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| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | Changes in circulating Foxp3^+ regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure显示文摘AIM:To longitudinally investigate cytokine gene expression and protein levels in Th17 and Treg cells,to observe T-cell phenotypes during hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACHBLF)and to analyze changes in Th17 and Treg phenotypes during disease progression.METHODS:We measured the expression of seven Th17/Treg differentiation-related genes and serum concentrations of the corresponding cytokines in 18ACHBLF,18 chronic hepatitis B(CHB)disease controls and 10 healthy controls(HCs)by real-time quantitative pCR and enzyme linked immunosorbent assay.peripheral Th17 and Treg cell frequencies were analyzed by flow cytometry.RESULTS:From the onset of ACHBLF,patients presented with a conductive Th17 differentiation cytokine environment accompanied by high Th17 frequency and high serum IL-17 levels,which were sustained throughout the disease course.The Treg-related cytokine IL-2and Foxp3 were also up-regulated from disease onset,and Foxp3 gene expression showed a gradually increasing trend during ACHBLF.The circular phenotype of Treg and Th17 cells showed changes from the onset of ACHGLF.At disease onset,Th17 frequency increased significantly compared with both CHB and HCs,but Treg cell frequency decreased significantly compared with CHB.During the ACHBLF event,Th17 frequency remained higher compared with HCs,but decreased sharply from the peak point to the recovery point;Treg cell frequency increased gradually during the ACHBLF event.Treg and Th17 cell counts correlated with ACHBLF development;in all patients,serum IL-17 levels significantly correlated with patient serum ALT levels.In survivors,Th17 frequency at the onset point and the Treg to Th17 ratio at the peak point correlated with the patient’s model for end stage liver disease(MELD)plus sodium(MELD-Na)score.The Treg to Th17 ratio and the Th17 frequency at onset were significant predictors of patient survival.Low Treg/Th17 cell ratios at the onset predicted poor survival.Survivors exhibited an initial decrease in the circulating Treg/Th17 ratio from the onset to the peak time,and subsequently displayed a continuous increase.CONCLUSION:Treg and Th17 cells showed changes in genes,protein levels and T cell phenotypes during ACHBLF events.An increased Treg/Th17 ratio was associated with the survival of ACHBLF patients. | Xue-Song Liang Cheng-Zhong Li Yin Zhou Wei Yin Ya Yun Liu Wen-Han Fan | 2014 | World Journal of Gastroenterology2014，20，26： | 44 |
| 3 | Role of Epstein-Barr Virus Encoded Latent Membrane Protein 1 in the Carcinogenesis of Nasopharyngeal Carcinoma显示文摘Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has been known to have oncogenic properties during latent infection in nasopharyngeal carcinoma (NPC). Our studies focused on the role of LMP1 in NPC, and showed that LMP1 triggers the NF-κB, AP-1 and STAT signaling pathways. Strikingly, LMP1 was found to mediate the formation of a new heterodimer between c-Jun and JunB. Also, we have identified JAK/STAT and PI-PLC-PKC activation triggered by LMP1 through upregulating the expression of JAK3 and enhancing the phosphorylation of STAT. The constitutive activation of these signaling cascades explains LMP1’s ability to induce such a diverse array of morphological and phenotypic effects in cells and provides insight into how LMP1 may induce cell transformation, in which multihit targeted genes in the downstream play an essential role. All signaling cascades triggered by LMP1 ultimately lead to the disruption of the cell cycle: the acceleration of G1/S phase and the arrest of G2/M phase. We also found that LMP1 induced the expression of hTERT and promoted cell immortalization. Importantly, by intervening physical intracellular signal transduction pathways and disturbing the progression of the cell cycle, LMP1, an important oncoprotein encoded by EBV, is thought to be a key modulator in the pathogenesis of NPC. Interfering LMP1 signaling could be a promising strategy to target the malignant phenotype of NPC. | Hui Zheng Lili Li Duosha Hu Xiyun Deng Ya Cao | 2007 | Cellular & Molecular Immunology2007，4，3： | 34 |
| 4 | Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-γ显示文摘蓼 multiflorum Thunb (下午) 的根在中国被使用了治疗许多疾病,例如便秘,头发和 hyperlipemia 的早 graying。最近的证据证明那位首相在人引起特质的导致药的肝损害(IDILI ) 。在这研究,我们基于 LPS 的非肝毒素的剂量在 IDILI 的一个老鼠模型调查了导致下午的肝损害的分子的基础。SD 老鼠口头上地被管理下午的 3 潜在地肝毒素的混合物:cis 芪配糖物(cis-SG, 50 mg/kg ) , trans-SG (50 mg/kg ) 或 emodin (5 mg/kg ) ,由 LPS 的注射列在后面(2.8 mg/kg, iv ) 。浆液和肝组织学被评估在 LPS 以后的 7 h 注射。在测试的 3 混合物之中, cis-SG,然而并非 emodin 或 trans-SG,当与 LPS 结合了时,在老鼠导致了严重的肝损害。在血浆的著名计算机生产厂商和在血浆和肝纸巾的煽动性的 cytokines 的层次显著地被提高。肝纸巾显示出增加的损害, hepatocyte apoptosis,和巨噬细胞渗入,并且减少房间增长。Microarray 分析揭示了在 peroxisome 之间的否定关联激活 proliferator 的受体 --(PPAR-) 并且 LPS/cis-SG-induced 肝损害。Immunohistochemical 染色和 RT-PCR 结果进一步证实 cis-SG 显著地在 LPS/cis-SG-treated 老鼠的肝纸巾禁止了 PPAR- 小径的激活。有 PPAR- 收缩筋 pioglitazone 的预告的处理(500 g/kg, ig ) 颠倒的 LPS/cis-SG-induced 肝损害,它与禁止原子因素 kappa B (NF-B ) 被联系小径。这些数据证明 cis 芪配糖物导致免疫学的通过在 IDILI 的一个老鼠模型压制 PPAR- 的特质的 hepatotoxicity。 | Ya-kun MENG Chun-yu LI Rui-yu LI Lan-zhi HE He-rong CUI Ping YIN Cong-en ZHANG Peng-yan LI Xiu-xiu SANG Ya WANG Ming NIU Ya-ming ZHANG Yu-ming GUO Rong SUN Jia-bo WANG Zhao-fang BAI Xiao-he XIAO | 2017 | Acta Pharmacologica Sinica2017，38，10： | 30 |
| 5 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 6 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 7 | Crustal P-wave velocity structure of the Longmenshan region and its tectonic implications for the 2008 Wenchuan earthquake显示文摘The P-wave velocity structure of the crust in the Longmenshan region has been imaged by seismic travel time tomography us ing local and regional first P-wave arrivals recorded from 2000 to 2008. The tomographic model provides a way to analyze the deep tectonics of the Longmenshan fault belt and the tectonic implications for the 2008 Ms8.0 Wenchuan earthquake. The P-wave velocity images indicate that the initial rupture site and focal depth of the Wenchuan earthquake, together with the di rection of rupture propagation, closely relate to the crustal structure of the Longmenshan region. The Pengguan massif to the west of the Longmenshan fault belt is characterized by high velocity anomalies, suggesting that the crust has a strong strain strength that can accumulate large stresses over a long period. The Ms8.0 Wenchuan earthquake is located at the southwestern end of the Pengguan massif and the western edge of the Sichuan Basin. The collision between the Pengguan massif and the Sichuan Basin becomes the primary reason for the occurrence of the Ms8.0 Wenchuan earthquake. To the north of Wenchuan, the occurrence and propagation of rupture benefit from low velocity anomalies along the Longmenshan fault belt; whereas to the south of Wenchuan, the brittle rupture can occur with more difficulty in relatively weak crust with low velocities. This may be one of the reasons for the absence of aftershocks to the south of Wenchuan, and the rupture induced by the Ms8.0 Wenchuan earthquake propagating from the north to the south along the Longmenshan fault belt. The deep geodynamics of the Ms8.0 Wenchuan earthquake may occur due to the discrepancy of crustal structures on the two sides of the Longmenshan fault belt. Ductile deformation and crustal flow can easily occur in the weak middle-lower crust beneath the Songpan-Garze orogenic belt. The eastward movement of the Tibetan Plateau is obstructed by the rigid lithosphere of the Sichuan Basin, and then the thick ening of the middle-lower crust and vertical deformation occur in the crust of the Longmenshan fault belt. In addition, the down-warping of the Moho and the basement thrusting onto the range front induced crustal deformation and strain accumula tion, which provided the potential energy to trigger the occurrence of the Ms8.0 Wenchuan earthquake. | LI ZhaWei XU Yi HUANG RunQiu HAO TianYao XU Ya LIU JingSong LIU JianHua | 2011 | Science China Earth Sciences2011，54，9： | 23 |
| 8 | Segmental transcatheter arterial embolization for primary hepatocellular carcinoma显示文摘INTRODUCTIONSegmentaltranscatheterarterialembolization(SLpTAE)hasbecomeoneofexcelentinterventionalmethodsforprimaryhepatocel... | LI Li, WU Pei Hong, LI Jin Qing, ZHANG Wei Zhang, LIN Hao Gao and ZHANG Ya Qi | 1998 | World Journal of Gastroenterology1998，4，6： | 22 |
| 9 | The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin显示文摘Emodin(1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field. | CUI Ya CHEN Liu-Jing HUANG Tu YING Jian-Qiong LI Juan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 23 |
| 10 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 11 | A hybrid dynamic programming-rule based algorithm for real-time energy optimization of plug-in hybrid electric bus显示文摘The optimization of the control strategy of a plug-in hybrid electric bus(PHEB) for the repeatedly driven bus route is a key technique to improve the fuel economy. The widely used rule-based(RB) control strategy is lacking in the global optimization property, while the global optimization algorithms have an unacceptable computation complexity for real-time application. Therefore, a novel hybrid dynamic programming-rule based(DPRB) algorithm is brought forward to solve the global energy optimization problem in a real-time controller of PHEB. Firstly, a control grid is built up for a given typical city bus route, according to the station locations and discrete levels of battery state of charge(SOC). Moreover, the decision variables for the energy optimization at each point of the control grid might be deduced from an off-line dynamic programming(DP) with the historical running information of the driving cycle. Meanwhile, the genetic algorithm(GA) is adopted to replace the quantization process of DP permissible control set to reduce the computation burden. Secondly, with the optimized decision variables as control parameters according to the position and battery SOC of a PHEB, a RB control is used as an implementable controller for the energy management. Simulation results demonstrate that the proposed DPRB might distribute electric energy more reasonably throughout the bus route, compared with the optimized RB. The proposed hybrid algorithm might give a practicable solution, which is a tradeoff between the applicability of RB and the global optimization property of DP. | ZHANG Ya Hui JIAO Xiao Hong LI Liang YANG Chao ZHANG Li Peng SONG Jian | 2014 | Science China(Technological Sciences)2014，57，12： | 20 |
| 12 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 13 | Echinococcus Granulosus 14-3-3 Protein:A Potential Vaccine Candidate Against Challenge with Echinococcus Granulosus in Mice显示文摘Objective To investigate the protective immunity against Echinococcus granulosus in mice immunized with rEg14-3-3.Methods ICR mice were subcutaneously immunized three times with rEg14-3-3,followed by the challenge with Echinococcus granulosus protoscoleces intraperitoneally and then sacrificed after six months of post-challenge to detect the proliferation of splenocytes by MTT assay,and to measure the secretion of IL-2,IL-4,IL-10,and IFN-γ by ELISA.The rate of reduced hydatid cyst and the levels of IgE,IgG and IgG subclasses in sera were examined.Results Mice vaccinated with rEg14-3-3 and challenged with protoscoleces revealed significant protective immunity of 84.47%.ELISA analysis indicated that the immunized mice generated specific high levels of IgG and the prevailing isotypes of IgG were IgG1 and IgG2a.Splenocytes from mice immunized with rEg14-3-3 showed a significant proliferation response.The secretion of IFN-γ and IL-2 increased significantly in the vaccinated mice whereas there was no significant difference in IL-4 and IL-10 levels between vaccinated and control mice.Conclusion The results indicate that the rEg14-3-3 vaccine could induce a high level of protective immunity as a promising vaccine candidate to prevent cystic echinococcosis. | LI Zong Ji WANG Ya Na WANG Qi ZHAO Wei | 2012 | Biomedical and Environmental Sciences2012，25，3： | 18 |
| 14 | Status and Trends in Research on Deep-Water Gravity Flow Deposits显示文摘Deep-water gravity flows are one of the most important sediment transport mechanisms on Earth. After 60 years of study,significant achievements have been made in terms of classification schemes,genetic mechanisms,and depositional models of deep-water gravity flows. The research history of deep-water gravity flows can be divided into five stages: incipience of turbidity current theory; formation of turbidity current theory; development of deep-water gravity flow theory; improvement and perfection of deep-water gravity flow theory; and comprehensive development of deep-water gravity flow theory. Currently,three primary classification schemes based on the sediment support mechanism,the rheology and transportation process,and the integration of sediment support mechanisms,rheology,sedimentary characteristics,and flow state are commonly used.Different types of deep-water gravity flow events form different types of gravity flow deposits. Sediment slump retransportation mainly forms muddy debris flows,sandy debris flows,and surge-like turbidity currents. Resuspension of deposits by storms leads to quasi-steady hyperpycnal turbidity currents(hyperpycnal flows). Sustainable sediment supplies mainly generate muddy debris flows,sandy debris flows,and hyperpycnal flows. Deep-water fans,which are commonly controlled by debris flows and hyperpycnal flows,are triggered by sustainable sediment supply; in contrast,deep-water slope sedimentary deposits consist mainly of debris flows that are triggered by the retransportation of sediment slumps and deep-water fine-grained sedimentary deposits are derived primarily from finegrained hyperpycnal flows that are triggered by the resuspension of storm deposits. Harmonization of classification schemes,transformation between different types of gravity flow deposit,and monitoring and reproduction of the sedimentary processes of deep-water gravity flows as well as a source-to-sink approach to document the evolution and deposition of deep-water gravity flows are the most important research aspects for future studies of deep-water gravity flows study in the future. | YANG Tian CAO Yingchang WANG Yanzhong LI Ya ZHANG Shao Min | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 18 |
| 15 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 16 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 17 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 18 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 19 | Uppermost mantle structure of the North China Craton: Constraints from interstation Pn travel time difference tomography显示文摘The uppermost mantle is the key area for exchange of heat flux and material convection between the crust and lithospheric mantle. Spatial variations of lithospheric thinning and dynamic processes in the North China Craton could inevitably induce the velocity heterogeneity in the uppermost mantle.In this study,we used Pn arrivals from permanent seismic stations in North China and surrounding regions to construct a tomographic image of the North China Craton.The tomographic method with Pn travel time difference data were used to study the velocity variations in the uppermost mantle.Pn velocities in the uppermost mantle varied significantly in the Eastern,Central and Western blocks of the North China Craton.This suggests that the lithosphere beneath different blocks of the North China Craton have experienced distinct tectonic evolutions and dynamic processes since the Paleo- zoic.The current uppermost mantle has been imprinted by these tectonic and dynamic processes.Fast Pn velocities are prominent beneath the Bohai Bay Basin in the Eastern Block of the North China Craton,suggesting residuals of the Archean lithospheric mantle.Beneath the Tanlu Fault Zone and Bohai Sea,slow Pn velocities are present in the uppermost mantle,which can be attributed to significant lithospheric thinning and asthenospheric upwelling.The newly formed lithospheric mantle beneath Yanshan Mountain may be the dominant reason for the existence of slow Pn velocities in this region.Conversely,the ancient lower crust and lithospheric mantle already have been delaminated.In the Central Block,significant slow Pn velocities are present in Taihangshan Mountain,which also extends northward to the Yinchuan-Hetao Rift on the northern margin of the Ordos Block and Yinshan Orogen.This characteristic probably is a result of hot asthenospheric upwelling along the active tectonic boundary on the margin of the Western Block.The protracted thermal erosion and underplating of hot asthenospheric upwelling may induce lithospheric thinning and significant slow velocities in the uppermost mantle.Fast velocities beneath the Western Block suggest that the thick,cold and refractory Archean lithospheric keel of craton still is retained without apparent destruction. | LI ZhiWei HAO TianYao XU Ya | 2011 | Chinese Science Bulletin2011，56，16： | 16 |
| 20 | Seasonal variations in leaf capturing of particulate matter, surface wettability and micromorphology in urban tree species显示文摘在叶微粒物质(下午) 的季节的变化在城市的树种类的累积,表面 wettability 和 micromorphology,包括 Sophora 装饰用的梨树(S。装饰用的梨树) , Platanus acerifolia (P。acerifolia ) 并且 Cedrus deodara (C。deodara ) ,在一个单个成长季节期间被学习。三种在下午累积显示出不同季节的趋势,从春天增加到秋天(或冬季) 甚至在雨季期间,但是以不同的率。在学习期间, P 的叶下午保留数量。acerifolia,有隆起的叶的种出现,比 S 的显著地高。装饰用的梨树和 C。deodara,有蜡制的叶表面的种类。除了在 S 的离开轴心的表面上,在叶子的水微滴的接触角度与叶年龄减少了。装饰用的梨树,它仍然保持在整个成长季节非可湿或高度非可湿;在 S 的近轴的表面上的接触角度的减少。装饰用的梨树更大什么时候与 P 相比。acerifolia 和 C。deodara。一种重要、否定的关系在所有三种的叶子的近轴的表面上在叶下午保留数量和接触角度之间存在。wettability 的增加,当 epicuticular 蜡被机械、化学的磨损破坏时,可能引起了,似乎是在叶下午累积导致季节的变化的主要因素。 | Huixia WANG Hui SHI Yangyang LI Ya YU Jun ZHANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，4： | 15 |
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