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| 1 | ATF4 regulates lipid metabolism and thermogenesis显示文摘(ATF4 ) 激活抄写因素 4 被显示了在许多生理的过程起关键作用。然而,没有报告表明在 ATF4 和类脂化合物新陈代谢之间的一个直接连接。我们注意到 Atf4 缺乏的老鼠是瘦的,建议为在调整类脂化合物新陈代谢的 ATF4 的一个可能的角色。我们的当前的学习的目标是在类脂化合物新陈代谢调查 ATF4 的参与并且阐明内在的机制。用 Atf4 缺乏的老鼠的研究揭示了增加的精力开销,由氧消费测量了。这些鼠标也显示出增加在分解,解开的表示蛋白质 2 (UCP2 ) 并且在在白脂肪质的织物(WAT ) 的 lipogenic 基因的表示的尾 - 氧化基因和减少,建议增加的利用和丰满的酸的减少的合成分别地。UCP1 的表示, 2 和 3 也在棕色的脂肪质的织物(蝙蝠) 被增加,建议增加了生热作用。在蝙蝠的 UCP 的表示上的 ATF4 删除的效果建议增加的生热作用可以位于增加的精力开销下面。因此,我们的学习在调整类脂化合物新陈代谢和生热作用为 ATF4 识别可能的新功能。 | Chunxia Wang Zhiying Huang Ying Du Ying Cheng Shanghai Chen Feifan Guo | 2010 | Cell Research2010，20，2： | 16 |
| 2 | The temporal and spatial patterns and potential evaluation of China's energy resources development显示文摘The issue of China's energy supply security is not only the key problem which affects China's rapid and sustainable development in the 21st century,but also the one which international attention focuses on.Based on the notable characteristic of spatial imbalance between energy production and consumption in China,this paper takes the evolution of China's primary energy resources development(excluding hydropower) from 1949 to 2007 as the study object,with the aim to sum up the evolutive characteristics and laws of China's energy resources development in the past nearly 60 years.Then,based on comprehensive considerations of coal's,oil's and natural gas's basic reserves,qualities,geological conditions,production status,and ecological service function of every province,this paper adopts development potential index(DP)to evaluate the development potential of every province's energy resources,and divide them into different ranks.Conclusions are drawn as follows:(1) Generally speaking,China's gross energy production was increasing in waves from 1949 to 2007.From the viewpoint of spatial patterns,China's energy resources development has shown a characteristic of 'concentrating to the north and central areas,and evolving from linear-shaped to 'T-shaped' pattern gradually since 1949.(2) The structure evolution of China's energy resources development in general has shown a trend of 'coal proportion is dominant but decreasing,while oil and gas proportions are increasing' since 1949.(3) At the provincial scale,China's energy resources development potential could be divided into large,sub-large,general and small ranks,four in all.In the future,the spatial pattern of China's energy production will evolve from 'T-shaped' to '∏-shaped pattern'.These conclusions will help to clarify the temporal and spatial characteristics and laws of China's energy resources development,and will be beneficial for China to design scientific and rational energy development strategies and plans,coordinate spatial imbalance of energy production and consumption,ensure national energy supply,avoid energy resources waste and disorderly development,and promote regional sustainable development under the globalization background with changeful international energy market. | MA Beibei LU Chunxia ZHANG Lei CHENG Xiaoling | 2010 | Journal of Geographical Sciences2010，20，3： | 8 |
| 3 | Spatiotemporal Evolution of Urban Land Uses in Modern Urbanization of China显示文摘Taking social statistic data as basic data,this paper extended the meaning of urban land uses,highlighted the meaning of urban land uses in modern urbanization,which includes direct,indirect and induced land uses,quantitatively simulated the indirect and induced land uses by the substitution method of agricultural consumption and urban carbon emission and then,analyzed the spatiotemporal evolution of urban land uses in China during 1952–2005 by spatial analysis tool of Geographic Information System. The results indicate that the area of urban land use in China had been increasing since 1952,showing an inversed pyramid structure,i.e.,the direct | ZHANG Shumin ZHANG Baolei ZHANG Lei LU Chunxia CHENG Xiaoling | 2010 | Chinese Geographical Science2010，20，2： | 5 |
| 4 | A quality evaluation strategy for Rhizoma coptidis from a variety of different sources using chromatographic fingerprinting combined with biological fingerprinting显示文摘Most of herbal medicines of different sources are used for the same treatment goal in clinic despite their tremendous differences of the quality.Because the clinical efficacy is closely related to the quality of medicines,the implementation of an effective quality control(QC)process is vital.Chemical methods based on content determination and chromatographic fingerprints(CFs)have been recommended as powerful tools.In spite of advances in QC,it is still difficult to determine that which of the chemical compositions can best reflect the correlation with the desired biological activity.Herein,we have focused on the biological activities of multi-source herbal medicines to establish an analytical method.By looking for correlations between the biological activities and their chemical compositions,the method can identify reasonable chemical indicators or chemical methods with biological activity information.In this study,high-performance liquid chromatography(HPLC)and microcalorimetry are combined as a useful method for evaluating the quality of Rhizoma coptidis from different sources.The results of biological fingerprints(BFs)showed that the antibacterial activity sequence of R.coptidis of different sources was Coptis teeta Wall.(CT)>Coptis chinensis Franch.(CC)>Coptis deltoidea C.Y.Cheng et Hsiao(CD).The'spectrum-activity'relationships between CFs and BFs were investigated using the canonical correlation analysis(CCA).Compared with the CCA result of CFs and BFs,the canonical correlation coefficient r1and r2were 0.9974 and 0.9752,respectively.It revealed that there are a close correlation between the spectrum-activity relationships and several of the major anti-bacterial components in the CFs,including jatrorrhizine,coptisine,palmatine,and berberine.Of course,R.coptidis was only a representative of multisource medical plants.The result of the current study will provide an effective reference for evaluating the quality of multisource herbal medicines. | LI JunXian YAN Dan MA LiNa XIONG Yin YAN ChunXia LI BaoCai PENG Cheng XIAO XiaoHe | 2013 | Chinese Science Bulletin2013，58，33： | 5 |
| 5 | Phosphofructokinase-1 Negatively Regulates Neurogenesis from Neural Stem Cells显示文摘Phosphofructokinase-1(PFK-1),a major regulatory glycolytic enzyme,has been implicated in the functions of astrocytes and neurons.Here,we report that PFK-1 negatively regulates neurogenesis from neural stem cells(NSCs)by targeting pro-neural transcriptional factors.Using in vitro assays,we found that PFK-1 knockdown enhanced,and PFK-1 overexpression inhibited the neuronal differentiation of NSCs,which was consistent with the findings from NSCs subjected to 5 h of hypoxia.Meanwhile,the neurogenesis induced by PFK-1 knockdown was attributed to the increased proliferation of neural progenitors and the commitment of NSCs to the neuronal lineage.Similarly,in vivo knockdown of PFK-1 also increased neurogenesis in the dentate gyrus of the hippocampus.Finally,we demonstrated that the neurogenesis mediated by PFK-1 was likely achieved by targeting mammalian achaete-scute homologue-1(Mash 1),neuronal differentiation factor(NeuroD),and sex-determining region Y(SRY)-related HMG box 2(Sox2).All together,our results reveal PFK-1 as an important regulator of neurogenesis. | Fengyun Zhang Xiaodan Qian Cheng Qin Yuhui Lin Haiyin Wu Lei Chang Chunxia Luo Dongya Zhu | 2016 | Neuroscience Bulletin2016，32，3： | 4 |
| 6 | Diagnosis and treatment of diverticulum of the uterus in pregnancy through hysteroscopy and methotrexate: a case report显示文摘A 27-year-old patient was diagnosed by hysteroscopy with uterine diverticulum in pregnancy and admitted to the hospital. Under the guidance of hysteroscopy combined with methotrexate, the scraping of the uterus was done and operation successfully completed. The management of this case showed that hysteroscopy was a kind of valuable approach to the diagnosis and treatment of uterine diverticulum and curettage of the uterus under hysteroscope combined with drug was a safe, effective and conservative treatment. | Pan Qiong Xue Min Li Xiang Wan Yajun Cheng Chunxia | 2010 | Journal of Medical Colleges of PLA(China)2010，25，2： | 2 |
| 7 | Advances in Biodegradation of Aflatoxins显示文摘Aflatoxins are secondary metabolites of fungi such as Aspergillus flavus and Aspergillus parasiticus. They are one of the contaminants most common in food and feed, with high toxicity and carcinogenicity. Aflatoxins usually enter animal body together with feed and then enter human body by food chain, thereby seriously threatening human health. In recent years, the degradation of aflatoxins has become a hot research topic. This study overviewed the characteristics and detoxification ways of aflatoxins, specifically for the advances in biodegradation and degradation products of aflatoxins. | Yi WANG Chunxia ZHAO Yucai LYU Wei CHENG Peng GUO | 2016 | Agricultural Science & Technology2016，17，4： | 2 |
| 8 | Heat Shock Protein 96 Induces Maturation of Dendritic Cells显示文摘客观:热吃惊蛋白质(HSP ) 有混杂的能力到女伴和现在到抗原介绍的肿瘤抗原的一个宽广全部剧目房间 includingDCs。在这份报告,我们由 HSP 96 (gp96 ) 分析了不成熟的 DC 的调整。方法:鼠科的导出 bonemarrow 的 DC 被 GM-CSF 正 IL-4 导致,它模仿了 DC.Cocultured DC 和 gp96 肽建筑群(gp96PC ) 的 immunostimulatory 效果或使 H22 房间失去活性, MHCclass Ⅱ的表示, CD40, CD80 被流动 cytometry 确定。在文化上层清液的 IL-12 和 TNF- 的集中被 ELISA 决定。C_r 版本试金被用来测试特定的 cytotoxicT 房间。结果:我们的学习证明 gp96PC 导致的 DC 成熟的程度,在 costimulatory 和 MHC Ⅱ分子的表面密度被反映,在 vitro 与 IL-12 的分泌物并且与 T 激活房间的潜力被相关。结论:热吃惊 protein96 能从 H22 被孤立并且净化房间并且能导致树枝状的房间的成熟。Ourfindings 可能是到在人的肿瘤的治疗疫苗的 DC 的使用的关联。 | Chunxia Cao Wei Yang Yonglie Chu Qingguang Liu Liang Yu Cheng' en Pan | 2006 | Journal of Nanjing Medical University2006，20，1： | 2 |
| 9 | Urban Fresh Water Resources Consumption of China显示文摘From the point of view of urban consumption behavior, urban fresh water consumption could be classified as three types, namely, direct, indirect and induced water consumption. A calculation approach of urban fresh water consumption was presented based on the theory of urban basic material consumption and the input-output method, which was utilized to calculate urban fresh water consumption of China, and to analyze its structural change and causes. The results show that the total urban fresh water consumption increased 561.7×109m3, and the proportion to the total national fresh water resources increased by 20 percentage points from 1952 to 2005. The proportion of direct and induced water consumption had been continuously rising, and it increased by 15 and 35 percentage points separately from 1952 to 2005, while the proportion of indirect water consumption decreased by 50 percentage points. Urban indirect water consumption was mainly related to urban grain, beef and mutton consumption, and urban induced water consumption had a close relationship with the amount of carbon emission per capita. Finally, some countermeasures were put forward to realize sustainable utilization of urban fresh water resources in China. | ZHU Peng LU Chunxia ZHANG Lei CHENG Xiaoling | 2009 | Chinese Geographical Science2009，19，3： | 2 |
| 10 | Cross-Modal Complementary Network with Hierarchical Fusion for Multimodal Sentiment Classification显示文摘Multimodal Sentiment Classification(MSC)uses multimodal data,such as images and texts,to identify the users'sentiment polarities from the information posted by users on the Internet.MSC has attracted considerable attention because of its wide applications in social computing and opinion mining.However,improper correlation strategies can cause erroneous fusion as the texts and the images that are unrelated to each other may integrate.Moreover,simply concatenating them modal by modal,even with true correlation,cannot fully capture the features within and between modals.To solve these problems,this paper proposes a Cross-Modal Complementary Network(CMCN)with hierarchical fusion for MSC.The CMCN is designed as a hierarchical structure with three key modules,namely,the feature extraction module to extract features from texts and images,the feature attention module to learn both text and image attention features generated by an image-text correlation generator,and the cross-modal hierarchical fusion module to fuse features within and between modals.Such a CMCN provides a hierarchical fusion framework that can fully integrate different modal features and helps reduce the risk of integrating unrelated modal features.Extensive experimental results on three public datasets show that the proposed approach significantly outperforms the state-of-the-art methods. | Cheng Peng Chunxia Zhang Xiaojun Xue Jiameng Gao Hongjian Liang Zhengdong Niu | 2022 | Tsinghua Science and Technology2022，27，4： | 2 |
| 11 | Robust face recognition based on illumination invariant in nonsubsam- pled Contourlet transform domain显示文摘 | Cheng Yong Hou Yingkun Zhao Chunxia | 2010 | Neurocomputing2010，73，10： | 1 |
| 12 | Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery显示文摘 | Cuimiao Zhang Chunxia Li Shanshan Huang Zhiyao Hou Ziyong Cheng Piaoping Yang Chong Peng Jun Lin | 2010 | Biomaterials2010，，12： | 1 |
| 13 | Preparation of Rice Seedling-raising Substrate with Spent Mushroom Substrate of Pleurotus eryngii显示文摘This study aimed to explore the effect of fermented spent mushroom substrate(SMS) of Pleurotus eryngii as a basic material on rice seedling-raising substrate. The physical and chemical indices of the SMS indicated that the fermented SMS was fully composted and was very suitable for preparing rice seedling-raising substrate. The fermented SMS effectively regulated the bulk density, total porosity, aeration porosity and water-holding porosity of rice seedling-raising substrate. With the increased addition amount of fermented SMS, the bulk density of rice seedling-raising substrate was decreased, but the total porosity, aeration porosity and water-holding porosity were increased. Compared with those in the substrates of 100% soil and 100% SMS,the height, chlorophyll content, 100-shoot dry weight, 100-root dry weight, root activity, nitrogen content, phosphorus content and potassium content of rice seedlings in the substrate composed of spent mushroom substrate of P. eryngii and soil were higher.The quality of rice seedlings in the substrate composed of 20% soil and 80% SMS was best, followed by that in the substrate composed of 30% soil and 70% SMS. | Dan ZHENG Yi WANG Chunxia ZHAO Jinguo CHEN Wei CHENG Peng GUO Zongjun CUI | 2016 | Agricultural Science & Technology2016，17，2： | 1 |
| 14 | Magnetic Fe304@ mesoporous silica composites for drug delivery and bioadsorption显示文摘 | Huang Shanshan Li Chunxia Cheng Ziyong Fan Yong Yang Piaoping Zhang Cuimiao Yang Kuiyue Lin Jun | 2012 | Journal of Colloid and lnterface Science2012，376，： | 1 |
| 15 | aeterization and antioxidant activities of polymannuronic acid phosphate, H-phosphonate and sulfate 显示文摘 | Quancai L Chunxia L Cheng Y | 2013 | Int J Biol Mac- romol2013，62，： | 1 |
| 16 | Hysteroscopyfor the diagnosis and treatment of pathologic changes inthe uterine cavity in women with an intact hymen显示文摘 | Dabao Xu Min Xue Chunxia Cheng | 2006 | JMinimally Invasive Gynecology2006，13，3： | 1 |
| 17 | Tyrosinase as a multifunctional reporter gene for photoaeoustic/MRI/PET triple modality molecular imaging显示文摘 | Qin Chunxia Cheng Kai Chen Kai | 2013 | Sei Rep2013，3，： | 1 |
| 18 | A magnetic, luminescent and mesoporous core–shell structured composite material as drug carrier显示文摘 | Piaoping Yang Zewei Quan Zhiyao Hou Chunxia Li Xiaojiao Kang Ziyong Cheng Jun Lin | 2009 | Biomaterials2009，，27： | 1 |
| 19 | Preparation of quaternarized N-halamine-grafted graphene oxide nanocomposites and synergetic antibacterial properties显示文摘At present,frequent outbreaks of bacteria and viruses have seriously affected people's normal lives.Therefore,the study of broad-spectrum antibacterial nanocomposites is very promising.However,most antibacterial materials have some disadvantages,such as single bactericidal mechanisms and unrepeatable use.Based on the current situation,a kind of nanocomposite with three structures of graphene oxide(GO),quaternary ammonium salt(QAs)and N-halamine was prepared,which showed synergistic effect to improve antibacterial activity and combined with a variety of sterilization mechanisms.Meanwhile,GO can provide richer ways of sterilization and high specific surface area,which is conducive to the grafting of quaternarized N-halamine.The advantages of physical sterilization of GO,charge adsorption of QAs,reuse of N-halamine and efficient sterilization are fully utilized.The results showed that the quaternarized N-halamine-grafted GO was obtained successfully.GO grafted with quaternarized N-halamine polymer showed strong speedy bactericidal activity against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)(99%).It had good storage and regeneration properties. | Danlin Bu Yu Zhou Chang Yang Hengyu Feng Chunxia Cheng Mengjie Zhang Zice Xu Linghan Xiao Yujing Liu Zhenai Jin | 2021 | Chinese Chemical Letters2021，32，11： | 1 |
| 20 | Ro- bust face recognition based on illumination invariant in nonsubsam- pied Contourlet transform domain 显示文摘 | CHENG YONG HOU YINGKUN ZHAO CHUNXIA | 2010 | Neurocomputing2010，73，101112： | 1 |
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