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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | 赞比亚伊索卡东部片麻岩锆石U-Pb年代学、地球化学特征及岩石成因显示文摘赞比亚伊索卡东部位于伊鲁米德带上,伊鲁米德带是一个北东走向的褶皱俯冲带,位于赞比亚中东部,南部以新元古代赞比西带为界,北东至赞比亚-坦桑尼亚-马拉维边境,并以北西向古元古代乌本迪带为界。锆石U-Pb测年结果表明,黑云母二长片麻岩、二云母石榴斜长片麻岩、含石榴黑云母钾长片麻岩和含石榴黑云母斜长片麻岩的岩浆侵位年龄为1949±18 Ma~2025±15 Ma,形成于古元古代。岩石地球化学分析结果表明,伊索卡东部片麻岩岩浆为过铝质高钾钙碱性—钾玄系列;稀土配分模式明显呈右倾型,富含轻稀土,贫重稀土,铕和铈表现为极微弱的负异常;微量元素原始地幔标准化蛛网图显示,富集Rb、K、La、Pb、Nd、Sm等元素,亏损Ba、Nb、Ta、Ce、Sr、P、Ti等元素。根据伊鲁米德带的构造演化阶段,可以判断伊索卡东部片麻岩形成于乌萨加兰期。 | 左立波 任军平 邱亮 王杰 古阿雷 孙宏伟 许康康 Alphet Phaskani DOKOWE Abraham MUKANGWA Daniel MALUNGA Chisamba MWANSA Peter CHIPUMBU | 2021 | 地质学报2021，95，4： | 3 |
| 3 | Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis显示文摘 | Liping Su Le Shen Daniel R. Clayburgh Sam C. Nalle Erika A. Sullivan Jon B. Meddings Clara Abraham Jerrold R. Turner | 2009 | Gastroenterology2009，，2： | 2 |
| 4 | Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure显示文摘 | Daniel E. Forman Javed Butler Yongfei Wang William T. Abraham Christopher M. O’Connor Stephen S. Gottlieb Evan Loh Barry M. Massie Michael W. Rich Lynne Warner Stevenson James B. Young Harlan M. Krumholz | 2004 | Journal of the American College of Cardiology2004，，1： | 2 |
| 5 | 赞比亚伊索卡南部Kachinga长石砂岩碎屑锆石U-Pb年龄、地球化学特征及地质意义显示文摘赞比亚东北部伊鲁米德带是一个北东向延伸的中元古代构造活动带,起自赞比亚中部,向北东一直延伸至赞比亚-坦桑尼亚边境,并进入马拉维北部;其东北部以古元古代乌本迪构造带为界;西北部以班韦乌卢地块为界;西部和西南部受新元古代的达马拉-卢菲利安弧-赞比西构造事件的影响。Kachinga长石砂岩位于伊鲁米德带的东北部伊索卡南部。本文获得Kachinga长石砂岩的416颗碎屑锆石U-Pb年龄多集中在1749±25~1920±23Ma之间,Kachinga长石砂岩的形成时代可能晚于1331±26Ma,属于中元古代。Kachinga长石砂岩碎屑锆石CL图像表明,大部分锆石为岩浆结晶锆石,少部分锆石颗粒为增生-混合型锆石,表明其经历了多期构造-热事件的改造。锆石中存在有一部分磨圆度较好的颗粒,表明其经历了多次搬运和沉积过程,从而指示了古老沉积岩为Kachinga长石砂岩提供了物源。主量元素、微量元素和稀土元素构造环境判别及物源分析表明了Kachinga长石砂岩物源主要为上地壳大陆长英质源区,并且可能混有古老沉积物成分,物源区构造背景为大陆岛弧环境。 | 杜明龙 纪山青 任军平 王杰 刘子江 邢仕 刘川 韦文国 DANIEL Malunga PETER Chipumbu ABRAHAM Mukangwa CHISAMBA Mwansa | 2021 | 地质学报2021，95，4： | 2 |
| 6 | Patients direct costs to undergo TB diagnosis显示文摘Background:A major impediment to the treatment of TB is a diagnostic process that requires multiple visits.Descriptions of patient costs associated with diagnosis use different protocols and are not comparable.Methods:We aimed to describe the direct costs incurred by adults attending TB diagnostic centres in four countries and factors associated with expenditure for diagnosis.Surveys of 2225 adults attending smear-microscopy centres in Nigeria,Nepal,Ethiopia and Yemen.Adults>18 years with cough>2 weeks were enrolled prospectively.Direct costs were quantified using structured questionnaires.Patients with costs>75^(th) quartile were considered to have high expenditure(cases)and compared with patients with costs<75^(th) quartile to identify factors associated with high expenditure.Results:The most significant expenses were due to clinic fees and transport.Most participants attended the centres with companions.High expenditure was associated with attending with company,residing in rural areas/other towns and illiteracy.Conclusions:The costs incurred by patients are substantial and share common patterns across countries.Removing user fees,transparent charging policies and reimbursing clinic expenses would reduce the poverty-inducing effects of direct diagnostic costs.In locations with limited resources,support could be prioritised for those most at risk of high expenditure;those who are illiterate,attend the service with company and rural residents. | Rachel M.Anderson de Cuevas Lovett Lawson Najla Al-Sonboli Nasher Al-Aghbari Isabel Arbide Jeevan B.Sherchand Emenyonu E.Nnamdi Abraham Aseffa Mohammed A.Yassin Saddiq T.Abdurrahman Joshua Obasanya Oladimeji Olanrewaju Daniel Datiko Sally J.Theobald Andrew Ramsay S.Bertel Squire Luis E.Cuevas | 2016 | Infectious Diseases of Poverty2016，5，1： | 1 |
| 7 | Bubbles and crashes: Gradient dynamics in financial markets显示文摘 | Daniel Friedman Ralph Abraham | 2008 | Journal of Economic Dynamics and Control2008，，4： | 1 |
| 8 | Arrhythmogenic Right Ventricular Dysplasia: A United States Experience显示文摘 | Darshan Dalal Khurram Nasir Chandra Bomma Kalpana Prakasa Harikrishna Tandri Jonathan Piccini Ariel Roguin Crystal Tichnell Cynthia James Stuart D. Russell Daniel P. Judge Theodore Abraham Philip J. Spevak David A. Bluemke Hugh Calkins | 2005 | Circulation2005，，25： | 1 |
| 9 | Sleep Apnea and Cardiovascular Disease显示文摘 | Virend K. Somers David P. White Raouf Amin William T. Abraham Fernando Costa Antonio Culebras Stephen Daniels John S. Floras Carl E. Hunt Lyle J. Olson Thomas G. Pickering Richard Russell Mary Woo Terry Young | 2008 | Journal of the American College of Cardiology2008，，8： | 1 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy显示文摘 | Daniel J. Klionsky Fabio C. Abdalla Hagai Abeliovich Robert T. Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A. Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizu | 2012 | Autophagy2012，，4： | 1 |
| 11 | Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma显示文摘 | Natalie M. Johnson Guoqing Qian Li Xu Danielle Tietze Alicia Marroquin-Cardona Abraham Robinson Melanie Rodriguez Linda Kaufman Kyle Cunningham James Wittmer Fernando Guerra Kirby C. Donnelly Jonathan H. Williams Jia-Sheng Wang Timothy D. Phillips | 2010 | Science of the Total Environment2010，，23： | 1 |
| 12 | Advances in autism genetics : on the threshold of a new neurobiology 显示文摘 | Brett S Abrahams Daniel H | 2008 | Nat Revi2008，9，： | 1 |
| 13 | Subdermabrasion in the Treatment of Post-Burn Facial Hypertrophic Scars显示文摘 | Ram Silfen Abraham Amir Meora Feinmesser Daniel J. Hauben | 2002 | Aesthetic Plastic Surgery2002，，2： | 1 |
| 14 | Hydrogen-enhanced localization of plasticity in an austenitic stainless steel显示文摘 | Daniel P. Abraham Carl J. Altstetter | 1995 | Metallurgical and Materials Transactions A1995，，11： | 1 |
| 15 | Risk Stratification in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy–Associated Desmosomal Mutation Carriers显示文摘 | Aditya Bhonsale Cynthia A. James Crystal Tichnell Brittney Murray Srinivasa Madhavan Binu Philips Stuart D. Russell Theodore Abraham Harikrishna Tandri Daniel P. Judge Hugh Calkins | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，3： | 1 |
| 16 | Solid-State water-catalyzed transformation at room temperature of a nonluminescent linear-chain uranyl phenylphosphonate into a luminescent one 显示文摘 | DANIEL GROHOL ABRAHAM CLEARFIELD | 1997 | J Am Chem Soc1997，119，20： | 1 |
| 17 | Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure显示文摘 | Daniel E. Forman Javed Butler Yongfei Wang William T. Abraham Christopher M. O’Connor Stephen S. Gottlieb Evan Loh Barry M. Massie Michael W. Rich Lynne Warner Stevenson James B. Young Harlan M. Krumholz | 2004 | Journal of the American College of Cardiology2004，，1： | 1 |
| 18 | Outcomes of Catheter Ablation of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy显示文摘 | Binu Philips Srinivasa Madhavan Cynthia James Crystal Tichnell Brittney Murray Darshan Dalal Aditya Bhonsale Saman Nazarian Daniel P. Judge Stuart D. Russell Theodore Abraham Hugh Calkins Harikrishna Tandri | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，3： | 1 |
| 19 | EARLY RENAL ISCHEMIA, WITH OR WITHOUT REPERFUSION, ACTIVATES NFκB AND INCREASES TNF-α BIOACTIVITY IN THE KIDNEY显示文摘 | KIRSTAN K. DONNAHOO DANIEL R. MELDRUM ROBERT SHENKAR CHUN-SHIANG CHUNG EDWARD ABRAHAM ALDEN H. HARKEN | 2000 | The Journal of Urology2000，，4： | 1 |
| 20 | Covert infrared image encoding through imprinted plasmonic cavities显示文摘Functional surfaces that can control light across the electromagnetic spectrum are highly desirable.Plasmonic nanostructures can assume this role by exhibiting dimension-tunable resonances that span multiple electromagnetic regimes.However,changing these structural parameters often impacts the higher-order resonances and spectral features in lower-wavelength domains.In this study,we discuss a cavity-coupled plasmonic system with resonances that are tunable across the 3–5 or 8–14μm infrared bands while retaining near-invariant spectral properties in the visible domain.This result is accomplished by regime-dependent resonance mechanisms and their dependence on independent structural parameters.Through the identification and constraint of key parameters,we demonstrate multispectral data encoding,where images,viewable in the infrared spectral domain,appear as uniform areas of color in the visible domain—effectively hiding the information.Fabricated by large area nanoimprint lithography and compatible with flexible surfaces,the proposed system can produce multifunctional coatings for thermal management,camouflage,and anti-counterfeiting. | Daniel Franklin Sushrut Modak Abraham Vázquez-Guardado Alireza Safaei Debashis Chanda | 2018 | Light(Science & Applications)2018，7，1： | 1 |
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