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| 1 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 2 | Socio-economic and Environmental Implications of the Hydroelectric Projects in Uttarakhand Himalaya, India显示文摘This paper deals with detailed analysis of the fiasco created by the Tehri High Dam in Uttarakhand, India, particularly in terms of resettlement and rehabilitation of the local inhabitants. Aspects pertaining to the environmental issues are also discussed. Currently, the river valleys in Uttarakhand state of India are the targets of increasing hydroelectric projects. Virtually all rivers are being exploited for generating environmental friendly power. Having being learned the hard lesson from Tehri Dam, it has been decided to opt for such schemes in which comparatively little submergence and tempering with the fragile eco-systems is involved.However, our observations suggest that even in such schemes if due care is not taken they may turn out to be a failure. | Naresh Rana S. P. Sati Y.P. Sundriyal Madan Mohan Doval Navin Juyal | 2007 | Journal of Mountain Science2007，4，4： | 3 |
| 3 | The Surgical Correction of Pierre Robin Sequence: Mandibular Distraction Osteogenesis versus Tongue-Lip Adhesion显示文摘 | Roberto L. Flores Sunil S. Tholpady Shawkat Sati Grant Fairbanks Juan Socas Matthew Choi Robert J. Havlik | 2014 | Plastic and Reconstructive Surgery2014，，6： | 2 |
| 4 | Influence of graphene nanoplatelet incorporation and dispersion state on thermal, mechanical and electrical properties of biodegradable matrices显示文摘Graphene nanoplatelets(GNPs) were used as multifunctional nanofiller to enhance thermal and mechanical properties as well as electrical conductivity of two different biodegradable thermoplastics: poly lactide(PLA) and poly(butylene adipate-co-terephthalate)(PBAT). Morphological investigations showed different levels of GNP dispersion in the two matrices, and consequently physical properties of the two systems exhibited dissimilar behaviours with GNP incorporation. Crystallinity of PLA, determined from differential scanning calorimetry, was observed to increase markedly with addition of GNPs in contrast to the decrease in crystallinity of PBAT. Isothermal and non-isothermal thermogravimetric analyses also revealed a more significant delay in thermal decomposition of PLA upon addition of GNPs compared to that of PBAT. Furthermore, results showed that increasing GNP content of PLA and PBAT nanocomposites influenced their Young's modulus and electrical conductivity in different ways. Modulus of PBAT increased continuously with increasing GNP loading while that of PLA reached a maximum at 9 wt%GNPs and then decreased. Moreover, despite the higher conductivity of pure PBAT compared to pure PLA, conductivity of PLA/GNP nanocomposites overtook that of PBAT/GNP nanocomposites above a certain GNP concentration. This demonstrated the determining effect of nanoplatelets dispersion state on the matrices properties. | Sima Kashi Rahul K.Gupta Nhol Kao S.Ali Hadigheh Sati N.Bhattacharya | 2018 | Journal of Materials Science & Technology2018，34，6： | 2 |
| 5 | Computer assisted knee surgery:diagnostics and planning of knee surgery显示文摘 | Sati M De Guise JA Drounin G | 1997 | Comput Aided Surg1997，2，2： | 1 |
| 6 | Epitopes of the CD4 antigen and HIV infection 显示文摘 | SATI'ENTAU Q J DALGLE1SH A G WEISS R A | 1986 | Science1986，234，4780： | 1 |
| 7 | Deterministic resampling: unbi- ased sampling to avoid sample impoverishment in particle filters显示文摘 | LI T SATI'AR T SUN S | 2012 | Signal Processing2012，92，7： | 1 |
| 8 | Thermal Protective Performance of Protective Clothing Used for Low Radiant Heat Protection显示文摘 | SONG G PASKALUK S SATI R | 2011 | Textile Re search Journal2011，81，3： | 1 |
| 9 | Market Structure and Audit Fees: A Local Analysis*显示文摘 | SATI P.BANDYOPADHYAY JENNIFER L.KAO | 2010 | Contemporary Accounting Research2010，，3： | 1 |
| 10 | Systems of Agriculture Farming in the Uttranchal Himalaya, India显示文摘Agricultural practices are the main stay of the people of Uttranchal. Out of the total population, more than 75% people are engaged either with the main occupation of agriculture or its allied practices, dominated by traditional subsistence cereal farming. Among them, the main crops are rice, wheat, millet, barley, all types of pulses, all types of oilseeds and almost all types of fruits. The crops, vegetables and fruits of all varieties are grown in the different climatic zones such as tropical, temperate, and cold because, the region is characterized by the different altitudinal zones elevated from 200 m to more than 8000m. As a result, different climates are found from hot tropical to sub temperate and chilly cold. Pulses varieties are grown extensively. Among vegetables, potato, onion, carrot, all types of green leaf vegetables, brinzal, pumpkin, ladyfinger, pea, gram, radish, ginger, garlic, etc, are grown widely. All fruit varieties are grown in the different altitudinal zones. The main fruits are orange, malta (a big size of orange), elephant citrus, lemon and all other types of citrus, apple, stone fruits including peach and pears, many kinds of nuts, and the fruits which are grown in the low lying areas. In spite of feasible climatic conditions, agricultural dominant society, and availability of all types of crops, the production and productivity of these crops are very low, even they are unable to meet the grain-need of the people in Uttaranchal. Agricultural crops are grown almost in all the altitudinal zones — from the low-lying areas, which are called ‘Gangarh’, to the highly elevated region, where the legendary term is given as ‘Danda’. The growing seasons vary according to the heights. The present paper aims to discuss the agricultural practices including cropping season, cropping pattern, land use, production of crops and ecological aspect of agricultural system in this Himalayan state and suggest some measures for developing farming system, which could lead the sustainability, in terms of meeting the food grain needs of the people on the one hand and restoring the ecological balance on the other. | Vishwambhar Prasad Sati | 2005 | Journal of Mountain Science2005，2，1： | 1 |
| 11 | Magnetic anisotropy of Co^2+ as signature of intrinsic ferromagnetism in ZnOCo显示文摘 | Sati P Hayn R Kuzian R | 2006 | Phys Rev Letts2006，96，01： | 1 |
| 12 | Structure of Bcl-XL-Bak peptide complex: recogni- tion between regulators of apoptosis 显示文摘 | SATI~ER M LIANG H NETTESHEIM D | 1997 | Science1997，275，5302： | 1 |
| 13 | The presence of kinesin super- family motor proteins KIFC1 and KIF17 in normal and pathological human placenta显示文摘 | Sati L Seval-Celik Y Unek G | 2009 | Placerta2009，30，84： | 1 |
| 14 | Diversity of aquatic hypho- mycetes as root endophytes on pteridophytic plants in Kumaun Himalaya显示文摘 | Sati S C Pargaein N Belwal M | 2009 | J Am Sci2009，5，4： | 1 |
| 15 | MAGE-A4, a germ cell specific marker,is expressed differentially in testicular tumors显示文摘 | Aubry F Satie AP Rioux Leclercq N | 2001 | Cancer2001，92，11： | 1 |
| 16 | Impact of retrograde cerebral perfusion on ascending aortic and arch aneurysm repair显示文摘 | Sati H J Letsou GV Iliopoulos DC | 1997 | Ann Thorac Surg1997，63，6： | 1 |
| 17 | 显示文摘 | Ruxandra F rosu Robert A S Sati N B | 1999 | Polymer1999，40，： | 1 |
| 18 | Modeling,Simulation and Analysis of Aircraft Arresting System Using Bond GraphApproach显示文摘 | Sati S C Kanaskar A S Kajale S R | 2011 | Simulation Modelling Practice and Theory2011，19，3： | 1 |
| 19 | Selectivity of hyaluronic acid binding for spermatozoa with normal Tygerberg strict morphology显示文摘 | Prinosilova P Kruger T Sati L | | 0，，2： | 1 |
| 20 | Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci显示文摘 | Sati S Ghosh S Jain V | 2012 | Nucleic Acids Res2012，40，10： | 1 |
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