036).Univariate analysis of pre- transplant variables identified platelet count,serum bilirubin,INR and Meld-Na score as predictors of EGD. In the multivariate analysis transplant Meld-Na score (P=0.025,OR:1.175)and pretransplant platelet count(P=0.043,OR:0.956)were independently associated with EGD. CONCLUSION:EGD can be identified preoperatively and is associated with increased morbidity after LRLT. A prompt recognition of EGD can trigger a timely treatment. | Salvatore Gruttadauria Fabrizio di Francesco Giovanni Battista Vizzini Angelo Luca Marco Spada Davide Cintorino Sergio Li Petri Giada Pietrosi Duilio Pagano Bruno Gridelli | 2009 | World Journal of Gastroenterology2009，15，36： | 2 |
| 9 | Liver regeneration after liver resection: Clinical aspects and correlation with infective complications显示文摘AIM:To investigate whether early liver regeneration after resection in patients with hepatic tumors might be influenced by post-operative infective complications.METHODS:A retrospective analysis of 27 liver resections for tumors performed in a single referral center from November 2004 to January 2010.Regeneration was evaluated by multidetector computed tomographyat a mean follow-up of 43.85 d.The Clavien-Dindo classification was used to evaluate postoperative events in the first 6 mo after transplantation,and Centers for Disease Control and Prevention definitions were used for healthcare associated infections data.Generalized linear regression models with Gaussian family distribution and log link function were used to reveal the principal promoters of early liver regeneration.RESULTS:Ten of the 27 patients(37%)underwent chemotherapy prior to surgery,with a statistically significant prevalence of patients with metastasis(P=0.007).Eight patients(30%)underwent embolization,3 with primary tumors,and 5 with secondary tumors.Twenty patients(74%)experienced complications,with 12(60%)experiencing Clavien-Dindo Grade 3a to 5 complications.Regeneration≥100%occurred in 10(37%)patients.The predictors were smaller future remnant liver volume(-0.002;P<0.001),and a greater spleen volume/future remnant liver volume ratio(0.499;P=0.01).Patients with a resection of≥5 Couinaud segments experienced greater early regeneration(P=0.04).Nine patients experienced surgical site infections,and in 7 cases Clavien-Dindo Grade 3a to 4 complications were detected(P=0.016).There were no significant differences between patients with primary or secondary tumors,and either onset or infections or severity of surgical complications.CONCLUSION:Regardless of the onset of infective complications,future remnant liver and spleen volumes may be reliable predictors of early liver regeneration after hepatic resection on an otherwise healthy liver. | Duilio Pagano Marco Spada Vishal Parikh Fabio Tuzzolino Davide Cintorino Luigi Maruzzelli Giovanni Vizzini Angelo Luca Alessandra Mularoni Paolo Grossi Bruno Gridelli Salvatore Gruttadauria | 2014 | World Journal of Gastroenterology2014，20，22： | 2 |
| 10 | Terlipressin and Albumin in Patients with Cirrhosis and Type I Hepatorenal Syndrome显示文摘 | Sergio Neri Davide Pulvirenti Mariano Malaguarnera Bruno M. Cosimo Gaetano Bertino Luca Ignaccolo Sebasiano Siringo Pietro Castellino | 2008 | Digestive Diseases and Sciences2008，，3： | 2 |
| 11 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 12 | 低剂量白细胞介素-2在11种自身免疫疾病中的免疫学和临床疗效:单中心开放临床试验显示文摘背景调节性T(Tregs)细胞可以预防自身免疫并控制炎症,在各种自身免疫性或自身炎症性疾病中的研究都表明Treg细胞不足。由于低剂量白细胞介素-2(low-dose interleukin-2,ld-IL2)能够扩增并激活Tregs细胞,因此ld-IL2具有广泛的治疗潜力。目的我们通过一项临床试验观察ld-IL2治疗11种自身免疫性疾病中1种的效果,旨在评估ld-IL2的治疗潜力并选择疾病,以用于进一步的临床开发。方法本研究为前瞻开放性Ⅰ~Ⅱa期临床观察,入选了46例轻中度患者,诊断分别为类风湿关节炎、强直性脊柱炎、系统性红斑狼疮、牛皮癣、白塞病、肉芽肿性多血管炎、大动脉炎、克罗恩病、溃疡性结肠炎、自身免疫性肝炎或硬化性胆管炎。所有患者都接受了ld-IL2(100万IU/天)5天,然后每两周注射一次,维持6个月。所有患者均接受了深入的免疫监测和临床评估。结果在任何疾病类型以及任何合并药物治疗的患者中,ld-IL2都显示出了良好的耐受性。通过经典的免疫表型分析和广泛的免疫表型分析发现所有患者的Tregs细胞均被特异性地扩增激活,而效应T细胞没有被活化,提示ld-IL2具有临床疗效的前景。结论本研究中所采用的IL-2剂量和治疗方案可以选择性地激活和扩增Tregs细胞,并且对于不同的疾病种类以及不同的合并用药都是安全的。这一临床疗效以及初步结果可以为ld-IL2在各种自身免疫和自身炎症性疾病中开展Ⅱ期临床试验观察疗效提供了依据。试验注册号NCT01988506. | Michelle Rosenzwajg Roberta Lorenzon Patrice Cacoub Hang Phuong Pham Fabien Pitoiset Karim El Soufi Claire RIbet Claude Bernard Selim Aractingi Beatrice Banneville Laurent Beaugerie Francis Berenbaum Julien Champey Olivier Chazouilleres Christophe Corpechot Bruno Fautrel Arsfene Mekinian Elodie Regnier David Saadoun Joe-Elie Salem Jeremie Sellam Philippe Seksik Anne Daguenel-Nguyen Valene Doppler Jeremie Mariau Eric Vicaut David Klatzmann 杨新蕾(译) 张卓莉(校) | 2019 | 英国医学杂志中文版2019，22，2： | 2 |
| 13 | Clinical and molecular genetic features of ARC syndrome显示文摘 | Paul Gissen Louise Tee Colin A. Johnson Emmanuelle Genin Almuth Caliebe David Chitayat Carol Clericuzio Jonas Denecke Maja Rocco Bj?rn Fischler David FitzPatrick Angeles García-Cazorla Delphine Guyot Sebastien Jacquemont Sibylle Koletzko Bruno Leheup Hann | 2006 | Human Genetics2006，，3： | 2 |
| 14 | Goodness-of-fit tests for copulas: A review and a power study显示文摘 | Christian Genest Bruno Rémillard David Beaudoin | 2007 | Insurance Mathematics and Economics2007，，2： | 2 |
| 15 | The mini nutritional assessment (MNA) and its use in grading the nutritional state of elderly patients显示文摘 | Bruno Vellas Yves Guigoz Philip J Garry Fati Nourhashemi David Bennahum Sylvie Lauque Jean-Louis Albarede | 1999 | Nutrition1999，，： | 2 |
| 16 | Right hepatic lobe living donation: A 12 years single Italian center experience显示文摘Mini invasive techniques are taking over conventional open liver resections in the setting of left lateral segmentectomy for living liver donation,and hydride procedure are being implemented for the living related right hepatectomy.Our center routinely performs laparoscopic left lateral segmentectomy for pediatric recipient and has been the first in the Europe performing an entirely robotic right hepatectomy.Great emphasis is posed on living donor safety which is the first priority during the entire operation,then the most majority of our procedures are still conventional open right hepatectomy(RHLD),defined as removal of a portion of liver corresponding to Couinaud segments 5-8,in order to obtain a graft for adult to adult living related liver transplant.During this 10 years period some changes,herein highlighted,have occurred to our surgical techniques.This study reports the largest Italian experience with RHLD,focused on surgical technique evolution over a 10 years period.Donor safety must be the first priority in right-lobe living-related donation:the categorization of complications of living donors,specially,after this'highly sensitive'procedure,reflects the need for prompt and detailed reports. | Salvatore Gruttadauria Duilio Pagano Davide Cintorino Antonio Arcadipane Mario Traina Riccardo Volpes Angelo Luca Giovanni Vizzini Bruno Gridelli Marco Spada | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 17 | Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1 H MRS at 1.5 T显示文摘 | Peter Stanwell Laurence Gluch David Clark Boguslaw Tomanek Luke Baker Bruno Giuffrè Cynthia Lean Peter Malycha Carolyn Mountford | 2005 | European Radiology2005，，5： | 2 |
| 18 | Comparison of Two Kinds of Intraperitoneal Chemotherapy Following Complete Cytoreductive Surgery of Colorectal Peritoneal Carcinomatosis显示文摘 | Dominique Elias MD PhD Emmanuel Benizri MD Daniela Pietrantonio MD Paola Menegon MD David Malka MD PhD Bruno Raynard MD | 2007 | Annals of Surgical Oncology2007，，2： | 2 |
| 19 | Pituitary adenylate cyclase-activating polypeptide and its receptors:from structure to functions显示文摘 | David Vaudry Bruno J Gonzalez | 2000 | Pharmacol Rev2000，52，2： | 1 |
| 20 | Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear显示文摘 | Patrick Ray Ghislaine Badarou-Acossi Alain Viallon David Boutoille Martine Arthaud David Trystram Bruno Riou | 2007 | American Journal of Emergency Medicine2007，，2： | 1 |
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