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| 1 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 2 | Improvement potential analysis for integrated fractionating and heat exchange processes in delayed coking units显示文摘A novel diagram-based representation approach is developed to analyze the thermodynamic efficiency and identify quickly the promising energy-use improvement for integrated fractionating and heat exchange processes in delayed coking units. For considering temperature dependence of heat capacity and integrating fractionating and heat exchange processes, an advanced energy level composite curve is constructed by using the simulation results and a stepwise procedure. More accurate results of exergy analysis are obtained and the interaction between different components of the integrated system can be properly revealed in an integrated figure. Then the exergy calculation is performed to validate the performance of processes and to define the targets for improvement. The avoidable exergy destruction is also analyzed by applying the concepts of avoidable and unavoidable exergy destructions for the integrated system. In a case study for a Chinese refinery, the results reveal that the heat exchange between gas oil and deethanization gasoline is the most inefficient process with the highest retrofitting potential, and the lowest exergy efficiency of component in the integration system is only29.4%. The improvement potential and exergy efficiency for the fractionator are 38.1% and 97.3%, respectively.It is obvious that the fractionator is not the most promising component for improvement. | Yang Lei Danlin Zeng Guanghui Wang | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 2 |
| 3 | Prevention of violence risk and interventions of Chinese and western medicine nursing on emotion显示文摘Accumulation of bad emotion with patients and their relations added violence risk.Workplace violence of nursing is an acute injury to nurse,and long-term threats and challenges to their physical and mental health and professional values. It also has an potential problem on parties negotiate the settlement of medical disputes,as well as boosting reform of national health system.Identifying and managing patients' emotion has positive impact on doubts and resentments elimination,anger escalation avoidance,violence prevention. This study proposed emotional intervention program in terms of traditional Chinese medicine and modern nursing care,which based on introducing the research status on nursing workplace violence. The purpose is to culture the ability of patients' self-identification and emotions regulation,take effective protective measure. The research provides the reference on perfecting the medical security system and related policy research. | LI Danlin PEI Xiao | 2017 | 中西医结合护理(中英文)2017，3，9： | 2 |
| 4 | A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet(Setaria italica)显示文摘 | Guanqing Jia Xuehui Huang Hui Zhi Yan Zhao QiangZhao Wenjun Li Yang Chai Lifang Yang Kunyan Liu Hengyun Lu Chuanrang Zhu Yiqi Lu Congcong Zhou Danlin Fan Qijun Weng Yunli Guo Tao Huang LeiZhang Tingting Lu Qi Feng Hangfei Hao HongkuanLiu Ping Lu Ning Zhang Yuhui Li Erhu Guo ShujunWang Suying Wang Jinrong Liu Wenfei Zhang GuoqiuChen Baojin Zhang Wei Li Yongfang Wang HaiquanLi Baohua Zhao Jiayang Li Xianmin Diao Bin HanJia | 2013 | Nature Genetics2013，45，8： | 1 |
| 5 | Monitoring and evaluating spatial variability of soil salinity in dry and wet seasons in the Werigan-Kuqa Oasis,China,using remote sensing and electromagnetic induction instruments显示文摘 | DING Jianli YU Danlin | 2014 | Geoderma2014，235，： | 1 |
| 6 | Human myoblast genome therapy显示文摘Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. Injection injury activates regeneration of host myofibers that fuse with the engrafted myoblasts, sharing their nuclei in a common gene pool of the syncytium. Thus, through nuclear transfer and complementation, the normal human genome can be transferred into muscles of patients with genetic disorders to achieve phenotype repair or disease prevention. Myoblasts are safe and efficient gene transfer vehicles endogenous to muscles that constitute 50% of body weight. Results of over 280 HMGT procedures on Duchenne Muscular Dystrophy (DMD) subjects in the past 15 years demonstrated absolute safety. Myoblast-injected DMD muscles showed improved histology. Strength increase at 18 months post-operatively averaged 123%. In another application of HMGT on ischemic cardiomyopathy, the first human myoblast transfer into porcine myocardium revealed that it was safe and effective. Clinical trials on approximately 220 severe cardiomyopathy patients in 15 countries showed a <10% mortality. Most subjects received autologous cells implanted on the epicardial surface during coronory artery bypass graft, or injected on the endomyocardial surface percutaneously through guiding catheters. Significant increases in left ventricular ejection fraction, wall thickness, and wall motion have been reported, with reduction in perfusion defective areas, angina, and shortness of breath. As a new modality of treatment for disease in the skeletal muscle or myocardium, HMGT emerged as safe and effective. Large randomized multi-center trials are under way to confirm these preliminary results. The future of HMGT is bright and exciting. | Peter K Law Danlin M Law Eugene KW Sim Khawja H Haider Margarita N Vakhromeeva Ilia I Berishvili Leo A Bockeria Choong-Chin Liew | 2006 | Journal of Geriatric Cardiology2006，3，3： | 1 |
| 7 | Potential involvement of BMP receptor type IB activation in a synergistic effect of chondrogenic promotion between rhTGFβ3 and rhGDF5 or rhBMP7 in human mesenchymal stem cells显示文摘 | DANLIN X U ZE'EV GECHTMAN ANNA HGUHES | 2006 | Growth Factors2006，24，4： | 1 |
| 8 | Solid stat( NMR studies of methanol-to-aromatics reaction over silver ex changed HZSM 5 zeolite显示文摘 | Zeng Danlin Yang Jun Wang Jiqing | 2007 | Microporous and Mesoporous Materials2007，98，123： | 1 |
| 9 | Upwelling in the Taiwan Strait during the summer monsoon detected by satellite and shipboard measurements显示文摘 | Tang Danlin Kester D R Ni I-Hsun | 2002 | Remote Sensing of Environment2002，83，： | 1 |
| 10 | Dielectric properties of saline soil based on a modified Dobson dielectric model显示文摘Soil salinization is a major concern for agricultural development in arid areas. In this paper, a modified Dobson dielectric model was applied to simulate the dielectric constant of saline soil in the Ugan-Kuqa river delta oasis of Xinjiang Uygur autonomous region, northwestern China. The model performance was examined through analyzing the influences of its parameters on the soil dielectric constant and the relationship between radar backscattering coefficient and the dielectric constant of saline soil. The results of the study indicate that:(1) The real part of the soil dielectric constant is affected by soil water content at low radar frequencies; the imaginary part is closely related with both the soil water content and soil salt content.(2) The soil water and salt contents are related with the coefficient of dialectical loss, which is consistent with the natural conditions of saline soil in arid areas and provides valuable references for the study of soil dielectric properties.(3) The changes of soil water content and soil salt content have instant influences on the dielectric constant of saline soil. Subsequently, the radar backscattering coefficient is affected to respond to the dielectric constant of saline soil. The radar backscattering coefficient is most responsible to the radar's cross polarization pattern with a correlation coefficient of R2=0.75. This study provides a potential method to monitor soil salinization and soil water content by using a soil dielectric model and radar techniques. | Nigara TASHPOLAT DING Jianli YU Danlin | 2015 | Journal of Arid Land2015，7，5： | 1 |
| 11 | Oxidative Desulfurization of Diesel Fuel Using Amphiphilic Quaternary Ammonium Phosphomolybdate Catalysts显示文摘 | Qiu Jianghua Wang Guanghui Zeng Danlin | 2009 | Fuel ProcessTechnol2009，90，12： | 1 |
| 12 | Monitoring and evaluating spatial variability of soil salinity in dry and wet seasons in the Werigan-Kuqa Oasis, China, using remote sensing and electromagnetic induction instruments显示文摘 | Ding Jianli Yu Danlin | 2014 | Geoderma2014，235，： | 1 |
| 13 | Monitoring and evaluating spatialvariability of soil salinity in dry and wet seasons in theWerigan-Kuqa Oasis, China, using remote sensing andelectromagnetic induction instruments显示文摘 | Ding Jianli Yu Danlin | 2014 | Geoderma2014，，235236： | 1 |
| 14 | Preparation of quaternarized N-halamine-grafted graphene oxide nanocomposites and synergetic antibacterial properties显示文摘At present,frequent outbreaks of bacteria and viruses have seriously affected people's normal lives.Therefore,the study of broad-spectrum antibacterial nanocomposites is very promising.However,most antibacterial materials have some disadvantages,such as single bactericidal mechanisms and unrepeatable use.Based on the current situation,a kind of nanocomposite with three structures of graphene oxide(GO),quaternary ammonium salt(QAs)and N-halamine was prepared,which showed synergistic effect to improve antibacterial activity and combined with a variety of sterilization mechanisms.Meanwhile,GO can provide richer ways of sterilization and high specific surface area,which is conducive to the grafting of quaternarized N-halamine.The advantages of physical sterilization of GO,charge adsorption of QAs,reuse of N-halamine and efficient sterilization are fully utilized.The results showed that the quaternarized N-halamine-grafted GO was obtained successfully.GO grafted with quaternarized N-halamine polymer showed strong speedy bactericidal activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)(99%).It had good storage and regeneration properties. | Danlin Bu Yu Zhou Chang Yang Hengyu Feng Chunxia Cheng Mengjie Zhang Zice Xu Linghan Xiao Yujing Liu Zhenai Jin | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 15 | Design and characterization of plasticized bacterial cellulose/waterborne polyurethane composite with antibacterial function for nasal stenting显示文摘A nasal stent capable of preventing adhesions and inflammation is of great value in treating nasal diseases.In order to solve the problems of tissue adhesion and inflammation response,we prepared plasticized bacterial cellulose(BCG)and waterborne polyurethane(WPU)composite with antibacterial function used as a novel nasal stent.The gelation behavior of BCG could contribute to protecting the paranasal sinus mucosa;meanwhile,the WPU with improved mechanical property was aimed at supporting the narrow nasal cavity.The thickness,size and the supporting force of the nasal stent could be adjusted according to the specific conditions of the nasal.Thermogravimetric analysis,contact angle and water absorption test were applied to investigate the thermal,hydrophilic and water absorption properties of the composite materials.The composite materials loaded with poly(hexamethylene biguanide)hydrochloride maintained well antibacterial activity over 12days.Animal experiments further revealed that the mucosal epithelium mucosae damage of BCG-WPU composite was minor compared with that of WPU.This new type of drug-loaded nasal stent can effectively address the postoperative adhesions and infections while ensuring the health of nasal mucosal,and thus has an immense clinical application prospects in treating nasal diseases. | Zhaoxuan Feng Minglu Li Xing Jin Yudong Zheng Junxiu Liu Liang Zhao Yansen Wang Hao Li Danlin Zuo | 2020 | Regenerative Biomaterials2020，7，6： | 1 |
| 16 | State policy and the globalization of Beijing:emerging themes显示文摘 | Yehua Dennis Wei Danlin Yu | 2005 | Habitat International2005，，6： | 1 |
| 17 | Expression Profiles of 10,422 Genes at Early Stage of Low Nitrogen Stress in Rice Assayed using a cDNA Microarray显示文摘 | Xingming Lian Shiping Wang Jianwei Zhang Qi Feng Lida Zhang Danlin Fan Xianghua Li Dejun Yuan Bin Han Qifa Zhang | 2006 | Plant Molecular Biology2006，，5： | 1 |
| 18 | Peculiarities of buried silicon oxynitride layer synthesis by sequential oxygen and nitrogen ion implantation in silicon显示文摘 | Drakin K A | 1991 | Nuclear Instruments and Methods in Physics Research1991，58，： | 1 |
| 19 | Genetic diversity and population structure of indigenous chicken breeds in South China显示文摘A total of 587 individuals from 12 indigenous chicken breeds from South China and two commercial breeds were genotyped for 26 microsatellites to investigate the genetic diversity and population structure.All microsatellites were found to be polymorphic.The number of alleles per locus ranged from 5 to 36,with an average of12.10±7.00(SE).All breeds,except White Recessive Rock,had high allelic polymorphism(>0.5).Higher genetic diversity was revealed in the indigenous chicken breeds rather than in the commercial breeds.Potential introgression from the commercial breeds into the indigenous chickens was also detected.The population structure of these indigenous chicken breeds could be explained by their geographical distribution,which suggested the presence of independent history of breed formation.Data generated in this study will provide valuable information to the conservation for indigenous chicken breeds in future. | Xunhe HUANG Jinfeng ZHANG Danlin HE Xiquan ZHANG Fusheng ZHONG Weina LI Qingmei ZHENG Jiebo CHEN Bingwang DU | 2016 | Frontiers of Agricultural Science and Engineering2016，3，2： | 1 |
| 20 | Distribution and gas-bearing properties of Permian igneous rocks in Sichuan Basin, SW China显示文摘Based on the analysis of outcrop, seismic, logging and drilling data, combined with exploration practice, the characteristics,distribution, reservoir performance and gas-bearing properties of Permian igneous rocks in Sichuan Basin are studied. The study shows that central volcanic eruptive facies are developed in Sichuan Basin, and their lithological assemblages and distribution characteristics show obvious differences. The igneous rocks are mainly distributed in three regions: the southwestern part of the basin has dominantly largescale overflow facies basalts; the central and western part of the basin, Jianyang-Santai area, develop intrusive rocks, volcanic lavas(basalts)and pyroclastic rocks; and the eastern part of Sichuan, Dazhou-Liangping area, only develop diabase and basalts. Five aspects of understandings are achieved:(1) The Upper Permian igneous rocks can be divided into intrusive rocks and extrusive rocks, with the extrusive rocks as the main body. The chemical compositions of the extrusive rocks are characterized by both alkaline basalt and tholeiitic basalt, and belong to the subalkaline type of transitional basalt magma eruption.(2) There are obvious rhythmic structures vertically among overflow facies basalt, and the single rhythmic layer consists of, from bottom up, pyroclastic rocks(undeveloped), gray and dark gray porphyritic basalts(unstable), dark gray and purple microcrystalline-cryptocrystalline basalts, dark greyish green porous and amygdaloid basalts; the central volcanic eruption shows the rhythm and the vertical sequence of volcanic clastic rocks(agglomerates and breccias), volcanic lava, tuffaceous lava from bottom to top.(3) The pore types of basalt and pyroclastic rocks are diverse, mainly dissolution pore and de-vitrification micropore, but their physical properties are different. Basalt is characterized by ultra-low pore permeability, small reservoir thickness, and reservoirs are distributed in the upper and middle parts of the cycle, with poor lateral comparability. Volcanic clastic rocks are medium to high porous reservoirs(Well YT1: porosity: 8.66%?16.48%, average 13.76%) with large thickness and good reservoir quality.(4) Natural gas in basalts in southwestern basin mainly comes from Middle Permian, and natural gas in volcanic clastic rocks in central and western basin comes from Cambrian Qiongzhusi Formation.(5) Analysis of igneous reservoir-forming conditions in different areas shows that there are relatively insufficient gas sources and great differences in preservation conditions in southwestern basin.Reservoirs are poorly developed and gas-bearing is complex. The Jianyang-Santai area in the central and western part of Sichuan Basin has abundant hydrocarbon sources, developed reservoir, favorable preservation conditions and favorable gas geological conditions, and it is a favorable area for gas exploration. | MA Xinhua LI Guohui YING Danlin ZHAGN Benjian LI Ya DAI Xin FAN Yi ZENG Yunxian | 2019 | Petroleum Exploration and Development2019，46，2： | 1 |
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