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| 1 | Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion显示文摘Osteocytes are mechanosensitive bone cells, but little is known about their effects on tumor cells in response to mechanical stimulation. We treated breast cancer cells with osteocyte-derived conditioned medium(CM) and fluid flow-treated conditioned medium(FFCM) with 0.25 Pa and 1 Pa shear stress. Notably, CM and FFCM at 0.25 Pa induced the mesenchymal-to-epithelial transition(MET), but FFCM at 1 Pa induced the epithelial-to-mesenchymal transition(EMT). This suggested that the effects of fluid flow on conditioned media depend on flow intensity. Fluorescence resonance energy transfer(FRET)-based evaluation of Src activity and vinculin molecular force showed that osteopontin was involved in EMT and MET switching. A mouse model of tumorinduced osteolysis was tested using dynamic tibia loadings of 1, 2, and 5 N. The low 1 N loading suppressed tumor-induced osteolysis, but this beneficial effect was lost and reversed with loads at 2 and 5 N, respectively. Changing the loading intensities in vivo also led to changes in serum TGFβ levels and the composition of tumor-associated volatile organic compounds in the urine.Collectively, this study demonstrated the critical role of intensity-dependent mechanotransduction and osteopontin in tumorosteocyte communication, indicating that a biophysical factor can tangibly alter the behaviors of tumor cells in the bone microenvironment. | Yao Fan Aydin Jalali Andy Chen Xinyu Zhao Shengzhi Liu Meghana Teli Yunxia Guo Fangjia Li Junrui Li Amanda Siegel Lianxiang Yang Jing Liu Sungsoo Na Mangilal Agarwal Alexander G.Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2020 | Bone Research2020，8，2： | 4 |
| 2 | Analytical and experimental studies on the gust response of a 52m tall steel lattice tower under wind loading显示文摘 | Harikrishna P Shanmugasundaram J Gomathinayagam S | 1999 | Computers and Structures1999，70，： | 1 |
| 3 | Modeling and control of saltwater intrusion in a coastal aquifer of Andhra Pradesh, India显示文摘 | Bithin Datta Harikrishna Vennalakanti Anirban Dhar | 2009 | Journal of Hydro-environment Research2009，，3： | 1 |
| 4 | Magnetic Resonance hnaging Finding in Patients meeting Task Force Criteria for Arrthythmogenic Right Ventricular Dysplasia 显示文摘 | Harikrishna T Hugh C Khurram N | 2003 | J Cardiovascu- lar E leetrophysiology2003，，： | 1 |
| 5 | Arrhythmogenic Right Ventricular Dysplasia: A United States Experience显示文摘 | Darshan Dalal Khurram Nasir Chandra Bomma Kalpana Prakasa Harikrishna Tandri Jonathan Piccini Ariel Roguin Crystal Tichnell Cynthia James Stuart D. Russell Daniel P. Judge Theodore Abraham Philip J. Spevak David A. Bluemke Hugh Calkins | 2005 | Circulation2005，，25： | 1 |
| 6 | Electrocardiographic Features of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy According to Disease Severity: A Need to Broaden Diagnostic Criteria显示文摘 | Khurram Nasir Chandra Bomma Harikrishna Tandri Ariel Roguin Darshan Dalal Kalpana Prakasa Crystal Tichnell Cynthia James Phillip Jspevak Frank Marcus Hugh Calkins | 2004 | Circulation2004，，12： | 1 |
| 7 | A review of stimuli-responsive nanocarriers for drug and gene delivery显示文摘 | Srinivas G Harikrishna D Mansoor A | 2008 | J Controlled Release2008，126，3： | 1 |
| 8 | Exercise Increases Age-Related Penetrance and Arrhythmic Risk in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Associated Desmosomal Mutation Carriers显示文摘 | Cynthia A. James Aditya Bhonsale Crystal Tichnell Brittney Murray Stuart D. Russell Harikrishna Tandri Ryan J. Tedford Daniel P. Judge Hugh Calkins | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 9 | Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone显示文摘Osteocytes are the most abundant cells in bone,which is a frequent site of breast cancer metastasis.Here,we focused on Wnt signaling and evaluated tumor-osteocyte interactions.In animal experiments,mammary tumor cells were inoculated into the mammary fat pad and tibia.The role of Lrp5-mediated Wnt signaling was examined by overexpressing and silencing Lrp5 in osteocytes and establishing a conditional knockout mouse model.The results revealed that administration of osteocytes or their conditioned medium(CM)inhibited tumor progression and osteolysis.Osteocytes overexpressing Lrp5 or β-catenin displayed strikingly elevated tumor-suppressive activity,accompanied by downregulation of tumor-promoting chemokines and upregulation of apoptosis-inducing and tumor-suppressing proteins such as p53.The antitumor effect was also observed with osteocyte-derived CM that was pretreated with a Wnt-activating compound.Notably,silencing Lrp5 in tumors inhibited tumor progression,while silencing Lrp5 in osteocytes in conditional knockout mice promoted tumor progression.Osteocytes exhibited elevated Lrp5 expression in response to tumor cells,implying that osteocytes protect bone through canonical Wnt signaling.Thus,our results suggest that the Lrp5/β-catenin axis activates tumor-promoting signaling in tumor cells but tumor-suppressive signaling in osteocytes.We envision that osteocytes with Wnt activation potentially offer a novel cell-based therapy for breast cancer and osteolytic bone metastasis. | Shengzhi Liu Di Wu Xun Sun Yao Fan Rongrong Zha Aydin Jalali Yan Feng Kexin Li Tomohiko Sano Nicole Vike Fangjia Li Joseph Rispoli Akihiro Sudo Jing Liu Alexander Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota | 2021 | Bone Research2021，9，4： | 1 |
| 10 | Analytical and experimental studies on the gust response of a 52m tall steel lattice tower under wind loading 显示文摘 | Harikrishna P Shanmugasundaram J Gomathinayagam S | 1999 | Computers and Structures1999，70，： | 1 |
| 11 | Malignant Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy with a Normal 12-Lead Electrocardiogram: A Rare but Under Recognized Clinical Entity显示文摘 | Anneline S.J.M. te Riele Cynthia A. James Aditya Bhonsale Judith A. Groeneweg Christian F. Camm Brittney Murray Crystal Tichnell Jeroen F. van der Heijden Dennis Dooijes Daniel P. Judge Richard N.W. Hauer Harikrishna Tandri Hugh Calkins | 2013 | Heart Rhythm2013，，： | 1 |
| 12 | Risk Stratification in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy–Associated Desmosomal Mutation Carriers显示文摘 | Aditya Bhonsale Cynthia A. James Crystal Tichnell Brittney Murray Srinivasa Madhavan Binu Philips Stuart D. Russell Theodore Abraham Harikrishna Tandri Daniel P. Judge Hugh Calkins | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，3： | 1 |
| 13 | Immune peptides modeling of Culex pipiens sp by in silico methods 显示文摘 | Harikrishna N Rao MS Murty US | 2012 | Journal of vector borne diseases2012，，1： | 1 |
| 14 | Incremental Value of Cardiac Magnetic Resonance Imaging in Arrhythmic Risk Stratification of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Associated Desmosomal Mutation Carriers显示文摘 | Anneline S.J.M. te Riele Aditya Bhonsale Cynthia A. James Neda Rastegar Brittney Murray Jeremy R. Burt Crystal Tichnell Srinivasa Madhavan Daniel P. Judge David A. Bluemke Stefan L. Zimmerman Ihab R. Kamel Hugh Calkins Harikrishna Tandri | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 15 | Analytical and experimental studies on the gust response of a 52 m tall steel lattice tower under wind loading显示文摘 | Harikrishna P Shanmugasundaram J Comathinayagam S etc | 1999 | Computers and Structures1999，，70： | 1 |
| 16 | Outcomes of Catheter Ablation of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy显示文摘 | Binu Philips Srinivasa Madhavan Cynthia James Crystal Tichnell Brittney Murray Darshan Dalal Aditya Bhonsale Saman Nazarian Daniel P. Judge Stuart D. Russell Theodore Abraham Hugh Calkins Harikrishna Tandri | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，3： | 1 |
| 17 | Right ventricular volume analysis by angiography in right ventricular cardiomyopathy显示文摘 | Julia Indik William Dallas Kathleen Gear Harikrishna Tandri David Bluemke Talal Moukabary Frank Marcus | 2012 | The International Journal of Cardiovascular Imaging2012，，5： | 1 |
| 18 | Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model显示文摘 | Harikrishna Devalapally Dinesh Shenoy Steven Little Robert Langer Mansoor Amiji | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 19 | Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysp-Lasia/cardiomyopathy显示文摘 | Darshan D Rahul J Harikrishna T | 2007 | J Am Coll Cardiol2007，50，： | 1 |
| 20 | Analysis of heavy metals in water, sediments and fish samples of Madivala Lakes of Bangalore, Karnataka 显示文摘 | Abida B Harikrishna S Irfanulla K | 2009 | International Journal of Chemistry Technology Research2009，1，2： | 1 |
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