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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Prevalence of infec-tion following hepatic chemoembolization with cross-linked colla-gen with administration of prophylactic antibiotics显示文摘 | Reed RA Teitelbaum GP Daniels JR | 1994 | J Vasc In-terv Radiol1994，5，2： | 1 |
| 4 | Coronary artery caliber in normal children and patients with kawasaki disease but without aneurysms:an echocardiographic and angiographic study显示文摘 | Arjunan K Daniels SR Mayer RA | 1986 | J AM Coll Cardiol1986，8，： | 1 |
| 5 | Incidence and mortality of acute renal failure in Medicare beneficiaries,1992 to 2001显示文摘 | Xue JL Daniels F Star RA | 2006 | J Am Soc Nephrol2006，17，4： | 1 |
| 6 | Variability in rates of arthrodesis procedures for patients with cervical spine injuries with and without associated spinal cord injury 显示文摘 | Daniels AH Arthur M Hart RA | 2007 | J Bone Joint Surg Am2007，89，2： | 1 |
| 7 | Incidence and m- ortality of acute renal failure in Medicare beneficiaries, 1992 to 2001 显示文摘 | Xue JL Daniels F Star RA | 2006 | J Am Soc Nephrol2006，17，4： | 1 |
| 8 | Incidence and mortality of acute renal failure in Medicare beneficiaryes,1992 to 2001显示文摘 | Xue JL Daniels F Star RA | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 9 | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk显示文摘 | Michella Ghassibe-Sabbagh Daniel E. Platt Sonia Youhanna Antoine B. Abchee Krista Stewart Danielle A. Badro Marc Haber Angelique K. Salloum Bouchra Douaihy Hamid el Bayeh Raed Othman Nabil Shasha Samer Kibbani Elie Chammas Aline Milane Rita Nemr Yoichiro | 2012 | Atherosclerosis2012，，1： | 1 |
| 10 | Cystic panereatie neoplasms: observe or operate显示文摘 | Spinelli KS Fromwiller TE Daniel RA | 2004 | Ann Surg2004，239，5： | 1 |
| 11 | Cystic pancreatic neoplasms : observe or operate 显示文摘 | Spinelli KS Fromwiller TE Daniel RA | 2004 | Ann Surg2004，239，5： | 1 |
| 12 | Effect of Oxalipl- atin, fluorouracil, and leucovorin with or without cetux- imab on survival among patients with resected stage 1I co- lon cancer: a randomized trial显示文摘 | Steven RA Daniel JS Suresh N | 2012 | JAMA2012，307，13： | 1 |
| 13 | Diversity, Endemism and Conservation of Ferns(Polypodiales) in the Mexican Mountain Component显示文摘We analyzed the distributional patterns of95 selected species of leptosporangiate ferns inhabiting the Mexican Mountain Component, using grid-cells of one geographical degree as unit areas,applying endemism indices and richness and beta diversity analyses.Distributional data were obtained from several herbaria and specialized literature.Five grid-cells appear to be important for fern species richness, as they contain 35 to 49 species.These gridcells are located in the Sierra Madre Oriental(SMO),Trans-Mexican Volcanic Belt(TMVB) and the Sierra Madre del Sur(SMS).Mean richness by latitudinal belts of one degree showed that the belts with highest values are related to the TMVB and SMS.A total of 13grid-cells were recognized as important from theperspective of endemism; most of them are located also in the SMO, TMVB and SMS.The richest gridcells coincided with one of the main centres of endemism for ferns obtained in this study, located in the convergence of the southern part of the SMO, the eastern portion of the TMVB and the northern part of the SMS, reflecting the high humidity existing on the mountain slopes facing the Gulf of Mexico.Some important grid-cells recognized from richness and endemism analyses coincide with Mexican Natural Protected Areas.The beta diversity analysis showed a low degree of similarity among grid-cells, implying a high species replacement, as the result of environmental heterogeneity occurring in the Mexican mountain systems.On the other hand, the spatial analysis suggested a pattern of phytogeographical regionalization comprising twomain areas: the Mexican Transition Zone and the Mexican Central Plateau.Ferns play an important role in the Mexican biodiversity and contributing to the beta diversity of Mexico. | SANGINéS-FRANCO Celia LUNA-VEGA Isolda CONTRERAS-MEDINA Raúl ESPINOSA David TEJERO-DíEZ José Daniel RIVAS Gerardo | 2015 | Journal of Mountain Science2015，12，4： | 1 |
| 14 | Dystroglycan is essential for early embryonic development:disruption of Reichert'S membrane in Dagl-null mice显示文摘 | Wiiliamson RA Henry MD Daniels KJ | 1997 | Hum Mol Genet1997，6，6： | 1 |
| 15 | Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract显示文摘 | Daniele Campa Mia Hashibe David Zaridze Neonila Szeszenia-Dabrowska Ioan Nicolae Mates Vladimir Janout Ivana Holcatova Eleonóra Fabiánová Valérie Gaborieau Rayjean J. Hung Paolo Boffetta Paul Brennan Federico Canzian | 2007 | Cancer Causes & Control2007，，4： | 1 |
| 16 | Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue显示文摘 | Daniels JT Geerling G Alexander RA | | 0，，： | 1 |
| 17 | Temporal and spatial expression of matrix metalloproteinases during wound healing of human corneal tissue显示文摘 | Daniels JT Geerling G Alexander RA | 2003 | Exp Eye Res2003，77，： | 1 |
| 18 | Validation of the national early warning score in the prehospital setting显示文摘 | Daniel J Alasdair RA Paul A | 2015 | Resuscita2015，89，1： | 1 |
| 19 | Cystic pancreatic neoplasms : observe or operate 显示文摘 | Spinelli KS Fromwiller TE Daniel RA | 2004 | Ann Surg2004，239，5： | 1 |
| 20 | A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release显示文摘 | Daniel S Noda M Cerione RA | 2002 | Biochemistry2002，41，30： | 1 |
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