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| 1 | New insights in bilirubin metabolism and their clinical implications显示文摘Bilirubin,a major end product of heme breakdown,is an important constituent of bile,responsible for its characteristic colour.Over recent decades,our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates,mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of hepatocytes.Several inherited disorders characterised by impaired bilirubin conjugation(Crigler-Najjar syndrome typeⅠand typeⅡ,Gilbert syndrome)or transport(Dubin-Johnson and Rotor syndrome)result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated type.Moreover,disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver disorders.In this review,we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor syndrome.The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood,from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.OATP1B proteins are also responsible for liver clearance of bilirubin conjugated in splanchnic organs,such as the intestine and kidney,and for a number of endogenous compounds,xenobiotics and drugs.Absence of one or both OATP1B proteins thus may have serious impact on toxicity of commonly used drugs cleared by this system such as statins,sartans,methotrexate or rifampicin.The liverblood cycling of conjugated bilirubin is impaired in cholestatic and parenchymal liver diseases and this impairment most likely contributes to jaundice accompanying these disorders. | Eva Sticova Milan Jirsa | 2013 | World Journal of Gastroenterology2013，19，38： | 24 |
| 2 | 酶联免疫吸附分析法测定土壤试样中的阿特拉津显示文摘报道一种高灵敏度、高重现性的酶联免疫吸附分析法(ELLSA)对土壤试样中阿特拉津(Atrazine)的测定.测定的线性范围为 0.05~5.0μg/L,由14条标准曲线求得的最低检出限在0.018~0.24μg/L之间,线性相关系数r=0.9922.加标土样分别用含水甲醇和含水乙腈提取的效率都接近100%,提取液用重蒸水1:200稀释后可消除基质效应和溶剂效应的影响,加标平均回收率为99.6%. | 邓安平 杨红 Franek Milan | 1999 | 分析化学1999，27，6： | 19 |
| 3 | Etiology and functional status of liver cirrhosis by ^(31)P MR spectroscopy显示文摘AIM: To assess the functional status and etiology of liver cirrhosis by quantitative 31p magnetic resonance spectroscopy (MRS).METHODS: A total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a 1H/31P surface coil by the 2D chemical shift imaging technique.Absolute concentrations of phosphomonoesters (PME),phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.RESULTS: MRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic,viral and cholestatic etiologies based on MR spectra.Alcoholic and viral etiology differed in PDE (alcoholic,viral, controls: 6.5±2.3, 6.5±3.1, 10.8±2.7 mmol/L,P<0.001) and ATP (alcoholic, viral, controls: 2.9±0.8, 2.8±0.9, 3.7±1.0 mmol/L, P<0.01) from the control group.Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2±0.4, 1.6±0.6mmol/L, P<0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4±2.7, 6.5±2.3, 6.5±3.1 mmol/L, P<0.005) in PDE.CONCLUSION: 31p MRS can significantly help in noninvasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury. | Monika Dezortova Pavel Taimr Antonin Skoch Julius Spicak Milan Hajek | 2005 | World Journal of Gastroenterology2005，11，44： | 17 |
| 4 | Primary colorectal lymphoma:An overview显示文摘Lymphomas represent common hematological malignancies with increasing incidence in recent years.The major site of extranodal non-Hodgkin lymphoma is the gastrointestinal tract.Involvement of the large intestine is rare in comparison to the stomach or small bowel.The disease appears later in life,predominantly in the male population.Complaints are nonspecific,requiring a high index of suspicion in order to establish the diagnosis.The treatment varies from chemotherapy alone to multimodal therapies combining surgery,chemotherapy and radiotherapy.The small number of patients with various histological subtypes and different stage at presentation results in unclear protocol for the treatment of primary colorectal lymphoma.The purpose of this paper is to review current data on primary lymphoma of the colon and rectum while analyzing reported case series and published material on the subject. | Goran Z Stanojevic Milica D Nestorovic Branko R Brankovic Miroslav P Stojanovic Milan M Jovanovic Milan D Radojkovic | 2011 | World Journal of Gastrointestinal Oncology2011，3，1： | 15 |
| 5 | Mucinous cystadenoma of the appendix associated with adenocarcinoma of the sigmoid colon and hepatocellular carcinoma of the liver:Report of a case显示文摘附录的粘蛋白的包囊腺瘤是一个稀罕条件并且与附录的普通名字粘液囊肿代表三个实体之一。它被腔的膀胱的膨胀在它内与粘液的壅滞描绘。组织病理学说地,粘液囊肿被划分成三个组:焦点或弥漫的粘膜增生,粘蛋白的包囊腺瘤和粘蛋白的包囊腺癌。这个条件经常与另外的瘤形成被联系,特别冒号和卵巢的腺癌。我们这里描述与腹的不快,便秘,在凳子的新鲜的血和经常的泌尿介绍了的 57 岁男性病人。他有与结肠的腺癌和肝的肝细胞癌联系的附录的一个大包囊腺瘤。病人经历了正确 haemicolectomy, S 字形的冒号切除术和肝的部分切除术。现在, 3 年以后,他没有疾病恶化的证据。根据这,我们在这些病人强调精确外科手术前的诊断的需要和整个腹部的 intraoperative 探索。 | Srdjan P Djuranovic Milan M Spuran Nada V Kovacevic Milenko B Uqliesic Dragutin M Kecmanovic Marian T Micev | 2006 | World Journal of Gastroenterology2006，12，12： | 12 |
| 6 | Comparison of two nutritional assessment methods in gastroenterology patients显示文摘AIM:To investigate and compare efficacy and differences in the nutritional status evaluation of gastroenterology patients by application of two methods:subjective global assessment(SGA) and nutritional risk index(NRI).METHODS:The investigation was performed on 299 hospitalized patients,aged 18-84 years(average life span 55.57 ± 12.84),with different gastrointe-stinal pathology,admitted to the Department of Gastroenterohepatology,Clinical and Hospital Center 'Bezanijska Kosa' during a period of 180 d.All the patients,after being informed in detail about the study and signing a written consent,underwent nutritional status analysis,which included two different nutritional indices:SGA and NRI,anthropometric parameters,bioelectrical impedance analysis,and biochemical markers,within 24 h of admission.RESULTS:In our sample of 299 hospitalized patients,global malnutrition prevalence upon admission varied from 45.7% as assessed by the SGA to 63.9% by NRI.Two applied methods required different parameters for an adequate approach:glucose level(5.68 ± 1.06 mmol/L vs 4.83 ± 1.14 mmol/L,F = 10.63,P = 0.001);body mass index(26.03 ± 4.53 kg/m2 vs 18.17 ± 1.52 kg/m2,F = 58.36,P < 0.001);total body water(42.62 ± 7.98 kg vs 36.22 ± 9.32 kg,F = 7.95,P = 0.005);basal metabolic rate(1625.14 ± 304.91 kcal vs 1344.62 ± 219.08 kcal,F = 9.06,P = 0.003) were very important for SGA,and lymphocyte count was relevant for NRI:25.56% ± 8.94% vs 21.77% ± 10.08%,F = 11.55,P = 0.001.The number of malnourished patients rose with the length of hospital stay according to both nutritional indices.The discriminative function analysis(DFA) delineated the following parameters as important for prediction of nutritional status according to SGA assessment:concentration of albumins,level of proteins,SGA score and body weight.The DFA extracted MAMC,glucose level and NRI scores were variables of importance for the prediction of whether admitted patients would be classif ied as well or malnourished.CONCLUSION:SGA showed higher sensitivity to predictor factors.Assessment of nutritional status requires a multidimensional approach,which includes different clinical indices and various nutritional param eters. | Branka F Filipovi Milan Gaji Nikola Milini Branislav Milovanovi Branislav R Filipovi Mirjana Cvetkovi Nela ibali | 2010 | World Journal of Gastroenterology2010，16，16： | 9 |
| 7 | Malignant schwannoma of the pancreas involving transversal colon treated with en-bloc resection显示文摘Pancreatic schwannoma is a very uncommon tumor of the pancreas,with only 27 cases reported.Most pancreatic schwannomas are benign,with only four malignant tumors reported.We describe a case of giant malignant schwannoma of the pancreatic body and tail,which involved the transverse colon.The tumor was treated successfully with en bloc distal splenopancreatectomy and colon resection.This is believed to be the first reported radical operation for malignant schwannoma of the pancreatic body,with infiltration of the transverse colon,with excellent longterm results.The patient is alive and well 28 mo after the operation.The authors conclude that pancreatic schwannomas should be considered in the differential diagnosis of cystic neoplasms of the pancreas,although the diagnosis can only be confirmed by microscopic examination.In the case of the benign tumors,local excision is adequate,but in the case of malignant schwannoma,oncological standards must be fulfilled. | Miroslav P Stojanovic Milan Radojkovic Ljiljana M Jeremic Aleksandar V Zlatic Goran Z Stanojevic Milan A Jovanovic Milos S Kostov Vuka P Katic | 2010 | World Journal of Gastroenterology2010，16，1： | 8 |
| 8 | 云母的命名显示文摘定义云母为层状硅酸盐。其结构单元由两个相向排列的四面体片(Ts)和夹于其间的一个八面体片(Os)组成。这些片构成一个单元层,层与层之间被非水化层间阳离子(I)分开,其顺序是:非水化阳离子层、四面体片、八面体片、四面体片、非水化阳离子层、四面体片、八面... | Milan Rieder,Giancarlo Cavazzini,Yurii S.D’yakonov, Viktor A.Frank Kamenetskii,Glauco Gottardi,Stephen Guggenheim,Pavel V.Koval′, Georg Muller,Ana M.R.Neiva,Edward W.Radoslovich,Jean Louis Robert, Francesco P.Sassi,Hiroshi Takeda,Zdenek Weiss,Davi | 1999 | 矿物岩石地球化学通报1999，18，3： | 8 |
| 9 | Technological advances in radiotherapy for esophageal cancer显示文摘Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning target volume (intensity-modulated radiotherapy and proton therapy).Reduction of radiotherapy-related toxicity is fundamental to the improvement of clinical results in esophageal cancer,although the dose escalation concept is controversial. | Milan Vosmik Jiri Petera Igor Sirak Miroslav Hodek Petr Paluska Jiri Dolezal Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，44： | 8 |
| 10 | Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis显示文摘中脑 dopaminergic (mDA ) 的损失神经原位于 Parkinson 的疾病的马达症状下面。向房间代替,研究集中了于位于胚胎的 mDA 生产下面的机制,作为导出 mDA 神经原 fromstem 房间的一个合理基础。我们将考察 -catenin, 的研究对 mDA specificationand 神经发生批评的 Wnt 串联的一个 obligate 部件。mDA 神经原有一个唯一的 originthe 中脑地板盘子(FP ) 。不同于脑的最后部和针的绳索 FP,中脑 FP 是高度神经原的, Wnt/-catenin 发信号对在神经原的潜力的这差别批评。In-catenin loss-of-function 实验,中脑 FP 类似于脑的最后部 FP,和象 Otx2, Lmx1a, Msx1,和 Ngn2 那样的关键 mDA 祖先基因而嘘被维持,是 downregulated。因此,中脑 FP 的神经原的能力被减少,导致更少 mDA 神经原。在 -catenin gain-of-function 实验,相反地,脑的最后部 FP 表示关键 mDA 祖先基因,并且是高度 neurogenic.Interestingly,当过多的 -catenin 被供应到中脑 FP 时,更少的 mDA 神经原被生产建议 Wnt/-catenin 发信号的 thedosage 是批评的。-catenin 的这些研究便于新协议导出 mDA neuronsfrom 干细胞。 | Milan Joksimovic Rajeshwar Awatramani | 2014 | Journal of Molecular Cell Biology2014，8，1： | 7 |
| 11 | Joint Motion Control of a Powered Lower Limb Orthosis for Rehabilitation显示文摘许多病人与针伤害被限制到轮椅,在 carer 上与第二等的病理和增加的依赖导致一种坐着的生活方式。增加的证据证明了运动训练减少这些第二等的病理的发生,但是物理努力在这涉及训练是以便有差的依从。这篇论文在一个新鈥渉u 人的设计和控制上报导友好鈥 ? orthosis (皮骨骼) ,以高力量灵魂肌肉致动器(pMAs ) 为动力。一个高度顺从的使活动系统的联合与臀部,膝,和脚关节放感觉的聪明的嵌入的控制机制,速度,加速和力量,生产强大还为半身不遂者病人的内在地安全的操作。这份报纸在零装载下面分析脚关节,膝,和新潮的关节的运动,并且装载哪个模仿人的手足质量,证明鈥渟o 英尺鈥 ? 致动器的使用能提供一个光滑的用户友好运动。这种技术的申请将极大地为半身不遂者病人改进使复权协议。关键词皮骨骼 - 集中人的机器人学 - 人的适应 Mechatronics - 灵魂肌肉致动器(pMAs )- 康复尼尔森肋前缘在计算机并且在 1999 的在机器的系统和自动化的在 1995 的电子设计和他的 M.Sc 收到了他的 B.Sc 度,在 Coimbra 的大学,葡萄牙。他当前在 Salford 的大学在先进机器人学正在追求博士,更大的英国曼彻斯特。他的研究兴趣包括传感器,致动器,电源来源,力量扩大皮骨骼,康复机器人学和触觉的反馈系统。米兰 Bezdicek 在 2003 在捷克的共和国从 Brno 工业大学在 Mechatronics 收到了他的 M.Sc。他当前在 Salford 的大学是机器人学和 haptics 的博士学生,英国。他的研究兴趣包括 biomechanics,电子学,计算机控制了分析的用机器制造的、人工的神经网络, haptics, DSP,聪明的传感器和结构。约翰· O ·格雷在控制工程从大学曼彻斯特获得了他的博士和 D.Sc 学位,他的早工作在非线性的控制系统, C.A.D 过程和精确的方面上集中了电磁的乐器学。在 1988,与学术、工业的同事一起,他建立了英国国家先进机器人学研究中心。在 1990 年代,他最近在先进机器人学和更多上组织了一系列 EC.sponsored 会议(2001 鈥 ? 005 ) 先进机器人学上的主持 EPSRC 和 IEE 网络。Darwin G. 考德威尔分别地在 1986 和 1990 从赫尔的大学在机器人学收到了他的 B.Sc 和博士。在 1994 在里面在管理收到了 M.Sc。自从 1999,他在 Salford 的大学是在机器人学和自动化的中心的先进机器人学的主席。他是超过 150 篇学术论文的作者或合作者并且有 4 项专利。他的研究兴趣包括为食物工业的创新致动器和传感器,触觉的反馈,力量扩大皮骨骼,灵巧的操纵者,类人动物机器人学, biomimetic 系统,康复机器人学和机器的系统。考德威尔教授当前是 IEEE (机器人学和自动化社会) 的 UKRI 区域的主席。史蒂芬·胡钦斯与 HPC 在 1978 作为 orthotist 毕业了是在在 Salford 和登记 orthotist 的大学的 Orthotics 的高级讲师。他为在预防的膝 bracing 要过去常的原型 orthotic 膝关节的设计在 1997 由研究在 Orthotics 获得了 M.Sc。他当前在断断续续的跛的处理在摇椅脚底开发的题目上正在追求博士。他在 orthotic 膝关节设计上有很多项英国专利。他的研究兴趣包括更低的手足 orthotics 和鞋类设计的所有方面。 | Nelson Costa Milan Bezdicek Michael Brown John O.Gray Darwin G.Caldwell Stephen Hutchins | 2006 | International Journal of Automation and computing2006，3，3： | 7 |
| 12 | Free radicals and antioxidants in normal physiological functions and human disease显示文摘 | Marian Valko Dieter Leibfritz Jan Moncol Mark T.D. Cronin Milan Mazur Joshua Telser | 2006 | International Journal of Biochemistry and Cell Biology2006，，1： | 6 |
| 13 | 盐酸溶液中双氧水浸出黄铜矿(英文)显示文摘本文旨在研究以双氧水为强氧化剂的黄铜矿精矿的盐酸浸出过程。研究搅拌速度、固液比、温度、HCl和H_2O_2浓度等浸出参数对金属浸出率的影响。室温下,用3.0 mol/L H_2O_2和0.5 mol/L HCl溶液与黄铜矿反应180 min后,获得33%的最大铜浸出率。结果表明,在反应的前60 min,铜的浸出率增大;此后,由于双氧水的快速催化分解,铜浸出率基本上保持不变。此外,固液比对铜的浸出率影响显著,而且在最稀的悬浮液中(即固液比1:100)铜的浸出率最高。溶出过程可用一级动力学方程描述,表观活化能为19.6 kJ/mol,表明溶出过程受扩散控制,对于HCl和H_2O_2的反应级数分别为0.30和0.53。浸出渣的XRD和SEM/EDS分析结果表明,矿物表面生成单质硫,抑制浸出率的提高。 | Sanja J.PETROVIC Grozdanka D.BOGDANOVIC Milan M.ANTONIJEVIC | 2018 | Transactions of Nonferrous Metals Society of China2018，28，7： | 6 |
| 14 | Impact of stress on solute transport in a fracture network: A comparison study显示文摘This paper compares numerical modeling of the effect of stress on solute transport (advection and matrix diffusion) in fractured rocks in which fracture apertures are correlated with fracture lengths. It is mainly motivated by the performance and safety assessments of underground radioactive waste repositories. Five research teams used different approaches to model stress/deformation, flow and transport processes, based on either discrete fracture network or equivalent continuum models. The simulation results derived by various teams generally demonstrated that rock stresses could significantly influence solute transport processes through stress-induced changes in fracture apertures and associated changes in permeability. Reasonably good agreement was achieved regarding advection and matrix diffusion given the same fracture network, while some observed discrepancies could be explained by different mechanical or transport modeling approaches. | Zhihong Zhao Jonny Rutqvist Colin Leung Milan Hokr Quansheng Liu Ivars Neretnieks Andrew Hoch Jirí Havlíek Yuan Wang Zhen Wang Yuexiu Wu Robert Zimmerman | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，2： | 6 |
| 15 | Free radicals and antioxidants in normal physiological functions and human disease显示文摘 | Marian Valko Dieter Leibfritz Jan Moncol Mark T.D. Cronin Milan Mazur Joshua Telser | 2006 | International Journal of Biochemistry and Cell Biology2006，，1： | 5 |
| 16 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 17 | Does Cold Plasma Affect Breaking Dormancy and Seed Germination? A Study on Seeds of Lamb's Quarters(Chenopodium album agg.)显示文摘Low-pressure discharge is applied for stimulation of germination of two seed lots of Lamb's Quarters(Chenopodium album agg.) with different starting germinations(17%,8%) and in different stages of dormancy.Different exposition durations with cold plasma treatment were applied.The variable of the ratio cumulative germination was calculated.The Richards' equation was used for curve-fitting and simulation of the growth curves.Population parameters,namely Vi-viability,Me-time,Qu-dispersion,and Sk-skewness,counted from the curves described the germination rate well.Significant differences among Qu confirmed the erratic dormancy and gradual germination of Lamb's Quarters.No difference in the Me parameter was found between two tested seed lots,and no interspecies characteristics were changed using low-pressure discharge. The results suggested that plasma treatment changed seed germination in Lamb's Quarters seeds. | Bozena ERA Michal ERY Vitězslav TRANAK Petr PATENKA Milan TICHY | 2009 | Plasma Science and Technology2009，11，6： | 5 |
| 18 | Mastitis Pathogens Isolated from Samples of Milk in Dairy Cows and Their Resistance against Antimicrobial Agents显示文摘The objective of this study was to evaluate the effectiveness of different antibiotics against mastitis causing microorganisms during first phase of lactation in herd of 320 Holstein cows in east of Slovakia. Milk samples from quarters were cultured and identified bacteria were subjected to antimicrobial susceptibility test by disc diffusion method to a large number of antibiotics. The results revealed higher sensitivity against tetradelta (100% of Strep. Agalactiae and Strep. uberis, Coagulase Negative Staphylococci), (94.4% of Stap. aureus) with highest number of bacterial isolates, followed by cefalexin + kanamycin amoxicillin plus clavulanat acid and ceftiotur (100% of Strep. agalactiae and Strep. uberis). Resistance was observed against penicillin (22.2% of Stap. aureus) amoxicillin (22.2% of Stap. aureus and 10.5% of Strep. uberis) and streptomycin (22.2% of Stap. aureus and 52.7% of Strep. uberis). | Frantiek Zigo Milan Vasil Juraj Elecko Martina Zigová Zuzana Farkasova | 2017 | Journal of Food Science and Engineering2017，7，2： | 4 |
| 19 | Organosolv Lignin for Non-Isocyanate Based Polyurethanes (NIPU) as Wood Adhesive显示文摘A non-isocyanate-based polyurethane(NIPU)wood adhesive was produced from organosolv lignin,which is a bio-sourced raw material,available in large quantities and produced as a by-product of the paper industry.The formulation of this new lignin-based NIPU adhesive,which is presented,was chemically characterised by Matrix-Assisted Laser Desorption Ionization Time of Flight(MALDI ToF)mass spectrometry and by Fourier Transform Infra-Red(FTIR)spectrometry analyses.The oligomers formed were determined and showed that the three species involved in the NIPU adhesive preparation were formed by the co-reaction of the three reagents used:lignin,dimethyl carbonate,and hexamethylene diamine.Linear and branched structures were both identi-fied.Mechanical properties of the adhesive were determined using the Automated Bonding Evaluation System(ABES)and internal bond(IB)strength test of the laboratory particleboard bonded with it.The adhesive has shown satisfactory mechanical properties after hot pressing at 230℃.Such a temperature is used industrially in the most modern particleboard factories,but since it is hardly feasible for more conventional wood bonding equipment,the reactivity of the NIPU adhesive was successfully increased with the addition of a small percentage of a silane coupling agent.With the addition of the silane,the proposed NIPU adhesive could also be used at a hot-pressing temperature lower than 200℃. | Jaša Saražin Antonio Pizzi Siham Amirou Detlef Schmiedl MilanŠernek | 2021 | Journal of Renewable Materials2021，9，5： | 4 |
| 20 | Human Anti–Tumor Necrosis Factor Monoclonal Antibody (Adalimumab) in Crohn’s Disease: the CLASSIC-I Trial显示文摘 | Stephen B. Hanauer William J. Sandborn Paul Rutgeerts Richard N. Fedorak Milan Lukas Donald MacIntosh Remo Panaccione Douglas Wolf Paul Pollack | 2006 | Gastroenterology2006，，2： | 4 |
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