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| 1 | miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer显示文摘AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of patients.METHODS We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC.We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility.We also investigated the expression levels of the selected miRNA not only in tissue but also in plasma samples.Moreover,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant potential.RESULTS Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric mucosa.Conversely,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC patients.In contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC patients.CONCLUSION miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC. | Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 6 |
| 2 | Matrix metalloproteinase-2 as a superior biomarker for peritoneal deterioration in peritoneal dialysis显示文摘AIM: To investigate the efficacy of effluent biomarkers for peritoneal deterioration with functional decline in peritoneal dialysis(PD). METHODS: From January 2005 to March 2013, the subjects included 218 PD patients with end-stage renal disease at 18 centers. Matrix metalloproteinase-2(MMP-2), interleukin-6(IL-6), hyaluronan, and cancer antigen 125(CA125) in peritoneal effluent were quantified with enzyme-linked immunosorbent assay. Peritoneal solute transport rate was assessed by peritoneal equilibration test(PET) to estimate peritoneal deterioration. RESULTS: The ratio of the effluent level of creatinine(Cr) obtained 4 h after injection(D) to that of plasma was correlated with the effluent levels of MMP-2(ρ = 0.74, P < 0.001), IL-6(ρ = 0.46, P < 0.001), and hyaluronan(ρ = 0.27, P < 0.001), but not CA125(ρ = 0.13, P = 0.051). The area under receiver operating characteristic curve for the effluent levels of MMP-2, IL-6, and hyaluronan against high PET category were 0.90, 0.78, 0.62, and 0.51, respectively. No patient developed new-onset encapsulating peritoneal sclerosis for at least 1.5 years after peritoneal effluent sampling.CONCLUSION: The effluent MMP-2 level most closely reflected peritoneal solute transport rate. MMP-2 can be a reliable indicator of peritoneal deterioration with functional decline. | Ichiro Hirahara Eiji Kusano Yoshiyuki Morishita Makoto Inoue Tetsu Akimoto Osamu Saito Shigeaki Muto Daisuke Nagata | 2016 | World Journal of Nephrology2016，5，2： | 4 |
| 3 | Directly modulated quantum dot lasers on silicon with a milliampere threshold and high temperature stability显示文摘Microring lasers feature ultralow thresholds and inherent wavelength-division multiplexing functionalities, offering an attractive approach to miniaturizing photonics in a compact area. Here, we present static and dynamic properties of microring quantum dot lasers grown directly on exact(001) GaP/Si. Effectively, a single-mode operation was observed at 1.3 μm with modes at spectrally distant locations. High temperature stability with T_0~103 K has been achieved with a low threshold of 3 mA for microrings with an outer ring radius of 15 μm and a ring waveguide width of 4 μm. Small signal modulation responses were measured for the first time for the microrings directly grown on silicon, and a 3 dB bandwidth of 6.5 GHz was achieved for a larger ring with an outer ring radius of 50 μm and a ring waveguide width of 4 μm. The directly modulated microring laser,monolithically integrated on a silicon substrate, can incur minimal real estate cost while offering full photonic functionality. | YATING WAN DAISUKE INOUE DAEHWAN JUNG JUSTIN C.NORMAN CHEN SHANG ARTHUR C.GOSSARD JOHN E.BOWERS | 2018 | Photonics Research2018，6，8： | 4 |
| 4 | Endoscopic ultrasound-guided biliary drainage for right hepatic bile duct obstruction: novel technical tips显示文摘 | Takeshi Ogura Tatsushi Sano Saori Onda Akira Imoto Daisuke Masuda Kazuhiro Yamamoto Masayuki Kitano Toshihisa Takeuchi Takuya Inoue Kazuhide Higuchi | 2014 | Endoscopy2014，，： | 3 |
| 5 | Accelerated degradation of a variety of aromatic compounds by Spirodela polyrrhiza-bacterial associations and contribution of root exudates released from S. polyrrhiza显示文摘Removal experiments of phenol,aniline,2,4-dichlorophenol,nonylphenol and bisphenol A(BPA) using Spirodela polyrrhizabacterial associations revealed that all compounds but BPA underwent accelerated removal.The mechanisms differed depending on the substrates.It was found that S.polyrrhiza has a great ability to release phenolic compound-rich root exudates,and the exudates seem to stimulate bacterial degradation of a variety of aromatic compounds. | Hai Hoang Ning Yu Tadashi Toyama Daisuke Inoue Kazunari Sei Michihiko Ike | 2010 | Journal of Environmental Sciences2010，22，4： | 3 |
| 6 | Screening of agonistic activities against four nuclear receptors in wastewater treatment plants in Japan using a yeast two-hybrid assay显示文摘To assess the potential endocrine disruptive effects through multiple nuclear receptors(NRs),especially non-steroidal NRs,in municipal wastewater,we examined the agonistic activities on four NRs(estrogen receptor α,thyroid hormone receptor α,retinoic acid receptor α and retinoid X receptor α) of untreated and treated wastewater from municipal wastewater treatment plants(WWTPs) in Japan using a yeast two-hybrid assay.Investigation of the influent and effluent of seven WWTPs revealed that agonistic activities against steroidal and non-steroidal NRs were always detected in the influents and partially remained in the effuents.Further investigation of four WWTPs employing conventional activated sludge,pseudo-anoxic-oxic,anoxic-oxic and anaerobic-anoxic-oxic processes revealed that the ability to reduce the agonistic activity against each of the four NRs varies depending on the treatment process.These results indicated that municipal wastewater in Japan commonly contains endocrine disrupting chemicals that exert agonistic activities on steroidal and non-steroidal NRs,and that some of these chemicals are released into the natural aquatic environment.Although the results obtained in yeast assays suggested that measured levels of non-steroidal NR agonists in the effluent of WWTPs were not likely to cause any biological effect,further study is required to assess their possible risks in detail. | Daisuke Inoue Koki Nakama Kazuko Sawada Taro Watanabe Hisae Matsui Kazunari Sei Tsuyoshi Nakanishi Michihiko Ike | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 7 | EUS-guided hepaticojejunostomy combined with antegrade stent placement显示文摘 | Takeshi Ogura Shoko Edogawa Akira Imoto Daisuke Masuda Kazuhiro Yamamoto Toshihisa Takeuchi Takuya Inoue Kazuhisa Uchiyama Kazuhide Higuchi | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 8 | Evaluation of combustion properties of wood pellets using a cone calorimeter显示文摘 | Daisuke Kamikawa Katsushi Kuroda Mariko Inoue Satoshi Kubo Takahiro Yoshida | 2009 | Journal of Wood Science2009，，6： | 1 |
| 9 | Novel synthetic collagen fibers,poly(PHG),stimulateplatelet aggregation through glycoprotein VI显示文摘 | Inoue Osamu Suzuki-Inoue Katsue Shinoda Daisuke etal | 2009 | FEBSLetters2009，583，1： | 1 |
| 10 | Overexpression of the miR-34 family suppresses invasive growth of malignantmelanoma with the wild-type p53 gene显示文摘 | Hitoshi Yamazaki Tsuyoshi Chijiwa Yoshimasa Inoue Yoshiyuki Abe Hiroshi Suemizu Kenji Kawai Masatoshi Wakui Daisuke Furukawa Masaya Mukai Sadahito Kuwao Makoto Saegusa Masato Nakamura | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 11 | Biodegradation ofbisphenol A and bisphenol F in the rhizosphere sediment ofPhragmites australis显示文摘 | Tadashi Toyama Yusuke Sato Daisuke Inoue | 2009 | Journal of Bioscience andBioengineering2009，108，2： | 1 |
| 12 | Monitoring and mathematical modeling of mitochondrial ATP in myotubes at single-cell level reveals two distinct population with different kinetics显示文摘Backgrounds ATP is the major energy source for myotube contraction,and is quickly produced to compensate ATP consumption and to maintain sufficient ATP level.ATP is consumed mainly in cytoplasm and produced in mitochondria during myotube contraction.To understand the mechanism of ATP homeostasis during myotube contraction,it is essential to monitor mitochondrial ATP at single-cell level,and examine how ATP is produced and consumed in mitochondria.Methods:We established C2C12 cell line stably expressing fluorescent probe of mitochondrial ATP,and induced differentiation into myotubes・We gave electric pulse stimulation to the differentiated myotubes,and measured mitochondrial ATP.We constructed mathematical model of mitochondrial ATP at single-cell level,and analyzed kinetic parameters of ATP production and consumption.Results:We performed hierarchical clustering analysis of time course of mitochondrial ATP,which resulted in two clusters.Cluster 1 showed strong transient increase,whereas cluster 2 showed weak transient increase.Mathematical modeling at single-cell level revealed that the ATP production rate of cluster 1 was larger than that of cluster 2,and that both regulatory pathways of ATP production and consumption of cluster 1 were faster than those of cluster 2.Cluster 1 showed larger mitochondrial mass than cluster 2,suggesting that cluster 1 shows the similar property of slow muscle fibers,and cluster 2 shows the similar property of fast muscle fibers.Conclusions Cluster 1 showed the stronger mitochondrial ATP increase by larger ATP production rate,but not smaller consumption.Cluster 1 might reflect the larger oxidative capacity of slow muscle fiber. | Naoki Matsuda Ken-ichi Hironaka Masashi Fujii Takumi Wada Katsuyuki Kunida Haruki Inoue Miki Eto Daisuke Hoshino Yasuro Furuichi Yasuko Manabe Nobuharu LFujii Hiroyuki Noji Hiromi Imamura Shinya Kuroda | 2020 | Quantitative Biology2020，8，3： | 1 |
| 13 | Biogenic volatile organic compound emission potential of forests and paddy fields in the Kinki region of Japan显示文摘 | Hai Bao Akira Kondo Akikazu Kaga Masaharu Tada Katsutoshi Sakaguti Yoshio Inoue Yoshiyuki Shimoda Daisuke Narumi Takashi Machimura | 2007 | Environmental Research2007，，2： | 1 |
| 14 | Biogenic volatile organic compound emission potential of forests and paddy fields in the Kinki region of Japan显示文摘 | Hai Bao Akira Kondo Akikazu Kaga Masaharu Tada Katsutoshi Sakaguti Yoshio Inoue Yoshiyuki Shimoda Daisuke Narumi Takashi Machimura | 2007 | Environmental Research2007，，2： | 1 |
| 15 | T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma显示文摘 | Moriwaki Atsushi Inoue Hiromasa Nakano Takako Matsunaga Yuko Matsuno Yukiko Matsumoto Takafumi Fukuyama Satoru Kan-o Keiko Matsumoto Koichiro Tsuda-Eguchi Miyuki Nagakubo Daisuke Yoshie Osamu Yoshimura Akihiko Kubo Masato Nakanishi Yoichi | 2011 | American Journal of Respiratory Cell and Molecular Biology2011，，4： | 1 |
| 16 | Fasudil Attenuates Myocardial Fibrosis in Association With Inhibition of Monocyte/Macrophage Infiltration in the Heart of DOCA/Salt Hypertensive Rats显示文摘 | Kazuhiro Ishimaru Hitoshi Ueno Satoshi Kagitani Daisuke Takabayashi Masanobu Takata Hiroshi Inoue | 2007 | Journal of Cardiovascular Pharmacology2007，，2： | 1 |
| 17 | Reduced AP-1-mediated transcription of interleukin-11 gene in marrow stromal cells as a mechanism of senile osteoporosis: lessons from SAMP6显示文摘 | Daisuke Inoue Toshio Matsumoto | 2003 | International Congress Series2003，，： | 1 |
| 18 | CT assessment of breast cancer for pathological involvement of four or more axillary nodes显示文摘 | Ichiro Ogino Yoshibumi Tayama Mito Arai Tomio Inoue Daisuke Shimizu Takashi Ishikawa | 2012 | Breast Cancer2012，，2： | 1 |
| 19 | Driving force and structural strength evaluation of a flexible mechanical system with a hydrostatic skeleton显示文摘The purpose of this study was to build a flexible mechanical system with a hydrostatic skeleton.The main components of this system are two type flexible bags.One is a structural bag with constant inner pressure.The other is an actuator bag with controlled inner pressure.To design the system,it was necessary to estimate both structural deformation and driving force.Numerical analysis of flexible bags,however,is difficult because of large nonlinear deformation.This study analyzed structural strength and driving force of flexible bags with the nonlinear finite element analysis (FEA) software ABAQUS.The stress concentration dependency on the bag shape is described and the driving force is calculated to include the large deformation.From the analytical results,this study derives an empirical equation of driving force.The validity of the equation was confirmed by condition-changed analyses and experimental results. | Daisuke MARUYAMA Hitoshi KIMURA Michihiko KOSEKI Norio INOU | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，4： | 1 |
| 20 | Evaluation of the safety and efficacy of esophagojejunostomy after totally laparoscopic total gastrectomy using a trans-orally inserted anvil: a single-center comparative study显示文摘 | Hiroaki Ito Haruhiro Inoue Noriko Odaka Hitoshi Satodate Manabu Onimaru Haruo Ikeda Daisuke Takayanagi Kenta Nakahara Shin-ei Kudo | 2014 | Surgical Endoscopy2014，，6： | 1 |
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